Articles tagged with Synthases
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study has discovered a potential link between an approved obesity drug and cancer treatment. Researchers found that the drug Orlistat can block fatty acid synthase, an enzyme crucial for tumor cell growth, promoting cell death instead.
For the first time, researchers have tracked cellulose fiber formation in real-time, providing evidence of a functional connection between cellulose synthase and microtubules. This breakthrough discovery has significant implications for designing energy-rich biofuel crops and improved fiber crops.
Researchers have designed a technique to steer the evolution of enzymes towards desired outcomes, creating specific products. The technique uses mathematical models and site-directed mutagenesis to rapidly evolve promiscuous enzymes into specialized ones.
Researchers at Yale University have identified a potential new target for treating vascular disease by inhibiting the protein kinase Akt1. The study found that Akt1 plays a crucial role in the formation of new blood vessels, which is essential for improving blood flow to muscles during exercise.
Inducible nitric oxide synthase (iNOS) produces nitric oxide, contributing to inflammation and host defense. eNOS-derived NO accelerates host-defense responses but also leads to excessive inflammation and sepsis.
A team from the Salk Institute has revealed the structural basis for tetraketide cyclization in stilbene synthase, which produces resveratrol, a beneficial phytonutrient found in red wine. The mechanism of stilbene synthesis is crucial for its pharmaceutical and medical interest.
Researchers have deciphered the three-dimensional structure of a plant enzyme that produces resveratrol, a key component of red wine with impressive health benefits. The study provides new insights into the relationships among plant proteins, shedding light on how grapes produce resveratrol to defend against fungal invasion.
A recent study by Dr. Wieslaw E. Kozak found that nitric oxide has a distinct role in fever regulation, involving three different enzymes: neuronal nitric oxide synthase, inducible nitric oxide synthase, and endothelial nitric oxide synthase. The researchers used knockout mice to study the impact of these enzymes on fever response.
Medical College of Georgia researchers have discovered a biochemical scaffold that enables blood pressure to remain low and heart bypass grafts to stay open. The discovery, which contradicts previous understanding, identifies the framework for how this positive health benefit occurs.
A genetic test for a cell-proliferation enzyme variant may predict poorer outcomes in children with acute lymphoblastic leukaemia, prompting individualized treatment approaches. The study found that children homozygous for the triple repeat were four times more likely to have a poor outcome.
Researchers have discovered that the compound C75 profoundly suppresses appetite by altering brain messengers in mice. This effect could lead to new ways to intervene in obesity-related diseases.
Biologists at the University of Pennsylvania have discovered a biochemical pathway in animals responsible for detoxification of heavy metals. The discovery establishes a firm basis for determining its ubiquity in other animals and clarifies how animals eliminate, sequester and metabolize heavy metals.
Researchers at the University of Michigan have discovered a powerful new antibiotic candidate, PD 404182, which is 10,000 times more effective than other known inhibitors of a key enzyme in Gram-negative bacteria. The compound targets KDO 8-P synthase, essential for bacterial cell surface formation, and shows promise in weakening bacte...