Articles tagged with Protein Analysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that Alzheimer's protein APP is related to the production of neurotransmitters and can curb their creation. The study suggests a new mechanism by which abnormal APP deposits in Alzheimer's patients disrupt nerve cell signaling.
Researchers from Helmholtz Centre for Environmental Research identified three teams of bacteria working together to degrade benzene, a highly toxic substance. By analyzing proteins, they shed light on the complex process, which could also apply to other bacterial cooperatives.
Scientists have assembled a massive catalogue of protein data using a new method, providing unprecedented insight into protein phosphorylation. This understanding brings researchers closer to unraveling the mechanisms of disease.
The study used proteomic techniques to analyze the effects of grafted methoxypoly(ethylene glycol) on plasma protein adsorption. Results showed that the polymer-mediated surface camouflage prevented immune recognition signals, enhancing biocompatibility and reducing alloimmunization.
Scientists at the University of Liverpool have developed a method to detect proteins associated with longevity, finding that certain proteins evolve in non-random ways in long-lived species. This suggests that these species have optimised pathways for repairing molecular damage, which could help develop anti-ageing interventions.
Researchers at Uppsala University have identified potential biomarkers for autism spectrum disorder using advanced mass spectrometry. The study found disruptions in the nervous system and a connection between protein C3 and ASD, which may lead to a reliable blood-based diagnostic tool.
A new method of monitoring protein molecules using gold nanoparticles has been developed by scientists at Johannes Gutenberg University Mainz. The technique allows for the detection of individual unlabeled proteins, providing insights into molecular processes and dynamics.
Researchers at NYU Tandon School of Engineering have developed a new method for creating nanofibers made of proteins that could improve drug delivery methods for treating cancers, heart disorders, and Alzheimer's disease. The fibers can also be used to regenerate human tissue, bone, and cartilage.
Manan Mehta developed a method to create circularly permuted proteins, which are useful for studying molecular evolution and designing biosensors. The new technique uses transposase engineering to create diverse protein variants with great control.
A recent study published in the Journal of Agriculture and Food Chemistry has evaluated a new method for determining protein quality. Soy protein was found to be a high-quality protein with a PDCAAS score of 1.00, comparable to animal-based proteins like eggs, dairy, and meat.
A team at Northwestern University has developed a new method to identify thousands of protein molecules quickly, which could lead to the discovery of biomarkers and early disease detection. The approach, known as top-down proteomics, measures proteins intact instead of breaking them down into smaller parts.
Researchers use yeast, worms, and rats to study the effects of amyloid beta peptide misfolding on cellular pathways. The study reveals a crucial link between protein misfolding and Alzheimer's disease, highlighting potential new avenues for understanding and combating the disorder.
Researchers have discovered that hemoglobin interacts with HbA1 within living red blood cells, affecting the condition of patients with thalassemia and other diseases. The study also found a positive correlation between blood sugar levels and multiband re-release of Hbs from RBCs in diabetic individuals.
Researchers use Photo Activated Localization Microscopy (PALM) to accurately count proteins on the cell surface, gaining insight into their interactions and evolution. This technique may help develop more effective drugs by understanding how cells react to external agents.
Researchers have uncovered the detailed dynamics of the Epac2 protein switch, which plays a critical role in cAMP-mediated cell signaling. This finding holds promise for developing new therapeutic strategies specifically targeting this pathway to combat diseases like diabetes and cancer.
Researchers have created a method to detect protein oligomers, small toxic aggregations that can initiate amyloid fiber formation in neurodegenerative diseases. The test uses fluorescence techniques and genetically modified yeast to locate and monitor oligomer formations.
Researchers at University of Michigan and University of California, Irvine discover DNA's building blocks 'rock and roll,' forming alternative structures with Hoogsteen base pairs. These fleeting states contain new layers of information stored in the genetic code, shedding light on critical interactions between DNA and proteins.
Researchers have created a new method for rapidly producing protein-polymers using overlap-extension rolling circle amplification. This technique allows for the synthesis of large libraries of proteins with subtle differences, which can be used to rapidly screen new combinations and develop new classes of protein-based polymers.
Researchers at IRB Barcelona discovered 200 new protein interactions that could be linked to Alzheimer's disease, bringing the total number of interactions to 6000. The study reveals new molecular mechanisms, including oxidative stress and inflammation, which may play a role in the development of the disease.
A CCNY professor has received a $1.3 million grant to develop an artificial blood substitute that can be administered to injured troops on the battlefield. The artificial hemoglobin binds oxygen in the presence of carbon monoxide, potentially preventing or treating carbon monoxide poisoning.
Researchers at Delft University of Technology and Oxford University have developed a new, more robust type of nanopore device that combines biological and artificial building blocks. This technology has the potential to revolutionize DNA analysis by making it faster and cheaper.
Researchers created a new method called BLINC to directly observe protein-protein interactions in live brain cells. They found that synaptic activity affects the growth of a complex that mediates signaling into neurons, leading to excitatory synapse maturation.
The Biophysical Society has recognized eight individuals with its 2011 awards for their significant contributions to the field of biophysics. The awardees include researchers who have made pioneering discoveries using NMR methods, membrane protein biochemistry, and single molecule fluorescence microscopy.
Researchers at Max-Planck-Gesellschaft successfully integrated three synthetic amino acids into a single protein, allowing for systematic improvement of existing protein qualities. This breakthrough has significant implications for industry and science, enabling the creation of new biological features and tailored proteins with novel p...
Researchers discovered a small group of genes in fruit flies that likely play important roles in regulating the formation of plaque-like protein aggregates within cells. The identified genes have human counterparts and may be manipulated to stop or slow the formation of these aggregates, which are a hallmark of Huntington's disease.
A new blood test has been found to identify patients with advanced non-small-cell lung cancer who are more likely to respond to erlotinib treatment. The test, which analyzes specific 'fingerprints' of a protein called EGFR, showed a significant response rate in patients with good proteomic profiles compared to those with poor profiles.
Scientists at TUM developed a novel biosensor chip that can detect specific proteins with high sensitivity, enabling early disease diagnosis. The chip can analyze multiple parameters, including protein concentration and alterations caused by diseases or medications.
Scientists at the University of Delaware have developed a new method for producing ubiquitylated proteins, which may hold the key to understanding cancer cell resistance to drugs and other diseases. The new approach combines intein chemistry and disulfide crosslinking to yield hundredsfold more proteins than current methods.
Researchers developed a new approach to quantify the influence of microRNAs on protein production, discovering that a single microRNA can regulate hundreds of proteins.
Researchers found that mouse Bloom's syndrome protein is involved in proper homologous chromosome pairing and segregation during meiosis. The protein also plays a role in synapsis without affecting the entry into prophase I stage.
A new technique called Fast Relaxation Imaging enables real-time observation of protein folding and unfolding in living cells. The method reveals that proteins are more stable and their thermal denaturation is more gradual in a cellular environment compared to an in vitro setting.
Researchers have developed a barley protein concentrate that can meet the protein needs of trout and other commercially produced fish, potentially replacing fishmeal and soy protein concentrate. The concentrate is produced through an enzymatic method and has been shown to be effective in feeding trials.
A team of University of Chicago scientists has developed a new micro-western array technology that enables the examination of hundreds of proteins simultaneously. This breakthrough may lead to more precise diagnoses and individualized treatments for cancers and other diseases.
The Pacific Northwest National Laboratory (PNNL) has been recognized for its partnerships with outside companies to develop new technologies. The lab's partnership with Pressure BioSciences led to the development of a pressurized process that quickly digests proteins, speeding up protein analysis by minutes. Additionally, PNNL partnere...
Researchers developed a universal method to analyze complex networks, including social networks, protein-protein interactions, and air transportation networks. The method accurately predicts missing and spurious connections by averaging all possible groupings of nodes, giving each grouping a weight that reflects its explanatory power.
Researchers at Stanford University developed a new magnetic-nano sensor chip that can detect cancer-associated proteins with high accuracy and search for up to 64 different proteins simultaneously. The sensor is up to 1,000 times more sensitive than current methods and can detect biomarkers in bodily fluids with low concentrations.
Researchers at Duke University have developed a new approach to attach polymers to proteins, improving their circulation and efficacy in animal models. The new conjugates showed longer half-lives and remained active for up to 18 hours, potentially reducing toxic effects.
Researchers compare two methods for studying protein folding: atomic force microscopy and chemical denaturant method. Both approaches reveal similarities in protein behavior, offering new insights into the forces that shape proteins.
An international collaboration has made identifying crucial proteins in diseases easier through improved protein analysis. The study, published in Nature Methods, reveals potential bottlenecks in current analysis techniques and highlights the importance of accurate reporting.
Researchers at Burnham Institute have developed a novel method to analyze the proteome of yeast, identifying 4,600 proteins. This breakthrough can lead to the discovery of new biomarkers for diseases and inform protein expression changes in response to stimuli.
Researchers at University of Copenhagen have developed a general method to study membrane proteins, reducing the development time for useful drugs substantially. The method uses amphipols to immobilize membrane proteins on surfaces, allowing for faster and more accurate testing.
Yale researchers identified proteins associated with early onset neonatal sepsis, a stealthy bacterial infection linked to premature birth and death. The biomarkers found have diagnostic value for infection and inflammation, allowing for earlier identification of babies at risk.
A team of Johns Hopkins biochemists identified five key proteins that may form the basis of an accurate early warning test for impending heart attacks. The test could provide advance warning to paramedics and physicians during the critical window before ischemia causes substantial heart tissue damage, allowing for urgent treatment to p...
A recent study published in Molecular and Cellular Proteomics has identified key proteins in sperm cells that are associated with male infertility. The research suggests that these protein biomarkers could be used to develop sensitive diagnostic tools and effective therapies, ultimately helping couples have a baby.
Scientists have developed a new imaging technique that enables the identification of proteins in cells by analyzing their energy flow. This technique, known as coherent two-dimensional infrared spectroscopy (2DIR), has been successfully tested in laboratory experiments and holds promise for improving protein analysis and discovery.
A team of researchers has developed a method to separate parasitic organisms from their host cells using fluorescent proteins, allowing for more detailed studies. The approach yielded the identification of 509 proteins in the parasites, providing valuable characteristics such as fatty acid degrading enzymes.
Researchers have successfully created new strains of infectious proteins called prions by mixing infectious prions from one species with normal prion proteins from another. This breakthrough could provide insight into the risk of prion diseases spreading between species and has significant implications for public health.
Researchers at Penn State have developed a computational method to trace evolutionary histories of proteins back to cells or viruses, aiming to settle the debate on which came first. The new approach uses phylogenetic profiles and tree-like diagrams to provide clearer insights into retroelement evolution.
Scientists have successfully detected changes in protein-water networks during protein folding using terahertz absorption spectroscopy. This technique allows for the observation of protein dynamics on a picosecond time scale, revealing new insights into the complex interactions between proteins and water molecules.
Researchers develop powerful tool for investigating gene function using siRNA and lentiviral vectors. The method enables long-term down-regulation of specific target genes in various cell types, facilitating cancer cell biology studies.
Researchers have developed a haplotype map of the human genome to study genetic diseases. The Cold Spring Harbor Protocols journal provides step-by-step instructions for analyzing HapMap data using tools like the Genome Browser and DDDP methods.
A new study found that elderly men with higher IGF-1 bioactivity have a significantly lower mortality rate compared to those with low bioactivity. The researchers used a new method to measure IGF-1 function, which revealed the association between high circulating IGF-1 bioactivity and extended survival.
Researchers at Carnegie Mellon University have developed a software toolbox that can automatically analyze protein patterns in human tissues. This tool can help identify biomarkers useful for cancer diagnosis and therapy, enabling a better understanding of how cells work and advancing disease detection.
Researchers developed a nano-bio-chip device that analyzes saliva to detect proteins associated with heart attack, offering a non-invasive and rapid diagnostic tool. The test can identify current heart attacks and predict future risk, potentially saving lives and preventing damage from cardiac disease.
Researchers at Uppsala University found that protein signal transfer may occur within small proteins, contradicting a previous study using statistical methods. Experiments showed nearby parts of the protein interact more than distant parts.
Researchers at the Wellcome Trust Sanger Institute have developed a novel method to identify weak and transient protein interactions. By analyzing over 6000 experiments in mammalian cells, they discovered 17 new pairs of interactions that could lead to novel therapeutic opportunities for diseases such as cancer, diabetes, and growth.
Researchers at UTMB have identified distinct subtypes of asthma using protein profiling, which could lead to tailored treatments. The study found four different asthma subtypes, including one associated with severe and treatment-resistant disease, offering new hope for more effective asthma therapies.
Cold Spring Harbor Protocols features methods to observe protein dynamics, including inserting lac operator sequences into mammalian cells and performing immunohistochemistry in whole mouse embryos. These techniques allow researchers to examine chromatin structure and protein activity during replication and transcription.
A Canadian research team uses IBM's World Community Grid to accelerate the analysis of cancer research data, unlocking insights into protein function and potential cancer-fighting drugs. With over 86 million images of proteins captured in 14.5 million experiments, this initiative aims to improve cancer diagnosis and treatment.
Researchers at UMass Medical School have identified a new pathway for cancer cell growth and survival, providing a blueprint for the design of novel anticancer agents. The study found that targeting the Hsp90 chaperone in the mitochondria can induce massive tumor cell death while sparing normal cells.