Proteasomal Degradation

A new experimental strategy enables the elimination of proteins involved in pathological processes

A new experimental strategy enables the forced elimination of proteins that help tumors survive chemotherapy, potentially overcoming cancer treatment resistance. The approach involves delivering proteins directly to the proteasome, bypassing the tagging step, and has shown promise in tests carried out in cancer cells.

SourceSpanish National Research Council (CSIC)·JournalNature Communications·TypeNews article·DateMay 6, 2026

Novel discovery reveals how brain protein OTULIN controls tau expression and could transform Alzheimer's treatment

Researchers discovered that brain enzyme OTULIN regulates tau protein accumulation and has implications for treating neurodegenerative diseases. The study revealed OTULIN's role in controlling gene expression and RNA metabolism, suggesting a potential therapeutic target.

SourceGenomic Press·JournalGenomic Psychiatry·TypeExperimental study·DateNov 25, 2025

Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)

Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.

New immune mechanism revealed in the cellular trash

A new study from Weizmann Institute of Science reveals an immune mechanism involving proteasome products, which can kill bacteria and offer a promising treatment for infections. The researchers discovered that certain peptides produced by the proteasome have antibacterial properties and can be used to develop personalized treatments.

SourceWeizmann Institute of Science·JournalNature·DateMar 10, 2025

How to build our body’s protein recycling factories

Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell's recycling process for obsolete and misshapen proteins—known as proteasomes—are formed. The research team shed new light on how two protein chaperones bind on the top of the alpha subunit ring as it is constructed.

SourceSanford Burnham Prebys·JournalNature Communications·TypeExperimental study·DateSep 26, 2024

From mutation to arrhythmia: desmosomal protein breakdown as an underlying mechanism of cardiac disease

Researchers found that a plakophilin-2 mutation leads to increased desmosomal protein degradation in ACM hearts, causing structural and functional changes. Studying human heart samples and mice models confirmed the role of protein degradation in ACM development.

SourceHubrecht Institute·JournalScience Translational Medicine·TypeExperimental study·DateMar 22, 2023

Apple AirPods Pro (2nd Generation, USB-C)

Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.