Articles tagged with Toxicology
The KIT National Center for Efficacy Evaluation of Respiratory Disease has secured funding for its second phase, which will focus on developing domestic respiratory disease products. The center will utilize a one-step solution combining inhalation testing with toxicology evaluation and clinical studies to evaluate product efficacy.
The study found that seven states have adopted their own guideline levels for PFOA and/or PFOS, with three setting levels lower than EPA's health advisory. State guidelines vary dramatically, from 13 nanograms per liter to 1,000 nanograms per liter.
A recent study found that consumers' knowledge about toxicological principles is limited, leading to misconceptions about man-made versus natural chemicals. Emotions such as disgust also play a significant role in accepting new food technologies, with a negative association between willingness to eat and disgust responses.
Researchers found a significant drop in hospital admissions for toxic effects of so-called legal highs after UK government restrictions and local council measures were implemented. This led to healthcare savings, suggesting that these measures were effective in preventing drug-related harm.
Researchers at Portland State University developed methods to measure free-base nicotine in e-cigarette liquids and vapor. The study found that JUUL products have low free-base levels but high total nicotine, making them tolerable for inhalation.
A study found that pangasius contains high levels of mercury, exceeding European limits. Researchers recommend avoiding the fish due to its low nutritional value and potential health risks, especially in children.
The special focus issue of Bioanalysis examines models and trends in outsourcing, featuring insights from key opinion leaders. The issue highlights the rapidly evolving aspect of drug discovery and development.
A study found that tweets about opioid misuse on Twitter were strongly correlated with state-by-state information from the National Surveys on Drug Usage and Health. The research used a list of keywords to extract relevant tweets, which were then clustered based on semantic distance and verified by medical toxicologists.
Researchers developed two new mechanistic models, Adverse Outcome Pathways (AOPs), to assess toxicological risk of chemicals without animal testing. The AOPs were recognized by PETA International Science Consortium for their contributions to non-animal approaches.
A new method for identifying illicit drugs has been developed, offering high sensitivity and fast results. This technique uses multi-dimensional chromatography combined with a micro-extraction method, allowing for rapid analysis in under 20 minutes.
The development of global standards for vaping products is essential to promote innovation and protect consumers. Different regulatory approaches in the EU and US can hinder growth and stifle innovation, as noted by British American Tobacco's Head of R&D, Marina Trani.
Researchers have developed a new technique to produce a faithful mimic of the in vivo liver inside a scalable fluid-handling device. The chip-based model demonstrates proof of principle for toxicology tests and opens up potential use in drug testing and personalized medicine.
Researchers at UMass Medical School found that Google Glass can effectively extend toxicology consults to remote hospitals, improving patient diagnosis and management. The device enables physicians to consult with remote specialists in real-time, validating bedside exams and diagnosing specific poisonings.
Researchers developed 3D human skin tissue models to detect sensitizers in medical devices, potentially replacing animal testing. The models showed ability to detect low levels of known skin sensitizers.
Researchers found that e-cig liquids contain primarily free-base nicotine, the most addictive form, and often do not match label concentrations. This suggests that e-cigarettes can be just as hazardous to health as traditional tobacco products.
Research in mice exposes pregnant females to phthalate DEHP, leading to male-to-female sex ratio imbalance and altered pup reproductive outcomes. Adult ovaries are also disrupted, with decreased follicle growth and steroid hormone production.
A study analyzing violent behaviors towards pregnant women found that 22.7% endure some form of violence, including emotional and physical abuse. The prevalence is higher in Spain than nearby countries, highlighting the need for routine detection and action protocols in pregnancy management.
Professor Daniel G. Cyr, a renowned toxicologist at INRS, has received the Gabriel L. Plaa Award of Distinction for his pioneering work on the effects of environmental contaminants on male reproductive health. His research aims to understand the underlying cellular mechanisms of male infertility, with a focus on endocrine disruptors.
The VCU Alcohol Research Center will investigate the genetic systems contributing to alcoholism using advanced statistical and bioinformatic methods. Researchers will focus on gene networks influencing alcohol behaviors in humans and animals.
A new non-animal skin sensitization method using a human-derived skin model has been validated to correctly identify chemicals causing allergic responses in humans. The method, SenCeeTox, uses a three-dimensional model that accurately replicates normal human skin, reducing the need for animal testing.
Calabrese's research reveals how the linear no-threshold dose-response approach was adopted despite experimental support for a threshold model. He accuses two geneticists of suppressing evidence to prevent consideration of an alternative model.
Renowned scientists at South Carolina College of Pharmacy, John Lemasters and Rick Schnellmann, have received national recognition from the Society of Toxicology for their groundbreaking work in toxicology research and education. The awards recognize their significant contributions to advancing our understanding of toxicology and promo...
A new study reveals that nonprescription medication abuse is a significant issue, with 48% of cases involving pharmaceutical overdoses. The most common medications involved were sleeping pills, muscle relaxants, and pain relievers, leading to 35 deaths in 2011.
A new study published in ACS' Journal of Agricultural and Food Chemistry has identified potential methods to minimize acrylamide formation in french fries. Researchers used computer models to link changes in natural potato components with acrylamide formation, providing a rigorous approach to product development.
Researchers found that female mice exposed to very high doses of phthalates develop significant reproductive alterations and precancerous lesions as they grow up. The study provides new insights into how these chemicals affect developing female reproductive systems, with the potential for long-term health effects.
Research reveals that a poor maternal diet can affect fat storage in later life, increasing the risk of type 2 diabetes and other age-related diseases. The team identified a molecule called miR-483-3p as the key player in this process, which suppresses a protein called GDF3.
The letter highlights growing concerns about chemicals like BPA and the need for experts from genetics, reproductive medicine, and other fields to interpret and evaluate science. The authors advocate for swifter and sounder testing procedures to prevent chemicals from entering the environment.
Studded winter tires grind away at road surfaces, generating dust particles linked to inflammation and diseases such as heart disease. Researchers found specific protein changes in cells related to road dust exposure, which could help understand the link between pavement dust and heart disease.
Thomas Miller, UCR entomologist, to advise State Department on biotechnology and pest management globally. He will also engage with non-specialists and travel to embassies to share expertise.
The new laboratory will provide forensic services in up to 5,000-6,000 criminal investigations annually, including toxicology analysis and drug identification. It is part of a larger program focused on criminal justice and related areas.
Researchers found that car brake particles can cause cellular stress and inflammation in lung cells, particularly with heavy braking. Brake wear particles contain metals like iron and copper, which can damage cell junctions through oxidative stress.
The National Institute of Environmental Health Sciences (NIEHS) has awarded $14 million in Recovery Act grants to study the potential health risks of bisphenol A (BPA). Researchers will investigate BPA's effects on human health, including behavior, obesity, diabetes, reproductive disorders, and cancer.
A new study found that people's bodies handle arsenic differently, with some individuals excreting up to 95% of ingested arsenic, while others store it in their bodies, posing a risk to health. The research suggests that existing standards for evaluating human health risks from arsenic may need to be reassessed.
Researchers have discovered new mosquito repellents that last up to three times longer than DEET, the current gold standard. The repellents do not cause skin irritation or unpleasant odors, making them a promising alternative for people sensitive to DEET.
Research found that maternal exposure to titanium dioxide nanoparticles affects gene expression related to the central nervous system in developing mice. This may have implications for diseases such as autistic disorder, epilepsy, and learning disorders, as well as Alzheimer's disease, schizophrenia, and Parkinson's disease.
Walter Leal, a UC Davis professor, received the ESA award for his groundbreaking research on mosquito repellent DEET. His lab discovered the mode of action for DEET, which doesn't mask the host's smell but rather repels mosquitoes through direct detection.
A team of international researchers formed the International Alliance for NanoEHS Harmonization (IANH) to establish reproducible toxicological testing protocols for nanomaterials. The alliance aims to address key gaps in scientific knowledge and accelerate understanding of nanotechnology's social implications.
International researchers establish protocols for reproducible toxicological testing of nanomaterials in cells and animals. The International Alliance for NanoEHS Harmonization aims to improve correlations between in vitro and animal testing.
The National Academies of Sciences report introduces new tools to assess health risks from chemicals, enabling better predictive toxicology and risk assessment. These technologies provide critical information on environmental agent interactions with human genes, helping identify individuals at higher disease risk.
Dr. Elliot V. Hersh has been recognized for his research on non-steroidal anti-inflammatory drugs and local anaesthetics used in dentistry, including the approval of articaine by the US FDA. He is a prominent figure in the IADR Pharmacology, Therapeutics & Toxicology Group, having served in leadership roles and organized symposia.
Dr. Meechan has received the IADR Pharmacology, Therapeutics, & Toxicology Research Award for his contributions to dental care management and medically compromised patients. The award recognizes his research interests in local anesthesia and pain control.
Dr. Moore's distinguished career has led to evidence-based frameworks for clinical dentistry, with notable contributions in pediatric sedation guidelines and diabetes research. His work has provided a foundation for optimal pain control and minimal adverse effects in clinical analgesics and anesthetics.
The William C. Rose Award lecture will focus on the importance of cytochrome P450s in drug development, endocrinology, and toxicology. Dr. Guengerich's recent work includes kinetic analysis and methods to define substrates and products of orphan P450s.
The International Association for Dental, Oral, and Craniofacial Research has awarded Dr. Haas the 2004 Pharmacology/Therapeutics/Toxicology Award for his extensive work on anxiolytic agents in dentistry. Dr. Haas has also made significant contributions to the field through his presentations and leadership roles.
A landmark analysis found that oxycodone was involved in only a small percentage of drug abuse deaths, with multiple drugs present in most cases. The study suggests that abusing opioids with other substances increases risk and calls for enhanced classification methods.
The National Toxicology Program (NTP) is hosting a public meeting to review its report on carcinogens and gather feedback from interested parties. Written and oral comments can be submitted until September 15, with the goal of informing the review process for the 10th edition of the Report on Carcinogens.