Articles tagged with Protein Analysis
A blood test taken at the time of Covid-19 infection could predict who is most likely to develop long Covid. Researchers identified a 'signature' in protein levels that predicted persistent symptoms after one year.
A novel stem cell-gene therapy has been shown to be safe in humans, with no serious side effects reported in the first trial. The treatment targets motor neurons that die in patients with amyotrophic lateral sclerosis (ALS), a fatal neurological disorder.
Researchers from Tokyo Metropolitan University have developed a method to directly measure the strength of skeletal muscle myotubes by analyzing wrinkles formed on an elastic substrate when stimulated with electric pulses. This new technique is more sensitive than existing measures and has great potential for accelerating drug discover...
A new study reveals how a rare genetic mutation affects an enzyme involved in learning and memory, leading to enhanced activation and potential treatment options. Researchers have developed a method of protein analysis that enabled them to identify a potential treatment using existing medicine.
A new study from USC researchers uncovers the sequence of early molecular changes caused by APOE4, a discovery that may help identify potential treatment targets in the brain's blood vessels. The research reveals problems with the blood-brain barrier and synapses, leading to behavioral deficits and cognitive dysfunction.
Researchers have identified a sex-adapted color-change gene in locusts that signals between males to reduce mating mistakes in swarming conditions. The discovery reveals a previously unknown sexual dimension to desert locusts' phase polyphenism, providing insights into the evolution of phenotypic plasticity.
Researchers at the University of Münster have identified a specific group of cells in plant roots that react to salt stress, forming a 'sodium-sensing niche' and triggering a calcium signal. This signal is controlled by a calcium-binding protein (CBL8) that helps pump out salt from the plant under severe stress conditions.
Researchers developed APTASHAPE to analyze protein and metabolite signatures in blood plasma for various diseases. The technology shows promise for non-invasive early detection of bladder cancer and other conditions.
Scientists have developed a new model to track protein signals that enable organ-to-organ communication, which could help understand disease onset and progression. The technology has the potential to identify novel secreted proteins and develop targeted treatments for diseases such as cancer and obesity.
Researchers at Karolinska Institutet have developed a method to create a three-dimensional gel from spider silk proteins that can be designed to deliver functional proteins. The gel has the potential to revolutionize regenerative medicine, enabling controlled drug release and tissue engineering applications.
Researchers developed a novel method to visualize proteins secreted by cells with high resolution, using plasmonic-fluor technology. The FluoroDOT assay is versatile, low-cost and adaptable, providing a more comprehensive look at these proteins.
A Singapore-based research team has created a systematic engineering approach for optimizing the production of 3D printed food inks with alternative proteins. The method uses Response Surface Methodology to minimize time and resources, resulting in visually appealing, flavorful, and nutritionally adequate foods enhanced with sustainabl...
Scientists analyzed DNA sequence data from nearly 71,000 people worldwide and identified mutations in ACE2 and TMPRSS2 genes that affect protein expression, influencing COVID-19 susceptibility and severity. The study suggests a potential new diagnostic method based on host cell variation rather than the evolving virus.
Researchers have created a new DNA atlas that provides insights into how genes in specific cells contribute to coronary artery disease. The atlas identifies over 200 independent genetic markers associated with disease risk, offering a potential roadmap for interpreting non-coding variants.
Researchers have developed a new test that can detect even slightly elevated levels of tau protein in cerebrospinal fluid, potentially identifying Alzheimer’s disease at its earliest stages. The method uses optical sensors and 'lab-on-fiber' technology to achieve high sensitivity.
MU researchers have identified specific mutations in the Omicron variant's spike protein that help it evade existing antibodies from vaccines or previous COVID-19 infections. These findings can inform developers of COVID-19 treatments and vaccines, which may need to target different parts of the virus to produce effective outcomes.
Researchers discovered a mechanism by which plants stabilize protein molecules during folding, even in low-oxygen conditions. The study found that the redox potential of supporting proteins plays a critical role in disulfide bridge formation and protein folding.
A Danish research study has made significant discoveries about the CRISPR/Cas9 protein and its gRNA component, enabling more accurate gene modification. The findings aim to optimize the effectiveness of gene editing, addressing concerns over 'off-target effects'.
Researchers used chemoproteomics to profile 53 HDAC drugs and found many had additional targets beyond their intended HDACs. The study identified MBLAC2 as a common off-target protein that affects extracellular vesicle accumulation.
Eating more protein during weight loss helps avoid lean mass loss and promotes healthier eating habits, according to a Rutgers study. The study found that higher protein intake is associated with increased green vegetable consumption, reduced refined grain and sugar intake, and improved retention of lean muscle mass.
A novel study has identified metabolic defects, impaired protein secretion, and altered phosphoproteomic signatures in alcohol-associated cirrhosis and hepatitis. These findings may lead to the development of new diagnostic and therapeutic approaches for a disease with limited treatment options.
Researchers developed a novel nanobody-based detection method for recombinant human interferon α2b (rhIFNα2b), which has a lower detection limit than existing methods. The assay's operation time was shortened from two days to a few minutes, making it suitable for rapid market counterfeit detection and early diagnosis of hepatitis.
A recent study at UC San Francisco discovered that fragmented tau protein in diseased neurons could be a new target for existing drugs, potentially improving diagnosis and treatment of Alzheimer's. The researchers found that measuring the fragments in cerebrospinal fluid may help distinguish between different forms of dementia.
A study published in eLife found that high-intensity interval training increases the production of proteins essential for energy metabolism and muscle contractions, as well as alters key metabolic proteins through acetylation. These changes may contribute to improved metabolic health.
Researchers discovered a previously unknown mutation in a child with epilepsy that affects the functioning of ion channels, which are crucial for brain function. The mutation has been found to decrease the function of normal proteins as well, highlighting the importance of studying genetic mutations.
A new study applies 'Deep Visual Proteomics' to cancer cells, revealing mechanisms driving tumor development and exposing therapeutic targets. The method integrates advances from four technologies to analyze protein landscapes, providing insights into cancer vulnerabilities.
Researchers have developed a new NMR method to monitor fast biomolecular events like protein folding, enabled by hyperpolarized water. This technique enhances signal intensities by up to 10,000-fold, allowing for real-time monitoring and tracking of individual amino acids.
Researchers created synthetic proteoglycans to dissect their functions in health and disease, discovering new insights into their roles in early cell development and cancer cell spreading. They found that both GAG chains and core proteins contribute to proteoglycan function.
Researchers have mapped the connections between DNA and blood proteins in two large populations, providing insights into disease causes and potential treatment targets. The study's findings could shed light on health disparities and help develop new therapies.
Researchers at Arizona State University have developed a new technique called evanescent scattering microscopy (ESM), which allows for the visualization of proteins and other vital biomolecules with unparalleled clarity. This label-free imaging method reduces light-induced heating and requires no fluorescent dye or gold coating, making...
Researchers at Karolinska Institutet have developed a method to identify the immune cells involved in autoimmune diseases and identified four new target molecules for personalized treatment of multiple sclerosis. This approach could lead to more precise treatments with fewer side effects, potentially benefiting other autoimmune diseases.
Researchers investigate plant-based meat substitutes to identify sensory weak points, finding muscle proteins emulsify fats and oils differently than plant proteins do. The study reveals fundamental differences in molecular structure and mouthfeel between meat and vegan sausages.
Researchers developed new method to visualize CNS fibroblasts and their intercellular interactions in the CNS. The technique provides a detailed picture of CNS fibroblasts, including their location, size, morphology, and gene/protein expression patterns.
H. Alex Choi receives NIH grant to develop protein biomarkers for delayed cerebral ischemia, a complication after subarachnoid hemorrhage that affects approximately 50,000 Americans annually. The goal is to predict which patients will worsen and identify biological processes causing worsening patients.
A study identifies new biomarkers that predict the presence of subclinical atherosclerosis, providing a non-invasive way to detect cardiovascular disease. The research team analyzed blood plasma samples and validated three proteins as biomarkers, improving the prediction of cardiovascular risk.
A multicenter study found mutations in the SARS-CoV-2 N protein associated with increased viral loads and severe disease symptoms. The changes enabled the virus to hijack host cell translation machinery, leading to a life-threatening cytokine storm.
New research from Rutgers University sheds light on the genetic mechanisms of reproductive disorders, including infertility and miscarriage. The study reveals how the RNA helicase YTHDC2 regulates meiosis, a critical step in egg and sperm development.
Researchers at NTU Singapore have developed a novel drug delivery system using protein-based microdroplets that can bypass the cell membrane and deliver biomacromolecules effectively. This breakthrough enables faster, safer, and more effective treatments for diseases such as cancer and metabolic disorders.
Research team finds mutations leading to omicron variant don't affect immune response in people with pre-existing immunity. This suggests individuals who were previously infected or vaccinated may still be protected against breakthrough infections, but humoral immunity may fail.
A Penn State-led team of researchers developed a new delivery system that improves the efficiency and lifespan of CRISPR gene-editing tools after delivery into stem cells. The method uses an enzyme called PiggyBac, which enables permanent integration of the editing tools into the cell's genetic code, resulting in 99% of mutated cells b...
Researchers at the University of Cologne's Institute of Organic Chemistry have created a novel method for producing synthetic messenger RNA (mRNA) with site-specifically introduced non-natural nucleotides. This approach allows for better therapeutic applications and study of cellular processes.
A new study found a causal link between blood group and severe COVID-19, identifying six proteins that may increase the risk of hospitalization or respiratory support/death. Meanwhile, eight proteins were linked to protection against these outcomes. The research suggests potential new targets for treatments.
Cedars-Sinai investigators discover that inhibiting RIPK2 function with drugs or CRISPR/Cas9 reduces prostate cancer metastasis in mice, offering new hope for advanced prostate cancer treatment. Targeting this protein could extend patients' lives by several years.
Researchers developed mpH^2 MM to analyze fluctuating molecular signals, enabling predictions of shape changes. The framework was applied to DNA and proteins, revealing distinct mechanisms for binding molecules.
A new method identifies proteins binding to R-loops, revealing the role of DDX41 in regulating R-loop levels and preventing DNA damage. Elevated R-loop levels increase cancer risk.
Researchers have identified the impact of protein corona formation on nanoparticles' physiochemical and biological properties. This knowledge can be used to optimize carriers for nanomedical applications, improving the efficiency and effectiveness of biopharmaceutical delivery.
A new study by Washington State University scientists reveals that viral proteins interact with each other to disable plant defenses, allowing viruses to hijack their hosts. When some of these proteins are disabled, the virus cannot move from cell to cell, highlighting a promising approach to prevent crop losses.
A Tel Aviv University study found a significant link between changes in G-protein-coupled receptors and brain adaptability. Disabling the voltage sensor of these proteins caused uncontrolled brain flexibility, leading to excessive habituation to odors.
A University of Massachusetts Amherst analysis found that packaged beef burgers contain more calories, protein, and fat than imitation and veggie burgers. Veggie burgers, on the other hand, are lower in fat and higher in vitamin A and C.
Researchers found that up to one in five patients experience increased troponin levels after major surgery, indicating potential heart damage. These patients were also more likely to be anaemic before the operation.
An experimental drug called NAP has been found effective in treating a broad spectrum of symptoms related to autism, intellectual disability, and Alzheimer's disease. Researchers discovered that NAP normalizes brain function in mice modeling ADNP syndrome, a rare disorder linked to these conditions.
Researchers discover ways to generate clean energy from less-profitable farmland, restore habitat for grassland birds and create sustainable polymers. These breakthroughs could help achieve both renewable energy and conservation goals, as well as reduce future plastic waste.
The study uses a new barcode system to track complex signaling activities in cancer cells and identify key protein interactions. The technique enables real-time analysis and synchronization of protein activity over time.
Researchers have discovered that certain molecules inhibiting thioredoxin reductase (TrxR) have a more specific effect than gold-based therapy auranofin. TRi-1 and TRi-2 compounds show promise as anticancer drugs, with higher specificity in their inhibition of TrxR.
Scientists at the University of Groningen have developed a nanopore-based method for protein identification and sequencing. They constructed a proteosome-nanopore system that can recognize proteins from peptide spectra and sequence entire proteins directly.
Researchers from Delft University of Technology and the University of Illinois at Urbana-Champaign have developed a method to identify individual proteins with single-amino acid resolution, reducing errors to practically zero. Using DNA nanopores and supercomputer simulations, they characterized protein sequences with high accuracy.
Researchers found that hepatitis C treatment reduces the activity of proteins involved in cirrhosis, potentially indicating an early sign of liver recovery. The study suggests a possible pathway toward healing scarred liver tissue after virus elimination.
Researchers from University of Copenhagen discover a protein analysis that can predict COVID-19 patient death or hospitalization with high accuracy, predicting 78.7% of hospitalizations and 93.9% of non-serious infections. This discovery has the potential to save lives by identifying high-risk individuals.
A new study led by the American Museum of Natural History suggests that the extinct ground sloth Mylodon was an omnivore, contrary to previous assumptions. The researchers analyzed amino acid nitrogen values in fossil samples to determine their diet, finding evidence of meat consumption.
Researchers at Uppsala University have designed new antibodies that bind to both large and small aggregates of the amyloid-beta protein, potentially providing a more effective treatment for Alzheimer's disease. The new antibody format is stronger in binding to clumps and can also target smaller aggregates.