Translational Elongation

New research from uOttawa-led team takes aim at limiting progression of breast cancer

A collaborative study led by Dr. Julie St-Pierre at the University of Ottawa found that promoting mitochondrial elongation in cancer cells hobbles their ability to metastasize. The research team identified a common signature that could help determine which pathways lead to decreased metastasis.

A ribosomal traffic jam that breaks the heart

Researchers found that a mutation in RPL3L, expressed only in heart and skeletal muscle, leads to impaired cardiac contractility by causing ribosomal collisions and protein folding abnormalities. The study aims to develop new treatments for cardiomyopathy and atrial fibrillation.

Rigol DP832 Triple-Output Bench Power Supply

Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.

Lost in translation: How “risky” amino acids abort elongation in protein synthesis

A recent study published in Nature Communications reveals that nascent peptide chains with N-terminal sequences rich in aspartic acid or glutamic acid can lead to abortion of translation in eukaryotic cells through intrinsic ribosome destabilization (IRD). This phenomenon is associated with biased amino acid usage in proteomes, where t...

Downtime at the nerve cell’s protein factories

Research reveals how genetic mutations in aminoacyl-tRNA synthetases cause CMT by halting protein production and inducing integrated stress response. The study's findings provide new avenues for therapies against the disease.