Articles tagged with Adipocytes
Scientists have developed a new method using CRISPR-Cas9 to target specific fat cells, reducing the time and cost of genetic discovery in obesity research. The technique allows researchers to study genes in brown adipose tissue, which plays a crucial role in regulating body temperature.
Researchers discovered that blood stem cells use high-energy fatty acids from the body's fat stores to power up their response to infection. This finding could lead to new approaches in treating bacterial infections, particularly in vulnerable and older individuals.
A recent study by the University of California - San Diego team discovered that glycogen regulates and promotes fat metabolism, helping to balance energy intake and expenditure. The research suggests modulating glycogen metabolism in fat cells could provide new approaches for weight loss and improved metabolic health.
Researchers aim to generate a model of brain-fat communication system to regulate metabolism during environmental challenges. The study uses cutting-edge techniques like immunolabeling-enabled imaging to identify new components of neural circuits controlling brown and white fat tissues.
A new study published in iScience reveals that fat cells play a central role in cognitive decline and neurodegeneration by controlling the systemic response to brain function. Targeting fat cells may improve outcomes for neurodegenerative disorders, according to researchers at Marshall University.
A study by Karolinska Institutet reveals that enlarged fat cells cause inflammation and pathology in adipose tissue, increasing the risk of type 2 diabetes. Researchers found that blocking the formation of senescent fat cells reduced pro-inflammatory factors, paving the way for novel treatment strategies.
Researchers found that COVID-19 patients with high blood sugar levels were more likely to develop severe lung dysfunction, require mechanical ventilation, and die. The study also suggests that SARS-CoV-2 may disrupt fat cells' production of adiponectin, a hormone regulating blood sugar levels.
Researchers at Karolinska Institutet discovered three different subtypes of mature fat cells in white adipose tissue, with only one subtype, Adipo PLIN, responding to insulin. The study suggests that changes in this specific subtype may contribute to metabolic diseases like Type 2 diabetes.
Researchers discovered that lowering iron content in fat cells limits the absorption of lipids by intestinal cells, leading to reduced weight gain and associated health issues. This finding could lead to new therapeutic approaches to protect against obesity and related diseases.
A new study reveals that a hormone in fat cells inside bone marrow helps regulate bone and fat production. The findings suggest potential new approaches to treating conditions like osteoporosis.
A study published in Nature found that altering eating habits or disrupting the circadian clock can lead to depletion of healthy fat cells, causing defects in fat storage and excess lipid spilling into organs. This disruption may be difficult to reverse, increasing the risk of Type 2 diabetes and insulin resistance.
A new study suggests that increasing a protein in brown adipose tissue remodels white fat to lower diabetes risk. The research found that genetically engineered mice with extra protein had lower blood sugar and insulin sensitivity.
A research team has developed an in vitro diseased skin model that displays the pathophysiological hallmarks of type 2 diabetes using 3D cell printing technology. The model exhibits slow re-epithelialization, insulin resistance, and pro-inflammatory response, similar to diabetic skin.
A study published in Nature Metabolism reveals that vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced energy-burning brown fat cells. This finding could lead to the development of new therapies targeting obesity and metabolic disorders by increasing overall energy expenditure.
Researchers discover adolescent adipose tissue differs from adult white fat in terms of precursor cell properties. Modulating Asc-1 function may help obese patients maintain a healthy metabolism and delay obesity treatment.
The Masonic Medical Research Institute has developed a novel technique for isolating brown fat cells, which can help study the relationship between brown fat cells and other cell types. This breakthrough could lead to better understanding of diseases and generate innovative cures and treatments.
Researchers found that limiting fat release from fat cells during heart failure can reduce inflammation and improve cardiac function. In a study, mice treated with a drug blocking fat release showed better outcomes than control groups.
Two studies shed light on the process of adding new fat cells, revealing a balance between existing fat cell expansion and new cell creation. A cancer drug can stimulate healthy fat cell formation, while inhibiting the development of new fat cells in one storage area can prevent diseases like diabetes and cardiovascular disease.
Scientists discovered that DCM-causing LMNA gene mutations disrupt the 'identity' of heart muscle cells by altering nuclear lamina-genome interactions and epigenetic marks. This disruption leads to abnormal gene regulation and loss of mechanical elasticity in heart cells.
Researchers at the University of New South Wales have created adaptive stem cells, called induced multipotent stem cells (iMS), from human fat. These cells can reprogram to act as stem cells and adapt to their surroundings, repairing a range of damaged tissues in mice.
Scientists at UT Southwestern Medical Center have discovered a type of cell responsible for triggering chronic inflammation in fat tissue. The study found that these cells, called fibro-inflammatory progenitors (FIPs), produce signals that encourage inflammation when exposed to high-fat diets.
Brown fat, a biological fuel that increases metabolic rate and decreases fat storage, continues to grow and divide after birth, according to Masonic Medical Research Institute researchers. This finding has major implications, as scientists can try to increase brown fat cells to prevent or reduce obesity.
A new drug, originally developed to treat bacterial infections, has shown the capacity to increase cell energy expenditure and reduce weight gain in mice fed a high-fat diet. The treatment works by reprogramming white adipose tissue cells to behave like brown adipose tissue, burning calories to generate heat.
Researchers found that SARS-CoV-2 infects fat cells and alters the quantity of signaling molecules released into the bloodstream. Adipocytes release more exosomes containing inflammatory factors, which may contribute to damage in organs such as the heart, lungs, and nervous system.
Researchers identify how night-shift work causes internal clock confusion by disrupting cell secretions during shift changes. This disruption leads to increased insulin resistance and other health issues, as cells in the body do not adjust quickly enough to shifts in sleep patterns.
Researchers demonstrate that epithelial cells can induce phenotypic and genotypic changes in HER2-positive breast cancer cells, known as cancer cell redirection. This phenomenon restricts proliferation of tumorigenic cells and shifts gene expression profiles towards a non-tumorigenic epithelial profile.
A NYUAD study reveals that the β-actin protein plays a crucial role in activating genes essential for fat tissue formation. The discovery sheds light on the molecular basis of adipogenesis, which can help researchers develop new treatments for metabolic diseases such as diabetes and obesity.
MarrowQuant, a new digital pathology software, can quantify bone marrow components in histological images without bias. The tool builds maps based on values to complement images, potentially re-examining historical sample collections and old clinical trials.
Researchers found that short-term exercise increases DICER levels in fat cells, enabling muscles to adapt and release fatty acids for energy. This signaling axis between muscle and fat tissue is central to the adaptive response to exercise training.
Scientists at Joslin Diabetes Center have developed a novel cell-based therapy using 'HUMBLE' cells, genetically modified human white fat cells that mimic heat-generating brown fat cells. Transplanted into mice with type 2 diabetes, these cells improved insulin sensitivity and glucose clearance, reducing weight gain and related chronic...
A study published in Nature Communications found that reversing age-related changes in fat cells may help prevent the development of lifestyle diseases such as diabetes and fatty liver. The research team discovered that inhibiting autophagy in adipocytes can restore function and prevent metabolic disorders.
A Marshall University researcher has been awarded a $444,000 grant to investigate the role of sodium pump signaling in fat cells and its potential as a treatment for uremic cardiomyopathy. The study aims to reveal more about oxidative stress and its impact on disease progression.
Researchers developed a vaccine targeting aged immune cells, which accumulated in fat tissues of obese individuals and caused chronic inflammation. Vaccination improved glucose metabolism, insulin resistance, and overall organ function in obese mice by removing senescent T cells.
New research from Marshall University finds that production of peptide NaKtide in fat cells inhibits sodium pump function, preventing the development of cardiomyopathy associated with renal failure. The study also suggests targeting adipocytes may serve as a viable clinical strategy for preventing and treating the condition.
Researchers at the University of Michigan have discovered a new signaling pathway that can regulate beige fat thermogenesis independently of adrenergic signaling. This discovery opens a new direction for approaching metabolic disorders and could potentially provide a treatment option for patients with catecholamine resistance.
A study reveals that fat cells' immune response amplifies inflammation, driving obesity-related disease. Type I Interferons produced by fat cells trigger a vicious cycle of inflammation, which can worsen metabolic issues and increase the risk of diseases like type 2 diabetes and COVID-19.
A study revealed that insufficient insulin action in adipocytes leads to the development of diabetes and NASH by hyperactivating the protein FoxO1. This finding could serve as a potential target for new drug development for these conditions.
Researchers at Joslin Diabetes Center have discovered two subtypes of human white subcutaneous fat cells with distinct patterns of gene expression, which may help control whether cells become mature fat cells. This study highlights the potential of bringing together biology, artificial intelligence, and data analysis to better understa...
Researchers from IKBFU, Moscow, and Kiev investigate the effects of deuterium on adipose tissue differentiation in an in vitro model. They found that varying deuterium concentrations can influence the formation of brown/beige or white adipocytes.
Researchers discovered a novel pathway that boosts brown fat cell's heat-generating capacity without increasing fat accumulation. This finding suggests that activating this pathway may benefit people with obesity, diabetes, and related metabolic diseases.
Researchers at Max Delbrück Center have identified protein EHD2 as a key regulator of fatty acid uptake in fat cells. The study found that people with normal weight produce more EHD2 than those who are overweight, suggesting a correlation between EHD2 levels and fat metabolism.
A new study by Salk scientists shows that caloric restriction can protect against aging in cellular pathways, reducing inflammation and increasing life span. The study found that 57% of age-related changes in cell composition were not present in rats on a restricted diet.
Scientists uncover how lymph nodes' development is controlled by the Hippo pathway, shedding light on their role in regulating immune responses. The research found that impaired Hippo signaling can lead to fibrosis or transformation of fat cells, highlighting potential therapeutic targets for diseases affecting systemic immunity.
Researchers found that light exposure regulates how two kinds of fat cells work together to produce energy. A lack of sunlight may lead to metabolic problems beyond seasonal affective disorder, with implications for human health.
Yale researchers identify O-GlcNAc transferase enzyme as key regulator of fat droplet doorman, which controls cellular access for nutrients and lipids. Mice lacking the enzyme exhibit reduced fat cell size and improved lipid burning, while overexpression triggers obesity by increasing carbohydrate intake.
Researchers have identified a genetic program controlling the development of beige fat cells, which can convert energy into heat. The study's findings suggest that people with more thermogenic fat cells may be less likely to develop obesity and related metabolic disorders.
A new study suggests that glutamine supplementation could help people with obesity reduce inflammation of fat tissue and reduce fat mass. Glutamine levels were found to alter gene expression in several different cell types, leading to anti-inflammatory effects on white blood cells and T-cells.
A study by Stanford University researchers found that omega-3 fatty acids influence stem cell division and fat cell formation. The findings suggest that consuming healthy fats can help regulate body weight and insulin sensitivity.
A study identified two types of genetic variants in the PM20D1 gene that regulate its expression in adipocytes, with one variant acting as an on/off switch and another similar to a dimmer switch; these variations are associated with obesity risk.
Researchers at the University of Copenhagen have mapped proteins secreted by adult human brown and white fat cells, revealing they send distinct signals to the rest of the body. Brown fat plays a key role in regulating the cellular immune system, while white fat promotes tissue plasticity.
Researchers found that coffee bean extracts reduced fat-induced inflammation and improved glucose absorption and insulin sensitivity in mice. The compounds protocatechuic acid and gallic acid showed promise as a strategy for preventing obesity-related chronic illnesses.
Researchers at UCLA have identified a new drug delivery pathway that uses reengineered fat cells to deliver chemotherapy drugs directly to tumors, suppressing growth and preventing recurrence. The approach could also be applied to other lipid metabolism-related diseases.
UTSW researchers identified a novel mechanism regulating fat creation in mammals. The miR-26 family of microRNAs strongly protects against weight gain and metabolic issues by controlling FBXL19 protein levels.
Researchers mapped distinct bone marrow niche populations and their differentiation paths for the production of bone, fat and cartilage. The study identified seven distinct cell states in two branching pathways and showed how transcription factors influence fate decisions to specific bone marrow lineages.
Research at Kobe University reveals that protein secretions by skin cells, keratinocytes, regulate the differentiation of subsurface skin fat cells into white or brown adipose tissue. The study found that suppressing growth factor proteins BMP2 and FGF21 can decrease white fat cell numbers and increase brown fat cells.
Research found that extracellular vesicles derived from kids' fat can disrupt cholesterol disposal in various tissues, regardless of weight. The study suggests that fat tissue plays a pivotal role in triggering cardiovascular disease, even before symptoms appear.
Researchers found that fat cells allow melanoma cells to penetrate the dermis and spread to vital organs. They discovered a way to block this transformation using therapies targeting cytokines and TGF beta.
A new study created the first comprehensive genomic map of fat cells, revealing unique features that appear to 'hard-wire' different types of fat. The findings may guide future research into the drivers of harm arising from fat build-up in different parts of the body.
Researchers found that intermittent fasting reduced pancreatic fat in mice, a key finding in the development of type 2 diabetes. The study suggests that excess weight-induced fat accumulation in the pancreas contributes to the onset of diabetes.
Joslin researchers will contribute to mapping specific tissues in the healthy human body using chemical imaging and single-cell sequencing. The goal is to understand how disease affects cells and develop new treatments for metabolic diseases.