Articles tagged with Peptides
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists at Lomonosov Moscow State University have identified a peptide complex formed in the brain during early stages of Alzheimer's disease. The complex, stabilized by zinc ions, can be targeted by new compounds to block disease progression.
Researchers at Ulsan National Institute of Science and Technology have developed a novel method to control cellular fate by introducing organelle-localized self-assembly of peptide amphiphiles. This approach enables targeted cancer chemotherapy by activating the intrinsic apoptotic pathway against cancer cells, reducing side effects.
Researchers at Oregon State University have identified a new therapy target for gonorrhea, an enzyme crucial for bacterial respiration in biofilms. A peptide that inhibits this enzyme's activity shows promise in killing the bacteria without promoting resistance.
Scientists at the University of Bath have developed a new molecule that stops breast cancer cells from multiplying in laboratory trials. The method used to create the molecule has potential to be applied to develop new treatments for other cancers and diseases.
Researchers developed two new tools to diagnose systemic sclerosis earlier: nailfold videocapillaroscopy and a blood test detecting SSc-specific autoantibodies. These tools show promise in identifying patients with the characteristic appearance of early SSc patterns, aiding targeted treatment before irreversible damage occurs.
A new study from Harvard Medical School suggests that RNA splicing errors, caused by a specific mutation in the C9ORF72 gene, may lead to the development of both Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD). The researchers found that toxic peptides produced by this mutation can prevent accurate assembly of the...
Scientists have developed a method to tune the optical and electrical properties of synthetic polymer analogs similar to melanin, a natural pigment affecting skin color. The study reveals that adjusting peptide sequences can produce noticeably different colors, ranging from beige to brown-black.
A new method developed by UK scientists makes peptide stapling cheaper and more versatile, allowing for easier manipulation of peptides in drug discovery. The approach enables the constraining, delivering, and unconstraining of peptides, improving their pharmacokinetic properties and potential as drugs.
Researchers at Washington University in St. Louis have developed a method to synthesize ß-lactone peptides, a new class of antibiotics, by copying bacterial enzymes. These peptides inhibit serine hydrolases and may be useful in treating cancer, obesity, and infectious diseases.
A molecule produced by a Thai liver parasite has been found to have the potential to supercharge healing and treat non-healing wounds in diabetics. The researchers have successfully produced a version of the molecule on a large enough scale to conduct laboratory tests, with promising results.
Researchers develop a cost-effective method to produce Aβ42 peptide, a key player in Alzheimer's disease, using isotope labeling and FPLC. This approach simplifies NMR-based structural studies of the peptide, paving the way for deeper understanding of AD.
A mutation in an immune system gene rapidly rose in frequency in Southeast Asia approximately 50,000 years ago, likely conferring protection against leprosy. The HLA-B*46:01 protein binds to molecules derived from the bacterium that causes leprosy, presenting foreign molecules to the immune system and destroying infected cells.
Researchers discovered a dual peptide called PGLP-1 that promotes insulin secretion and inhibits gluconeogenesis, potentially improving glycemic control in type 1 diabetes. It also shows promise in reducing insulin resistance in patients with type 2 diabetes.
Researchers at Hokkaido University developed a novel method combining p53 and BMPep to control nanostructure of inorganic materials. The method successfully created hexagonal silver nanoplates with enhanced specificity and crystal growth regulation.
Researchers investigate the differences between A1 and A2 milk proteins, finding that a specific peptide is present in both types. However, the content of this peptide is higher in A1 milk, suggesting that more research is needed to determine its impact on human health.
Researchers have identified a frog peptide, urumin, that can destroy many strains of human flu and protect mice against infection. The peptide targets the hemagglutinin protein on the virus, destabilizing it and killing it.
Research teams identified two cyclic peptides that can shut down an enzyme long thought to be undruggable for fighting disease-causing parasites and bacteria. The finding could lead to the development of new antimicrobial drugs.
Researchers use bee-venom peptide apamin to develop a novel strategy for delivering medications to the brain. They modified apamin to eliminate toxicity while maintaining its ability to cross the blood-brain barrier, resulting in a promising version called Mini-Ap4.
Researchers from Michigan Medicine have identified a novel strategy to target the genetic anomaly that occurs in half of all prostate cancers. They developed large molecule peptides that can effectively target and degrade the ERG fusion with little impact on regular cell function.
A peptide targeting senescent cells has shown evidence of improving healthspan in naturally-aged mice and mice genetically engineered to rapidly age. The approach reverses age-related loss of fur, poor kidney function, and frailty by blocking the ability of a protein implicated in senescence.
Researchers at Lund University have produced images that predate beta-amyloid plaque formation, contradicting the 'popcorn plaques' theory. The discovery reveals structural changes in the brain and suggests stabilizing beta-amyloid could slow disease progression.
Researchers developed software RODEO to identify clusters of genes indicating an organism's ability to synthesize therapeutically promising molecules. The tool uses machine learning approach to recognize predictive genomic features and has been successfully applied to a class of molecules called lasso peptides.
PSGs are recognized as trophoblast quality and embryo viability markers, with immunomodulatory and anti-inflammatory functions. The discovery of PSG receptors and interactions with integrins suggests new avenues for drug design and therapeutic intervention.
Researchers at Nagoya University identified two peptides, CIF1 and CIF2, that regulate Casparian strip assembly in response to developmental and environmental cues. The study found that these peptides are necessary for the formation and maintenance of the barrier, which helps maintain ion homeostasis and adapt to harsh soil conditions.
Cyst nematodes hijack vascular stem cell pathways to attack their hosts, causing billions of dollars in global crop losses. Understanding the molecular basis of these interactions could lead to new strategies for controlling agricultural pests.
Researchers found a peptide called STAT6-IP can reduce inflammation and 'twitchy' airways in mice infected with RSV. The treatment, administered at neonatal stage, significantly reduced asthma-like responses upon adult re-infection.
Researchers develop a new peptide that suppresses abnormal blood vessel growth and leakage in the eye, causing regression of established vessels. The peptide lasts longer than current treatments, potentially requiring only annual injections instead of monthly ones.
Researchers at Michigan State University have genetically sequenced two species of poisonous mushrooms, discovering that they can produce billions of compounds through one molecular assembly line. This could lead to more efficient synthesis of new compounds for treating lethal diseases.
Scientists from North Carolina State University have successfully isolated and sequenced additional collagen peptides from an 80-million-year-old Brachylophosaurus specimen, lending further support to the idea that organic molecules can persist in fossils for tens of millions of years. The study demonstrates that peptide sequences can ...
Researchers at Scripps Florida have developed a new protease tool to study protein structure and post-translational modifications, which can alter protein stability and function. The new tool helps shed light on these chemical changes and could lead to new tools for mass spectrometry.
Researchers have developed small proteins called peptides that selectively block a certain type of G-protein signaling. These peptides will be used to study this process in cells and develop potential drugs for diseases involving abnormal G-protein signaling, including melanoma.
A new treatment strategy that creates new nerve synapses in the brain may improve recovery after stroke, allowing for faster learning and motor function recovery. The study found sustained improvement in mice treated with C3a peptide, which was administered through nasal drops.
A new study found that sweet potato peptide, produced from the water wasted during processing, helps reduce body weight and fat levels in mice fed high-fat diets. The peptide activates appetite suppression and controls lipid metabolism, suggesting a potential slimming effect.
A study published in ACS Central Science reveals that MAO activity increases with Aβ plaque formation in patients with Alzheimer's, suggesting it could serve as a biomarker for diagnosis and monitoring. The research also identified three distinct phases of MAO activity that change along with disease progression.
Researchers create new sensors that detect proteins and induce blood flow changes, allowing for non-radiative imaging of molecules in the brain. This approach enables detection of biologically low-level molecules and monitoring of dynamic processes in the brain.
Scientists have created peptide probes that attach to proteins with comparable efficiency to antibodies, improving image resolution. These probes can help shed light on protein layout and quantification, opening new possibilities for neurobiological research.
A systematic review found that achieving brain-type natriuretic peptide (BNP) and pro-brain-type natriuretic peptide (NT-proBNP) predischarge thresholds is associated with reduced mortality and readmission in patients hospitalized for acute decompensated heart failure. The evidence was low-strength, but the studies consistently showed ...
A new study reveals an efficient means of attaching lipids to peptides, which can improve the molecules' drug-delivery capabilities. This breakthrough enables peptides to be more druglike, overcoming issues with poor absorption and breakdown.
Researchers have designed small compounds to correct mitochondrial dysfunction in Charcot-Marie-Tooth disease, potentially slowing its progression. The compounds, GoFuse and TetherX, work by targeting the mitofusin 2 protein, which is essential for healthy mitochondria and tissues.
Researchers at St. Jude Children's Research Hospital discovered that toxic peptides from ALS and FTD can incapacitate membrane-less organelles, leading to tissue degeneration. The study provides new insights into the molecular mechanisms of these debilitating diseases.
Long-term clinical data supports the efficacy of PRRT in treating neuroendocrine tumors, improving tumor response rates and progression-free survival. To minimize toxicity, steps such as timing of therapy, patient selection criteria, dose optimization, and adequate monitoring can be taken.
Researchers develop genetically engineered peptides to transmit information between biological systems and synthetic materials, enabling a coherent bioelectronic interface. The discovery enables the creation of biomolecular solid-state devices with potential applications in biomedical and electro-optical devices.
Scientists have created peptide-based materials that can reorganize their sequences to adapt to their environment, paving the way for new product possibilities including drug delivery, food science, and cosmetics. The method allows for unbiased discovery of optimized structures through self-selection.
New research points to relaxin-3 as a potential treatment target for mental illnesses like depression and anxiety. Developments in peptide technology could lead to selectively targeting RXFP3 to develop new class of drugs.
Researchers have discovered a key substance called EPFL2 that creates plant teeth and found out how they work. The peptide inhibits the accumulation of auxin at the skirts of tooth tips, preventing the generation of leaf teeth in plants that are unable to make EPFL2.
Scientists have discovered unique genome variants linked to cancer development, which can be used to detect weaknesses in tumor cells. The new approach uses proteogenomics and mass spectrometry data to identify variant peptides, providing valuable information for gene annotation and potential drug targets.
Researchers at IRB Barcelona have made significant advances in developing shuttle peptides that can transport drugs across the blood-brain barrier. These peptide vectors show promise for treating neurological diseases with improved efficiency and lower side effects.
After major trauma, debris from damaged cell powerhouses triggers an immune response in the kidneys, leading to permanent damage or destruction. Researchers aim to prevent this by understanding how formyl peptide receptors activate the immune system.
An international research team identified a signal peptide required for awn elongation in wild rice and found its dysfunction in cultivated Asian rice. The study suggests human selection pressure led to the loss of this peptide's function, resulting in awnlessness.
A team of Danish researchers has developed a new method for creating artificial proteins by combining oligonucleotides and peptides. This breakthrough could lead to better treatments for diseases like cancer and diabetes, as well as improved control over protein properties.
A European and US research team has successfully determined the structure of the most disease-relevant beta-amyloid peptide 1–42 fibrils at atomic resolution. The findings simplify the targeted search for drugs to treat Alzheimer's dementia, offering hope for a potential cure in the next decade.
A new analytical tool for detecting double-stranded RNA (dsRNA) has been developed, exhibiting sequence-selective fluorescence upon binding. This probe offers a significant improvement over conventional methods by allowing single-base pair resolution and preferential binding to dsRNA over dsDNA.
Researchers have developed iron catalysts that can diversify chiral amino acids into 21 different structures while preserving their handedness. This technology allows for the creation of modified peptides or entirely new structures, expanding the pool of unnatural chiral amino acids available to researchers.
Researchers found that tomatoes can detect a parasitic vine's peptide, triggering an immune response and increased resistance. This discovery could lead to new strategies for mitigating crop losses caused by parasitic plants worldwide.
Researchers explore cyclic opioid peptides with constrained topographical structure, offering improved affinities and selectivities at target receptors. The benefits of cyclization have been enhanced through the generation of polycyclic peptides, promoting increased stability and therapeutic potential for novel therapeutics.
Scientists developed a novel peptide that protects cognitive function after mild traumatic brain injury by reducing inflammation, cell death, and cognitive impairments in mice. The peptide, called TXM-peptide, mimics the antioxidant activity of thioredoxin and inhibits the inflammatory pathway.
Researchers at EMBL-EBI develop an algorithm to cluster peptide mass spectra, identifying 9 million consistently unidentified spectra. This breakthrough simplifies the detection of post-translational modifications and variants, paving the way for more efficient exploitation of proteomics data.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have discovered a peptide sequence that can carry molecules and nanoparticles to acutely damaged areas of the brain, providing a new means of delivering therapeutics for traumatic brain injuries. This technology has the potential to minimize the effects of secondary injur...
Scientists have isolated two small peptides from crop species that show effective antimicrobial effects on bacteria implicated in food spoilage and poisoning. These peptides, similar to a human peptide used to guard against beer-spoiling bacteria, offer a promising new approach to combatting antibiotic resistance.
Researchers at Rice University have created 'missing tooth' hydrogels that can trap and slowly release hydrophobic small-molecule drugs, making them ideal for targeted delivery. The biodegradable gel can be injected where needed and releases medication over time.