Articles tagged with Adipocytes
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Researchers at UT Southwestern Medical Center discovered that brown fat cells are generated through new cell formation rather than converting white fat cells. This finding could lead to therapeutic strategies to activate precursor cells to produce more brown fat cells for weight management and related diseases.
Researchers found that ovarian cancer cells colonize milky spots in the omentum, which promotes cell growth and spread. The study suggests an alternative model of omental colonization, where both milky spots and fat cells play a role in attracting cancer cells.
Research found epigenetic changes in fat cells after exercise, influencing genes linked to type 2 diabetes and obesity. The study provides new insights into the mechanisms of how physical activity affects disease risk.
Researchers discovered a thermogenic secondary sexual character in male sea lampreys, producing heat through a rare type of fat. The 'rope tissue' plays a crucial role in courtship and mating, making it an essential component of the species' reproductive behavior.
Researchers discovered a fat cell near male sea lampreys' dorsal fin produces heat when approached by females, a previously unknown mechanism in spawning. This finding sheds new light on the invasive species' biology and may help reduce its numbers or eliminate it from the Great Lakes.
Research suggests that social stress can lead to increased metabolism in breast fat cells, which in turn stimulates nearby pre-cancerous cells to proliferate more rapidly. This local effect of fat cells in the breast may contribute to the development of triple-negative breast cancer.
Researchers have discovered that medications used to treat heart failure and high blood pressure can also aid in reducing obesity by preventing weight gain and increasing the production of energy-burning fat cells. The study found that these drugs helped increase brown fat cells, which burn energy to prevent weight gain.
Researchers at UCLA have isolated a new population of pluripotent stem cells, called Multi-lineage Stress-Enduring (Muse-AT) cells, from fat tissue that can differentiate into virtually every cell type in the human body. These cells are stress-resistant and may even be activated by severe stress, making them potentially superior source...
Researchers at Sahlgrenska Academy, University of Gothenburg, have discovered two different kinds of brown fat cells in humans, which can burn energy and turn it into heat. The discovery offers new possibilities for developing methods to stimulate the brown fat tissue and prevent obesity.
Scientists at ETH Zurich demonstrated that white and brown fat cells can convert into each other, challenging current beliefs. This interconversion process is likely to occur in humans as well, offering a novel strategy for treating obesity by promoting brown fat formation.
Scientists decode a 'toggle switch' in mice that significantly stimulates fat burning by converting white fat cells into brown fat cells, potentially combating obesity.
Researchers found that human brown adipose tissue is abundant in deep neck regions and can be grown into functional cells. These findings open possibilities for studying BAT's role in metabolism and developing treatments to combat obesity.
Researchers found that human hematopoietic stem cells can survive for longer periods when cultured with a feeder layer of adipocytes, or fat cells. The study demonstrates the potential for using fat cells to extend the lifespan of hHSCs in vitro, which could be crucial for developing advanced cell therapies.
Researchers have discovered that a protein switch called Ebf2 determines the development of brown fat cells, which are thought to counteract obesity by burning excess energy. The study found that Ebf2 regulates the binding activity of PPAR-gamma, a protein that regulates differentiation of developing cell types.
Researchers at Whitehead Institute have identified long noncoding RNAs as essential regulators of white fat cell development, which can lead to obesity. The study found that knocking down specific lncRNAs reduced the formation of lipid droplets in fat cells.
A University of Florida study has identified a protein called TRIP-Br2 that helps regulate fat storage and release in cells. When absent, this protein enables mice to burn fat and resist obesity, even on high-fat diets.
A recent study published in Nature Medicine identified a key protein called mitoNEET that plays a crucial role in fat cell metabolism. Elevated levels of this protein were found to expand fat tissue without leading to obesity-related health issues, such as type 2 diabetes.
A new study by University of Pennsylvania researchers found that deleting the Arntl clock gene in fat cells causes mice to become obese due to a shift in eating timing. Supplementing with fish oil-like fatty acids can rescue this phenotype.
A recent study found that short-term sleep deprivation significantly decreases insulin sensitivity in fat cells, a key finding with implications for metabolic disorders. The researchers also discovered that regular sleep deprivation may lead to metabolic problems such as diabetes and obesity over time.
Researchers at the University of Chicago Medical Center discovered that not getting enough sleep has a harmful impact on fat cells, reducing their ability to respond to insulin. This finding suggests that sleep plays a crucial role in energy metabolism, comparable to its role in brain function.
Researchers at Dana-Farber Cancer Institute found that the protein TRPV4 is highly expressed in white fat cells, enabling them to burn calories instead of storing excess energy. The study provides a potential target for treating obesity and related metabolic diseases.
Researchers at Joslin Diabetes Center have identified a key molecular process in fat cells that affects aging and stress resistance. The study found that reducing microRNA processing in fat tissue promotes longevity and stress resistance, providing potential new avenues for treatment.
Scientists discovered that invariant natural killer T-cells (iNKT) in fat tissue regulate inflammation and protect against obesity, diabetes, and metabolic syndrome. iNKT cells can be restored through weight loss and activated by alpha-galactosylceramide, a lipid known to improve metabolism.
Higher serum ferritin levels are linked to lower adiponectin production, a protein regulating blood glucose. Reducing ferritin levels improves insulin sensitivity and glucose tolerance in humans.
Researchers discovered that injecting heat-generating cells into mice reduced visceral fat by 20% and converted existing belly fat cells into thermogenic cells. The study suggests a potential new therapy for obesity, targeting patients with aging-related visceral fat accumulation and those who cannot exercise or reduce calorie intake.
Scientists have decoded signals that boost the burning of fat, focusing on the conversion of white fat cells into beige fat cells. Beige fat cells are efficient at converting energy from food into heat and can form from white fat cells.
Researchers found that CCR9 is abundant in early stage colon cancer but lacks in invasive and metastatic cancer, suggesting its role in reducing cancer spread. Activation of NOTCH promotes degradation of CCR9, inhibiting the chemokine-induced signaling pathway.
Researchers found that disabling a protein called FAS reduces white fat stores, allowing brown fat to thrive and burn more energy. Inhibiting PexRAP also shows promise as a potential treatment strategy for obesity and diabetes.
Researchers identified a third type of fat cell, beige adipocytes, that can be activated to burn energy and generate heat in both mice and humans. Beige fat cells are genetically intermediate between white and brown fat, and respond to hormone irisin, which is released during exercise.
Researchers at Dana-Farber Cancer Institute have identified a new type of energy-burning fat cell, called 'beige fat,' which may have therapeutic potential for treating obesity and diabetes. Beige fat cells can burn off calories rather than store them, unlike 'white fat' cells.
Scientists identify WNT signaling pathway as potential therapeutic target for obesity. Antibiotic treatment after Lyme disease shows fluorescent bacterial debris remains without causing infection. Oxidative stress contributes to parasite persistence in host tissues, opening new avenue for anti-Trypanosoma cruzi drugs.
Research found that SFRP5-deficient mice showed increased metabolic activity and were resistant to diet-induced obesity, revealing the mechanism of SFRP5-mediated fat cell generation. The study suggests targeting the WNT signaling pathway could be a therapeutic approach to treat obesity.
Researchers at the University of Michigan have made a surprising finding about WNT signaling and its role in fat cell growth. They discovered that Sfrp5, a molecule previously thought to have an opposing effect, actually stimulates fat cells to grow larger and burn fat slower.
A recent study has found that exposure to the fungicide tolylfluanid can induce insulin resistance in fat cells, providing new evidence of the link between environmental pollutants and diabetes. This discovery raises concerns about the potential health risks of using this chemical on farm crops.
Researchers at Brigham and Women's Hospital have identified a new candidate pathway for treating visceral obesity by manipulating vitamin A metabolism. By inhibiting the enzyme Aldh1a1, white fat cells can take on characteristics of brown fat, leading to reduced fat storage and improved metabolic health.
A new study reveals that black pepper's piperine interferes with genes controlling fat cell formation, potentially leading to a metabolic chain reaction. This finding may lead to wider use of piperine or black-pepper extracts in fighting obesity and related diseases.
Researchers at the University of Delaware have identified a protein called endoglin that regulates the creation of fat cells. By decreasing the amount of this protein on the surface of cells, it may be possible to force fat cells to transform into other cell types, potentially leading to new treatments for osteoporosis and obesity.
Researchers at the University of Cincinnati have found a cellular pathway linked to obesity-related disorders such as diabetes, heart disease, and fatty liver disease. Deleting the enzyme histone deacetylase 9 (HDAC9) completely protected mice against high-fat feeding's negative health consequences.
A compound found in red wine and fruits can block the development of immature fat cells, according to a Purdue University study. The compound, piceatannol, alters gene expressions and insulin action during adipogenesis, delaying or inhibiting the formation of mature fat cells.
A new study finds a protective gene in fat cells that helps regulate blood sugar and insulin levels, potentially leading to a new therapeutic strategy for preventing and treating type 2 diabetes. The discovery challenges popular notions of body fat and health.
Scientists at UCSF have identified a protein called PRDM16 that can convert ordinary white fat cells into brown fat cells, which burn calories. This discovery makes PRDM16 a possible target for future obesity treatments.
Researchers discovered that cardiac natriuretic peptides can convert white fat cells into brown fat cells in mice and humans, increasing energy usage and potentially aiding in weight loss. The study suggests a new approach to combating the obesity epidemic.
A new study at Sanford-Burnham Medical Research Institute suggests that the heart hormone natriuretic peptides play a role in breaking down fat. The peptides turn on a molecular mechanism similar to what's activated when the body is exposed to cold and burns fat to generate heat.
Dr. Philipp Scherer's groundbreaking research on adiponectin, a protein that declines with weight gain, has potential as a good predictor of diabetes, heart disease, and cancer risk. His work also highlights the importance of understanding fat cells' role in body energy homeostasis.
Researchers at UC San Diego and EPFL found that removing a regulatory protein called NCoR dramatically improved insulin sensitivity in mice. The study reveals a new role for NCoR in regulating fatty acid storage and glucose metabolism, which could lead to the development of targeted treatments for type 2 diabetes.
A pilot study of 31 obese people with gum disease found that those who underwent gastric bypass surgery had better periodontal outcomes than those who did not. The researchers believe that removing excess fat cells may help reduce inflammation and improve the body's response to treatment.
Researchers from the Chinese University of Hong Kong have developed a technique to reprogram stem cells into a more primitive state, increasing their survival rates and therapeutic efficacy. This breakthrough could lead to improved treatment outcomes for conditions such as degenerative diseases and blood supply disorders.
A large pad of fat cells in the abdomen provides nutrients that promote the spread and growth of ovarian cancer. Cancer cells reprogram their metabolism to thrive on lipids acquired from fat cells, leading to rapid tumor growth.
A Yale research team discovered a mechanism that enables fat cells to expand when excess metabolic energy is present, helping them store and use fatty acids efficiently. This process is crucial for maintaining cellular balance and preventing the breakdown of fat storage capacity in obese individuals.
Scientists at Karolinska Institutet found that fat cells in overweight people have a higher capacity for storing fats but a lower capacity for ridding themselves of them. This can lead to an accumulation of triglycerides and cholesterol in the blood, increasing the risk of metabolic diseases.
A study by Sanford Burnham Prebys reveals that CDP138 is a crucial protein for insulin-stimulated glucose uptake in muscle and fat cells. The researchers found that optimal insulin response requires the correct insertion of GLUT4 into the cellular membrane, with CDP138 playing a key role.
Researchers explore the effects of thiazolidinediones on fat tissue, finding that they remodel adipose tissue and lead to weight gain. The studies also reveal a link between rosiglitazone's vascular benefits and the hormone adiponectin.
Scientists have discovered a protein marker on the surface of adipose stromal cells (ASCs), which drive fat expansion in the body. The finding may lead to developing a method to inactivate these cells, potentially treating obesity and improving regenerative therapies.
Researchers at Mount Sinai School of Medicine discovered a cellular signaling pathway governing fat tissue and vascular smooth muscle differentiation. Elevated PDGFRβ signaling inhibits the formation of fat cells, offering new therapeutic targets for preventing obesity and cardiovascular disease.
A Finnish twin study suggests that adaptation of fat cell membranes to obesity may play a key role in early stages of inflammatory disorders. The study found that obese individuals have higher amounts of certain lipids in their adipose tissues, which may help preserve membrane function as cells expand.
A Finnish twin study found that obese individuals have higher amounts of polyunsaturated fatty acids in their adipose tissues than non-obese twins. The researchers suggest that this adaptation helps preserve membrane function as the cells expand, but breaks down in morbidly obese individuals.
Researchers discovered large amounts of brown fat in adults and found it can be grown in labs, burning substantial calories. The discovery suggests brown fat could be used to treat obesity and diabetes, but cannot replace traditional approaches.
Research suggests that a mother's nutritional or psychological stress during pregnancy and lactation may create a signature on her child's genes that put the child at increased risk for obesity later in life. Female offspring are more susceptible to developing abdominal fat, prediabetes, and impaired glucose metabolism.
Researchers found that blueberry polyphenols suppress adipocyte differentiation and reduce lipid content in mice tissue cultures. The highest dose yielded a 73% decrease in lipids.
Researchers identify protein TLE3 as a key regulator of fat cell development, which can be targeted to improve adipose tissue function and alleviate symptoms of diabetes. By understanding how fat cells form, scientists aim to develop better treatments for obesity and related disorders.