Articles tagged with Adipocytes
Scientists have discovered a protein marker on the surface of adipose stromal cells (ASCs), which drive fat expansion in the body. The finding may lead to developing a method to inactivate these cells, potentially treating obesity and improving regenerative therapies.
Researchers at Mount Sinai School of Medicine discovered a cellular signaling pathway governing fat tissue and vascular smooth muscle differentiation. Elevated PDGFRβ signaling inhibits the formation of fat cells, offering new therapeutic targets for preventing obesity and cardiovascular disease.
A Finnish twin study suggests that adaptation of fat cell membranes to obesity may play a key role in early stages of inflammatory disorders. The study found that obese individuals have higher amounts of certain lipids in their adipose tissues, which may help preserve membrane function as cells expand.
A Finnish twin study found that obese individuals have higher amounts of polyunsaturated fatty acids in their adipose tissues than non-obese twins. The researchers suggest that this adaptation helps preserve membrane function as the cells expand, but breaks down in morbidly obese individuals.
Researchers discovered large amounts of brown fat in adults and found it can be grown in labs, burning substantial calories. The discovery suggests brown fat could be used to treat obesity and diabetes, but cannot replace traditional approaches.
Research suggests that a mother's nutritional or psychological stress during pregnancy and lactation may create a signature on her child's genes that put the child at increased risk for obesity later in life. Female offspring are more susceptible to developing abdominal fat, prediabetes, and impaired glucose metabolism.
Researchers found that blueberry polyphenols suppress adipocyte differentiation and reduce lipid content in mice tissue cultures. The highest dose yielded a 73% decrease in lipids.
Researchers identify protein TLE3 as a key regulator of fat cell development, which can be targeted to improve adipose tissue function and alleviate symptoms of diabetes. By understanding how fat cells form, scientists aim to develop better treatments for obesity and related disorders.
Researchers discovered a novel regulatory role for lincRNA in determining cell protein selection and identity. The study identifies HOTTIP as a molecule that marks key genes as 'open for business,' allowing cells to maintain their characteristic patterns.
Researchers discovered a continuum of cells with varying levels of PPAR gamma and lipids, contradicting the long-held theory that PPAR gamma equals fat. This finding has implications for type 2 diabetes treatment and may lead to the development of new drugs targeting coactivators.
Scientists at Joslin Diabetes Center have identified progenitor cells in mouse white fat tissue and skeletal muscle that can be transformed into brown fat cells. The study found that exposure to the protein BMP-7 and the diabetes drug rosiglitazone increased conversion rates, suggesting a potential for cell-based brown fat therapies.
Researchers discovered a genetic link between the gene CRTC3 and obesity. Mice lacking the gene were protected from weight gain on high-fat diets, suggesting that increased brown fat cells may control obesity. Human studies also found a higher incidence of obesity in individuals with an active version of the gene.
Research reveals that exposure to fine-particulate air pollution in early life increases abdominal fat and insulin resistance in mice, regardless of diet. The study suggests a potential mechanism for pollution's effects on health, highlighting the need for therapeutic options targeting specific genes.
Researchers at Tel Aviv University have created a new computer method to measure mechanical stress in fat cells, which can help control the amount of fat produced by these cells. The study has direct applications in weight loss programs, treating bedsores, and managing chronic diabetes.
Cardiac researchers at the University of Cincinnati found a new cellular pathway that could help develop therapeutic treatments for obesity-related disorders, including diabetes and heart disease. The study identified histone deacetylase 9 (HDAC9) as a potential target for intervention.
Research reveals that morbidly obese people's fat cells reach a storage limit, leading to changes in metabolism that may increase the risk of diabetes and cardiovascular disease. SFRP1 protein production is linked to these changes, which may trigger metabolic syndrome and other health problems.
Scientists have identified 80 different proteins produced by human fat cells, including six new proteins and 20 previously undetected ones. These findings suggest that fat cells play an active role in hormone secretion and may contribute to diseases like heart disease and diabetes.
Researchers found that increased abdominal fat increases the risk of metabolic disease, while fat gain in the thighs lowers the risk. The study challenges the concept that the number of fat cells remains stable in adults and suggests a potential protective effect of lower-body fat cells.
Researchers mapped histone modifications in fat cells to identify two transcription factors SRF and PLZF involved in fat cell development. The study provides a roadmap for understanding normal fat cell development and has potential implications for metabolic diseases such as obesity and Type 2 diabetes.
Researchers at NIH used high-resolution microscopy to understand how fat cells absorb glucose in response to insulin. The findings may aid in identifying the interval when someone becomes at risk for developing type 2 diabetes.
Scientists have discovered 20 new hormones and substances secreted by human fat cells, including six new proteins and dozens of previously known hormones. This finding could lead to a better understanding of the role of hormone-secreting fat cells in heart disease, diabetes, and other diseases.
Researchers at Ohio State University used mathematics to study the proteins that influence the birth of a human fat cell, identifying three key proteins: NF-kB, PPAR-gamma, and cyclin D. The study's findings could lead to a better understanding of obesity and insulin resistance.
Researchers at University of Colorado Anschutz Medical Campus discover bone marrow progenitor-derived adipocytes, a new type of fat cell that poses health threats. The discovery may help explain the link between obesity and heart disease.
Researchers have successfully reprogrammed adult mouse fat cells and neural cells to become induced pluripotent stem cells (iPS) that can differentiate into various cell types. The study demonstrates that adipose tissue-derived cells are the most amenable to reprogramming, making them a promising source for clinical applications.
A laboratory study found that fructose makes fat cells in belly fat more mature and less responsive to insulin. The findings suggest a link between high fructose intake during childhood and increased visceral obesity, which raises cardiometabolic risk.
A team of scientists found an intermediate state during the formation of fat cells, induced by hormones related to cortisol. This transition state could be targeted for new therapies to combat obesity and metabolic disorders.
Researchers have developed a microscope-based cell scanner to measure physical parameters in Petri dishes, allowing scientists to investigate fat cells at the cellular level. This tool enables rapid assessment of individual cell changes under experimental conditions, providing clues about treatment toxicity or effectiveness.
Scientists have developed tissue-engineered grafts composed of adult stem cells that can replace synthetic vascular bypass grafts. The study found that these grafts prevented clotting and thickening of the graft wall, improving their effectiveness in treating peripheral artery disease and dialysis access grafting.
Researchers found that a certain form of body fat inflammation is necessary for fat cell turnover in lean, healthy individuals. This challenges the theory that inflammation in adipose tissue only causes insulin resistance and type 2 diabetes.
Researchers at University of Cincinnati identify p62 and ERK as a critical protein duo involved in adipogenesis. The study shows how the interplay between these proteins leads to uncontrolled ERK activity, highlighting ERK as a promising target for obesity therapies.
A study found that calorie-restricted diets alter proteins in abdominal subcutaneous fat cells, which could serve as markers for improving or tracking therapy effects. Volunteers who lost an average of 21 pounds showed changes in protein levels, offering new insights into the mechanisms behind these diets.
High urea levels in chronic kidney failure have been found to be toxic, leading researchers to suggest a potential new treatment strategy. Antioxidant therapy was shown to restore insulin sensitivity in mice with end-stage kidney disease. Similarly, targeting the molecular link Mdm2 may help prevent progression of late-stage metastatic...
Scientists at the University of Bonn have discovered a way to turn on the 'natural heating system' in brown fat cells, which can lead to increased energy expenditure and reduced body weight. By activating this mechanism, it may be possible to fight obesity with fat.
A team of researchers found that high levels of urea produce toxic molecules in fat cells, leading to insulin resistance and characteristics of end-stage kidney disease. Blocking the effects of high urea levels may improve quality of life and lifespan for individuals with chronic kidney failure.
Researchers have identified a counterbalancing role for the phosphorylation of alpha-synuclein amino acid 125 in nerve cell protection against alpha-synuclein-mediated toxicity. Higher levels of this phosphorylated form were found to decrease toxic soluble oligomers and protect against Parkinson's disease symptoms.
A new study reveals that inhibiting autophagy in mice leads to an increase in brown fat cells and a reduction in body mass. The researchers conclude that autophagy has a crucial role in regulating the formation of distinct fat cell types, providing a potential avenue for treating obesity.
Recent findings published online first in Cancer Research show that obesity is associated with increased incidence and mortality of leukemia in children. The study reveals that fat cells can block chemotherapy drugs from reaching cancerous cells, leading to reduced treatment effectiveness.
A new study from the University of Gothenburg reveals that middle-aged women with large abdominal fat cells are at higher risk of developing type 2 diabetes. The study uses waist circumference divided by body height as a predictor, suggesting a simpler and faster way to identify those at risk.
Researchers found that enlarged fat cells and a higher waist-to-height ratio are key indicators of future diabetes in women. The study, published in the FASEB Journal, provides a simple tool for identifying women at risk of developing type 2 diabetes.
Researchers have identified versatile cells in liposuction leftovers that can be quickly converted into induced pluripotent stem cells (iPS cells), potentially revolutionizing regenerative medicine. The study shows a 20-fold improvement in efficiency compared to skin cells, which are more challenging to reprogram.
A new study found that exercise reduces appetite and burns fat first, then carbohydrates, slowing weight regain and overeating. Exercise also prevents the increase in fat cells during weight regain, making it easier to stay on a diet.
Researchers have identified a new genetic mechanism controlling body's fat-building process, potentially leading to new treatments for obesity and type 2 diabetes. The study found that the MCPIP gene controls fat cell development, offering a new direction for developing drugs to prevent obesity-related chronic diseases.
Researchers at Dana-Farber Cancer Institute engineered mouse cells to produce brown fat, a natural energy-burning type of fat that counteracts obesity. Transplanted into adult mice, the synthetic brown fat precursors burned excess energy at a high rate.
PEDF, secreted by fat cells, leads to insulin resistance and dyslipidemia. Blocking PEDF action may reverse health complications associated with obesity.
A study published in Nature found that fat cells in bone marrow suppress blood production, making it harder for patients to recover from chemotherapy or radiation. Blocking this fatty infiltration could enhance blood recovery after transplant.
Research found that ghrelin hormone increases appetite and promotes the accumulation of abdominal fat, linked to higher blood pressure, type 2 diabetes, and metabolic syndrome. Ghrelin's twin action on the organism opens doors for future treatment of obesity.
Researchers have found that white tea extract effectively reduces the generation of new adipocytes and stimulates fat mobilization from mature fat cells. White tea, a less processed version of green tea, contains ingredients such as methylxanthines and epigallocatechin-3-gallate that may be responsible for its anti-adipogenic effects.
Researchers at UC Berkeley discovered a gene, DNA-PK, that plays a critical regulatory role in converting dietary carbohydrates to fat. The study found that disabling this gene in mice resulted in lower levels of body fat despite a high-carb diet.
Researchers at UT Southwestern Medical Center found that mice lacking collagen VI developed 'healthy' obesity when fed a high-fat diet, without inflammation or insulin resistance. The study highlights the role of collagen VI in modulating fat-cell physiology and its potential as a target for intervention.
A new study by UC Berkeley researchers reveals that disabling a key enzyme in fat cells allows mice to overeat without gaining weight. The enzyme, AdPLA, plays a crucial role in regulating fat metabolism and body weight, making it a promising target for obesity treatment.
Researchers have successfully transplanted de-differentiated fat (DFAT) cells into animal models, promoting functional recovery and motor function after spinal cord injury. The study suggests that DFAT cells could be a source for cell replacement therapy to treat central nervous system disorders.
Researchers discovered adiponectin is a metabolic link between obesity and reduced bone mineral density. Adiponectin levels were lower in obese humans and mice compared to lean controls. Higher levels of adiponectin impede bone development, leading to weaker bones and increased risk of fractures.
A study from Karolinska Institutet reveals that bad cholesterol inhibits the breakdown of peripheral fat in cells. The discovery opens up new theories for the association between blood lipids and metabolic syndrome.
Researchers mapped thousands of positions where PPAR gamma regulates genes in fat cells, potentially leading to new therapies for reducing fat cell numbers or altering function. The findings aim to decrease side effects associated with antidiabetic drugs.
Scientists have discovered an important fat precursor cell that may explain how changes in fat cells lead to obesity. The discovery could also shed light on conditions like diabetes and cardiovascular disease.
Researchers at Indiana University discovered that healthy endothelial cells lining blood vessels can reduce the tendency of precursor cells to develop into fat cells. This finding could lead to new treatment options for cardiovascular diseases and obesity.
Researchers at UT Southwestern Medical Center have found immature fat cells embedded in blood vessel walls that can grow into adult monsters with excess calories. These cells, called progenitor cells, could be used to treat obesity, diabetes and other metabolic conditions by isolating them from unwanted fat.
Researchers have created a rapid cell inspection technique that can identify metastatic breast cancer cells, which have compromised the cell's structure and compromise deformation. The technique uses an electrical field within a microscopic fluid-filled channel and has been shown to expand cells by 75% in metastatic cases.
Researchers identified a new class of hormones called lipokines, which help regulate metabolism and improve insulin sensitivity in mice. The discovery could lead to new treatments for obesity-related conditions such as diabetes and fatty liver disease.
A recent study published in the journal Diabetes found that fat tissue in obese patients has impaired cellular function, leading to increased risk of insulin resistance and related conditions. The researchers discovered significant differences in the cellular structure and function of fat cells between lean and obese individuals.