Articles tagged with Toxicology
Researchers at NIST developed a new, faster, and more accessible method for screening skin allergens without animal testing. The electrophilic allergen screening assay (EASA) achieved similar results to existing methods with 77% agreement rate, paving the way for potential standardization and increased international trade.
Researchers found that maintaining hard water reduces zinc accumulation and oxidative stress in goldfish, mitigating toxic effects. This study provides an eco-friendly approach to address aquatic ecosystem pollution caused by heavy metal contamination.
The Chemical Insights Research Institute has received a prestigious award from the National Institutes of Health to study the link between electronic nicotine delivery system (ENDS) usage and periodontal disease. The researchers will analyze consumer vaping behavior data and biosamples to identify biomarkers of exposure and injury, aim...
A new study finds that many children's products, including those labeled as water- or stain-resistant, contain harmful PFAS chemicals. The research highlights the need for stricter safety standards in green certifications and retailer accountability to prevent toxic chemical pollution.
Researchers have found that two sugar substitutes, acesulfame potassium and sucralose, inhibit the activity of P-glycoprotein, a vital protein in liver detoxification. This can lead to impaired transport of toxins and drugs, potentially affecting people taking certain medications. Further studies are needed to confirm these findings.
A study has found that lead poisoning from gun ammunition has suppressed the populations of birds of prey across Europe, resulting in a loss of around 55,000 adult birds. The impact is particularly significant for species like eagles and Red Kites, which are long-lived and breed later in life.
Researchers found that exposure to 6PPD-quinone at environmentally relevant levels can be deadly for rainbow and brook trout, but not for Arctic char or white sturgeon. The study suggests possible non-lethal effects on the latter species, warranting further examination.
The study reveals that asbestos minerals undergo changes that resemble self-defense when internalized by human lung cells. These changes include the formation of an iron-rich layer on the minerals, which may be a mechanism to protect the cell from toxicity.
A new study reveals that construction workers are at high risk of tracking multiple toxic metals into their homes, including arsenic, chromium, and lead. The study found a range of factors, such as lack of work lockers and poor hygiene practices, can impact metal concentrations in home dust.
A national study found that states with higher labor underutilization, non-Hispanic white populations, and opioid prescriptions had higher SIM rates. States with centralized medicolegal death investigation systems detected more SIM cases due to toxicologic testing.
A US study found that e-cigarettes were less popular as a smoking cessation aid in 2017 compared to FDA-approved pharmaceuticals. However, researchers did not see any reduction in relapse rates among those who quit using e-cigarettes.
A team of researchers has developed a new approach to discover the thousands of human-made 'forever' chemicals, PFAS, using advanced mass spectrometry. The technique enables them to characterize and catalog the chemical compounds in the PFAS family.
A study found that 31.4% of trauma patients at Hospital das Clínicas in São Paulo, Brazil, tested positive for psychoactive substance use, including alcohol (23%), cocaine (12%), and marijuana (5%). The study contributes to the development of public policies to prevent accidents.
A two-year randomized trial found that cannabis use significantly impaired driving ability, particularly in the first few hours after smoking. Despite varying levels of THC content and user history, participants displayed diminished skills on simulated driving tests.
Researchers at Hiroshima University discovered that a broccoli compound, DIM, induces controlled cell death and recycling of cellular components in fission yeast. The study suggests that targeting the nuclear envelope could be an early target for future anti-cancer treatments.
A new study by the University of California - San Francisco found an association between increased drinking and hospital visits for atrial fibrillation in a large population. The study linked acute alcohol consumption with a higher risk of new-onset AF in previously undiagnosed individuals.
A recent study by Universitat Rovira i Virgili's TecnATox research group detected seven emerging flame retardants in indoor spaces in Tarragona, Spain, including at high levels. The findings suggest potential health risks for adults and children due to inhalation, ingestion, and skin contact.
A recent UC San Diego study has found that e-cigarette use does not help smokers stay off cigarettes, but rather increases the risk of relapse. Former smokers who switched to e-cigarettes were more likely to relapse compared to those who remained tobacco-free.
A study by UCSF researchers found that emergency department visits and hospitalizations made by patients with addictions increased by 30% and 57%, respectively, between 2014-2018. The authors highlight the urgent need for hospitals to develop systems of hospital-based interventions to provide addiction treatment.
Scientists at Kobe University have created plants that can identify polychlorinated biphenyls and endocrine-disrupting chemicals, which contaminate soil and water. The plant-based method offers a convenient and inexpensive way to monitor toxicity levels.
A team of scientists discovered molecules called 'toxin sponges' in poison frogs and birds that can act as mops to clean up the poisons, potentially leading to a treatment for paralytic shellfish poisoning. The study found that captive-raised poison frogs were resistant to deadly toxins due to these toxin-sponging proteins.
The article examines autopsy, toxicological, and psychiatric reports of Portugal's first major forensic case. It highlights the importance of toxicological analysis and suggests potential new insights with current knowledge.
A study reveals that xylazine, a non-opioid sedative, is implicated in nearly a third of fatal overdoses involving heroin and/or fentanyl in Philadelphia. The substance has been increasingly appearing in the illicit drug supply across the US.
A research team led by Prof. Dr. Robert Grosse has found that bundled fibers of actin play a crucial role in the expansion of cell nuclei after division. This process is essential for reorganizing genetic information and processing chromatin.
A toxicology study found that nonprescribed fentanyl and stimulants were the primary contributors to overdose mortality in BC. Only 8.7% of individuals had taken prescribed opioids, highlighting the need for alternative strategies to address the current overdose crisis.
A new diagnostic/treatment algorithm complements early guidance from the CDC for managing vaping product use associated lung injury (EVALI). The tool was developed by pulmonary and toxicology experts at the University of Rochester Medical Center and the New York State Department of Health.
A new study by Imperial Brands found that Blu vapor did not trigger significant toxicological responses in human lung cells, unlike cigarette smoke. The research used a 3D model of human lung tissue and found no decrease in cilia or ciliated cells after four weeks of exposure.
A clinical trial found that all four tested sunscreen active ingredients (avobenzone, oxybenzone, octocrylene, and ecamsule) were detected in blood samples at levels exceeding the FDA's recommended toxicology threshold. The study's limitations include lack of exposure to heat, sunlight, or humidity, which may impact absorption rates.
A new study investigates potential botanical-drug interactions (BDIs) with Boswellia serrata extract, a widely used anti-inflammatory supplement. The study compared two in vitro methods and found that the sandwich-cultured human hepatocyte model is a more accurate predictor of BDIs.
Researchers found no significant increase in opioid-involved fatal crashes in Maryland from 2006 to 2017. A new approach defined by limiting analysis to those who died at the scene with opioids in their systems versus those who died later revealed this steady trend.
The KIT National Center for Efficacy Evaluation of Respiratory Disease has secured funding for its second phase, which will focus on developing domestic respiratory disease products. The center will utilize a one-step solution combining inhalation testing with toxicology evaluation and clinical studies to evaluate product efficacy.
The study found that seven states have adopted their own guideline levels for PFOA and/or PFOS, with three setting levels lower than EPA's health advisory. State guidelines vary dramatically, from 13 nanograms per liter to 1,000 nanograms per liter.
A recent study found that consumers' knowledge about toxicological principles is limited, leading to misconceptions about man-made versus natural chemicals. Emotions such as disgust also play a significant role in accepting new food technologies, with a negative association between willingness to eat and disgust responses.
Researchers found a significant drop in hospital admissions for toxic effects of so-called legal highs after UK government restrictions and local council measures were implemented. This led to healthcare savings, suggesting that these measures were effective in preventing drug-related harm.
Researchers at Portland State University developed methods to measure free-base nicotine in e-cigarette liquids and vapor. The study found that JUUL products have low free-base levels but high total nicotine, making them tolerable for inhalation.
A study found that pangasius contains high levels of mercury, exceeding European limits. Researchers recommend avoiding the fish due to its low nutritional value and potential health risks, especially in children.
The special focus issue of Bioanalysis examines models and trends in outsourcing, featuring insights from key opinion leaders. The issue highlights the rapidly evolving aspect of drug discovery and development.
A study found that tweets about opioid misuse on Twitter were strongly correlated with state-by-state information from the National Surveys on Drug Usage and Health. The research used a list of keywords to extract relevant tweets, which were then clustered based on semantic distance and verified by medical toxicologists.
Researchers developed two new mechanistic models, Adverse Outcome Pathways (AOPs), to assess toxicological risk of chemicals without animal testing. The AOPs were recognized by PETA International Science Consortium for their contributions to non-animal approaches.
A new method for identifying illicit drugs has been developed, offering high sensitivity and fast results. This technique uses multi-dimensional chromatography combined with a micro-extraction method, allowing for rapid analysis in under 20 minutes.
The development of global standards for vaping products is essential to promote innovation and protect consumers. Different regulatory approaches in the EU and US can hinder growth and stifle innovation, as noted by British American Tobacco's Head of R&D, Marina Trani.
Researchers have developed a new technique to produce a faithful mimic of the in vivo liver inside a scalable fluid-handling device. The chip-based model demonstrates proof of principle for toxicology tests and opens up potential use in drug testing and personalized medicine.
Researchers at UMass Medical School found that Google Glass can effectively extend toxicology consults to remote hospitals, improving patient diagnosis and management. The device enables physicians to consult with remote specialists in real-time, validating bedside exams and diagnosing specific poisonings.
Researchers developed 3D human skin tissue models to detect sensitizers in medical devices, potentially replacing animal testing. The models showed ability to detect low levels of known skin sensitizers.
Researchers found that e-cig liquids contain primarily free-base nicotine, the most addictive form, and often do not match label concentrations. This suggests that e-cigarettes can be just as hazardous to health as traditional tobacco products.
Research in mice exposes pregnant females to phthalate DEHP, leading to male-to-female sex ratio imbalance and altered pup reproductive outcomes. Adult ovaries are also disrupted, with decreased follicle growth and steroid hormone production.
A study analyzing violent behaviors towards pregnant women found that 22.7% endure some form of violence, including emotional and physical abuse. The prevalence is higher in Spain than nearby countries, highlighting the need for routine detection and action protocols in pregnancy management.
Professor Daniel G. Cyr, a renowned toxicologist at INRS, has received the Gabriel L. Plaa Award of Distinction for his pioneering work on the effects of environmental contaminants on male reproductive health. His research aims to understand the underlying cellular mechanisms of male infertility, with a focus on endocrine disruptors.
The VCU Alcohol Research Center will investigate the genetic systems contributing to alcoholism using advanced statistical and bioinformatic methods. Researchers will focus on gene networks influencing alcohol behaviors in humans and animals.
A new non-animal skin sensitization method using a human-derived skin model has been validated to correctly identify chemicals causing allergic responses in humans. The method, SenCeeTox, uses a three-dimensional model that accurately replicates normal human skin, reducing the need for animal testing.
Calabrese's research reveals how the linear no-threshold dose-response approach was adopted despite experimental support for a threshold model. He accuses two geneticists of suppressing evidence to prevent consideration of an alternative model.
Renowned scientists at South Carolina College of Pharmacy, John Lemasters and Rick Schnellmann, have received national recognition from the Society of Toxicology for their groundbreaking work in toxicology research and education. The awards recognize their significant contributions to advancing our understanding of toxicology and promo...
A new study reveals that nonprescription medication abuse is a significant issue, with 48% of cases involving pharmaceutical overdoses. The most common medications involved were sleeping pills, muscle relaxants, and pain relievers, leading to 35 deaths in 2011.
A new study published in ACS' Journal of Agricultural and Food Chemistry has identified potential methods to minimize acrylamide formation in french fries. Researchers used computer models to link changes in natural potato components with acrylamide formation, providing a rigorous approach to product development.
Researchers found that female mice exposed to very high doses of phthalates develop significant reproductive alterations and precancerous lesions as they grow up. The study provides new insights into how these chemicals affect developing female reproductive systems, with the potential for long-term health effects.
Research reveals that a poor maternal diet can affect fat storage in later life, increasing the risk of type 2 diabetes and other age-related diseases. The team identified a molecule called miR-483-3p as the key player in this process, which suppresses a protein called GDF3.
The letter highlights growing concerns about chemicals like BPA and the need for experts from genetics, reproductive medicine, and other fields to interpret and evaluate science. The authors advocate for swifter and sounder testing procedures to prevent chemicals from entering the environment.
Studded winter tires grind away at road surfaces, generating dust particles linked to inflammation and diseases such as heart disease. Researchers found specific protein changes in cells related to road dust exposure, which could help understand the link between pavement dust and heart disease.
Thomas Miller, UCR entomologist, to advise State Department on biotechnology and pest management globally. He will also engage with non-specialists and travel to embassies to share expertise.
The new laboratory will provide forensic services in up to 5,000-6,000 criminal investigations annually, including toxicology analysis and drug identification. It is part of a larger program focused on criminal justice and related areas.