Articles tagged with Peptides
Researchers develop a new peptide that suppresses abnormal blood vessel growth and leakage in the eye, causing regression of established vessels. The peptide lasts longer than current treatments, potentially requiring only annual injections instead of monthly ones.
Researchers at Michigan State University have genetically sequenced two species of poisonous mushrooms, discovering that they can produce billions of compounds through one molecular assembly line. This could lead to more efficient synthesis of new compounds for treating lethal diseases.
Scientists from North Carolina State University have successfully isolated and sequenced additional collagen peptides from an 80-million-year-old Brachylophosaurus specimen, lending further support to the idea that organic molecules can persist in fossils for tens of millions of years. The study demonstrates that peptide sequences can ...
Researchers at Scripps Florida have developed a new protease tool to study protein structure and post-translational modifications, which can alter protein stability and function. The new tool helps shed light on these chemical changes and could lead to new tools for mass spectrometry.
Researchers have developed small proteins called peptides that selectively block a certain type of G-protein signaling. These peptides will be used to study this process in cells and develop potential drugs for diseases involving abnormal G-protein signaling, including melanoma.
A new treatment strategy that creates new nerve synapses in the brain may improve recovery after stroke, allowing for faster learning and motor function recovery. The study found sustained improvement in mice treated with C3a peptide, which was administered through nasal drops.
A study published in ACS Central Science reveals that MAO activity increases with Aβ plaque formation in patients with Alzheimer's, suggesting it could serve as a biomarker for diagnosis and monitoring. The research also identified three distinct phases of MAO activity that change along with disease progression.
A new study found that sweet potato peptide, produced from the water wasted during processing, helps reduce body weight and fat levels in mice fed high-fat diets. The peptide activates appetite suppression and controls lipid metabolism, suggesting a potential slimming effect.
Researchers create new sensors that detect proteins and induce blood flow changes, allowing for non-radiative imaging of molecules in the brain. This approach enables detection of biologically low-level molecules and monitoring of dynamic processes in the brain.
Scientists have created peptide probes that attach to proteins with comparable efficiency to antibodies, improving image resolution. These probes can help shed light on protein layout and quantification, opening new possibilities for neurobiological research.
A systematic review found that achieving brain-type natriuretic peptide (BNP) and pro-brain-type natriuretic peptide (NT-proBNP) predischarge thresholds is associated with reduced mortality and readmission in patients hospitalized for acute decompensated heart failure. The evidence was low-strength, but the studies consistently showed ...
A new study reveals an efficient means of attaching lipids to peptides, which can improve the molecules' drug-delivery capabilities. This breakthrough enables peptides to be more druglike, overcoming issues with poor absorption and breakdown.
Researchers have designed small compounds to correct mitochondrial dysfunction in Charcot-Marie-Tooth disease, potentially slowing its progression. The compounds, GoFuse and TetherX, work by targeting the mitofusin 2 protein, which is essential for healthy mitochondria and tissues.
Researchers at St. Jude Children's Research Hospital discovered that toxic peptides from ALS and FTD can incapacitate membrane-less organelles, leading to tissue degeneration. The study provides new insights into the molecular mechanisms of these debilitating diseases.
Long-term clinical data supports the efficacy of PRRT in treating neuroendocrine tumors, improving tumor response rates and progression-free survival. To minimize toxicity, steps such as timing of therapy, patient selection criteria, dose optimization, and adequate monitoring can be taken.
Scientists have created peptide-based materials that can reorganize their sequences to adapt to their environment, paving the way for new product possibilities including drug delivery, food science, and cosmetics. The method allows for unbiased discovery of optimized structures through self-selection.
Researchers develop genetically engineered peptides to transmit information between biological systems and synthetic materials, enabling a coherent bioelectronic interface. The discovery enables the creation of biomolecular solid-state devices with potential applications in biomedical and electro-optical devices.
New research points to relaxin-3 as a potential treatment target for mental illnesses like depression and anxiety. Developments in peptide technology could lead to selectively targeting RXFP3 to develop new class of drugs.
Researchers have discovered a key substance called EPFL2 that creates plant teeth and found out how they work. The peptide inhibits the accumulation of auxin at the skirts of tooth tips, preventing the generation of leaf teeth in plants that are unable to make EPFL2.
Scientists have discovered unique genome variants linked to cancer development, which can be used to detect weaknesses in tumor cells. The new approach uses proteogenomics and mass spectrometry data to identify variant peptides, providing valuable information for gene annotation and potential drug targets.
Researchers at IRB Barcelona have made significant advances in developing shuttle peptides that can transport drugs across the blood-brain barrier. These peptide vectors show promise for treating neurological diseases with improved efficiency and lower side effects.
After major trauma, debris from damaged cell powerhouses triggers an immune response in the kidneys, leading to permanent damage or destruction. Researchers aim to prevent this by understanding how formyl peptide receptors activate the immune system.
An international research team identified a signal peptide required for awn elongation in wild rice and found its dysfunction in cultivated Asian rice. The study suggests human selection pressure led to the loss of this peptide's function, resulting in awnlessness.
A team of Danish researchers has developed a new method for creating artificial proteins by combining oligonucleotides and peptides. This breakthrough could lead to better treatments for diseases like cancer and diabetes, as well as improved control over protein properties.
A European and US research team has successfully determined the structure of the most disease-relevant beta-amyloid peptide 1–42 fibrils at atomic resolution. The findings simplify the targeted search for drugs to treat Alzheimer's dementia, offering hope for a potential cure in the next decade.
A new analytical tool for detecting double-stranded RNA (dsRNA) has been developed, exhibiting sequence-selective fluorescence upon binding. This probe offers a significant improvement over conventional methods by allowing single-base pair resolution and preferential binding to dsRNA over dsDNA.
Researchers have developed iron catalysts that can diversify chiral amino acids into 21 different structures while preserving their handedness. This technology allows for the creation of modified peptides or entirely new structures, expanding the pool of unnatural chiral amino acids available to researchers.
Researchers found that tomatoes can detect a parasitic vine's peptide, triggering an immune response and increased resistance. This discovery could lead to new strategies for mitigating crop losses caused by parasitic plants worldwide.
Researchers explore cyclic opioid peptides with constrained topographical structure, offering improved affinities and selectivities at target receptors. The benefits of cyclization have been enhanced through the generation of polycyclic peptides, promoting increased stability and therapeutic potential for novel therapeutics.
Scientists developed a novel peptide that protects cognitive function after mild traumatic brain injury by reducing inflammation, cell death, and cognitive impairments in mice. The peptide, called TXM-peptide, mimics the antioxidant activity of thioredoxin and inhibits the inflammatory pathway.
Researchers at EMBL-EBI develop an algorithm to cluster peptide mass spectra, identifying 9 million consistently unidentified spectra. This breakthrough simplifies the detection of post-translational modifications and variants, paving the way for more efficient exploitation of proteomics data.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have discovered a peptide sequence that can carry molecules and nanoparticles to acutely damaged areas of the brain, providing a new means of delivering therapeutics for traumatic brain injuries. This technology has the potential to minimize the effects of secondary injur...
Scientists have isolated two small peptides from crop species that show effective antimicrobial effects on bacteria implicated in food spoilage and poisoning. These peptides, similar to a human peptide used to guard against beer-spoiling bacteria, offer a promising new approach to combatting antibiotic resistance.
Researchers at Rice University have created 'missing tooth' hydrogels that can trap and slowly release hydrophobic small-molecule drugs, making them ideal for targeted delivery. The biodegradable gel can be injected where needed and releases medication over time.
Scientists have developed a set of universal protein tags that enable accurate quantification of proteins using targeted proteomics techniques. The new tags, named PQS, are designed to work with selective reaction monitoring (SRM) and eliminate the need for labor-intensive assay development.
Researchers at RIKEN discovered that acrolein can combine with polyamines to form substances that prevent the aggregation of amyloid-beta peptides, a process linked to Alzheimer's disease. The findings suggest that acrolein may have an anti-fibrillation effect, potentially influencing the progression of neurological disorders.
Scientists developed an approach for non-invasive testing of pregnant women with preeclampsia, identifying potential peptide biomarkers in their urine. The study found 35 potential biomarkers associated with the condition's severity.
Researchers reviewed scientific evidence on fermented milk's antihypertensive effects and identified opportunities to develop functional foods based on new lactic acid bacteria. The study found that some strains of Lactobacillus helveticus can reduce blood pressure, but more research is needed to confirm this.
Researchers discovered a new vulnerable site on HIV called the fusion peptide, which has a simpler structure than other sites studied. A broadly neutralizing antibody targeting this site could help prevent HIV infection by binding to key cell-surface molecules.
TP508 has significantly increased survival and delayed mortality when injected up to 24 hours after lethal radiation exposure in controlled preclinical studies. The award brings total NIAID funding to over $6M and allows Chrysalis to complete FDA approval studies.
Researchers investigate the interaction of nucleotide chains with metallic nanoparticles in carbon nanotubes using hybrid molecular dynamics simulation methods. The study highlights the potential of these systems for designing electronic diagnostic tools and drug delivery systems.
Researchers at University of Guelph found that soy isoflavones and peptides can effectively inhibit the growth of certain bacterial pathogens, including Listeria and Pseudomonas. This natural alternative could benefit the food industry by reducing reliance on synthetic additives and addressing growing concerns about antibiotic resistance.
Researchers at the Medical University of South Carolina discovered that the M10 peptide protects against fibrotic damage in a mouse model of ILD and is likely due to its modulation of the TGF-β1 pathway. The anti-fibrotic effects of M10 may also be effective in treating other forms of pulmonary fibrosis.
The novel blood test detects misfolded Amyloid beta peptides in body fluids, revealing potential for early detection of Alzheimer's. The test has achieved high diagnostic precision with a sensitivity of up to 90% and is being further optimized in ongoing studies.
Researchers developed a new imaging technique that uses tagged peptides to track gelatinase activity in stroke patients. This method may lead to better understanding of how to treat strokes and prevent brain damage. The study was published in the Journal of Cerebral Blood Flow and Metabolism.
Researchers at Lomonosov Moscow State University discovered the key trigger of Alzheimer's disease development, involving zinc ions and peptide aggregation. They propose a mechanism for transforming healthy peptides into toxic ones, paving the way for new medicine to block beta-amyloid peptide aggregation.
Researchers convert tarantula toxins into painkillers by targeting neural receptors, providing an alternative to current treatments with limited pain relief and side effects. The study reveals the importance of cell membranes in peptide toxin activity and opens opportunities for designing new drugs.
Researchers are developing longer-lived imaging agents to target soluble oligomers, a potentially neurotoxic form of amyloid beta peptide. This approach may lead to more accurate diagnoses and better understanding of the disease process.
Researchers at the Advanced Science Research Center have developed tunable peptide emulsifiers with biocompatible and biodegradable properties. These peptides can form oil-in-water emulsions with varying stability under different environmental conditions.
Researchers have identified antigens that activate autoreactive T cells in autoimmune diabetes, a potential trigger for the disease. The discovery provides insight into how the immune system is tricked into destroying the body's own beta cells.
Researchers identified hybrid insulin peptides (HIPs) that trigger autoimmune response in T1D patients, prompting immune system to attack insulin-producing cells. These findings may help explain the mystery of why people with T1D are affected by incorrect insulin peptide bonding.
Researchers at IRB Barcelona have synthesized peptides that target the Epidermal Growth Factor (EGF) protein, which accelerates tumour cell growth. These peptides show promise as a potential treatment for cancer, and further studies are underway to develop stronger compounds.
McGill researchers have taken 3D images of a large section from a medicine-synthesizing enzyme in action. The images reveal the intricate way these proteins function and could lead to the development of new antibiotics. This breakthrough may bring scientists closer to understanding how many antibiotics are made.
Researchers at Salk Institute identify nuclear factor kB as a key player in glioblastoma multiforme proliferation. Targeting this protein with NBD peptide or Timp1 gene slows tumor growth and increases mouse survival time, offering potential new treatment avenues.
A study published in the Biophysical Journal reveals a hepatitis C virus-derived peptide that kills a range of viruses while leaving host cells unharmed. The peptide targets cholesterol-rich membranes shared by many viruses, offering a promising strategy for developing new antiviral drugs.
Researchers at Penn State University have developed a system to replicate the formation and dissolution of liquid organelles in a lab setting. By controlling the electrostatic charge of molecules, they were able to create synthetic liquid organelles that can assemble and disassemble in a biologically-reasonable way.
A short peptide, SKY peptide, has been developed by researchers at LMU to inhibit the activation of a signal pathway in monocytes, which enables their adhesion to endothelial cells and penetration into sites of acute inflammation. This can lead to chronic inflammatory reactions and tissue damage.
Researchers at UMass Amherst have identified a key molecule in nitrogen-fixing bacteria that may hold promise for improving crop yields without increasing fertilizer use. The discovery of the 'double agent' peptide could be a key factor in future efforts to improve legume crops and promote sustainable farming practices.
A novel immunotherapeutic approach, personalized peptide vaccination, showed significant improvement in overall survival for patients with advanced bladder cancer. The study found a median overall survival of almost twice as long as that for patients without the treatment, at 7.9 months versus 4.1 months.
Researchers at the University of California, San Diego, have developed a simple way to send peptides into cells and tissues. The new method uses a densely packed brush to protect peptides from digestion and enhance their ability to enter cells without altering their biological function.