Articles tagged with Peptides
Scientists have discovered a beet compound that may help alleviate Alzheimer's symptoms by inhibiting the misfolding of proteins in the brain. The study found that betanin, a compound in beet extract, reduced oxidation of proteins associated with the disease, potentially slowing its progression.
A new bioinformatics analysis method has been developed to study viral infections, revealing over 500 different proteins and peptides, including 200 previously unknown to science. This discovery improves the identification of translation events and opens up new possibilities to understand the effects of viral infections on the organism.
A new biocompatible catalyst selectively oxygenates and degrades amyloid-β peptide under near-infrared light irradiation, reducing its pathogenic properties. The catalyst is applicable for treating peripheral amyloid diseases and Alzheimer's disease.
Researchers discovered that a hydrogel developed by the Rice University lab exhibits significant therapeutic properties, rapidly infiltrating host cells and promoting healing. The hydrogel can be delivered through a syringe and degrades over six weeks, leaving behind healthy tissue.
Researchers at ETH Zurich have made a groundbreaking discovery that protein amyloids can self-replicate, challenging the long-held RNA hypothesis as the origin of life. The findings suggest that early life forms may have used amyloids as information carriers and catalytic units.
Researchers at Technical University of Munich have developed a strategy for designing peptides that can be administered orally, overcoming the major challenge of stability and absorption. This breakthrough simplifies the creation of peptide medications, potentially offering new treatments for various diseases.
Researchers at Joslin Diabetes Center discovered that four viruses can produce insulin-like hormones that bind to human insulin receptors and stimulate cellular signaling. This finding opens up a new field of study in microbial endocrinology, potentially revealing biological mechanisms behind diabetes, autoimmune disease, and cancer.
Researchers have identified the crucial role of peptide uptake in Borrelia burgdorferi's viability and ability to infect mammals. Blocking this process could lead to novel therapeutic interventions for Lyme disease.
Scientists have identified a new family of peptides in wasp venom that can control insect behavior, which may also help develop Parkinson's disease treatments. The peptides, called ampulexins, were found to immobilize cockroaches, and further research aims to identify cellular targets for potential treatment applications.
Researchers at University of Toronto have developed technology for creating durable disease-fighting molecules that can last longer in the body, reducing frequent drug injections. Mirror-image versions of existing drugs, such as GLP1 and PTH, have been created using computational approach, showing longer-lasting effects on cells.
Researchers at the University of Würzburg have discovered how honeybees manage to visit flowers at the right time and communicate this information to other bees. The study found that a specific peptide called PDF plays a central role in regulating circadian clocks, transferring day-night information to brain areas that control complex ...
A Brazilian research team discovered a cellular signaling pathway involved in both the immune response to Zika and neurogenesis, a process of new neuron formation. The study found that peptides from the renin-angiotensin system played a key role in this pathway.
Researchers create virus-like nanoparticles that can detect and process environmental inputs, producing controllable outputs. The modified viruses can display multiple peptides on their surface, enabling efficient delivery of protein- or peptide-based therapeutics to specific cells or tissues.
Researchers at Hong Kong Baptist University have invented multifunctional cyanine compounds that can be used for detection, imaging and treatment of Alzheimer's disease. The discovery has been granted US patents and a Chinese patent.
Researchers at UNICAMP developed a new method to increase the resolution of proteomic analysis by mass spectrometry, identifying 10,390 proteins expressed in oligodendrocytes. This improved resolution enables the study of previously undetectable proteins, potentially leading to novel therapeutic approaches for schizophrenia.
Researchers at Nagoya University and Tsinghua University have analyzed the crystal structure of LURE bound to its receptor protein PRK6, revealing a unique binding scheme that controls pollen tube growth. The study provides insights into the precise mechanism of direction control in fertilization.
Researchers have developed a new method to design ordered peptide macrocycles with high accuracy, solving long-standing problems in peptide therapeutics development. The approach uses natural amino acids and their mirror opposites to improve pharmacological properties and provide a diverse range of shapes.
Researchers at Arizona State University have created a high-throughput technology that can produce up to 1,000 doses of antimicrobial treatments within a week. The system uses synthetic antibodies, or synbodies, which are made from short protein fragments and can be quickly screened against a large number of pathogens.
A metallopeptide has been synthesized to target and disrupt mitochondrial function in breast cancer stem cells, inducing apoptosis. The peptide effectively delivers ROS and impairs mitochondrial metabolism.
Researchers at Goethe University Frankfurt have successfully designed non-ribosomal peptide synthetases to produce completely new natural products. This breakthrough enables the creation of novel therapeutics and peptides with improved yields and modified structures, offering new avenues for biotechnology and drug development.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a peptide that can predict early Alzheimer's disease by recognizing vasculature associated with brain inflammation. The discovery may provide a means of homing drugs to diseased areas of the brain, targeting treatments before amyloid plaques appear.
Researchers from Kumamoto University have created a comprehensive genetic resource collection of plants with knocked out CLE peptides-encoding genes using CRISPR/Cas9 technology. This collection is expected to contribute significantly to future studies on the function of plant peptide hormones.
Scientists discovered a new binding motif that enables positively charged amino acids to bind with negatively charged terminal groups in peptides or proteins. This discovery may help rationalize why certain peptides easily pass through cell membranes and aid in designing efficient transport of drug molecules.
Researchers at the University of Queensland have discovered modified peptides that can enhance plant growth and development. The study, published in Cell Chemical Biology, found that these peptides can regulate root development and increase productivity, leading to improved agricultural sustainability and food security.
Researchers at Scripps Research Institute developed artificial peptide molecules that neutralize a broad range of influenza virus strains. The peptides show high binding affinity and potent ability to neutralize infections with these viruses.
Researchers at Scripps Research Institute (TSRI) have developed a peptide probe that can detect non-native TTR oligomers, potentially leading to early diagnosis and treatment of amyloid diseases. The study revealed higher levels of non-native TTR oligomers in patients with TTR amyloid polyneuropathy.
Researchers from Kumamoto University have identified a new cyclic peptide that facilitates the absorption of biopharmaceutical products in the small intestine. The discovery has significant implications for the development of orally administered drugs, including insulin and other life-saving medications.
Researchers developed a peptide mass fingerprint technique to identify whale species from old baleen samples too degraded for microscopy. The method accurately identified 10 species of whales and helped archaeologists understand which species prehistoric groups hunted and how resources were used.
A study published in Science Signaling reveals that enhanced natriuretic peptide signaling in adipose tissue protects against obesity and insulin resistance. Boosting levels of NPs in adipose tissue may be an important avenue for combating metabolic disease.
A recent study published in the Journal of Virology has pinpointed how a tiny protein speeds up Ebola's contagiousness. The researchers identified that the delta peptide weakens protective membranes in gastrointestinal cells, allowing viruses to enter and wreak havoc.
Researchers have identified a potential method to screen for Zika virus exposure using proteomics in saliva. The study found that specific protein signatures can be detected in the saliva of infected individuals, allowing for earlier detection and treatment of the virus.
Researchers found manmade peptides significantly reduce metastasis in a mouse model of aggressive breast cancer. These peptides directly disrupt the WASF3 gene, which helps cancer cells move and invade other tissues.
Researchers have identified a cyclic peptide that can bind to hair under shampooing conditions, increasing the deposition of fragrance compounds. This results in stronger fragrance smells on hair for up to 24 hours after shampooing.
Scientists at EPFL have developed a new ligand that can extend the half-life of peptide drugs from minutes to several days. The ligand, which is easy to synthesize and has high affinity for human albumin, can be appended to peptides using standard synthesizing techniques.
Scientists at Lomonosov Moscow State University have identified a peptide complex formed in the brain during early stages of Alzheimer's disease. The complex, stabilized by zinc ions, can be targeted by new compounds to block disease progression.
Researchers at Ulsan National Institute of Science and Technology have developed a novel method to control cellular fate by introducing organelle-localized self-assembly of peptide amphiphiles. This approach enables targeted cancer chemotherapy by activating the intrinsic apoptotic pathway against cancer cells, reducing side effects.
Researchers at Oregon State University have identified a new therapy target for gonorrhea, an enzyme crucial for bacterial respiration in biofilms. A peptide that inhibits this enzyme's activity shows promise in killing the bacteria without promoting resistance.
Scientists at the University of Bath have developed a new molecule that stops breast cancer cells from multiplying in laboratory trials. The method used to create the molecule has potential to be applied to develop new treatments for other cancers and diseases.
Researchers developed two new tools to diagnose systemic sclerosis earlier: nailfold videocapillaroscopy and a blood test detecting SSc-specific autoantibodies. These tools show promise in identifying patients with the characteristic appearance of early SSc patterns, aiding targeted treatment before irreversible damage occurs.
A new study from Harvard Medical School suggests that RNA splicing errors, caused by a specific mutation in the C9ORF72 gene, may lead to the development of both Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD). The researchers found that toxic peptides produced by this mutation can prevent accurate assembly of the...
Scientists have developed a method to tune the optical and electrical properties of synthetic polymer analogs similar to melanin, a natural pigment affecting skin color. The study reveals that adjusting peptide sequences can produce noticeably different colors, ranging from beige to brown-black.
A new method developed by UK scientists makes peptide stapling cheaper and more versatile, allowing for easier manipulation of peptides in drug discovery. The approach enables the constraining, delivering, and unconstraining of peptides, improving their pharmacokinetic properties and potential as drugs.
Researchers at Washington University in St. Louis have developed a method to synthesize ß-lactone peptides, a new class of antibiotics, by copying bacterial enzymes. These peptides inhibit serine hydrolases and may be useful in treating cancer, obesity, and infectious diseases.
A molecule produced by a Thai liver parasite has been found to have the potential to supercharge healing and treat non-healing wounds in diabetics. The researchers have successfully produced a version of the molecule on a large enough scale to conduct laboratory tests, with promising results.
Researchers develop a cost-effective method to produce Aβ42 peptide, a key player in Alzheimer's disease, using isotope labeling and FPLC. This approach simplifies NMR-based structural studies of the peptide, paving the way for deeper understanding of AD.
A mutation in an immune system gene rapidly rose in frequency in Southeast Asia approximately 50,000 years ago, likely conferring protection against leprosy. The HLA-B*46:01 protein binds to molecules derived from the bacterium that causes leprosy, presenting foreign molecules to the immune system and destroying infected cells.
Researchers discovered a dual peptide called PGLP-1 that promotes insulin secretion and inhibits gluconeogenesis, potentially improving glycemic control in type 1 diabetes. It also shows promise in reducing insulin resistance in patients with type 2 diabetes.
Researchers at Hokkaido University developed a novel method combining p53 and BMPep to control nanostructure of inorganic materials. The method successfully created hexagonal silver nanoplates with enhanced specificity and crystal growth regulation.
Researchers investigate the differences between A1 and A2 milk proteins, finding that a specific peptide is present in both types. However, the content of this peptide is higher in A1 milk, suggesting that more research is needed to determine its impact on human health.
Researchers have identified a frog peptide, urumin, that can destroy many strains of human flu and protect mice against infection. The peptide targets the hemagglutinin protein on the virus, destabilizing it and killing it.
Research teams identified two cyclic peptides that can shut down an enzyme long thought to be undruggable for fighting disease-causing parasites and bacteria. The finding could lead to the development of new antimicrobial drugs.
Researchers use bee-venom peptide apamin to develop a novel strategy for delivering medications to the brain. They modified apamin to eliminate toxicity while maintaining its ability to cross the blood-brain barrier, resulting in a promising version called Mini-Ap4.
A peptide targeting senescent cells has shown evidence of improving healthspan in naturally-aged mice and mice genetically engineered to rapidly age. The approach reverses age-related loss of fur, poor kidney function, and frailty by blocking the ability of a protein implicated in senescence.
Researchers from Michigan Medicine have identified a novel strategy to target the genetic anomaly that occurs in half of all prostate cancers. They developed large molecule peptides that can effectively target and degrade the ERG fusion with little impact on regular cell function.
Researchers at Lund University have produced images that predate beta-amyloid plaque formation, contradicting the 'popcorn plaques' theory. The discovery reveals structural changes in the brain and suggests stabilizing beta-amyloid could slow disease progression.
Researchers developed software RODEO to identify clusters of genes indicating an organism's ability to synthesize therapeutically promising molecules. The tool uses machine learning approach to recognize predictive genomic features and has been successfully applied to a class of molecules called lasso peptides.
PSGs are recognized as trophoblast quality and embryo viability markers, with immunomodulatory and anti-inflammatory functions. The discovery of PSG receptors and interactions with integrins suggests new avenues for drug design and therapeutic intervention.
Cyst nematodes hijack vascular stem cell pathways to attack their hosts, causing billions of dollars in global crop losses. Understanding the molecular basis of these interactions could lead to new strategies for controlling agricultural pests.
Researchers at Nagoya University identified two peptides, CIF1 and CIF2, that regulate Casparian strip assembly in response to developmental and environmental cues. The study found that these peptides are necessary for the formation and maintenance of the barrier, which helps maintain ion homeostasis and adapt to harsh soil conditions.
Researchers found a peptide called STAT6-IP can reduce inflammation and 'twitchy' airways in mice infected with RSV. The treatment, administered at neonatal stage, significantly reduced asthma-like responses upon adult re-infection.