Articles tagged with Peptides
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have developed a set of universal protein tags that enable accurate quantification of proteins using targeted proteomics techniques. The new tags, named PQS, are designed to work with selective reaction monitoring (SRM) and eliminate the need for labor-intensive assay development.
Researchers at RIKEN discovered that acrolein can combine with polyamines to form substances that prevent the aggregation of amyloid-beta peptides, a process linked to Alzheimer's disease. The findings suggest that acrolein may have an anti-fibrillation effect, potentially influencing the progression of neurological disorders.
Scientists developed an approach for non-invasive testing of pregnant women with preeclampsia, identifying potential peptide biomarkers in their urine. The study found 35 potential biomarkers associated with the condition's severity.
Researchers reviewed scientific evidence on fermented milk's antihypertensive effects and identified opportunities to develop functional foods based on new lactic acid bacteria. The study found that some strains of Lactobacillus helveticus can reduce blood pressure, but more research is needed to confirm this.
Researchers discovered a new vulnerable site on HIV called the fusion peptide, which has a simpler structure than other sites studied. A broadly neutralizing antibody targeting this site could help prevent HIV infection by binding to key cell-surface molecules.
TP508 has significantly increased survival and delayed mortality when injected up to 24 hours after lethal radiation exposure in controlled preclinical studies. The award brings total NIAID funding to over $6M and allows Chrysalis to complete FDA approval studies.
Researchers investigate the interaction of nucleotide chains with metallic nanoparticles in carbon nanotubes using hybrid molecular dynamics simulation methods. The study highlights the potential of these systems for designing electronic diagnostic tools and drug delivery systems.
Researchers at University of Guelph found that soy isoflavones and peptides can effectively inhibit the growth of certain bacterial pathogens, including Listeria and Pseudomonas. This natural alternative could benefit the food industry by reducing reliance on synthetic additives and addressing growing concerns about antibiotic resistance.
Researchers at the Medical University of South Carolina discovered that the M10 peptide protects against fibrotic damage in a mouse model of ILD and is likely due to its modulation of the TGF-β1 pathway. The anti-fibrotic effects of M10 may also be effective in treating other forms of pulmonary fibrosis.
The novel blood test detects misfolded Amyloid beta peptides in body fluids, revealing potential for early detection of Alzheimer's. The test has achieved high diagnostic precision with a sensitivity of up to 90% and is being further optimized in ongoing studies.
Researchers developed a new imaging technique that uses tagged peptides to track gelatinase activity in stroke patients. This method may lead to better understanding of how to treat strokes and prevent brain damage. The study was published in the Journal of Cerebral Blood Flow and Metabolism.
Researchers at Lomonosov Moscow State University discovered the key trigger of Alzheimer's disease development, involving zinc ions and peptide aggregation. They propose a mechanism for transforming healthy peptides into toxic ones, paving the way for new medicine to block beta-amyloid peptide aggregation.
Researchers convert tarantula toxins into painkillers by targeting neural receptors, providing an alternative to current treatments with limited pain relief and side effects. The study reveals the importance of cell membranes in peptide toxin activity and opens opportunities for designing new drugs.
Researchers are developing longer-lived imaging agents to target soluble oligomers, a potentially neurotoxic form of amyloid beta peptide. This approach may lead to more accurate diagnoses and better understanding of the disease process.
Researchers at the Advanced Science Research Center have developed tunable peptide emulsifiers with biocompatible and biodegradable properties. These peptides can form oil-in-water emulsions with varying stability under different environmental conditions.
Researchers have identified antigens that activate autoreactive T cells in autoimmune diabetes, a potential trigger for the disease. The discovery provides insight into how the immune system is tricked into destroying the body's own beta cells.
Researchers identified hybrid insulin peptides (HIPs) that trigger autoimmune response in T1D patients, prompting immune system to attack insulin-producing cells. These findings may help explain the mystery of why people with T1D are affected by incorrect insulin peptide bonding.
Researchers at IRB Barcelona have synthesized peptides that target the Epidermal Growth Factor (EGF) protein, which accelerates tumour cell growth. These peptides show promise as a potential treatment for cancer, and further studies are underway to develop stronger compounds.
McGill researchers have taken 3D images of a large section from a medicine-synthesizing enzyme in action. The images reveal the intricate way these proteins function and could lead to the development of new antibiotics. This breakthrough may bring scientists closer to understanding how many antibiotics are made.
Researchers at Salk Institute identify nuclear factor kB as a key player in glioblastoma multiforme proliferation. Targeting this protein with NBD peptide or Timp1 gene slows tumor growth and increases mouse survival time, offering potential new treatment avenues.
A study published in the Biophysical Journal reveals a hepatitis C virus-derived peptide that kills a range of viruses while leaving host cells unharmed. The peptide targets cholesterol-rich membranes shared by many viruses, offering a promising strategy for developing new antiviral drugs.
Researchers at Penn State University have developed a system to replicate the formation and dissolution of liquid organelles in a lab setting. By controlling the electrostatic charge of molecules, they were able to create synthetic liquid organelles that can assemble and disassemble in a biologically-reasonable way.
A short peptide, SKY peptide, has been developed by researchers at LMU to inhibit the activation of a signal pathway in monocytes, which enables their adhesion to endothelial cells and penetration into sites of acute inflammation. This can lead to chronic inflammatory reactions and tissue damage.
Researchers at UMass Amherst have identified a key molecule in nitrogen-fixing bacteria that may hold promise for improving crop yields without increasing fertilizer use. The discovery of the 'double agent' peptide could be a key factor in future efforts to improve legume crops and promote sustainable farming practices.
A novel immunotherapeutic approach, personalized peptide vaccination, showed significant improvement in overall survival for patients with advanced bladder cancer. The study found a median overall survival of almost twice as long as that for patients without the treatment, at 7.9 months versus 4.1 months.
Researchers at the University of California, San Diego, have developed a simple way to send peptides into cells and tissues. The new method uses a densely packed brush to protect peptides from digestion and enhance their ability to enter cells without altering their biological function.
Researchers discovered peptides that inhibit metastatic spreading and even lead to regression of existing metastases in pancreatic cancer models. The CD44v6 protein drives the spread of tumor cells, but small segments of the protein can be successfully inhibited by peptides.
Researchers developed a new method that identifies more proteins and peptides in mass spectrometry data, analyzing pairs of overlapping peptide spectra. The method improves performance by up to four-fold, overcoming the bottleneck created by vast amounts of raw data.
Researchers at University of the Pacific have developed a method to significantly extend the lifespan of peptides. By tagging peptides with a compound, they enable it to survive in the bloodstream longer and avoid degradation. This breakthrough technology has the potential to improve peptide therapies for cancer and other diseases.
University of Missouri researchers have created a biodegradable active layer in organic electronics using peptides, enabling full biodegradability. The discovery could significantly reduce electronic waste in landfills and minimize health risks associated with e-waste exposure.
A recent animal study broadens understanding of the flu virus's impact on the immune system, revealing a more dynamic process that engages multiple biological pathways. This research may lead to the development of more effective vaccines against influenza and other viruses.
Researchers at Queen Mary University of London developed a method for self-assembling organic molecules into complex tissue-like structures without moulds or 3D printing. This discovery could enable the engineering of tissues like veins, arteries, or the blood-brain barrier, facilitating disease research and implant development.
Researchers have identified a new protein fragment, amyloid-η, which antagonizes the hyperactive effect of beta-amyloid on nerve cells. This finding has immediate implications for ongoing clinical trials targeting beta-amyloid, suggesting that unanticipated side-effects may occur if eta-amyloid levels increase
Researchers are developing 3D-printed biodegradable polymer scaffolds to accelerate bone growth in head and neck injuries. The technology has the potential to produce mechanically strong replaced bone with minimal inflammation and within a short healing period.
A new peptide drug, TP508, has been shown to significantly increase survival in mice when administered 24 hours after nuclear radiation exposure. The study found that the drug counteracts damage to the gastrointestinal system, delaying mortality and increasing chances of survival.
Researchers found that comet impacts can synthesize peptides, the first building blocks of life, under cold conditions. This suggests that comet impacts played a crucial role in delivering life's seeds to early Earth.
Researchers have developed a new probe that can detect blood clots in any part of the body using positron emission tomography (PET). The probe, called FBP8, contains copper-64 and has shown promise in detecting blood clots in rats, paving the way for future human trials.
Researchers at Toyohashi University of Technology developed new agents to inhibit the production of amyloid-beta peptides, a main cause of Alzheimer's disease. The novel curcumin derivatives were proposed through molecular simulations and shown to bind strongly to amyloid precursor protein.
Researchers have developed a method to increase nitric oxide production in nasal passages, which is linked to chronic sinusitis. The approach involves boosting NO levels using low-molecular-weight peptides that were created from an already-approved drug compound.
University of North Carolina researchers provide evidence that amino acids evolved into proteins, and single cells formed plants and animals. The close linkage between the physical properties of amino acids, genetic code, and protein folding is crucial to life's origins.
Researchers at Princeton University have revealed the structure and biosynthesis of streptide, a peptide involved in bacterial quorum sensing. The study used a combination of chemical and biological approaches to determine the structure of streptide and its mechanism of production.
Scientists at University of California, San Diego School of Medicine demonstrate ability to reprogram large parts of a cell's signaling network by manipulating key hub in communication networks. This approach shows potential to slow or reverse disease progression, including cancer driven by abnormal cell signaling.
A new review of the amyloid-beta peptide, a key component of senile plaques in Alzheimer's disease, has been published in Chemical Reviews. The study combines experimental and theoretical aspects and provides a comprehensive state-of-the-art overview of research on this protein.
Researchers at Tel Aviv University have developed a novel DNA-peptide structure that can be used to produce thin, transparent, and flexible screens. The new material is light, organic, and environmentally friendly, emitting a full range of colors in one pliable pixel layer.
A promising new antivenom derived from opossum serum has shown promise in neutralizing snake venom, with potential for widespread distribution and a single injectable dose. The peptide-based treatment could save thousands of lives worldwide without the side effects of current treatments.
Scientists develop peptide that binds to misshapen α-synuclein protein, stopping toxic fibril formation and brain cell death. The research offers a potential new approach for slowing Parkinson's disease progression.
Researchers at UMBC isolated a peptide that binds strongly to lithium manganese nickel oxide, improving the potential power and stability of electrode materials. The peptides can latch onto nanoscale components, forming a bridge between conductive components and maintaining a connection through multiple charging cycles.
Researchers at Ben Gurion University of the Negev have discovered a promising peptide called humanin that can counteract cell death caused by hypoxia. The peptide's derivatives were tested on neuronal cells and showed successful results, potentially leading to new treatments for necrosis-related diseases.
A team of chemists at IRB Barcelona has developed a shuttle that can cross the blood-brain barrier and transport various substances into the brain, opening up new possibilities for treating diseases such as glioblastoma and Friedreich's Ataxia.
Researchers have identified a peptide called PACAP that reduces food intake and leads to weight loss when administered in the brain's central amygdala. The study suggests PACAP may be a target for medications treating obesity and binge-eating disorders.
Researchers at Oregon Health & Sciences University successfully tested a peptide developed by Case Western Reserve neurosciences professor Jerry Silver, PhD, which showed 100% success in animal models, regenerating nerves into heart attack scar tissue and preventing arrhythmia.
Researchers have developed nanoparticles that can efficiently transport charge-neutral oligonucleotide analogs into cells, enabling them to retain biological activity. This breakthrough delivery approach has the potential to treat various therapeutic targets.
A review on Urotensin II has shown its ability to modulate biologic activities in the cardiovascular system, kidneys, and central nervous system. The peptide can constrict and dilate blood vessels, making it a promising candidate for treating various cardiovascular diseases.
Researchers from North Carolina State University have developed a new technique to bind peptides to gallium nitride surfaces, making them stable even in water and radiation. This breakthrough could lead to the creation of injectable biosensors for detecting specific molecules in biological environments.
In a breakthrough study, researchers at Georgia Institute of Technology have developed a technique to activate biomaterials containing peptide signaling molecules using ultraviolet light. By designing molecular 'hats' that shield the peptides from recognition by cells, they can deliver drugs or particles with their signal in the 'off' ...
Researchers at University of Strathclyde and City University of New York have developed a screening method to accurately predict how peptides can combine to form stable gels. This breakthrough simplifies the discovery of functional gels for various applications, including food, cosmetics, and biomedicine.
Researchers have made breakthroughs in personalized vaccine technology for all types of cancer, using genes expressed in tumors to create tailored vaccines. The approach has shown promise in improving biological responses and disease control.
Researchers have designed peptides to target Ebola's N-trimer protein, allowing for universal inhibition across all known and future strains. This approach enables the selection of effective drugs that block virus entry into cells.
A team of researchers has made a breakthrough in understanding how a powerful antibiotic agent is produced in nature. They found that a special enzyme called dehydratase plays a crucial role in giving the antibiotic its final shape and function.
Researchers discovered that certain peptides undergo a triplet state when exposed to UV light, leading to greater damage than fragmentation. This finding may help develop better UV protection mechanisms.