Articles tagged with T Cell Receptors
Scientists at Albert Einstein College of Medicine genetically engineered immune cells to target and kill HIV-infected cells. This approach, using genes from elite controllers' immune systems, could lead to a new strategy for combating AIDS. The study shows promise in both test tubes and animal models.
COX-2 inhibitors increase myocardial infarction and stroke risk due to suppression of prostacyclin and PGE2. Inhibiting microsomal PGE synthase-1 may offer anti-inflammatory effects without cardiovascular consequences, suggesting a potential alternative therapeutic option.
Scientists have discovered the roles of two proteins in recognizing blockages in transcription and initiating efficient repair. Their results suggest a previously unsuspected mechanism for the repair process, shedding light on Cockayne Syndrome, a fatal form of accelerated aging.
Researchers describe the interaction between T-cell receptors and coreceptors during an immune response. They found that T-cell receptors and CD8 coreceptors are brought together during antigen sensing, increasing their interaction with endogenous non-stimulatory peptides.
Weakened T-cell receptor signals shift T-cell lineage towards the gamma-delta pathway, enabling immune surveillance against external disease-causing agents. Gamma-delta T cells appear particularly adept at combating skin cancers and may play a role in detecting potential cancers.
University of Illinois scientists developed a method to improve T-cell receptor properties, allowing for manipulation of the immune system's recognition molecules. This breakthrough could lead to new therapeutic approaches for diseases such as AIDS, cancer, and multiple sclerosis.