Articles tagged with Peptides
Researchers have developed two new classes of compounds that target the gamma-secretase enzyme to treat Alzheimer's disease. These compounds produce shorter forms of amyloid peptide 38, which do not aggregate into neurotoxic plaques. Early-onset hereditary forms of Alzheimer's may be linked to mutations in the APP protein gene, leading...
Researchers found that Arg-Phe-amide-related peptide-1 modulates the hypothalamus-pituitary-gonadal axis by inhibiting kisspeptin-activated gonadotropin-releasing hormone neurons. The study also revealed a potential role for gonadotropin-inhibitory hormone in regulating reproductive development.
A study found that collaborative care with brain-type natriuretic peptide (BNP) screening reduced the combined rates of left ventricular systolic dysfunction, diastolic dysfunction, and heart failure. BNP levels above 50 pg/mL identified patients at higher risk for cardiovascular events.
Researchers have synthesized peptides that change shape upon irradiation with light, allowing control of protein-protein interactions and endocytosis. These molecules have immediate applicability for studying cancer cells and developmental biology, paving the way for optopharmacology and personalized medicine.
A study found that diet high in saturated fat increased LD αβ levels, while diet low in saturated fat decreased these fractions. The study suggests that lipidation states of apolipoproteins and amyloid peptides may play a role in AD pathological processes.
A new study found a link between fetal exposure to bisphenol A (BPA) and lower levels of insulin-like peptide 3, a key testicular hormone. This could be a co-factor in the development of cryptorchidism, a common birth defect in boys.
Researchers at Tel Aviv University developed a peptide called NAP that protects and restores microtubule function in brain cells. In animal models with microtubule damage, NAP maintained or revived protein transport, ameliorating neurodegeneration symptoms.
Researchers at Araclon Biotech have developed a blood test to measure beta amyloid peptides, which are associated with Alzheimer's disease. The test shows a high level of association between peptide levels and the disease, suggesting a potential biomarker for early diagnosis.
Researchers at OHSU have discovered a strategy to increase the number of viral peptides that T cells recognize, allowing them to more effectively respond to HIV. The method uses cytomegalovirus (CMV) to generate SIV-specific T cells that can target multiple viral peptides, providing a better targeting system for the immune system.
Researchers have discovered a cell-permeable peptide that reduces nuclear NF-ĸB activity in vascular smooth muscle cells and macrophages of aortic plaques. The peptide also inhibits lesion development in mice with a high-fat diet.
Scientists have engineered a protein from flesh-eating bacteria to act as a molecular 'superglue' that adheres tightly and resists harsh conditions. This technology has potential applications in diagnostic tests for early detection of cancer cells and other diseases, offering new possibilities for medical breakthroughs.
Researchers found that egg white protein peptide RVPSL reduces blood pressure in laboratory rats, comparable to a low dose of Captopril. The study suggests that egg white peptides could become useful as an adjunct to high-blood-pressure medication.
Researchers found that peptides derived from soybean meal inhibit cancer cell growth by up to 73%, making it a potential nutraceutical for reducing colon, liver and lung cancer cell growth. This breakthrough could lead to the development of new cancer treatments.
Researchers genetically engineered tomatoes to produce a peptide that mimics the action of good cholesterol, reducing inflammation and plaque build-up in mice. The study suggests that targeting the small intestine may be a new strategy to prevent diet-induced atherosclerosis.
A recent study by the European Association of Urology has shown promising results for a combined vaccine and steroid drug therapy in treating chemotherapy-naive castration-resistant prostate cancer (CRPC). The therapy, which involves multi-peptide vaccination therapy with low-dose dexamethasone, has been shown to significantly improve ...
Researchers identified a genetic mutation that alters the kinetics of an ion channel in red blood cells, leading to anemia. The defect causes the channel to stay open too long, causing an ion leak and affecting the cell's volume regulation.
Scientists at UCLA discovered a peptide called hypocretin that increases happiness and alertness in humans, while another peptide MCH plays a key role in sleep regulation. The study provides a potential new approach to treating psychiatric disorders like depression.
Harvard researchers show that insulin-like peptides play a crucial role in regulating learning and memory by fine-tuning neuronal activity. The study reveals a bidirectional regulation of learning, with some peptides inhibiting learning while others facilitate it.
Penn researchers create a protein 'passport' that allows nanoparticles to bypass the immune system, facilitating targeted drug delivery and implant device functionality. The innovative approach could improve treatment efficacy by reducing inflammation and prolonging nanoparticle retention.
Researchers synthesized a peptide called Tat-beclin 1, which induces autophagy, a recycling process crucial for cell health. Mice treated with the peptide were resistant to several infectious diseases, including West Nile virus and HIV infection.
Scientists found that people with type 2 diabetes face twice the risk of developing Alzheimer's disease due to peptide deposits. Researchers discovered the molecular interactions between amyloid beta and amylin peptides, which may lead to protein aggregation and disease progression.
Duke University engineers developed a novel delivery system that overcomes the limitations of peptide drugs, which are used to treat diseases like diabetes and cancer. The new system, called POD, uses a fusion protein that releases the drug slowly and steadily, reducing side effects.
Researchers develop small peptide that blocks antibody recognition of desmogleins, improving cell-cell adhesion and preventing skin blistering in mice. The peptide could serve as a potential treatment option for pemphigus vulgaris, a life-threatening autoimmune skin disease.
Researchers found a small peptide that blocks antibody recognition of desmogleins, improving cell-cell adhesion and preventing skin blistering in pemphigus vulgaris. Additionally, spironolactone reduced vascular calcification in kidney disease mice, increasing their life span. A glioblastoma fusion gene promoted tumor growth and progre...
Scientists have developed a pill that breaks down gluten peptides, making it possible for people with celiac disease to consume gluten-containing foods. The enzyme, called KumaMax, has been engineered to break down over 95% of the offending peptides in acidic conditions like those in the stomach.
Researchers discovered an organic compound, D737, that restored motor function and longevity to fruit flies with Alzheimer's disease. The compound prevented protein clumps, a hallmark of the disease, by inhibiting amyloid beta 42 aggregation.
Researchers have engineered natural gut peptides to carry small steroids, improving insulin secretion, blood glucose, and body weight in mice. The study's findings suggest a potential breakthrough in treating type 2 diabetes and metabolic syndrome, with minimal risk of estrogen-related side effects.
Researchers at Queen Mary University of London discovered genes in sea urchins and sea cucumbers that can change collagen elasticity, potentially leading to new ways to keep skin looking young and healthy. The study found peptides that cause rapid stiffening or softening of collagen, which could be used to combat aging-related wrinkles.
Researchers at Kansas State University have designed a membrane-bounded vesicle formed entirely of peptides that can safely deliver drugs to specific cells in the body. The peptide vesicles offer advantages over existing drug delivery systems, such as improved stability and durability.
Researchers found that eliminating an enzyme called jnk3 leads to a 90% reduction in amyloid beta peptides, a hallmark of Alzheimer's disease. This finding suggests jk3 could be a new target for Alzheimer's intervention.
Researchers at Ohio State University discovered that combining two peptide agents with a low-dose chemotherapy drug can delay tumor onset and progression in breast cancer models. The treatments caused few side effects.
A new study found that gastric bypass surgery changes the gut microbiota composition in rats, increasing beneficial bacteria and altering peptide release. This shift resembles prebiotic treatment effects, suggesting a potential link between postsurgical gut modulations and improved metabolic outcomes.
Scientists have engineered a peptide inhibitor to target specific skin proteases, offering potential relief for people with conditions such as eczema and dermatitis. By modifying the binding surface of sunflower trypsin inhibitor, researchers created novel inhibitors that may help restore the skin's original state.
Researchers have mapped the female fruit fly's post-coital behavioral switch using neural circuitry analysis. The study reveals that stimulation of specific neuronal clusters triggers a dramatic change in behavior, influencing both the female's and male's actions.
A hybrid vaccine has demonstrated a 43% reduction in risk of recurrence, with an estimated rate of 10.3% compared to 18% in control group, in patients with varying levels of HER2 expression.
Researchers have designed and tested molecules that can block or enhance aspects of the immune system's activity, offering a potential new treatment for inflammatory diseases. The breakthrough, published in Journal of Medicinal Chemistry, uses a novel optimization-based approach to design peptides with unprecedented potency and precision.
Researchers at Tel Aviv University develop a peptide therapy that mimics DJ-1's normal function, protecting dopamine-producing neurons and reducing mobility dysfunctions. The treatment has shown promising results in pre-clinical trials on mice, indicating a viable option for Parkinson's patients.
UC Davis researchers have discovered novel compounds that disrupt amyloid formation and reduce inflammation in neurons, potentially preventing or delaying Alzheimer's disease damage. The spin-labeled fluorene compounds demonstrate excellent detection of amyloid and anti-inflammatory properties.
Researchers create iPhage particles that penetrate cells using penetratin, targeting specific organelles like mitochondria and ribosomes. They discover a peptide ligand that disrupts ribosomal function, killing cancer cells and reducing cell survival in malignant and non-malignant cells.
Researchers developed a new method to identify antigens that induce autoimmune reactions by generating cells emitting green fluorescent light when stimulated. The technique uses genetic engineering techniques and is highly sensitive, allowing for the analysis of millions of antigens in hours.
Researchers have identified three active variants of a conotoxin that blocks the transmission of pain signals in nerves. These venomous peptides, derived from cone snails, show great promise for developing new painkillers with minimal dependency and faster degradation rates.
Researchers at Mayo Clinic are conducting a study to investigate the potential of a novel snake-venom peptide, cenderitide, to reduce cardiac and renal injury following a heart attack. The therapy may help prevent deterioration of cardiac and renal function in treated patients.
Researchers at Tufts University have combined two peptides to successfully stimulate wound healing. The combination promotes blood vessel growth, tissue re-growth, and cell migration, demonstrating a 50% increase in blood vessel wall development.
Biochemists at TUM have determined the first crystal structure of an immunoproteasome, a specialized protein complex involved in immune defense. The study reveals atomic differences between immunoproteasomes and constitutive proteasomes, enabling the development of new drugs that selectively target the immunoproteasome.
A new study at Sanford-Burnham Medical Research Institute suggests that the heart hormone natriuretic peptides play a role in breaking down fat. The peptides turn on a molecular mechanism similar to what's activated when the body is exposed to cold and burns fat to generate heat.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have identified a cell-permeable peptide that blocks viral replication in liver cancer and cirrhosis. The peptide targets heat shock proteins (HSPs) 40 and 70, which are important factors in hepatitis C virus infection.
Researchers identified a series of synthetic compounds that interfere with the self-assembly of amyloid beta peptides, satisfying an initial condition for Alzheimer's treatment. Disordered peptide structure controls interactions with active compounds.
A Scripps Research Institute study found that an anti-stress peptide can prevent and reverse some cellular effects of acute alcohol and alcohol dependence in animal models. The researchers suggest that drugs derived from this peptide could play a role in treating complex disease.
Researchers have developed a new technique that can identify protein structures in just hours, revolutionizing the pharmaceutical industry. The enhanced NMR spectroscopy method using dynamic nuclear polarisation (DNP) enables significant structural data to be gained from small biological samples.
Researchers at Institut de recherches cliniques de Montreal (IRCM) have discovered therapeutic peptides affecting mitochondria. These compounds target cell mitochondria to treat various acute and chronic diseases, including ischemia reperfusion injury and neurodegenerative conditions.
Researchers have identified two peptides that target an enzyme in cancerous cells, leading to a rise in tumor suppressor protein p53 levels and cell death. The discovery shows promise for new cancer treatments.
Researchers at North Carolina State University and Purdue University have shown that gallium nitride (GaN) is non-toxic and biocompatible, making it a promising material for biomedical implants. The material was found to be stable in environments mimicking the human body and bonded effectively with cells when coated with peptides.
Researchers discovered that A-beta oligomers form calcium-permeable pores in the plasma membrane, inducing excess calcium influx into cells. This influx disrupts synaptic signaling and stimulates cell death, contributing to neurodegeneration associated with Alzheimer's disease.
Biodesign researchers are developing a state-of-the-art pipeline to generate synthetic affinity reagents called 'DNA synbodies' to study protein function and disease. The goal is to create low-cost, high-quality reagents for the entire human proteome, revolutionizing molecular medicine.
A new study found that genetic factors beyond major histocompatibility complex (MHC) molecules play a crucial role in determining the effectiveness of an Alzheimer's vaccine. The findings suggest that vaccines could be designed to prevent neuroinflammatory reactions, improving treatment outcomes for patients.
Scientists at Sanford-Burnham and Salk Institute developed a method to combine peptides and nanoparticles to eliminate glioblastoma in previously untreatable mouse models. The nanosystem proved effective in treating two different mouse models, curing most tumors and significantly delaying tumor development.
Dr. Andrei Yudin's innovative process makes linear peptides circular, increasing their stability and ability to enter cells effectively. A library of macrocycles will be built to test properties and identify potential therapeutic compounds.
Researchers at Northwestern University have discovered a new protein called P21, which acts as a protective barrier against hyperactive immune cells in people with rheumatoid arthritis. By inhibiting the immune cells' destructive rampage, the bouncer molecule halts the disease process, offering a promising new avenue for future therapies.
Masaaki Tamura's team creates a targeted therapy to combat lung cancer by delivering a receptor gene to cancer cells via nanoparticles, stimulating the immune system to prevent tumor growth. The therapy uses a cationic peptide to guide the gene to cancerous cells, offering a non-invasive treatment option for lung cancer patients.
Researchers at Arizona State University have developed a new method for producing antibody-like binding agents, called DNA synbodies, which can be rapidly optimized for high affinity. The technique uses pre-existing ligands to create artificial antibodies capable of detecting diseases, offering a promising alternative to traditional mo...