Articles tagged with Transcription Factors
Researchers at St. Jude Children's Research Hospital discovered that histone deacetylase enzymes cooperate with CBP/p300 histone acetylases to trigger expression of genes responding to hypoxia. The study suggests that developing new therapies targeting both mechanisms may enhance treatment efficacy for solid tumors.
The researchers created an artificial mammalian replication origin that can specify a DNA replication origin and enable scientists to explore the mechanism of replication initiation. This discovery will provide a new direction for creating vectors for gene therapy that are less mutagenic than current integrating vectors.
A new transcription factor system in bacteria has been identified, which represses expression of genes involved in DNA replication. The system was discovered using comparative genomics and phylogenetic footprinting, revealing a highly conserved signal sequence and the regulatory transcription factor that binds it.
Researchers discovered that overexpressing insulin transcription factors MafA, PDX-1, and NeuroD in the liver of diabetic mice increased insulin gene expression and improved glucose tolerance. This breakthrough suggests a crucial role for MafA as a novel therapeutic target for diabetes.
Scientists at the Vollum Institute have developed a technique to understand gene regulation, uncovering 6,300 regulatory regions that map to distinct sites on the genome. This breakthrough may help unravel the genomic instruction set governing gene expression in different cell types.
Scientists have created a comprehensive map of brain genes that regulate brain development, linking specific genes to specific brain locations. The Mahoney Transcription Factor Atlas will aid researchers in studying brain tumors and other disorders.
Steve McKnight's research on gene regulation and the body's internal clock has led to discoveries that may help understand and treat insomnia and depression. The NIH Pioneer Award recognizes his innovative work in taking creative risks and achieving groundbreaking accomplishments.
Researchers create synthetic transcription factors, mimicking natural regulators to probe gene regulation and explore new treatment approaches. The artificial activation domains developed in Mapp's lab were as effective as a natural activation domain at turning on genes.
YY1 regulates p53 at multiple levels, decreasing its amount in cells and blocking its interaction with cofactors. This discovery offers new targeting options for therapies to prevent transcription factors from interacting with other proteins.
Scientists discovered that deleting three circadian genes in mice results in severe epilepsy and accelerated aging. The mice lacking all three genes are prone to epileptic seizures and display early mortality, with a significant increase in deaths on Mondays and Thursdays due to sound-induced attacks.
Scientists have developed a new genomics tool that enables the efficient mapping of genome binding sites for transcription factors in human organs. This technology has been used to study the role of transcription factor HNF4 in type 2 diabetes, revealing its association with about half of all genes needed to make the pancreas and liver.
Researchers use genome-wide location analysis to study how a transcription factor Ste12 responds differently under various environmental conditions. By pinpointing the mechanism, scientists can make predictions of cellular behavior and potentially disrupt certain diseases at the cellular level.
Researchers at UNC identified two key genes involved in blood vessel development: BMPER and HOXB5. The study found that BMPER inhibits further differentiation of endothelial cells, while HOXB5 activates the endothelial cell program, increasing vessel formation.
Researchers at Whitehead Institute have created a global script describing how the yeast genome produces life, revealing the complex relationships between genes and proteins. This breakthrough allows for a vast network of interactions to be mapped, enabling targeted pharmaceutical approaches for diseases such as cancer.
The grant will develop new technologies to study G protein-coupled receptors and transcription factors, crucial for physiological responses. Researchers aim to create flat panels with multiple GPCRs to quickly assess drug candidates' effects.
Researchers at Dartmouth have discovered a novel photoreceptor protein that absorbs light and regulates the circadian rhythm. The protein, White Collar-1, is part of a genetic system that can be exploited to develop new drug delivery systems for treating fungal diseases.
A study suggests that insulin can suppress a pro-inflammatory transcription factor that promotes clot formation in blood vessels. Insulin infusion reduced levels of tissue factor and plasminogen activator inhibitor-1, key players in the development of human and mouse atherosclerosis.
Researchers James E. Darnell and Ali H. Brivanlou propose a reclassification of all known transcription factors, grouping them by their behavior rather than physical structure. This framework aims to provide a better understanding of how cells 'read' genetic instructions and may lead to new drug therapies for diseases such as cancer an...
Researchers at the Gladstone Institute have discovered a new pathway that regulates the activity of NF-kB, a protein controlling key inflammatory and immune responses. The study reveals how acetylation and deacetylation control NF-kB's ability to trigger biological processes.
Researchers found that Drosophila neural precursor cells sequentially activate four different transcription factors, allowing them to maintain differences based on their time of birth. This 'memory' is crucial for normal brain development and may have implications for understanding human neural development.
Yale researchers have identified virtually all of the gene targets for a key protein, known as transcription factors, using new DNA chip technology. The study reveals that these proteins control cell proliferation in yeast and can be used to understand how cells become specialized.
Lehman et al. show that PGC-1 is limiting for mitochondrial proliferation in cardiac muscle, directing changes in mitochondrial population across cells. Overexpressing PGC-1 increases fatty acid oxidation capacity and coupled OxPhos, but constitutive expression leads to dilated cardiomyopathy.
Researchers demonstrate that different concentrations of transcription factor PU.1 control blood cell progenitor development into B lymphocytes or macrophages, two distinct types of white blood cells. High levels of PU.1 block B cell development and promote macrophage formation.
Researchers identified two genetic elements, AE5' and AE3', that regulate human Factor IX expression, leading to increased coagulation capacity with age. The study provides insight into the molecular basis of age-related changes in blood clotting.
Researchers at St. Jude Children's Research Hospital have discovered a novel leukemia-producing transcription factor called E2A-HLF, which transforms immature lymphocytes by preventing normal destruction programs. This finding provides a potential window into understanding leukemias that result from altered survival signals.