Articles tagged with Transcription Factors
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
YY1 regulates p53 at multiple levels, decreasing its amount in cells and blocking its interaction with cofactors. This discovery offers new targeting options for therapies to prevent transcription factors from interacting with other proteins.
Scientists discovered that deleting three circadian genes in mice results in severe epilepsy and accelerated aging. The mice lacking all three genes are prone to epileptic seizures and display early mortality, with a significant increase in deaths on Mondays and Thursdays due to sound-induced attacks.
Scientists have developed a new genomics tool that enables the efficient mapping of genome binding sites for transcription factors in human organs. This technology has been used to study the role of transcription factor HNF4 in type 2 diabetes, revealing its association with about half of all genes needed to make the pancreas and liver.
Researchers use genome-wide location analysis to study how a transcription factor Ste12 responds differently under various environmental conditions. By pinpointing the mechanism, scientists can make predictions of cellular behavior and potentially disrupt certain diseases at the cellular level.
Researchers at UNC identified two key genes involved in blood vessel development: BMPER and HOXB5. The study found that BMPER inhibits further differentiation of endothelial cells, while HOXB5 activates the endothelial cell program, increasing vessel formation.
Researchers at Whitehead Institute have created a global script describing how the yeast genome produces life, revealing the complex relationships between genes and proteins. This breakthrough allows for a vast network of interactions to be mapped, enabling targeted pharmaceutical approaches for diseases such as cancer.
The grant will develop new technologies to study G protein-coupled receptors and transcription factors, crucial for physiological responses. Researchers aim to create flat panels with multiple GPCRs to quickly assess drug candidates' effects.
Researchers at Dartmouth have discovered a novel photoreceptor protein that absorbs light and regulates the circadian rhythm. The protein, White Collar-1, is part of a genetic system that can be exploited to develop new drug delivery systems for treating fungal diseases.
A study suggests that insulin can suppress a pro-inflammatory transcription factor that promotes clot formation in blood vessels. Insulin infusion reduced levels of tissue factor and plasminogen activator inhibitor-1, key players in the development of human and mouse atherosclerosis.
Researchers James E. Darnell and Ali H. Brivanlou propose a reclassification of all known transcription factors, grouping them by their behavior rather than physical structure. This framework aims to provide a better understanding of how cells 'read' genetic instructions and may lead to new drug therapies for diseases such as cancer an...
Researchers at the Gladstone Institute have discovered a new pathway that regulates the activity of NF-kB, a protein controlling key inflammatory and immune responses. The study reveals how acetylation and deacetylation control NF-kB's ability to trigger biological processes.
Researchers found that Drosophila neural precursor cells sequentially activate four different transcription factors, allowing them to maintain differences based on their time of birth. This 'memory' is crucial for normal brain development and may have implications for understanding human neural development.
Yale researchers have identified virtually all of the gene targets for a key protein, known as transcription factors, using new DNA chip technology. The study reveals that these proteins control cell proliferation in yeast and can be used to understand how cells become specialized.
Lehman et al. show that PGC-1 is limiting for mitochondrial proliferation in cardiac muscle, directing changes in mitochondrial population across cells. Overexpressing PGC-1 increases fatty acid oxidation capacity and coupled OxPhos, but constitutive expression leads to dilated cardiomyopathy.
Researchers demonstrate that different concentrations of transcription factor PU.1 control blood cell progenitor development into B lymphocytes or macrophages, two distinct types of white blood cells. High levels of PU.1 block B cell development and promote macrophage formation.
Researchers identified two genetic elements, AE5' and AE3', that regulate human Factor IX expression, leading to increased coagulation capacity with age. The study provides insight into the molecular basis of age-related changes in blood clotting.
Researchers at St. Jude Children's Research Hospital have discovered a novel leukemia-producing transcription factor called E2A-HLF, which transforms immature lymphocytes by preventing normal destruction programs. This finding provides a potential window into understanding leukemias that result from altered survival signals.