Articles tagged with Adipocytes
Researchers at UCLA have discovered a protein combination that significantly improves clinical bone restoration, offering potential therapeutic treatments for osteoporosis and bone skeletal defects. The combination of NELL-1 and BMP2 stimulates bone production while inhibiting fat cell formation.
Scientists at Gladstone Institutes discovered a novel regulator of body weight: the P75 neurotrophin receptor. Lowering levels of p75 NTR protected mice from developing obesity, diabetes, and fatty liver disease on a high-fat diet. The receptor plays a key role in regulating metabolic processes that control body weight.
Researchers at OIST discovered a molecular mechanism involved in storing and burning fat. They found that mice lacking two specific genes remain lean even after eating a high-fat diet due to increased expression of Ucp1, which helps convert stored fat into heat.
A study by Kyoto University found that fish oil activates receptors in the digestive tract, fires the sympathetic nervous system, and induces storage cells to metabolize fat. This may increase beige cells, which are less common in adults but play a crucial role in burning fat for energy.
Researchers found that increasing energy expenditure with brown or brite/beige fat cells could be an effective way to fight obesity. The study suggests harnessing the body's natural mechanism of converting white fat cells into beige fat cells by using heat production and increasing the sympathetic nervous system's supply of blood vessels.
A study published in Nature Communication found that a protein called sLR11 acts to inhibit thermogenesis, or heat production, in fat cells, making it harder for the body to burn excess fat. This protein is produced by fat cells and increases with total fat mass, suggesting its role in storing energy over long periods.
Researchers have found that bone marrow stem cells can produce fat cells that contribute to chronic illnesses like diabetes and cardiovascular disease. The discovery highlights the possibility of genetically modifying fat-storing cells to prevent or reverse fat-related diseases.
Researchers at the University of California, San Diego have made significant breakthroughs in understanding how fat cells metabolize nutrients to produce fatty acids. This discovery could lead to new insights into potential irregularities in fat cell metabolism and help identify better drug targets for treating diabetes and obesity.
Researchers at UNC School of Medicine found a new way to force stem cells to become bone cells by altering gene expression with cytochalasin D. This discovery could lead to therapies for people who heal slowly from bone injuries or need replacement joints.
Recent stem cell research has made significant progress in deriving induced pluripotent stem cells from various sources, including adipose tissue-derived cells. The study also explores epigenetic roles in somatic reprogramming, embryonic development, and disease treatment. Researchers have identified critical factors for efficient gene...
A new adipogenic cocktail D&R has been developed to induce functional mature adipocytes from MSCs. This cocktail improves energy homeostasis by inducing cells with characteristics of a mature adipocyte, including fat droplets and sensitivity to insulin.
A review in Plastic and Reconstructive Surgery found no single technique superior to others for processing harvested fat cells. Studies show several viable methods, but more research is needed to compare outcomes and evaluate new techniques.
A breakthrough study has identified a neural mechanism responsible for fat breakdown, allowing researchers to develop novel anti-obesity therapies. The study found that fat tissue is innervated and direct stimulation of neurons in fat can induce fat breakdown, providing new hopes for treating central leptin resistance.
Researchers found fetal cartilage-derived progenitor cells (FCPCs) have superior cartilage repair capabilities than mesenchymal stem cells (MSCs). FCPCs showed yields approximately 24 times greater and possess self-renewal and multi-lineage differentiation abilities.
Researchers successfully transplanted mesenchymal stromal cells (MSCs) derived from human amniotic membranes into laboratory mice with oxygen-induced retinopathy, demonstrating the potential of MSCs to suppress causes of diabetic retinopathy and macular degeneration. The study found that AMSCs secrete growth factors that inhibit angiog...
A study led by Beth Israel Deaconess Medical Center and MIT reveals a genetic circuit controlling fat storage versus burning. The research identifies two key genes, IRX3 and IRX5, which are under the control of the FTO gene variant associated with obesity. Manipulating this pathway may offer a new treatment approach for obesity.
Researchers at MIT and Harvard Medical School discovered a new pathway that controls human metabolism by prompting adipocytes to store or burn fat. The study identified two master controllers of thermogenesis, IRX3 and IRX5, which turn off fat storage genes and restore energy balance.
Researchers identified a gene called 14-3-3zeta, which controls the production of fat cells and growth. Silencing this gene in mice resulted in a 50% reduction in specific unhealthy white fat, regardless of food intake.
Researchers have found two different types of fat cells in bone marrow, regulated and constitutive, which store different types of fat molecules. The discovery paves the way for more research on how marrow fat influences the body and its role in diseases like osteoporosis.
A recent study published in Cellular and Molecular Gastroenterology and Hepatology found that intra-abdominal fat cells may promote inflammation in IBD patients. The research isolated and cultured pre-intra-abdominal fat cells from healthy subjects and those with IBD, revealing significant differences in signaling mediators produced by...
Researchers have discovered that white fat can be transformed into a form resembling brown fat, increasing metabolic rate and lowering blood glucose levels. This finding has significant implications for the treatment of complications associated with obesity and sedentary lifestyle.
Researchers have induced structures within cells to produce laser light, emitting specific wavelengths that allow for precise labeling and measurement of individual cells. This technology has the potential to tag up to a trillion cells, matching the estimated number of human body cells, enabling applications in basic research and disea...
Researchers found that bone marrow-derived cells can develop into fat cells, with BMI playing a significant role. The study suggests potential new therapies for metabolic diseases and obesity-related conditions.
Stem cell transplantation has been shown to accelerate healing in laboratory rats with severe burns. The treatment uses bone marrow-derived mesenchymal stromal cells (MSCs), which enhanced local blood supply, modulated the immune system, and secreted growth factors with anti-inflammatory properties.
Researchers created human cell lines to study gene expression in precursor cells, enabling the prediction of UCP1 expression and potential transformation of white fat cells into brown fat cells. This breakthrough offers a promising tool for developing personalized obesity treatments.
Researchers pinpoint cell that triggers scarring in fatty tissue, leading to insulin resistance and diabetes. The study reveals a potential new target for treating metabolic disorders.
Dr. Philipp Scherer, Director of UT Southwestern's Touchstone Center for Diabetes Research, receives the prestigious Banting Medal for his significant contributions to understanding and treating diabetes. His research focuses on adipocytes and has demonstrated an initially protective role for obesity in regulating metabolism.
Scientists at Walailak University and Hokkaido University report the first full 3D scan of a single biological cell, achieving micron resolution with picosecond ultrasonics. This technique allows for nondestructive imaging of living cells, opening new avenues for studying their physical properties.
A new technique using fat grafting improves the cosmetic outcomes of breast augmentation, producing a more natural shape and softening the 'medial transition zone'. The study found that women who underwent this procedure had a narrower distance between their breasts and reported high satisfaction rates.
Researchers discovered a gene called Plexin D1 that controls fat storage and cell shape, which is associated with health risks. Zebrafish without the gene had less abdominal fat and were protected from insulin resistance.
Researchers at Queen Mary University of London found that regulating primary cilia length in stem cells can prevent the production of new fat cells. This study provides new insight into the regulation of fat cell formation and obesity, potentially leading to a new type of treatment called 'cilia-therapy'.
Researchers found that hemin treatment suppresses hypertriglyceridemia and hypercholesterolemia while reducing pericardial adiposity. Hemin also attenuates adipocyte inflammation and oxidative insults, promoting regeneration of proteins such as beta-catenin and Oct3/4.
Researchers discovered the brain's role in regulating body fat by combining hormones leptin and insulin, which stimulate the conversion of white fat to brown fat through the nervous system. This process normally maintains body weight but goes awry in diet-induced obesity.
Researchers at the University of Michigan have identified how a promising drug, amlexanox, improves sugar metabolism by generating a new signal between fat cells and the liver. The findings suggest a new pathway for future treatments for obesity, diabetes, and fatty liver disease.
A recent mouse study from Johns Hopkins Medicine found that modifying fat cells' metabolism does not result in obesity. The research team discovered that even when fat cells cannot burn fat, mice do not become overweight.
Researchers have identified two transcription factors, GR and VDR, that play a crucial role in the development of insulin resistance. Epigenomic modifications, such as changes in DNA structure, can be passed from cell to cell and between generations, and this study provides insights into how these modifications contribute to the condit...
Research in the FASEB Journal found that cold temperatures can induce cells to change from white to brown fat, which may help treat type 2 diabetes. About 30% of cells that appear white before cold stress rapidly turn into brown adipocytes.
Fat cells in the skin produce antimicrobial peptides that help protect against bacterial infections, contradicting previous assumptions about the immune response. The study's findings suggest that these peptides can provide a crucial first line of defense against infection.
Researchers calculate that lungs excrete 8.4kg of CO2 when 10kg of fat is fully oxidized, shedding unwanted pounds. By breathing, individuals can lose up to 200 grams of carbon daily, with exercise further increasing weight loss through increased metabolic rate.
A team of researchers from the University of Southern Denmark has successfully reprogrammed white adipose tissue cells to become 'brite' (brown-in-white) fat cells, increasing energy consumption and potentially treating obesity. The study identified KLF11 as a key gene required for this process, paving the way for future treatments.
Researchers at the University of Rochester Medical Center discovered that the Thy1 protein plays a fundamental role in controlling whether primitive cells become fat cells. Restoring Thy1 expression may help prevent or reduce obesity.
Researchers at Harvard University have developed a system using human stem cells to screen for compounds that can turn white, or 'bad', fat cells into brown, or 'good' fat cells. They have identified two compounds that can accomplish this in human cells, taking the first step towards a potential pill for obesity treatment.
Researchers have discovered that brown fat, which burns calories and absorbs excess sugar, could be used to control blood glucose levels in people with type 2 diabetes. The study found that activating brown fat cells could lead to a new way of managing the disease without daily insulin injections.
A newly discovered signaling pathway in brown fat cells stimulates glucose uptake, potentially treating type 2 diabetes. The mTORC2 pathway, involving protein kinase mTOR, enhances GLUT1 transport to the surface of brown fat cells.
Scientists at the University of Bonn have discovered a new signaling pathway that utilizes adenosine to stimulate brown fat cells. This 'browning' process may help convert white fat cells into energy-burning brown cells, potentially aiding in weight loss and reducing the risk of chronic diseases.
A Purdue University study reveals that blocking Notch signaling in fat cells can transform white fat into a healthier beige fat type, potentially reducing obesity and related health issues. The research also found that suppressing Notch signaling improves glucose balance and insulin sensitivity.
Researchers at Helmholtz Munich have developed a new approach to treat obesity and type 2 diabetes, targeting the brown adipose tissue. By identifying specific surface proteins, they aim to selectively deliver substances to this tissue to reduce excess weight without side effects.
Researchers at The Scripps Research Institute have identified a signaling pathway that activates the powerful calorie-burning process in brown fat cells. The study found that a protein called GADD45γ works alongside PGC-1α to boost thermogenesis, offering new possibilities for treating obesity and diabetes.
Researchers found that stress can disrupt the process of fat tissue development, leading to issues with fat storage within cells and in the bloodstream. The study identified a key signaling pathway involving adenosine receptors and stem cell factors that regulates this process.
A new study by Beth Israel Deaconess Medical Center identifies IRF4 as a key regulator of brown fat's thermogenic process, driving energy expenditure and cold tolerance. The findings provide a crucial clue to understanding how brown fat burns energy and may lead to the development of novel therapies for obesity and diabetes.
Joslin researchers found that microRNAs play a major role in fat cell development and whole body metabolism. They also discovered that low levels of Dicer expression in fat tissue may contribute to the development of HIV-related lipodystrophy, a complication limiting therapy in some patients.
Two studies found that adolescents' brains respond to glucose with increased blood flow in reward-motivation regions, unlike adults. Additionally, obese children as young as six years old develop larger and more dysfunctional fat cells, leading to inflammation and insulin resistance.
Researchers found that periodic fasting can convert bad cholesterol in fat cells to energy, reducing the risk of diabetes and metabolic problems. After 10-12 hours of fasting, the body starts scavenging for other sources of energy, pulling LDL cholesterol from fat cells and using it as energy.
Researchers at UC San Diego School of Medicine discovered that a lack of oxygen in fat cells leads to inflammation and insulin resistance in obesity-induced diabetes. Inhibiting key proteins like ANT2 and HIF-1alpha may provide therapeutic targets for prevention or reversal.
Research reveals a key role for HIF-1 alpha in insulin resistance, type 2 diabetes, and obesity-related inflammation. The protein's inhibition shows promise as a potential treatment for these conditions, including its application to cancer.
A new study by UC San Francisco researchers found that two signaling molecules secreted by immune cells trigger the conversion of white fat cells to beige fat cells, leading to weight loss. The discovery provides a potential new strategy for weight loss focused on the immune system rather than the brain.
Researchers at Karolinska Institutet identified the EBF1 gene driving unhealthy adipose tissue development, associated with increased risk of insulin resistance and type 2 diabetes. The study found that individuals with large fat cells had lower EBF1 expression, altered lipid mobilization, and insulin resistance.
Researchers from University of Southern Denmark have discovered that proteins called transcription factors work together in a new and complex way to reprogram the DNA strand when a stem cell develops into a specific cell type. This discovery could lead to new ways of making stem cells develop into exactly the type of cells that a physi...
Researchers found that activating a receptor, Gpr109a, can inhibit inflammation in the retina and prevent vision damage in diabetes. The new grant will enable long-term studies to evaluate the therapeutic potential of this approach.
Researchers have developed robust new liver and fat cell models that report circadian clock function, allowing for high-throughput drug screening to find promising small molecules to resynchronize or help body clocks function normally.