Articles tagged with Protein Analysis
Researchers used protein sequence-based methods to diagnose an ancient and atypical form of Paget's disease in medieval skeletons. The study found extensive pathological changes, high disease prevalence, and low age-at-death estimations for affected skeletons.
Two studies analyze the adhesive properties of the Dusky Arion slug's defensive glue, identifying key proteins and structures that contribute to its strength and flexibility. Insights gained could lead to the development of organic synthetic adhesives with reduced risk of complications.
A team of international scientists used big data analysis to study how neurons communicate with each other in the brain, identifying patterns related to memory and discovering major proteins responsible for changes observed in neurons.
Researchers report an assay that uses cell-free DNA mutations and protein biomarkers to detect hepatocellular carcinoma in asymptomatic individuals. In a sample of 331 hepatitis B virus-infected individuals, the assay correctly identified 17% who had liver cancer without symptoms.
Researchers have developed an RNA-guided endonuclease - in situ labelling (RGEN-ISL) method that preserves chromatin intact and allows real-time visualization of DNA-labelling. This new tool outperforms conventional methods, enabling investigation of genome structure and function.
A team of researchers from Germany has successfully developed a new method for creating wound-healing tissue scaffolds using plasma protein. The scaffold can be attached or detached from a surface and retains the properties of the protein, making it suitable for various biomedical applications such as blood coagulation and drug screening.
The Proteomic Skin Atlas maps human skin molecules and functions, shedding light on skin diseases like psoriasis and eczema. Researchers hope to accelerate research and develop new treatments for the 3,000 known skin diseases.
Researchers have developed a simplified method for cell-free protein synthesis, allowing for faster, cheaper, and more flexible production of proteins in a test tube. This technique enables researchers to harness the genetic code directly, providing new opportunities for pharmaceutical and genetic research.
Researchers have discovered a squid protein that can be processed into fibers and films for applications in health monitoring, self-healing recyclable fabrics and sustainable textiles. The protein's unique properties make it an eco-friendly alternative to plastics.
A new technique developed at Purdue University could lead to faster and more accurate detection of cancer cells in patient blood samples. The method uses near-infrared spectroscopy to analyze proteins expressed on cancer cells, enabling early diagnosis and potentially improving outcomes.
Researchers found that clusterin protein is strongly related to insulin resistance, increased cardiovascular disease risk, and high blood pressure in obese patients. The study also linked clusterin to fatty liver disease and mortality.
A University of Illinois study developed an algorithm to predict both end-of-season yield and grain composition by analyzing weather patterns during three critical periods in corn development. The predictions apply to the entire Midwest corn crop and could influence global markets for animal feed applications.
Recent advances in computational methods enhance the accuracy and reproducibility of label-free quantification (LFQ) in cancer proteomics, enabling discovery of anti-cancer targets and drugs. The study evaluates popular acquisition techniques and state-of-the-art quantification tools to improve LFQ performance.
Researchers have developed a new method to study the flu virus, allowing them to visualize individual proteins and understand how they contribute to the virus's success. The study suggests that variations in protein composition may be beneficial for the virus, enabling it to spread infection more effectively.
A fast new way to check nutrient levels in grasslands allows farmers to quickly monitor changes and adapt grazing methods. Overgrazing below 7cm significantly reduces protein and digestibility.
A team of researchers at UC Davis has developed a new method to estimate the biological sex of human skeletal remains based on protein traces from teeth. This method uses sensitive mass spectrometry to measure proteins and can be used alongside existing techniques.
Researchers developed a new approach to identify flavor-giving protein fragments in fermented foods. The 'sensoproteomics' method efficiently and quickly identified the decisive fragments responsible for bitter flavors in cheese, reducing possibilities from 1,600 to 17. This innovation aims to optimize the taste of various products.
Rice University scientists have developed a simple and efficient method to attach drugs or substances to antibodies, which are central to the body's immune system. The technique, called pClick, uses non-canonical amino acids to bind to specific sites on antibodies without the need for re-engineering or harsh chemicals.
A new protein sequencing method has been developed, enabling the identification of individual protein molecules with high sensitivity and throughput. This advance has the potential to reveal new biomarkers for cancer diagnosis and enhance understanding of healthy cell function.
Researchers analyzed proteins in ancient ceramics to determine the diet of early farmers at Çatalhöyük. The study found evidence of cereals, legumes, dairy products, and meat, including specific species such as barley, wheat, peas, vetches, sheep, goats, cattle, and deer.
USC Stem Cell scientist Andy McMahon and collaborators aim to identify key proteins enabling organs to communicate with each other. By using a tiny molecule as a tag, the team hopes to develop a new tool to enhance knowledge of normal physiology and disease.
UCSB researchers have developed a highly efficient genome editing method that offers complete spatiotemporal control, allowing users to target specific cells or regions within the cell. This approach enables precise and transient gene editing with minimal long-term effects on DNA.
A new technology developed by McGill University scientists can detect hundreds of proteins with a single blood sample, improving the analysis of biological markers and providing key information on health. The technique uses multicolour fluorescent dyes to barcode micro-beads, enabling detection of multiple proteins in parallel.
A $318,696 NSF award will support the development of a novel biosensing nanotechnology to visualize trace biomarker proteins under a microscope. This technology has the potential to greatly advance protein sensing, enabling accurate diagnoses based on biopsies and improving basic biomedical research.
Researchers have developed a new method to directly measure synaptic loss in individuals with Alzheimer's disease, using PET imaging technology. The study found that participants with Alzheimer's disease had a 41% reduction in synaptic density compared to those with normal cognition.
Researchers at the University of Warwick have created a new tagging device called FerriTag that allows for the precise visualization of proteins within human cells. This breakthrough method eliminates the need for external tags, reducing cell damage and enabling more accurate studies on protein behavior.
Scientists have developed a method to track protein movement using nanosensors, allowing for the observation of protein distribution and transport within cells. The technique uses genetically altered nanobodies that can fluoresce, enabling researchers to follow protein pathways in living cells.
Researchers at Princeton University have improved a proteomics method to accurately count proteins in cells under different circumstances. The new approach, TMTc+, uses a combination of cell sample preparation and computer algorithm changes to provide superior measurement accuracy and precision compared to existing methods.
Researchers have identified a critical aspect of healthy cell division and revealed how a vital protein called CENP-A is incorporated into chromosomes. A two-step process was found to be essential for replenishing the protein, involving targeting and transcription-induced remodelling of chromatin.
Researchers developed a method to 'decorate' gold nanoparticles with proteins, allowing drugs to target specific areas in the body. This technology can improve drug delivery and overcome biological barriers.
UCLA biochemists have developed a new technique called cryo-electron microscopy that allows them to view large biomolecules like viruses in extraordinary detail. Using this method, they have successfully imaged the smallest protein ever seen by this technique, paving the way for better understanding of disease-causing proteins.
A Yale-led research group has identified two olfactory receptors that respond to musk compounds, which could advance the study of the pharmacological effects of musks. The discovery may have implications for understanding how human smell works at a molecular level and its impact on behavior.
Timothy M. Miller receives award for work on effective therapies for ALS, developing method to turn off toxic protein production in brain and spinal fluid. His approach is currently being tested in human clinical trials.
Researchers employed computational approaches to estimate the fitness landscape of gp160, a polyprotein that comprises HIV's spike. The inferred landscape was validated through comparisons with diverse experimental measurements.
Researchers at Tohoku University have created a visual database of metabolites from over 5,000 Japanese volunteers, offering valuable insights into how specific compounds relate to each other. The jMorp database contains information on 306 metabolites and 256 common proteins, with graphical correlation tools to facilitate further study.
A new approach identifies and measures changes in thousands of proteins as Xenopus eggs undergo fertilization, revealing details of protein destruction and release to prevent multiple fertilization. This method enables comprehensive analyses of protein dynamics and sheds light on cellular changes driving disease.
Researchers develop computer-designed mini-proteins that bind to specific therapeutic targets with high selectivity, stability and potency. The approach has potential applications in fighting infectious diseases and neutralizing toxins.
Scientists at ETH Zurich and Roche have developed a new diagnostic method using light diffraction on molecules, allowing for quick and easy disease detection in doctors' offices. The technique uses molecular recognition and focused laser light to identify specific protein interactions.
Researchers have found that a protein called FBXL5 plays a crucial role in regulating iron levels by adding molecular tags to IRP-1, which can then be degraded. This discovery sheds light on the complex network of checks and balances underlying cellular iron regulation.
Researchers have developed a new high-throughput technique to determine protein interactions, generating massive libraries and revealing over 8,000 interactions in Arabidopsis transcription factors. This approach enables faster study of fundamental biological interactions and potential treatments for metabolic dysfunction.
Researchers at Uppsala University have developed a new method to measure proteins in dry blood samples, allowing for easier and cheaper healthcare. The study found that this method has great potential to save resources and enable early diagnostics, with minimal changes to protein levels over time.
Researchers created a detailed analysis of human proteins in cultivated cell lines, mapping them to cellular compartments and substructures with single-cell resolution. The study found that about half of the proteins are found in more than one compartment, shedding new light on cellular complexity.
Researchers at Hokkaido University developed a novel method combining p53 and BMPep to control nanostructure of inorganic materials. The method successfully created hexagonal silver nanoplates with enhanced specificity and crystal growth regulation.
Researchers at University of Illinois conducted a study to calculate protein scores for eight sources of protein derived from both plants and animals. The digestible indispensable amino acid score (DIAAS) method was used, which showed all dairy proteins met Food and Agriculture Organization standards as 'excellent/high' quality sources.
Sai Veeraraghavan, a research assistant professor at Virginia Tech Carilion Research Institute, has received the George Palade Award for his work on conductive behavior between heart cells. His novel analysis software, STORM-RLA, allows researchers to quickly parse through the locations of single molecules to determine protein interact...
Researchers at the University of East Anglia have developed a novel mass spectrometry method to study iron-sulfur cluster proteins, which are crucial for various biological processes. The study successfully detects all reaction components simultaneously, providing detailed insights into their conversion process.
Researchers developed a novel technology to tackle the 'secret ubiquitin code' by enabling systematic analysis of linear ubiquitination targets. This breakthrough will improve understanding of linear ubiquitination's role in diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
Scientists discover a culture method that unlocks the natural fighter function of immune T cells when exposed to alarm signals, allowing for the growth of natural armies trained to recognize and target cancer proteins. The method has been tested on three cancer-associated proteins and shown success in stimulating T cell responses.
Researchers developed a method to introduce proteins into plant cells using non-thermal atmospheric pressure plasmas. The technique successfully showed high protein uptake in tobacco, rice, and Arabidopsis leaves, offering potential applications in genome editing and analysis of protein function.
Chemists have developed a new technique called redox activated chemical tagging (ReACT) that selectively links chemicals to proteins. This method could transform the way drugs are developed, proteins are probed, and molecules are tracked and imaged.
The article discusses protein engineering techniques used in synthetic biology, including rational design, de novo design, directed evolution, and combinatorial approaches. These methods have been widely adopted in the biomedical and biotechnological sectors, with recent patents obtained using engineered proteins.
Researchers have invented a new method called EF-X, which stimulates protein motions and visualizes them in real-time at atomic resolution. This approach enables the creation of video-like images of proteins in action, opening up new avenues for understanding protein function and potential applications in medicine.
Researchers from Vetmeduni Vienna analyzed MUP genes and proteins in wild house mice, finding no variation among individuals. The study refutes the 'barcode hypothesis' that MUPs provide individual signatures for kin recognition.
A team of researchers at Osaka University developed a method to visualize intracellular protein trafficking, specifically the glucose transporter type 4 (GLUT4), which is associated with type II diabetes. The study reveals that abnormalities in the N-glycan chain lead to transient translocation and rapid internalization of GLUT4.
Researchers discovered that around one-tenth of proteins remain stable and live longer than expected as they age. This finding could explain why additional gene copies don't automatically result in more protein production.
Researchers from the University of Copenhagen have reviewed the use of NIR spectroscopy to detect food fraud in Current Opinion in Food Science. The method can reveal far more food fraud than current methods, including intentional misrepresentation and undeclared introduction of cheaper substances. By examining large quantities of raw ...
Researchers used computer simulations to study the formation of superoxides, a type of free radical that can damage cells and contribute to aging. The study found that an oxygen molecule can penetrate specific locations in proteins, leading to the formation of superoxides.
Scientists at the University of Basel have developed an artificial metalloenzyme, biot-Ru-SAV, that can catalyse olefin metathesis reactions in living cells. The breakthrough uses the periplasm as a reaction compartment to overcome limitations of organometallic-based enzymes.
Scientists have discovered a possible explanation for the high prevalence of Russian tuberculosis strains by analyzing their protein and genome features. The study found that these strains produce more proteins producing long-chain fatty acids and less proteins destroying them, making them more effective at evading the immune system.
Researchers at the Gladstone Institutes have developed a new method to consistently activate mesenchymal stromal cells to produce anti-inflammatory proteins, enhancing their immune-suppressing effects. This breakthrough could lead to improved treatments for inflammatory bowel disease and organ transplant rejection.