A new bilateral tumor model was demonstrated to be useful for investigating the relationship between T-cell repertoire and cancer immunotherapy's therapeutic effects. The study found that T-cell profiles of both tumors were almost identical, indicating a similar anti-tumor response in a single mouse.
SourceTokyo University of Science·JournalFrontiers in Immunology·TypeExperimental study·DateJan 19, 2022
Researchers at Peking University created a comprehensive single-cell landscape of tumor-infiltrating T cells across 21 cancer types, revealing heterogeneity and dynamics. This study provides an immune-typing scheme that could inform targeted therapy.
Researchers at UCLA have identified rare T cells capable of targeting a protein found in SARS-CoV-2 and other coronaviruses. By adding a fragment of this protein to vaccines, they hope to create a longer-lasting immune response and increase protection against new variants. This breakthrough could lead to more effective COVID-19 vaccines.
SourceUniversity of California - Los Angeles Health Sciences·JournalCell Reports·TypeExperimental study·DateDec 10, 2021
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A new approach for identifying shared patterns in immune cell receptor sequences may help determine if a person has previously been infected or vaccinated against a given pathogen. Researchers have developed software called tcrdist3 to facilitate this process.
A researcher at MUSC's Hollings Cancer Center is developing 'living drugs' by precision-engineering CAR Tregs to treat autoimmune diseases. The CAR Tregs can delay or reduce damaging inflammation, offering a potential solution for conditions like Type 1 diabetes.
SourceMedical University of South Carolina·JournalFrontiers in Immunology·DateNov 16, 2021
Researchers developed an AI technique, pMTnet, to predict which cell surface peptides are recognized by the immune system. The algorithm shows high accuracy in identifying binding or nonbinding combinations of neoantigens and T cell receptors.
SourceUT Southwestern Medical Center·JournalNature Machine Intelligence·DateSep 23, 2021
A new approach has identified T cells in Covid-19 patients, revealing their appearance, number, and activity level against SARS-CoV-2. The study distinguishes between active and dormant T cells, enabling a better understanding of the immune response to the virus.
SourceTechnical University of Munich (TUM)·JournalNature Communications·DateAug 19, 2021
Researchers from Monash University have made a fundamental advance in understanding how T cells become activated when encountering pathogens. The study found that T cells need to recognize pathogens in a particular orientation to receive a strong activating signal, revealing a critical mechanism for effective T cell immunity.
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers are exploring the potential of individual immunomes to provide unprecedented insight into health. By analyzing antibodies and T-cell receptors, scientists can identify patterns and develop a near-universal blood test. This could lead to targeted therapies for various conditions, revolutionizing personalized medicine.
SourceBeth Israel Deaconess Medical Center·JournalFrontiers in Immunology·DateMay 4, 2021
Researchers have developed DeepTCR, a software package that employs deep-learning algorithms to analyze T-cell receptor sequencing data. The software can identify patterns in the receptors that confer the function of the T cell to recognize and kill pathological cells.
SourceJohns Hopkins Medicine·JournalNature Communications·DateApr 5, 2021
Researchers developed a new method to study molecular characteristics of T cells, enabling easier analysis of T cell receptors. Using this approach, they discovered that the variety of TCRs in T cells has a weaker influence on functional status in cancer patients.
SourceUT Southwestern Medical Center·JournalNature Methods·DateJan 6, 2021
A study of over 600 patients with colorectal cancer found that higher levels of T cells and greater diversity of T cell receptors are associated with better outcomes. The new biomarker, called TCR immuno-sequencing, measures the amount of infiltrated T lymphocytes and their clonality.
SourceIDIBELL-Bellvitge Biomedical Research Institute·JournalPLOS Medicine·DateOct 6, 2020
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers from Texas A&M University have made significant discoveries on how the immune system detects hidden intruders. The study found that T-cells increase their detection power mechanically, using a 'catch bond' between T-cell receptors and MHC molecules when force is applied.
SourceTexas A&M University·JournalProceedings of the National Academy of Sciences·DateSep 16, 2020
Researchers at UCLA Jonsson Comprehensive Cancer Center identified a phenomenon where some patients' T cells lose expression of transgenic TCR over time, potentially due to DNA methylation. This study aims to inform the design of future cellular immunotherapies and improve treatment outcomes for advanced cancer patients.
SourceUniversity of California - Los Angeles Health Sciences·JournalCancer Discovery·DateJul 22, 2020
Researchers at the University of Freiburg have identified a previously undiscovered domain of the T-cell receptor called RK motif. This discovery enables more precise control over T cells, potentially improving therapies for cancer and autoimmune diseases.
SourceUniversity of Freiburg·JournalNature Immunology·DateJul 20, 2020
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers utilized a computational method to analyze the CDR3 regions of T-cell receptors from high-grade serous ovarian cancers. The study found that patients with low T-cell infiltration but diverse or focused repertoires had clinical outcomes similar to highly-infiltrated tumors. The authors identified the degree of divergence bet...
SourceImpact Journals LLC·JournalOncotarget·DateJul 7, 2020
A new study suggests that challenges simulating clouds are causing some climate models to be more sensitive to carbon dioxide, potentially leading to a warmer future. The updated models have shown a greater range of responses than previous generations, with some models showing higher sensitivity and others lower.
SourceNational Center for Atmospheric Research/University Corporation for Atmospheric Research·JournalScience Advances·DateJun 24, 2020
Researchers at Oak Ridge National Laboratory are refining their design of a 3D-printed nuclear reactor core and developing methods to confirm the consistency and reliability of its printed components. The Transformational Challenge Reactor Demonstration Program aims to turn on the first-of-its-kind reactor by 2023.
Researchers at Cardiff University have discovered a new type of killer T-cell with a unique T-cell receptor (TCR) that recognizes and kills most human cancer cells while ignoring healthy cells. This breakthrough has the potential to create a 'one-size-fits-all' cancer therapy, targeting a wide range of cancers in all patients.
SourceCardiff University·JournalNature Immunology·DateJan 20, 2020
A technique identified T cells that react to peanut allergens by analyzing their RNA expression. The study could help guide researchers in developing new treatments for food allergies.
SourceMassachusetts Institute of Technology·JournalNature Immunology·DateNov 19, 2019
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new study reveals the narrow escape problem, a classic math puzzle, plays a key role in determining immune responses. The unique shape of T cells creates a close-contact zone for triggering molecules, and the size of this zone depends on the surface protrusions, keeping the process sensitive to invaders.
SourceMacquarie University·JournalProceedings of the National Academy of Sciences·DateSep 16, 2019
Researchers engineered T cell receptors that can specifically stick to cells infected with cytomegalovirus, offering a new potential treatment option. These receptors could aid in developing CMV vaccines and target brain tumors.
SourceAmerican Society for Biochemistry and Molecular Biology·JournalJournal of Biological Chemistry·DateFeb 22, 2019
Scientists at Helmholtz Zentrum München have developed an analytic method that can precisely detect viral infections using immune responses. This method could help identify gaps in protection early on and make transplants safer in the future.
SourceGerman Center for Infection Research·JournalThe Journal of Immunology·DateJan 8, 2019
Researchers at University of Notre Dame discover that T-cell receptors can be more cross-reactive than previously thought, increasing the challenge of developing effective immunotherapies. This finding highlights the need to reassess predictions for building models for therapy and recognizing targets.
SourceUniversity of Notre Dame·JournalNature Chemical Biology·DateSep 18, 2018
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers created a biomimetic surface that simulates antigen-presenting cell features and found that precise ligand spacing is crucial for T-cell triggering. The study sheds light on the role of CD45 exclusion in receptor activation, offering new insights into T-cell stimulation.
SourceColumbia University School of Engineering and Applied Science·JournalNature Nanotechnology·DateApr 30, 2018
Researchers at TU Wien and Medical University of Vienna have discovered that T cell antigen receptors operate alone, contrary to previous assumptions. This groundbreaking finding has significant implications for understanding immune responses and developing effective therapies against cancer and autoimmune diseases.
SourceVienna University of Technology·JournalNature Immunology·DateApr 18, 2018
Scientists have identified a common target shared by the T-cell receptors of two patients with colorectal cancer, paving the way for personalized immunotherapies. The breakthrough could lead to the development of broadly effective treatments that harness the immune system to fight cancer.
SourceHoward Hughes Medical Institute·JournalCell·DateDec 21, 2017
Researchers from Brigham and Women's Hospital and Monash University uncover the basis for T cell receptor autoreactivity to self-phospholipids, with implications for psoriasis, contact hypersensitivities, and allergies. The study highlights the physical structures that enable lipid recognition by T cells.
SourceBrigham and Women's Hospital·JournalScience Immunology·DateOct 20, 2017
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers developed moving subtrajectory analysis to study TCR microclusters, revealing kinetic and spatial details of CD3 and CD45 behavior. The study shows that the two molecules exhibit distinct mobility states, depending on their location relative to the microcluster, providing new insights into T cell activation mechanisms.
SourceTokyo Institute of Technology·JournalScientific Reports·DateAug 16, 2017
A team at TUM found that the number and type of cells produced from a single naive T cell vary widely, contradicting the prevailing hypothesis. Mathematical models may help improve vaccination strategies by understanding the probabilities involved in T cell development.
SourceTechnical University of Munich (TUM)·JournalCell Reports·DateJul 31, 2017
Researchers found that identical twins share more T-cell clone receptors than expected due to potential exchange of T cells through cord blood before birth. This phenomenon suggests that some immune system cell clones created before birth can persist for about 40 years, shedding light on the diversity of T cell receptors in adults.
SourcePLOS·JournalPLOS Computational Biology·DateJul 6, 2017
Researchers developed an algorithm that functions like a Rosetta Stone to decipher how the immune system recognizes and binds antigens. The algorithm correctly assigned 81% of human T cells to one of 10 different viral epitopes, showcasing its potential in personalized cancer immunotherapy.
SourceSt. Jude Children's Research Hospital·JournalNature·DateJun 21, 2017
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers at Salk Institute have discovered that T cell receptors amplify 'invader' signals by producing and releasing ZAP70 protein, enabling rapid signal transmission throughout the cell. This finding could lead to the development of more effective treatments for cancer and autoimmune diseases.
SourceSalk Institute·JournalNature Immunology·DateNov 21, 2016
Researchers develop domain-swapped T cell receptors that increase the safety of TCR gene therapy by preventing mispairing between introduced and resident chains. These new receptors retain functional domains and prevent autoimmune disease in mice and human cells, offering a promising tool for cancer treatment.
SourceCalifornia Institute of Technology·DateNov 8, 2016
Researchers found that culturing T cells in N-acetyl cysteine (NAC) before infusion improved effectiveness and outcomes in a preclinical model of melanoma. Nearly 40% of NAC-cultured T cells were detectable in tumors after transfer, compared to approximately 1.2% of standard-culture T cells.
SourceMedical University of South Carolina·JournalCancer Research·DateOct 14, 2016
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers at University of Notre Dame develop new T cell receptor technology to enhance immune system's ability to target specific cancer antigens. The engineered receptors allow for a more directed and accurate immune response against cancer cells.
SourceUniversity of Notre Dame·JournalStructure·DateJun 15, 2016
Researchers developed a novel technique called iTAST to measure T-cell affinity, finding a correlation between aging and reduced effectiveness in fighting hepatitis C virus. This breakthrough could expedite scientific discoveries and improve immunotherapy and vaccine development.
SourceUniversity of Texas at Austin·JournalScience Translational Medicine·DateJun 1, 2016
Researchers from the University Freiburg have developed a new model of T cell activation, demonstrating that cholesterol prevents an immune response even when no antigen is present. The study reveals a specific interaction between cholesterol and inactive T cell receptors, regulating their conformation and activity.
SourceBIOSS - Centre for Biological Signalling Studies·JournalImmunity·DateMay 27, 2016
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers developed DNA-based tension sensors to study T cell interactions. They found that T cells use precise mechanical tugs to test whether a cell is a friend or foe, with stronger tugs indicating a foreign invader. This discovery could aid in the development of immune therapies for cancer and treatments for autoimmune diseases.
SourceEmory Health Sciences·JournalProceedings of the National Academy of Sciences·DateMay 5, 2016
Researchers developed a new technique called TraCeR that determines both the sequence of T-cell receptors in individual cells and each cell's gene expression profile. This allows for the study of how different populations of T cells respond to disease, enabling the exploration of immune responses in various conditions.
SourceEuropean Molecular Biology Laboratory - European Bioinformatics Institute·JournalNature Methods·DateMar 7, 2016
Researchers develop gene therapy using T cells to target cancer mutations, reducing side effects. The approach involves transferring tumor-specific T cell receptors into fresh T cells, enabling them to fight tumors.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalJournal of Clinical Investigation·DateFeb 19, 2016
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A new NASA study finds that accurately accounting for climate drivers like aerosols and land use changes is crucial for predicting future global temperatures. The research calculated the temperature impact of each variable based on historical observations, revealing their complexity and correcting earlier underestimations.
SourceNASA/Goddard Space Flight Center·JournalNature Climate Change·DateDec 18, 2015
T cells' activation relies on a dynamic protein network at the cell surface, with proteins coming and going in rapid intervals. Understanding this process could help boost the immune response against diseases like cancer or infections.
SourceSalk Institute·JournalNature Immunology·DateAug 3, 2015
Scientists discovered that Tregs need continuous contact with their environment to function correctly and require the T cell receptor for protection. The study showed that Tregs without the receptor lose their special ability to suppress excessive immune reactions.
SourceTechnical University of Munich (TUM)·JournalImmunity·DateJan 8, 2015
Researchers discovered that mechanical forces play a crucial role in T-cell recognition and signaling. The study found that the magnitude, duration, frequency, and timing of force application determine the outcome of an interaction between an antigen and a TCR. This new understanding adds another dimension to interactions with T-cells.
SourceGeorgia Institute of Technology·JournalCell·DateApr 10, 2014
A study found fractal patterns in T cell receptor families of stem cell transplant donors and recipients, which may help predict transplant complications. The researchers hope this information will aid in understanding immune system recovery after transplantation.
SourceVirginia Commonwealth University·JournalBiology of Blood and Marrow Transplantation·DateMay 1, 2013
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers at St. Jude Children's Research Hospital identified a 'rheostat' mechanism in T cell receptors that regulates the immune response, enabling cells to scale their response according to the threat. This finding offers insights into advancing understanding and treatment of problems like autoimmune disorders and cancer.
SourceSt. Jude Children's Research Hospital·JournalNature Immunology·DateApr 30, 2013
Researchers developed a new method to identify antigens that induce autoimmune reactions by generating cells emitting green fluorescent light when stimulated. The technique uses genetic engineering techniques and is highly sensitive, allowing for the analysis of millions of antigens in hours.
SourceLudwig-Maximilians-Universität München·JournalNature Medicine·DateApr 10, 2012
Researchers at National Jewish Health found that T-cell receptors from mice continue to function with shark, frog, and trout receptor pieces substituted in. This interaction between the T cell and MHC molecules is crucial for immune defense and organ transplants.
SourceNational Jewish Health·JournalImmunity·DateSep 29, 2011
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers have cataloged T-cell receptor diversity in blood samples from healthy individuals, identifying over 1 million unique sequences. The study provides insights into the limitations and variability of immune system repertoires.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateFeb 23, 2011
T cell receptors first bind with antigen on pathogen-invaded cell, triggering signaling process that amplifies effect. Co-receptor plays key role in discrimination process, contributing to stronger binding when combined with T cell receptor.
SourceGeorgia Institute of Technology·JournalImmunity·DateJan 20, 2011
Researchers at Monash University have discovered a protein called pre-T alpha that guides the correct expression of T cell receptors, enabling the immune system to effectively destroy harmful viruses and bacteria. The finding has significant implications for understanding immune development and potential treatments for childhood leukemia.
A recent study by scientists at the Fred Hutchinson Cancer Center found that any two people share tens of thousands of identical T-cell receptors, challenging previous dogma. This discovery has significant implications for diagnosing and treating autoimmune diseases and cancer, as it suggests a common immune response to disease.
SourceFred Hutchinson Cancer Center·JournalScience Translational Medicine·DateSep 1, 2010
Scientists have created a mouse with highly effective human immune system components, enabling it to specifically target and destroy cancer cells. This breakthrough could lead to new immunotherapy approaches for cancer treatment.
SourceHelmholtz Association·JournalNature Medicine·DateAug 8, 2010
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A new study challenges existing knowledge about the kinetics of T cell receptors, finding that interactions with potent antigens are short-lived and occur rapidly. The research uses two techniques to analyze receptor-antigen interactions on cell surfaces, revealing a broader dynamic range than previous studies.
SourceGeorgia Institute of Technology·JournalNature·DateMar 31, 2010
Researchers at Dana-Farber Cancer Institute discovered that T cell receptors are mechanosensors that rely on sheer mechanical force to shift between scanning and fighting modes. This fundamental understanding may lead to the development of precisely targeted therapies for cancers and infections, eliminating harsh side effects.
SourceDana-Farber Cancer Institute·JournalJournal of Biological Chemistry·DateNov 2, 2009
A clinical trial at Scottsdale Healthcare-TGen demonstrated tumor shrinkage and limited side effects in patients with advanced basal cell carcinoma. The therapy, which targets the Hedgehog signaling pathway, offers new hope for this aggressive form of skin cancer.
SourceThe Translational Genomics Research Institute·JournalNew England Journal of Medicine·DateSep 2, 2009
Researchers have engineered T cells that can recognize HIV-1 strains that evade the immune system, a breakthrough with implications for treating patients with chronic infection. The engineered T cells respond vigorously to HIV, allowing fewer cells to control infection.
SourceUniversity of Pennsylvania School of Medicine·JournalNature Medicine·DateNov 9, 2008
Researchers at St. Jude Children's Research Hospital discovered T cells use molecular controls to modulate development and avoid autoimmunity. Subtle defects in these controls may explain the delayed onset of autoimmune diseases.
SourceSt. Jude Children's Research Hospital·JournalNature Immunology·DateMay 12, 2008
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Scientists at Albert Einstein College of Medicine genetically engineered immune cells to target and kill HIV-infected cells. This approach, using genes from elite controllers' immune systems, could lead to a new strategy for combating AIDS. The study shows promise in both test tubes and animal models.
SourceAlbert Einstein College of Medicine·JournalJournal of Virology·DateMar 6, 2008