Articles tagged with Toxicology
Dr. Jake Johnson explains the challenges of studying canine cocaine toxicosis, including limited data and messy clinical reality. He shares insights on diagnosing symptoms, prevention measures, and the importance of owner honesty in seeking veterinary help.
Researchers developed a new engineered protein-based therapy called RcoM-HBD-CCC, which acts like a sponge to soak up carbon monoxide from the blood. The therapy was tested on mice and showed promising results, clearing half of the carbon monoxide in the blood in less than a minute.
A survey of scientific literature on micro- and nanoplastics in human health identifies key challenges and proposes best practices for analysis, including digestion treatments and shape considerations. The study aims to improve our understanding of plastics' impact on human bodies.
TDCPP's binding to the membrane thyroid hormone receptor impairs motor neuron development and causes locomotor dysfunction in zebrafish. The study establishes a novel adverse outcome pathway framework for predicting TDCPP's neurotoxicity.
This study uses AI to pinpoint optimal synergies in combination therapies, slashing experimental costs and accelerating discovery by up to 7.2% in accuracy.
Researchers emphasize the need to distinguish between harmful PFAS and essential fluoropolymers used in medical devices, which have not been linked to health issues. Experts advocate for a balanced approach to protect both human health and environmental concerns.
Research suggests that nine commonly used pesticides in viticulture have significantly underestimated environmental impact, with half-lives exceeding two days and potential for long-range transport.
Researchers evaluated the safety profiles of ethylhexyl triazone (EHT) and diethylhexyl butamido triazone (HEB) using integrated genotoxicity and phototoxicity assessments. The studies found no significant increases in mutagenic or chromosomal damage, and only minor micronucleus increases at high concentrations.
Researchers found no significant genotoxic effects of triazine UV filters in bacterial reverse mutation, chromosomal aberration, and micronucleus assays. Phototoxicity assessments also confirmed safety using 3T3 neutral red uptake and guinea pig models. The results support the use of these filters in topical applications.
Scientists have discovered that certain species of gut bacteria can absorb PFAS, potentially protecting against its harmful effects. The researchers plan to develop probiotic dietary supplements to boost the levels of these helpful microbes in our gut.
Researchers studied the effects of 6-PPDQ on the citric acid cycle in C. elegans, finding disruptions at environmentally relevant concentrations. The study revealed reductions in key metabolites and enzyme gene expressions, contributing to mitochondrial dysfunction and toxicity.
A study by the University of California, Davis found that disposable e-cigarettes release higher amounts of toxic metals than older e-cigarettes and traditional cigarettes. The devices contain hazardous levels of neurotoxic lead, carcinogenic nickel, and antimony, posing significant health risks to users.
The BfR Summer Academy, an international event, brings together 23 participants from 17 countries to discuss food safety and risk assessment. Participants learn about the legal and institutional background of food safety in Germany and Europe.
A study reveals that metal-organic frameworks (MOFs) can be toxic to mice, causing disruptions in blood cell formation and immune balance. The researchers found that the MOFs suppressed production of certain cells but also triggered a rebound effect, leading to increased inflammation.
Researchers found that co-exposure to bisphenol A and retinoic acid disrupts neurodevelopmental gene signaling, leading to brain abnormalities. The study suggests a potential link between chemical exposure and neurodevelopmental disorders like autism spectrum disorder and attention deficit hyperactivity disorder.
The Human Exposome Moonshot initiative aims to map the physical, chemical, biological and psychosocial exposures driving 80% of chronic diseases. The exposome project integrates advanced technologies to create a comprehensive understanding of environmental influences on health.
New study reveals insights into giant viruses and their role in marine ecosystems, including photosynthesis manipulation and public health hazards. The discovery of 230 novel giant viruses has significant implications for predicting and managing harmful algal blooms.
A new study finds that the Salton Sea emits hydrogen sulfide at rates exceeding state air quality standards, with emissions regularly going unreported by government monitoring systems. The presence of these toxic emissions poses significant health risks to local communities already burdened by environmental and socioeconomic stressors.
A new study by UC Riverside researchers reveals that ultrasonic cigarettes may pose significant health risks due to the presence of harmful metals in their liquids and aerosols. The study found elevated levels of metals like arsenic and selenium in u-cigarette products, which can lead to lung diseases, organ damage, and cancer.
The Human Exposome is a global scientific effort to understand the environmental factors that underpin disease and health. The Exposome Moonshot Forum aims to chart this exposome, providing usable metrics and data points for targeted public health interventions.
Researchers found that sulfur runoff can dramatically increase methylmercury concentrations in fish up to 10 million times greater than the waters they lived in. This poses a significant risk to human health and wildlife due to methylmercury's neurotoxic effects.
A new study reveals that over half of Black and Latina women reported using personal care products with formaldehyde-releasing preservatives, highlighting critical safety gaps in product regulation. The study found that these chemicals are present in a wide range of products, including shampoo, lotions, and eyelash glue.
The updated Maurer, Meyer, Helfer, Weber: LC-HR-MS/MS Library contains over 5,500 mass spectra for parent drugs and poisons, along with their metabolites. This comprehensive dataset enables scientists to confidently identify unknown compounds and assess toxic substance risks.
Researchers propose GLDH as a more liver-specific biomarker for detecting liver injury, offering greater specificity than current ALT and AST tests. The test performed similarly to ALT for detecting liver injury but was not impacted by associated muscle injury.
The article discusses the need for bioanalytical assays to measure immune responses to oligonucleotide therapeutic drugs, especially when they include carriers or conjugates. Highly specific antibodies may enhance the development and production of ONTs, expanding studies on their safety and efficacy.
A new study by Silent Spring Institute reveals how California's Proposition 65 law has driven companies to reformulate products, reducing the use of toxic chemicals and promoting safer consumer goods. The research found that companies prioritize eliminating Prop 65 chemicals altogether to avoid warnings and litigation.
Cadmium induces hyaluronan synthase 3 expression via the c-Jun N-terminal kinase–c-Jun pathway, leading to increased hyaluronan synthesis. This process accelerates atherosclerosis progression in vascular endothelial cells.
A new study suggests that COVID-19 likely emerged from the natural fusion of two rare infectious diseases, glanders and Sennetsu fever, with some common human diseases. DNA methylation patterns at 865,859 CpG sites in blood samples from early COVID-19 patients revealed strong genetic link evidence supporting this theory.
A recent study by UCLA researchers has discovered high amounts of bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate (BTMPS) in illicitly sold fentanyl. BTMPS is not approved for human consumption and has been linked to serious health effects such as cardiotoxicity and ocular damage.
A new clinical study by the BfR found that tattoo ink contains smaller amounts of liquid components than previously thought. The researchers were able to detect metabolites in blood samples shortly after tattooing began and showed that metabolism functions differently when substances are taken up through the skin.
Researchers at Boston University School of Medicine found significant inconsistencies in hospital toxicology screening practices following serious motor vehicle collisions. The study highlights the need for standardized, equitable reporting protocols to ensure every patient receives consistent care.
Researchers at Chalmers University of Technology found that biochar significantly reduces DDT uptake by earthworms in contaminated soil, halving the toxin's presence. This method could enable farming on land deemed unusable due to environmental risks.
Researchers at the University of Konstanz have discovered that different mutations of the tumour suppressor p53 affect pancreatic carcinomas differently. The study found that two variants of p53 selectively control distinct metabolic pathways, providing new insights into cancer development.
University of Delaware researchers develop a method to remove toxic particles from tires by upgrading a molecule that provides UV protection into safe chemicals. The leftover crumb rubber can be recycled using classic plastic recycling methods or converted into aromatics and carbon black.
A WVU research partnership with the DEA aims to improve fast and accurate identification of psychoactive substances like fentanyl. The Expert Algorithm for Substance Identification (EASI) will enable labs using different instruments to share data on chemical profiles, helping to identify drugs like fentanyl.
The study reveals that the hadal snailfish has unique metabolic adjustments to store energy, optimize energy utilization, and maintain membrane fluidity. The fish increases lipid reserves, elevates CoQ and ATPase levels, and adjusts fatty acid ratios to withstand food scarcity and high pressure.
Recreational cannabis legalization in California is associated with higher rates of cannabis use during early pregnancy, driven by jurisdictions allowing adult-use retailers. The study found that individuals living in these areas were more likely to use cannabis during early pregnancy.
Researchers discovered that tire-wear particle leachates induce hepatic oxidative stress, inflammation, and histopathology changes in black-spotted frogs. These disruptions can lead to long-term health issues for affected organisms.
A study from Goethe University Frankfurt reveals that venomous crustaceans, specifically remipede crabs in Mexican cenote caves, contain a variety of toxins with pharmacological potential. The xibalbines peptides effectively inhibit potassium channels and activate signaling pathways involved in pain sensitization.
Experts propose a series of scientific principles and experimental approaches to assess potential carcinogenicity of gene therapies. Data transparency is crucial, with publicly accessible data from viral integrations site studies and clinical settings.
Researchers created nanomicelles containing substances already approved for human use, which reduced inflammation in the tumor microenvironment and facilitated the action of the immune system. The treatment induced a reduction of over five times in tumor volume compared to untreated tumors.
A new AI method developed by Swedish researchers can identify toxic substances based on their chemical structure, potentially replacing animal testing. The method has been shown to be more accurate and broadly applicable than existing computational tools, offering a promising alternative for environmental research and authorities.
A new study published in Clinical Chemistry and Laboratory Medicine reveals that smartphone swabs can successfully detect drugs on phone surfaces. The method, which uses dry swabs, identified MDMA, cocaine, and THC as the most common substances, with other drugs including ketamine, LSD, and heroin also detected.
Calls to US poison centers involving psilocybin among teens and young adults tripled and doubled, respectively, after decriminalization, leading to alarming concern over potential long-term consequences. Most calls involved intentional consumption, with adverse reactions including hallucinations, agitation, and heart rate issues.
A new EWG study has found chlormequat, a little-known pesticide, in 77% of urine samples from people tested between 2017 and 2023. The chemical is linked to reproductive and developmental problems in animal studies, suggesting potential harm to humans. EWG calls for increased research and regulation on chlormequat.
Researchers in Argentina have found that cyanobacteria blooms are becoming more intense in five reservoirs, particularly in the warmest areas. The team also detected positive records of cyanotoxins only in the last four years of the study period, highlighting a significant underestimation of the problem.
Researchers have identified a sequence within therapeutic mRNAs that causes unintended immune responses and found a way to correct these errors. By designing 'slip-resistant' mRNAs, the team aims to produce future mRNA vaccines with improved safety and efficacy.
Researchers at Osaka Metropolitan University have decoded the metabolism of three major flavonoids - naringenin, apigenin, and genistein - revealing how human enzymes modify them in a similar way to plants. This understanding may lead to improved health benefits associated with plant-based diets.
Researchers found that urine biomarkers can be more accurate than serum biomarkers for detecting specific diseases. The study highlights the potential of combining urinary and serum biomarkers for holistic disease diagnosis and management. However, challenges remain in standardizing urinary biomarker assays and expanding their applicat...
A study of 74 children in rural Ethiopian villages found that higher exposure to fluoride was linked to more errors on drawing and memory tests. The results suggest a potential association between high fluoride levels and cognitive impairment, particularly during early brain development and childhood.
Researchers measured metabolite concentrations of two herbicides in urine samples from Ecuadorian adolescents and found negative associations with attention, memory, and language. Glyphosate was also linked to social perception issues.
A study of 194 patients found that those with alcohol-related diagnoses made 44% more visits and had a 138% higher death rate over 20 years compared to controls. Targeted interventions in emergency departments may help reduce this significant health burden.
The new facility will enhance the lab's capabilities to study the impact of chemicals and nanomaterials on human health, with applications in areas like toxicology and disease prevention.
A recent study published in Water Biology and Security challenges the hypothesis that cyanobacteria produce β-N-methylamino-L-alanine (BMAA), a non-protein amino acid linked to neurodegenerative diseases. The study found no detectable levels of BMAA in laboratory-cultured strains and natural cyanobacterial bloom samples.
A study using a placenta-on-a-chip model investigated the transport of pharmaceutical agents, such as naltrexone, to the fetus. The research revealed significantly higher expression levels of interleukin-6 and tumor necrosis factor-alpha in neural cells exposed to these agents.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Researchers at TUM develop an RNA agent for a lung spray that slows macrophage activity, reducing lung inflammation and fibrosis. The active substance RCS-21 is delivered via an inhaler through a special sugar molecule, showing promise in treating acute inflammatory lung damage.
A new study reveals that illicit drug use is involved in nearly one in three sudden cardiac deaths (SCDs) among young adults in Victoria, Australia. The analysis of data from a statewide registry found higher levels of illicit drugs and multiple substance use among SCD patients.
A study published in Science reveals that ganglia in the neck region are responsible for disrupting melatonin production and causing sleep disturbances in people with heart conditions. Researchers found that macrophages accumulate in the ganglion, leading to inflammation and scarring, which can be treated with drugs.
A study investigates the impact of industrial sludge on zebrafish development, revealing concentration-dependent mortality, decreased hatchability, and disrupted thyroid hormone levels. The findings highlight the need for biomonitoring endpoints to predict and assess PAH pollution in Bohai Bay.