Articles tagged with Peptides
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have engineered a protein from flesh-eating bacteria to act as a molecular 'superglue' that adheres tightly and resists harsh conditions. This technology has potential applications in diagnostic tests for early detection of cancer cells and other diseases, offering new possibilities for medical breakthroughs.
Researchers found that egg white protein peptide RVPSL reduces blood pressure in laboratory rats, comparable to a low dose of Captopril. The study suggests that egg white peptides could become useful as an adjunct to high-blood-pressure medication.
Researchers found that peptides derived from soybean meal inhibit cancer cell growth by up to 73%, making it a potential nutraceutical for reducing colon, liver and lung cancer cell growth. This breakthrough could lead to the development of new cancer treatments.
Researchers genetically engineered tomatoes to produce a peptide that mimics the action of good cholesterol, reducing inflammation and plaque build-up in mice. The study suggests that targeting the small intestine may be a new strategy to prevent diet-induced atherosclerosis.
A recent study by the European Association of Urology has shown promising results for a combined vaccine and steroid drug therapy in treating chemotherapy-naive castration-resistant prostate cancer (CRPC). The therapy, which involves multi-peptide vaccination therapy with low-dose dexamethasone, has been shown to significantly improve ...
Researchers identified a genetic mutation that alters the kinetics of an ion channel in red blood cells, leading to anemia. The defect causes the channel to stay open too long, causing an ion leak and affecting the cell's volume regulation.
Scientists at UCLA discovered a peptide called hypocretin that increases happiness and alertness in humans, while another peptide MCH plays a key role in sleep regulation. The study provides a potential new approach to treating psychiatric disorders like depression.
Harvard researchers show that insulin-like peptides play a crucial role in regulating learning and memory by fine-tuning neuronal activity. The study reveals a bidirectional regulation of learning, with some peptides inhibiting learning while others facilitate it.
Penn researchers create a protein 'passport' that allows nanoparticles to bypass the immune system, facilitating targeted drug delivery and implant device functionality. The innovative approach could improve treatment efficacy by reducing inflammation and prolonging nanoparticle retention.
Researchers synthesized a peptide called Tat-beclin 1, which induces autophagy, a recycling process crucial for cell health. Mice treated with the peptide were resistant to several infectious diseases, including West Nile virus and HIV infection.
Scientists found that people with type 2 diabetes face twice the risk of developing Alzheimer's disease due to peptide deposits. Researchers discovered the molecular interactions between amyloid beta and amylin peptides, which may lead to protein aggregation and disease progression.
Duke University engineers developed a novel delivery system that overcomes the limitations of peptide drugs, which are used to treat diseases like diabetes and cancer. The new system, called POD, uses a fusion protein that releases the drug slowly and steadily, reducing side effects.
Researchers found a small peptide that blocks antibody recognition of desmogleins, improving cell-cell adhesion and preventing skin blistering in pemphigus vulgaris. Additionally, spironolactone reduced vascular calcification in kidney disease mice, increasing their life span. A glioblastoma fusion gene promoted tumor growth and progre...
Researchers develop small peptide that blocks antibody recognition of desmogleins, improving cell-cell adhesion and preventing skin blistering in mice. The peptide could serve as a potential treatment option for pemphigus vulgaris, a life-threatening autoimmune skin disease.
Scientists have developed a pill that breaks down gluten peptides, making it possible for people with celiac disease to consume gluten-containing foods. The enzyme, called KumaMax, has been engineered to break down over 95% of the offending peptides in acidic conditions like those in the stomach.
Researchers discovered an organic compound, D737, that restored motor function and longevity to fruit flies with Alzheimer's disease. The compound prevented protein clumps, a hallmark of the disease, by inhibiting amyloid beta 42 aggregation.
Researchers have engineered natural gut peptides to carry small steroids, improving insulin secretion, blood glucose, and body weight in mice. The study's findings suggest a potential breakthrough in treating type 2 diabetes and metabolic syndrome, with minimal risk of estrogen-related side effects.
Researchers at Queen Mary University of London discovered genes in sea urchins and sea cucumbers that can change collagen elasticity, potentially leading to new ways to keep skin looking young and healthy. The study found peptides that cause rapid stiffening or softening of collagen, which could be used to combat aging-related wrinkles.
Researchers at Kansas State University have designed a membrane-bounded vesicle formed entirely of peptides that can safely deliver drugs to specific cells in the body. The peptide vesicles offer advantages over existing drug delivery systems, such as improved stability and durability.
Researchers found that eliminating an enzyme called jnk3 leads to a 90% reduction in amyloid beta peptides, a hallmark of Alzheimer's disease. This finding suggests jk3 could be a new target for Alzheimer's intervention.
Researchers at Ohio State University discovered that combining two peptide agents with a low-dose chemotherapy drug can delay tumor onset and progression in breast cancer models. The treatments caused few side effects.
A new study found that gastric bypass surgery changes the gut microbiota composition in rats, increasing beneficial bacteria and altering peptide release. This shift resembles prebiotic treatment effects, suggesting a potential link between postsurgical gut modulations and improved metabolic outcomes.
Scientists have engineered a peptide inhibitor to target specific skin proteases, offering potential relief for people with conditions such as eczema and dermatitis. By modifying the binding surface of sunflower trypsin inhibitor, researchers created novel inhibitors that may help restore the skin's original state.
Researchers have mapped the female fruit fly's post-coital behavioral switch using neural circuitry analysis. The study reveals that stimulation of specific neuronal clusters triggers a dramatic change in behavior, influencing both the female's and male's actions.
A hybrid vaccine has demonstrated a 43% reduction in risk of recurrence, with an estimated rate of 10.3% compared to 18% in control group, in patients with varying levels of HER2 expression.
Researchers have designed and tested molecules that can block or enhance aspects of the immune system's activity, offering a potential new treatment for inflammatory diseases. The breakthrough, published in Journal of Medicinal Chemistry, uses a novel optimization-based approach to design peptides with unprecedented potency and precision.
Researchers at Tel Aviv University develop a peptide therapy that mimics DJ-1's normal function, protecting dopamine-producing neurons and reducing mobility dysfunctions. The treatment has shown promising results in pre-clinical trials on mice, indicating a viable option for Parkinson's patients.
UC Davis researchers have discovered novel compounds that disrupt amyloid formation and reduce inflammation in neurons, potentially preventing or delaying Alzheimer's disease damage. The spin-labeled fluorene compounds demonstrate excellent detection of amyloid and anti-inflammatory properties.
Researchers create iPhage particles that penetrate cells using penetratin, targeting specific organelles like mitochondria and ribosomes. They discover a peptide ligand that disrupts ribosomal function, killing cancer cells and reducing cell survival in malignant and non-malignant cells.
Researchers developed a new method to identify antigens that induce autoimmune reactions by generating cells emitting green fluorescent light when stimulated. The technique uses genetic engineering techniques and is highly sensitive, allowing for the analysis of millions of antigens in hours.
Researchers have identified three active variants of a conotoxin that blocks the transmission of pain signals in nerves. These venomous peptides, derived from cone snails, show great promise for developing new painkillers with minimal dependency and faster degradation rates.
Researchers at Mayo Clinic are conducting a study to investigate the potential of a novel snake-venom peptide, cenderitide, to reduce cardiac and renal injury following a heart attack. The therapy may help prevent deterioration of cardiac and renal function in treated patients.
Researchers at Tufts University have combined two peptides to successfully stimulate wound healing. The combination promotes blood vessel growth, tissue re-growth, and cell migration, demonstrating a 50% increase in blood vessel wall development.
Biochemists at TUM have determined the first crystal structure of an immunoproteasome, a specialized protein complex involved in immune defense. The study reveals atomic differences between immunoproteasomes and constitutive proteasomes, enabling the development of new drugs that selectively target the immunoproteasome.
A new study at Sanford-Burnham Medical Research Institute suggests that the heart hormone natriuretic peptides play a role in breaking down fat. The peptides turn on a molecular mechanism similar to what's activated when the body is exposed to cold and burns fat to generate heat.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have identified a cell-permeable peptide that blocks viral replication in liver cancer and cirrhosis. The peptide targets heat shock proteins (HSPs) 40 and 70, which are important factors in hepatitis C virus infection.
Researchers identified a series of synthetic compounds that interfere with the self-assembly of amyloid beta peptides, satisfying an initial condition for Alzheimer's treatment. Disordered peptide structure controls interactions with active compounds.
A Scripps Research Institute study found that an anti-stress peptide can prevent and reverse some cellular effects of acute alcohol and alcohol dependence in animal models. The researchers suggest that drugs derived from this peptide could play a role in treating complex disease.
Researchers have developed a new technique that can identify protein structures in just hours, revolutionizing the pharmaceutical industry. The enhanced NMR spectroscopy method using dynamic nuclear polarisation (DNP) enables significant structural data to be gained from small biological samples.
Researchers at Institut de recherches cliniques de Montreal (IRCM) have discovered therapeutic peptides affecting mitochondria. These compounds target cell mitochondria to treat various acute and chronic diseases, including ischemia reperfusion injury and neurodegenerative conditions.
Researchers have identified two peptides that target an enzyme in cancerous cells, leading to a rise in tumor suppressor protein p53 levels and cell death. The discovery shows promise for new cancer treatments.
Biodesign researchers are developing a state-of-the-art pipeline to generate synthetic affinity reagents called 'DNA synbodies' to study protein function and disease. The goal is to create low-cost, high-quality reagents for the entire human proteome, revolutionizing molecular medicine.
Researchers at North Carolina State University and Purdue University have shown that gallium nitride (GaN) is non-toxic and biocompatible, making it a promising material for biomedical implants. The material was found to be stable in environments mimicking the human body and bonded effectively with cells when coated with peptides.
Researchers discovered that A-beta oligomers form calcium-permeable pores in the plasma membrane, inducing excess calcium influx into cells. This influx disrupts synaptic signaling and stimulates cell death, contributing to neurodegeneration associated with Alzheimer's disease.
A new study found that genetic factors beyond major histocompatibility complex (MHC) molecules play a crucial role in determining the effectiveness of an Alzheimer's vaccine. The findings suggest that vaccines could be designed to prevent neuroinflammatory reactions, improving treatment outcomes for patients.
Scientists at Sanford-Burnham and Salk Institute developed a method to combine peptides and nanoparticles to eliminate glioblastoma in previously untreatable mouse models. The nanosystem proved effective in treating two different mouse models, curing most tumors and significantly delaying tumor development.
Dr. Andrei Yudin's innovative process makes linear peptides circular, increasing their stability and ability to enter cells effectively. A library of macrocycles will be built to test properties and identify potential therapeutic compounds.
Researchers at Northwestern University have discovered a new protein called P21, which acts as a protective barrier against hyperactive immune cells in people with rheumatoid arthritis. By inhibiting the immune cells' destructive rampage, the bouncer molecule halts the disease process, offering a promising new avenue for future therapies.
Masaaki Tamura's team creates a targeted therapy to combat lung cancer by delivering a receptor gene to cancer cells via nanoparticles, stimulating the immune system to prevent tumor growth. The therapy uses a cationic peptide to guide the gene to cancerous cells, offering a non-invasive treatment option for lung cancer patients.
Researchers at Arizona State University have developed a new method for producing antibody-like binding agents, called DNA synbodies, which can be rapidly optimized for high affinity. The technique uses pre-existing ligands to create artificial antibodies capable of detecting diseases, offering a promising alternative to traditional mo...
Researchers found that seaweed proteins can reduce blood pressure like ACE inhibitor drugs, and the macroalgae have potential to be used in functional foods. The variety of species and ease of cultivation make them a relatively untapped source of new bioactive compounds.
Researchers at Penn Vet found a cancer drug that shrinks dog tumors and may lead to human treatment. The study discovered the same aberrant activation of a critical pathway in dogs with lymphoma as humans.
A previously understudied amyloid peptide, A-beta-43, is more abundant and neurotoxic than previously studied peptides in promoting Alzheimer's disease. The findings suggest a potential role for A-beta-43 as a biomarker for diagnosis and a new approach for preventing AD-causing amyloidosis.
A new near-infrared fluorescence agent has been developed to detect deep vein thrombosis, a potentially deadly cardiovascular disease. The agent uses a biomarker that targets fibrin, a protein involved in blood clot formation, and has shown high-resolution imaging capabilities in phase II clinical trials.
Researchers at Indiana University School of Medicine have discovered a peptide, CBD3, that short circuits a pathway for chronic pain without debilitating side effects. The peptide has been shown to block pain signals by interfering with calcium channels, making it potentially safer than addictive opioids or cone snail toxin.
Researchers at Scripps Research Institute found a way to disrupt a critical enzyme interaction that prevents cell death, potentially leading to new treatments for heart attack and stroke. The discovery could provide a new therapeutic target against conditions including neurodegenerative diseases like Parkinson's.
The FASEB MARC Program has awarded 3 travel grants totaling $4,950 to support underrepresented minority students and postdoctorates at the 22nd American Peptide Symposium. The program aims to increase diversity in biomedical research by promoting participation of young scientists from underrepresented groups.
Researchers at the Ragon Institute identified variations in peptide stability that alter targeting of infected cells by CD8 T cells. The study found that specific mutations can reduce peptide stability, impairing immune response and increasing HIV resistance.
Researchers at the University of Strathclyde have developed a new technique that can detect Alzheimer's disease earlier than current methods. This approach uses fluorescence signals to identify clusters of peptide associated with the disease, allowing for potential treatment development and screening patients without needles or wires.
Researchers at Arizona State University have developed a superior method for immobilizing enzymes on surfaces, enabling precise control over their orientation. This technique uses high-affinity peptides to covalently bind enzymes, increasing efficiency and stability.