Articles tagged with Adipocytes
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New research reveals cinnamaldehyde's ability to induce thermogenesis in fat cells, improving metabolic health. The compound may offer a non-pharmacological approach to combating obesity and related health issues.
Scientists have identified a novel biological pathway in beige fat cells that burns excess blood glucose to produce heat, suggesting a new strategy for treating metabolic disorders. This discovery could lead to the development of anti-obesity drugs.
A genetic variant in ankyrin-B gene causes cells to store more fat, leading to obesity. This variant is carried by millions of Americans and can be identified through family history and physiological traits.
Researchers found that adipocytes can metabolize daunorubicin, making it less toxic to leukemia cells. This discovery highlights the need for new chemotherapy strategies that are resistant to fat cell enzymes.
A study published in Cell Research found that intermittent fasting can be beneficial for the metabolism, reducing fat build-up and stabilizing glucose and insulin systems. After sixteen weeks of on-and-off fasting, mice weighed less and had lower body fat compared to control groups.
Researchers at McMaster University have discovered that bolstering fat cells in the bone marrow can suppress leukemia cells while also regenerating healthy red blood cells. This innovative approach presents a new potential therapeutic strategy for treating acute myeloid leukemia, which often leads to anemia and infection.
A study by Georgia State University researchers found that brown fat's role in generating heat is more complex than previously thought. They discovered that lipolysis, which breaks down stored fat, is not essential for heat production in response to cold exposure, but rather regulates fuel selection and white fat browning.
Researchers found that altering stem cell volume changes its internal dynamics and influences the cell's fate, with removing water making it stiff pre-bone cells and adding water forming soft pre-fat cells. This study adds a new tool to understanding stem cell biology for regenerative medicine.
Aging is associated with a decrease in Cbf-beta protein, leading to an imbalance in bone maintenance and increased fat cell creation. Maintaining Cbf-beta may be essential to preventing age-associated osteoporosis.
Researchers found that increasing BMP4 levels can improve metabolic health in lean mice by promoting beige fat cell activity, but overweight mice showed reduced effectiveness. Gene therapy with BMP4 also protected against insulin resistance in both lean and overweight mice.
Research found that small amounts of house dust containing endocrine-disrupting chemicals can spur fat cells to accumulate triglycerides and divide, promoting weight gain. The study suggests that indoor dust is a likely exposure source of chemicals disrupting metabolic health, particularly in children.
A study published in JAMA Surgery found that fat grafting may improve breast satisfaction, psychosocial well-being, and sexual well-being in patients after mastectomy. However, the procedure was associated with lower satisfaction rates one year post-op, but similar outcomes two years later.
Researchers found that cold-resistant pig breeds such as Tibetan and Min pigs use UCP3 to produce heat, unlike other breeds that rely on shivering. This discovery has important implications for the swine industry and could lead to new strategies for reducing neonatal mortality in cold climates.
Researchers at the University of Iowa discovered a protein that controls glucose uptake in fat cells based on cell swelling, leading to insights into the relationship between obesity and type 2 diabetes. Mice lacking this protein developed insulin resistance and glucose intolerance despite having smaller fat cells.
Researchers found that exercising burns fat in bone marrow, leading to improved bone health. The study suggests that exercise is beneficial even more so for obese individuals, who may experience greater bone formation and strength.
Research reveals survivin protein protects fat cells from death in obese individuals, potentially leading to new obesity and cancer treatments. The study found higher levels of survivin in obese subjects, suggesting it could be a target for therapy.
A team of researchers has discovered that the epigenetic enzyme Lsd1 plays a key role in maintaining beige adipocytes, which burn fat to generate heat. By targeting this gene, they were able to prevent premature transformation of beige to white adipose tissue and reduce metabolic disorders.
Researchers found that TRPM8 and TRPP3 receptors can create more 'good' fat (brown adipose tissue) than 'bad' fat (white adipose tissue), potentially converting bad fat to good. This discovery has implications for treating obesity, diabetes, and related metabolic disorders.
Researchers at Kanazawa University discovered that sulforaphane can lower body weight gain rates and reduce visceral fat. The compound also improves energy consumption and fat burning, likely due to its effects on the gut microbiome.
Researchers at Rutgers and other universities created a new way to identify stem cells' state and fate, allowing for better manipulation of cells for therapy. The approach uses super-resolution microscopy to analyze epigenetic modifications, identifying changes that signal a cell's future type.
Researchers at Umeå University discover a new mechanism for protein EHD2, which stabilizes the cell membrane by forming oligomers. This discovery sheds light on the role of caveolae in maintaining cellular structure and function.
Researchers at UT Southwestern Medical Center discovered that PARP-1 enzyme plays a crucial role in inhibiting fat cell formation and maintaining embryonic stem cells. The study highlights the importance of PARP-1 in normal physiological processes and its potential as a target for treating metabolic disorders.
Researchers at Joslin Diabetes Center identified a new therapeutic approach by studying the role of microRNAs released from fat cells into the bloodstream. They found that these microRNAs can regulate gene expression in other organs and tissues, potentially leading to new treatments for metabolic diseases and cancer.
Researchers found that weight loss significantly reduces the risk of Type 2 diabetes by resetting the chemical messages sent by fat cells. After gastric bypass surgery, volunteers showed improved insulin sensitivity and metabolic health, with reduced markers of disease risk.
Researchers at the University of Pennsylvania School of Medicine have made a groundbreaking discovery in wound healing by transforming myofibroblasts into fat cells. This innovation has the potential to revolutionize dermatology and develop new treatments for conditions such as HIV-related complications and aging skin.
Researchers at the University of Bonn found that inflammation in abdominal fat blocks fat-burning by inhibiting cGMP signaling. Administering cGMP-stimulating active ingredients may be a possible starting point for treating obesity and preventing related complications.
Researchers at the University of Pennsylvania School of Medicine have discovered a molecular trigger that can activate a 'browning program' in white adipocytes, making them more like energy-burning brown adipocytes. This discovery could lead to new treatments for obesity and diabetes.
Peter Arner's research revealed processes that contribute to obesity and diabetes, including the turnover of fat tissue and the production of adipokines. His work also showed that fat cells are renewed relatively rapidly, regardless of weight loss, and that a molecule called TNFα alters leptin levels.
Researchers found that epigenetic enzyme Lsd1 maintains brown fat tissue's metabolic properties. Inhibiting Lsd1 leads to whitening of brown adipose tissue, storing energy instead of expending it.
Researchers identify Adamts1 as a key regulator of fat cell differentiation, triggered by high-fat diets and stress hormones. The hormone's production affects fat storage in different parts of the body, with implications for obesity treatment.
A study by Purdue University researchers reveals that overactive Notch signaling can drive the formation of cancerous fatty tumors, while normal signaling is required for healthy cell differentiation. The findings suggest a potential new approach for treating a subtype of liposarcomas and other metabolic conditions.
Researchers have discovered a new strategy to cultivate beneficial beige fat, which can help ward off obesity and diabetes. By preventing beige fat cells from digesting their own mitochondria, the intervention successfully protected against obesity and pre-diabetic symptoms in mice, raising hopes for future applications in human patients.
A new therapy has been developed to replace essential steroids in the body, which could help people with conditions like Addison's disease and congenital adrenal hyperplasia. The treatment uses corticosterone instead of cortisol, resulting in fewer side effects on fat cells.
Researchers at Boston University School of Medicine discover a novel protein called PTRF linked to type 2 diabetes and insulin resistance. The study finds that most obese individuals develop insulin resistance despite having normal fat cells.
A new study published in Cell Reports explains how a blood pressure hormone system can promote obesity. The renin-angiotensin system (RAS) controls energy balance and metabolic rate, with elevated brain RAS increasing energy expenditure and weight loss, while peripheral RAS suppressing resting metabolism and increasing weight gain.
Researchers aim to create more small, energy-burning fat cells that enable the body to use fat as fuel rather than store it as unhealthy padding. By studying the protein HDAC9, they hope to develop new treatments for obesity-related diseases like diabetes and cardiovascular disease.
Researchers developed a microfluidic chip to study adipose-derived adult stem cells' development into mature fat cells. The platform successfully converted cells into mature fat cells while decoding signalling pathways.
Scientists at Dana-Farber Cancer Institute have identified a natural molecular pathway that enables brown and beige fat cells to burn calories as heat rather than store them as fat. The discovery raises the possibility of a new approach to treating obesity, diabetes, and other related metabolic disorders.
Researchers are studying exercise's effects on muscle loss and weakness in people with chronic kidney disease, a condition affecting 20 million Americans. They aim to determine the optimal dose of exercise and explore whether it can mitigate disease progression.
Researchers have found that copper helps regulate fat burning by blocking an enzyme that prevents fat breakdown when it's not needed. Without enough copper, fat builds up in cells, leading to obesity and diabetes. The study suggests a new role for copper in metabolism and opens the door to new therapeutic approaches.
Researchers at Lund University discovered that cancer cells can accumulate fat droplets, making them more aggressive and increasing their ability to spread. The fat serves as fuel for the stressed cells, allowing them to grow and spread.
A new study found that 24 hours of fasting induces a miRNA-149-3p-mediated subcutaneous to visceral fat switch via suppression of PRDM16 in mice. This switch may play a crucial role in maintaining energy balance and could have implications for obesity and metabolic disease prevention.
A study in mice lacking the proinflammatory signaling molecule TAK1 demonstrates protection against diet-induced obesity and insulin resistance. The removal of TAK1 from mice fed a high fat diet prevented additional weight gain and improved glucose tolerance.
Researchers at McGill University have found a way to reprogram white fat cells into energy-burning beige or brown fat cells. This 'browning' process can help manage obesity and other metabolic disorders by burning excess energy instead of storing it.
University of Bonn researchers have discovered a new method to measure the activity of energy-consuming brown fat cells in humans and mice. They found that microRNA-92a can be used as an indirect measure of brown fat cell activity, with a small blood sample sufficient for analysis.
Researchers track NADPH production through a novel pathway, revealing an environmental-dependent switch between two recognized routes. The findings have implications for diseases such as cancer and diabetes, highlighting the importance of understanding NADPH pathways in cellular processes.
Researchers have developed a stem cell repair system similar to salamander limb regeneration, capable of regenerating human tissue damaged by injury, disease or ageing. The technique involves reprogramming adult fat cells into induced multipotent stem cells (iMS) that can repair multiple tissue types.
A new study found that exposure to bisphenol S, a chemical used in BPA-free products, can encourage the formation of fat cells. Researchers created a human cell model and tested the effects of BPS exposure on fat cell metabolism.
A team of scientists at the University of Bonn discovered a switch that can convert unwanted white fat cells into energy-burning brown cells by blocking Gq proteins. This breakthrough has significant implications for obesity treatment, as it may lead to the development of pharmaceutical products that target this pathway.
Scientists have discovered that some human fat cells originate from stem cells in bone marrow, which could lead to new strategies for preventing and reversing fat-related chronic diseases. By manipulating the production of these cells, researchers hope to reduce the risk of conditions like cardiovascular disease and obesity.
A Georgia State University biologist has received a four-year, $1.37 million grant from the National Institute of Health (NIH) to study epigenetic mechanisms and their link to obesity. The researcher aims to induce brown adipocytes in white fat tissues to prevent and treat obesity.
A recent study by Hiroshima University has identified a key protein responsible for burning excess energy in the body, UCP1, found in brown fat cells. Increasing UCP1 levels can lead to a higher metabolism and less weight gain.
A new study from Michigan State University finds that fat cells, not lean cells, have a longer lifespan. The researchers used yeast to demonstrate that increasing the cellular content of triacylglycerol, or fat, extends lifespan. This finding supports the obesity paradox theory and has implications for human aging and health.
Scientists discover that activating mTOR pathway plays a critical role in beiging of white fat cells to fight diabetes. Rapamycin, a drug previously used as an immunosuppressant, is found to induce beige fat cell formation and improve glucose metabolism.
Researchers at UCLA have discovered a protein combination that significantly improves clinical bone restoration, offering potential therapeutic treatments for osteoporosis and bone skeletal defects. The combination of NELL-1 and BMP2 stimulates bone production while inhibiting fat cell formation.
Scientists at Gladstone Institutes discovered a novel regulator of body weight: the P75 neurotrophin receptor. Lowering levels of p75 NTR protected mice from developing obesity, diabetes, and fatty liver disease on a high-fat diet. The receptor plays a key role in regulating metabolic processes that control body weight.
A study by Kyoto University found that fish oil activates receptors in the digestive tract, fires the sympathetic nervous system, and induces storage cells to metabolize fat. This may increase beige cells, which are less common in adults but play a crucial role in burning fat for energy.
Researchers at OIST discovered a molecular mechanism involved in storing and burning fat. They found that mice lacking two specific genes remain lean even after eating a high-fat diet due to increased expression of Ucp1, which helps convert stored fat into heat.
Researchers found that increasing energy expenditure with brown or brite/beige fat cells could be an effective way to fight obesity. The study suggests harnessing the body's natural mechanism of converting white fat cells into beige fat cells by using heat production and increasing the sympathetic nervous system's supply of blood vessels.
Researchers have found that bone marrow stem cells can produce fat cells that contribute to chronic illnesses like diabetes and cardiovascular disease. The discovery highlights the possibility of genetically modifying fat-storing cells to prevent or reverse fat-related diseases.