Articles tagged with Toxicology
The VCU Alcohol Research Center will investigate the genetic systems contributing to alcoholism using advanced statistical and bioinformatic methods. Researchers will focus on gene networks influencing alcohol behaviors in humans and animals.
A new non-animal skin sensitization method using a human-derived skin model has been validated to correctly identify chemicals causing allergic responses in humans. The method, SenCeeTox, uses a three-dimensional model that accurately replicates normal human skin, reducing the need for animal testing.
Calabrese's research reveals how the linear no-threshold dose-response approach was adopted despite experimental support for a threshold model. He accuses two geneticists of suppressing evidence to prevent consideration of an alternative model.
Renowned scientists at South Carolina College of Pharmacy, John Lemasters and Rick Schnellmann, have received national recognition from the Society of Toxicology for their groundbreaking work in toxicology research and education. The awards recognize their significant contributions to advancing our understanding of toxicology and promo...
A new study reveals that nonprescription medication abuse is a significant issue, with 48% of cases involving pharmaceutical overdoses. The most common medications involved were sleeping pills, muscle relaxants, and pain relievers, leading to 35 deaths in 2011.
A new study published in ACS' Journal of Agricultural and Food Chemistry has identified potential methods to minimize acrylamide formation in french fries. Researchers used computer models to link changes in natural potato components with acrylamide formation, providing a rigorous approach to product development.
Researchers found that female mice exposed to very high doses of phthalates develop significant reproductive alterations and precancerous lesions as they grow up. The study provides new insights into how these chemicals affect developing female reproductive systems, with the potential for long-term health effects.
Research reveals that a poor maternal diet can affect fat storage in later life, increasing the risk of type 2 diabetes and other age-related diseases. The team identified a molecule called miR-483-3p as the key player in this process, which suppresses a protein called GDF3.
The letter highlights growing concerns about chemicals like BPA and the need for experts from genetics, reproductive medicine, and other fields to interpret and evaluate science. The authors advocate for swifter and sounder testing procedures to prevent chemicals from entering the environment.
Studded winter tires grind away at road surfaces, generating dust particles linked to inflammation and diseases such as heart disease. Researchers found specific protein changes in cells related to road dust exposure, which could help understand the link between pavement dust and heart disease.
Thomas Miller, UCR entomologist, to advise State Department on biotechnology and pest management globally. He will also engage with non-specialists and travel to embassies to share expertise.
The new laboratory will provide forensic services in up to 5,000-6,000 criminal investigations annually, including toxicology analysis and drug identification. It is part of a larger program focused on criminal justice and related areas.
Researchers found that car brake particles can cause cellular stress and inflammation in lung cells, particularly with heavy braking. Brake wear particles contain metals like iron and copper, which can damage cell junctions through oxidative stress.
The National Institute of Environmental Health Sciences (NIEHS) has awarded $14 million in Recovery Act grants to study the potential health risks of bisphenol A (BPA). Researchers will investigate BPA's effects on human health, including behavior, obesity, diabetes, reproductive disorders, and cancer.
A new study found that people's bodies handle arsenic differently, with some individuals excreting up to 95% of ingested arsenic, while others store it in their bodies, posing a risk to health. The research suggests that existing standards for evaluating human health risks from arsenic may need to be reassessed.
Researchers have discovered new mosquito repellents that last up to three times longer than DEET, the current gold standard. The repellents do not cause skin irritation or unpleasant odors, making them a promising alternative for people sensitive to DEET.
Research found that maternal exposure to titanium dioxide nanoparticles affects gene expression related to the central nervous system in developing mice. This may have implications for diseases such as autistic disorder, epilepsy, and learning disorders, as well as Alzheimer's disease, schizophrenia, and Parkinson's disease.
Walter Leal, a UC Davis professor, received the ESA award for his groundbreaking research on mosquito repellent DEET. His lab discovered the mode of action for DEET, which doesn't mask the host's smell but rather repels mosquitoes through direct detection.
A team of international researchers formed the International Alliance for NanoEHS Harmonization (IANH) to establish reproducible toxicological testing protocols for nanomaterials. The alliance aims to address key gaps in scientific knowledge and accelerate understanding of nanotechnology's social implications.
International researchers establish protocols for reproducible toxicological testing of nanomaterials in cells and animals. The International Alliance for NanoEHS Harmonization aims to improve correlations between in vitro and animal testing.
The National Academies of Sciences report introduces new tools to assess health risks from chemicals, enabling better predictive toxicology and risk assessment. These technologies provide critical information on environmental agent interactions with human genes, helping identify individuals at higher disease risk.
Dr. Elliot V. Hersh has been recognized for his research on non-steroidal anti-inflammatory drugs and local anaesthetics used in dentistry, including the approval of articaine by the US FDA. He is a prominent figure in the IADR Pharmacology, Therapeutics & Toxicology Group, having served in leadership roles and organized symposia.
Dr. Meechan has received the IADR Pharmacology, Therapeutics, & Toxicology Research Award for his contributions to dental care management and medically compromised patients. The award recognizes his research interests in local anesthesia and pain control.
Dr. Moore's distinguished career has led to evidence-based frameworks for clinical dentistry, with notable contributions in pediatric sedation guidelines and diabetes research. His work has provided a foundation for optimal pain control and minimal adverse effects in clinical analgesics and anesthetics.
The William C. Rose Award lecture will focus on the importance of cytochrome P450s in drug development, endocrinology, and toxicology. Dr. Guengerich's recent work includes kinetic analysis and methods to define substrates and products of orphan P450s.
The International Association for Dental, Oral, and Craniofacial Research has awarded Dr. Haas the 2004 Pharmacology/Therapeutics/Toxicology Award for his extensive work on anxiolytic agents in dentistry. Dr. Haas has also made significant contributions to the field through his presentations and leadership roles.
A landmark analysis found that oxycodone was involved in only a small percentage of drug abuse deaths, with multiple drugs present in most cases. The study suggests that abusing opioids with other substances increases risk and calls for enhanced classification methods.
The National Toxicology Program (NTP) is hosting a public meeting to review its report on carcinogens and gather feedback from interested parties. Written and oral comments can be submitted until September 15, with the goal of informing the review process for the 10th edition of the Report on Carcinogens.