Articles tagged with Regulatory Genes
A multi-centered team of researchers found a link between a specific gene abnormality and autism, potentially leading to more precise diagnosis and treatments. The study identified a shortened form of the serotonin transporter gene promoter as a key factor in autistic children.
Scientists have identified a key genetic pathway responsible for 90 percent of colon cancers, which could lead to the development of targeted therapies. The mutation of the APC gene disrupts normal cell regulation, causing uncontrolled growth and cancer.
Researchers at the Weizmann Institute of Science have identified a key gene called NIK that plays a crucial role in triggering the immune response. By removing the 'brake' on the NF-kappaB protein, NIK activation sets off an immune response that could be harnessed to develop new medications for autoimmune diseases and HIV.
A team of researchers has solved a centuries-old puzzle in eye development by discovering that the embryo has a single eye field that normally separates into two. The study found that an inhibitory signal shuts off gene expression in the middle of the eye field, leading to cyclopia if this fails to happen.
Researchers at Johns Hopkins Medicine identify TWIST gene as cause of Saethre-Chotzen syndrome, a rare genetic disorder characterized by craniofacial abnormalities and limb defects. The study confirms the role of the TWIST protein in human development and provides insight into the confusion with Crouzon syndrome.
Researchers at Oregon Health Sciences University discovered how a mutated agouti gene leads to overeating and excess body fat in mice. The study shows that the agouti gene, when expressed in brain cells, disrupts a hormonal signaling pathway that regulates feeding behavior.
Researchers have found a way to reduce guesswork and errors in genetic engineering by eliminating unwanted or 'junk' genes from plant chromosomes. This new method allows for targeted gene insertion and excision, enabling more precise control over genetic transformations.
Researchers have identified two interacting genes linked to adult-onset diabetes, which regulate gene expression in the liver, kidney, and intestine. The discovery opens up new avenues for treating this complex disorder.
Researchers at UNC-CH and Penn State University have identified a gene called KiSS-1 that controls the spread of malignant melanoma in laboratory mice. This finding may help doctors distinguish between tumors that will colonize other organs and those that will not.
Researchers created genetically engineered mice with a mutated gene linked to AD, producing 50% more A-beta42 peptide. This discovery may lead to targeted drug treatment for AD by understanding the mechanism of presenilin-1 and APP production.
Researchers at Roswell Park Comprehensive Cancer Center found that p53 mutation does not trigger cancer development for colorectal cancer, contrary to long-held dogma. Instead, they identified a mysterious enigma controlling cell progression to cancerous states.
Scientists have isolated and cloned the gene responsible for Fanconi anemia (FA), a rare disorder causing severe bone marrow failure, birth defects, and leukemia. The discovery enables the development of a quick diagnostic test for 65% of FA patients and may lead to better treatments, including gene therapy.
A recent study by Johns Hopkins Medicine has identified a genetic mutation that may be associated with an increased risk of osteoporosis. The mutation, found in the calcium-sensing receptor gene, was discovered in people with primary hyperparathyroidism and showed no link to this condition, but may play a role in other bone diseases.
Researchers found a mutant gene in C. elegans that doubles adult lifespan when mutated, suggesting its role in regulating aging. The gene encodes a PI(3)K enzyme, which may trigger a biochemical program leading to decreased aging and senescence.
Researchers have identified the gene responsible for Chediak-Higashi syndrome, a fatal childhood disease that weakens the immune system and increases cancer risk. The discovery could lead to new treatments and diagnostic tests for patients with cancer or autoimmune disorders like lupus.
Researchers identified a single gene regulating wing formation in fruit flies, revealing a fundamental understanding of how genes mastermind limb development. The discovery may lead to new avenues for preventing birth defects caused by genetic miscommunication.
Researchers at Duke University have identified a gene in mice that may predispose people to autoimmune diseases such as arthritis and dermatitis. By studying the role of this gene, the team discovered its connection to inflammation and found that neutralizing a specific protein can reverse symptoms in affected animals.
Researchers discovered that a malfunctioning gene, M6P/IGF2r, acts as a tumor suppressor in human liver tumors. The gene's loss or mutation may predispose cells to cancerous growth, leading to the formation of liver cancer. This finding could lead to the development of early diagnostic tests and new treatments for the disease.