Articles tagged with Peptides
Researchers discovered that signal peptides can inhibit glutamate receptor trafficking, leading to potentiation of synaptic responses. The study provides new insights into the molecular mechanisms underlying glutamate receptor trafficking and its role in neurological disorders.
Researchers at IRB Barcelona develop peptide shuttle using scorpion venom to transport drugs across blood-brain barrier, improving efficacy for neurological treatments. The miniCTX3 peptide shows great efficiency in carrying compounds of different nature across the BBB.
Research with mice suggests exercise strengthens resolve against drug addiction by changing peptide levels in the brain. Re-exposure to drug-related cues affects exercise and sedentary mice differently.
Scientists at IOCB Prague have discovered a previously unknown passive mechanism by which positively charged short peptides can penetrate cells. This process is based on membrane fusion induced by the transported peptides and shares the same mechanistic basis as known processes in neurons during nerve impulses.
Researchers identify significant impact of genetic diversity on peptide binding to HLA molecules, with implications for understanding HIV elite control and drug hypersensitivity. The study may also aid in the development of personalized vaccines.
A novel technology for profiling protein turnover and degradation has been developed, revealing distinct evidence of a signature pattern in autoimmune disorders. The technique focuses on degraded proteins, providing clues about the state of protein monitoring and potentially leading to better diagnostic techniques.
Scientists have successfully explained the structure and function of docking domains in peptide natural products. This breakthrough allows researchers to redesign docking domain interactions, modulating the product spectrum of a rhabdopeptide-synthesizing NRPS. The discovery has promising implications for creating new substances.
Researchers develop structure-disrupting peptides to target bacterial proteins' structural core, reducing likelihood of resistance development. The study finds promising results in inhibiting multidrug-resistant bacteria growth and treating gonococcal infections.
Researchers have discovered a genetic risk factor for Alzheimer's disease and related dementias, which may lead to new treatments. Humanin, a naturally occurring mitochondrial peptide, decreases with age and is associated with an increased risk of diseases linked to older age.
Researchers at University of Notre Dame discover that T-cell receptors can be more cross-reactive than previously thought, increasing the challenge of developing effective immunotherapies. This finding highlights the need to reassess predictions for building models for therapy and recognizing targets.
Researchers analyzed ant venom from a tropical species and identified over 2,800 venom peptides, including 37 full-length peptide precursors called myrmicitoxins. The peptides showed sequence similarities with those produced by other insects, suggesting they evolved from ancestral genes.
A recent study suggests that specific immune system peptides could influence brain activity and drug cravings, offering a potential partner in the fight against opioid addiction. The research focuses on targeting these peptides to reduce cravings in human patients.
Researchers found that positively charged calcium ions enhance Ti-1 peptide adhesion to titanium surfaces while limiting access for Ti-2 peptide, revealing principles for designing peptides with tunable affinity to titanium applications.
Rutgers researchers discovered a primordial peptide with two types of amino acids and a metal cluster similar to iron-sulfur minerals, suggesting it could have emerged spontaneously on early Earth. The short peptide may have served as a catalyst for life-producing chemistry.
Researchers from Far Eastern Federal University have discovered a new group of Kunitz-type peptides in Heteractis magnifica sea anemones, which exhibit neuroprotective properties. The peptides inhibit the development of inflammations and reduce levels of active oxygen forms that cause cell damage.
Scientists develop peptide hydrogel that stimulates new blood vessel and dental pulp growth in teeth after root canals. The material aims to preserve more of the existing dental pulp and help grow new tissue, making the procedure less invasive.
Researchers have mapped how peptides reduce infection and inflammation by deactivating toxic substances formed in the process. The study reveals that these peptides form a C-shaped structure which enables the capturing and inactivation of lipopolysaccharides, a necessary part of our immune defence system.
Scientists at TUM have discovered a new class of designed macrocyclic peptides that are highly potent inhibitors of amyloid formation, which could be an alternative to current antibody-based approaches. The researchers are now planning further investigations to verify their effectiveness in in vivo models.
Researchers synthesized tetrapeptide PAGY and its analogues using solid phase peptide synthesis, screening their antioxidant properties. The results showed that PSGY exhibited the highest DPPH inhibition activity, while modifications in amino acid sequences increased or decreased antioxidant activity.
Researchers have discovered peptides that can inhibit autophagy in living animals, providing a promising treatment against various diseases. The peptides are derived from giant ankyrins and can be used to occlude autophagy spatiotemporally.
Researchers at the University of British Columbia have created a matchmaking service to pair peptides with antibiotics, increasing treatment success rates against antimicrobial resistant bacteria. Seven combinations were identified that worked better than antibiotics alone, offering up to a 100-fold improvement.
The new molecules are formed by a chain of 7 amino acids, each composed of only two different amino acids. These peptides have numerous applications, including generating electrical nanoconductors and fibrillar mini enzymes capable of acting as catalysts in the formation of organic nanomaterials.
Amyloid peptides prevent CamKII from participating in synaptic plasticity, leading to synapse loss and cognitive deficiencies. Researchers aim to understand the molecular mechanism behind amyloid aggregate interactions with CamKII to develop potential treatments for early Alzheimer's disease.
Researchers have discovered a novel treatment that reduces the deadly immune response triggered by trauma, which can lead to systemic inflammatory response syndrome and sepsis. The drug, deformylase, neutralizes N-formyl peptides released from damaged mitochondria, improving survival rates in animal models.
Researchers developed a peptide-infused dressing that promotes dermal cell adhesion and proliferation, accelerating wound closure and tissue regeneration in diabetic mice. The dressing showed significant benefits compared to control treatments.
Researchers have discovered that beef peptides can block bitter taste receptors on the tongue, potentially leading to improved flavors in food and medicine. The most effective peptides were produced through enzymatic hydrolysis using trypsin and pepsin enzymes.
Beta peptides can self-assemble into robust biomaterials when placed inside other organic molecules. A new study has expanded their capabilities, allowing bioengineers to create more flexible materials for tissue engineering and biomedicine.
A Northwestern-led synthetic biology research team has developed a new biotech technique called GlycoSCORES that promises to accelerate research into protein therapies. The technique uses cell-free protein synthesis, protein glycosylation, and mass spectrometry to rapidly screen sequences for making glycoproteins.
Researchers at EPFL have developed a new peptide format called double-bridged peptides that can bind to any disease target with high affinity and stability. By creating an enormous diversity of peptide architectures, they were able to isolate high-affinity binders to important protein targets, including kallikrein and interleukin-17.
Researchers have designed and synthesized molecules that can interact together to assemble complex molecular structures at the nanoscale. By mimicking biological self-assembly processes, chemists can learn new methods of chemical synthesis for nano/micro-structures.
Researchers successfully created chirality-evolving gold nanoparticles with amino acids and peptides. The new synthesis method enables color modulation by controlling light polarization, paving the way for future displays.
Researchers at La Jolla Institute for Immunology develop a peptide vaccine that induces protective T cells and decreases plaque size in atherosclerotic mice. The vaccine targets the 'bad cholesterol' protein and expands a class of protective T cells, curbing inflammation.
Researchers at the University of Washington have designed a convenient and natural product that uses proteins to rebuild tooth enamel and treat dental cavities. The new technology restores mineral structure found in native tooth enamel, enabling daily use as part of preventive dental care routine.
Researchers at RIKEN Center for Sustainable Resource Science discovered a small hormone, CLE25, that moves from roots to leaves to prevent water loss. The study shows how CLE25 induces ABA synthesis and closes pores in leaf surfaces.
A team of plant geneticists at Cold Spring Harbor Laboratory identified a protein receptor on stem cells that issues different instructions depending on the peptide fragment activating it. This multi-functional receptor has important implications for boosting crop yields, particularly in crops like corn and rice.
Scientists have discovered a beet compound that may help alleviate Alzheimer's symptoms by inhibiting the misfolding of proteins in the brain. The study found that betanin, a compound in beet extract, reduced oxidation of proteins associated with the disease, potentially slowing its progression.
Researchers from Hong Kong University of Science and Technology identified a family of D-stereospecific peptidases (DRPs) that are involved in combating widely-distributed antibiotics. These genes are phylogenetically widespread and pose a significant threat to treating antibiotic-resistant bacteria.
A new bioinformatics analysis method has been developed to study viral infections, revealing over 500 different proteins and peptides, including 200 previously unknown to science. This discovery improves the identification of translation events and opens up new possibilities to understand the effects of viral infections on the organism.
A new biocompatible catalyst selectively oxygenates and degrades amyloid-β peptide under near-infrared light irradiation, reducing its pathogenic properties. The catalyst is applicable for treating peripheral amyloid diseases and Alzheimer's disease.
Researchers discovered that a hydrogel developed by the Rice University lab exhibits significant therapeutic properties, rapidly infiltrating host cells and promoting healing. The hydrogel can be delivered through a syringe and degrades over six weeks, leaving behind healthy tissue.
Researchers at ETH Zurich have made a groundbreaking discovery that protein amyloids can self-replicate, challenging the long-held RNA hypothesis as the origin of life. The findings suggest that early life forms may have used amyloids as information carriers and catalytic units.
Researchers at Technical University of Munich have developed a strategy for designing peptides that can be administered orally, overcoming the major challenge of stability and absorption. This breakthrough simplifies the creation of peptide medications, potentially offering new treatments for various diseases.
Researchers at Joslin Diabetes Center discovered that four viruses can produce insulin-like hormones that bind to human insulin receptors and stimulate cellular signaling. This finding opens up a new field of study in microbial endocrinology, potentially revealing biological mechanisms behind diabetes, autoimmune disease, and cancer.
Researchers have identified the crucial role of peptide uptake in Borrelia burgdorferi's viability and ability to infect mammals. Blocking this process could lead to novel therapeutic interventions for Lyme disease.
Scientists have identified a new family of peptides in wasp venom that can control insect behavior, which may also help develop Parkinson's disease treatments. The peptides, called ampulexins, were found to immobilize cockroaches, and further research aims to identify cellular targets for potential treatment applications.
Researchers at University of Toronto have developed technology for creating durable disease-fighting molecules that can last longer in the body, reducing frequent drug injections. Mirror-image versions of existing drugs, such as GLP1 and PTH, have been created using computational approach, showing longer-lasting effects on cells.
Researchers at the University of Würzburg have discovered how honeybees manage to visit flowers at the right time and communicate this information to other bees. The study found that a specific peptide called PDF plays a central role in regulating circadian clocks, transferring day-night information to brain areas that control complex ...
A Brazilian research team discovered a cellular signaling pathway involved in both the immune response to Zika and neurogenesis, a process of new neuron formation. The study found that peptides from the renin-angiotensin system played a key role in this pathway.
Researchers create virus-like nanoparticles that can detect and process environmental inputs, producing controllable outputs. The modified viruses can display multiple peptides on their surface, enabling efficient delivery of protein- or peptide-based therapeutics to specific cells or tissues.
Researchers at Hong Kong Baptist University have invented multifunctional cyanine compounds that can be used for detection, imaging and treatment of Alzheimer's disease. The discovery has been granted US patents and a Chinese patent.
Researchers at UNICAMP developed a new method to increase the resolution of proteomic analysis by mass spectrometry, identifying 10,390 proteins expressed in oligodendrocytes. This improved resolution enables the study of previously undetectable proteins, potentially leading to novel therapeutic approaches for schizophrenia.
Researchers at Nagoya University and Tsinghua University have analyzed the crystal structure of LURE bound to its receptor protein PRK6, revealing a unique binding scheme that controls pollen tube growth. The study provides insights into the precise mechanism of direction control in fertilization.
Researchers have developed a new method to design ordered peptide macrocycles with high accuracy, solving long-standing problems in peptide therapeutics development. The approach uses natural amino acids and their mirror opposites to improve pharmacological properties and provide a diverse range of shapes.
Researchers at Arizona State University have created a high-throughput technology that can produce up to 1,000 doses of antimicrobial treatments within a week. The system uses synthetic antibodies, or synbodies, which are made from short protein fragments and can be quickly screened against a large number of pathogens.
A metallopeptide has been synthesized to target and disrupt mitochondrial function in breast cancer stem cells, inducing apoptosis. The peptide effectively delivers ROS and impairs mitochondrial metabolism.
Researchers at Goethe University Frankfurt have successfully designed non-ribosomal peptide synthetases to produce completely new natural products. This breakthrough enables the creation of novel therapeutics and peptides with improved yields and modified structures, offering new avenues for biotechnology and drug development.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a peptide that can predict early Alzheimer's disease by recognizing vasculature associated with brain inflammation. The discovery may provide a means of homing drugs to diseased areas of the brain, targeting treatments before amyloid plaques appear.
Researchers from Kumamoto University have created a comprehensive genetic resource collection of plants with knocked out CLE peptides-encoding genes using CRISPR/Cas9 technology. This collection is expected to contribute significantly to future studies on the function of plant peptide hormones.
Scientists discovered a new binding motif that enables positively charged amino acids to bind with negatively charged terminal groups in peptides or proteins. This discovery may help rationalize why certain peptides easily pass through cell membranes and aid in designing efficient transport of drug molecules.
Researchers at the University of Queensland have discovered modified peptides that can enhance plant growth and development. The study, published in Cell Chemical Biology, found that these peptides can regulate root development and increase productivity, leading to improved agricultural sustainability and food security.