Articles tagged with Synthases
A new study has discovered a potential link between an approved obesity drug and cancer treatment. Researchers found that the drug Orlistat can block fatty acid synthase, an enzyme crucial for tumor cell growth, promoting cell death instead.
For the first time, researchers have tracked cellulose fiber formation in real-time, providing evidence of a functional connection between cellulose synthase and microtubules. This breakthrough discovery has significant implications for designing energy-rich biofuel crops and improved fiber crops.
Researchers have designed a technique to steer the evolution of enzymes towards desired outcomes, creating specific products. The technique uses mathematical models and site-directed mutagenesis to rapidly evolve promiscuous enzymes into specialized ones.
Researchers at Yale University have identified a potential new target for treating vascular disease by inhibiting the protein kinase Akt1. The study found that Akt1 plays a crucial role in the formation of new blood vessels, which is essential for improving blood flow to muscles during exercise.
Inducible nitric oxide synthase (iNOS) produces nitric oxide, contributing to inflammation and host defense. eNOS-derived NO accelerates host-defense responses but also leads to excessive inflammation and sepsis.
Researchers have deciphered the three-dimensional structure of a plant enzyme that produces resveratrol, a key component of red wine with impressive health benefits. The study provides new insights into the relationships among plant proteins, shedding light on how grapes produce resveratrol to defend against fungal invasion.
A team from the Salk Institute has revealed the structural basis for tetraketide cyclization in stilbene synthase, which produces resveratrol, a beneficial phytonutrient found in red wine. The mechanism of stilbene synthesis is crucial for its pharmaceutical and medical interest.
A recent study by Dr. Wieslaw E. Kozak found that nitric oxide has a distinct role in fever regulation, involving three different enzymes: neuronal nitric oxide synthase, inducible nitric oxide synthase, and endothelial nitric oxide synthase. The researchers used knockout mice to study the impact of these enzymes on fever response.
Medical College of Georgia researchers have discovered a biochemical scaffold that enables blood pressure to remain low and heart bypass grafts to stay open. The discovery, which contradicts previous understanding, identifies the framework for how this positive health benefit occurs.
A genetic test for a cell-proliferation enzyme variant may predict poorer outcomes in children with acute lymphoblastic leukaemia, prompting individualized treatment approaches. The study found that children homozygous for the triple repeat were four times more likely to have a poor outcome.
Researchers have discovered that the compound C75 profoundly suppresses appetite by altering brain messengers in mice. This effect could lead to new ways to intervene in obesity-related diseases.
Biologists at the University of Pennsylvania have discovered a biochemical pathway in animals responsible for detoxification of heavy metals. The discovery establishes a firm basis for determining its ubiquity in other animals and clarifies how animals eliminate, sequester and metabolize heavy metals.
Researchers at the University of Michigan have discovered a powerful new antibiotic candidate, PD 404182, which is 10,000 times more effective than other known inhibitors of a key enzyme in Gram-negative bacteria. The compound targets KDO 8-P synthase, essential for bacterial cell surface formation, and shows promise in weakening bacte...