Articles tagged with Adult Stem Cells
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Researchers at UNC School of Medicine have shown that transplantation of adult stem cells enriched with IGF-I can help mend bone fractures not healing properly. The treatment speeds up the healing process, restoring bone formation and strength.
Adult planarians possess pluripotent stem cells capable of producing diverse tissue types, allowing for the rebuilding of entire organisms from a single cell. The discovery could lead to insights into human regenerative medicine, as many genes in the planarian genome have human counterparts.
A study from Cold Spring Harbor Laboratory suggests that adult stem cells in the brain are 'disposable' and lose their ability to produce neurons with age, leading to a decline in new neuron production. This decline may contribute to age-related cognitive decline.
Researchers have discovered a new way to reprogram adult cells into an embryonic stem cell-like state using specific microRNAs and Hdac2 suppression, offering a more efficient alternative to traditional methods. This breakthrough could lead to improved strategies for developing stem cells for therapeutic use.
Researchers developed induced conditional self-renewing progenitor cells, which can differentiate into active neurons and other brain cell types. The new stem cell approach shows promising results in an adult rat model of intracerebral hemorrhagic stroke, with no adverse effects observed over five months.
A new method allows for quick and comprehensive characterization of induced pluripotent stem cells (iPS) and embryonic stem cell lines, enabling high-throughput assessment of quality and differentiation efficiency. The approach yields genome-wide reference maps detailing epigenetic and gene expression landscapes.
Researchers at Scripps Research Institute successfully converted adult skin cells into beating heart cells through a direct reprogramming strategy, bypassing the need for embryonic-like stem cells. This breakthrough discovery has the potential to lead to new treatments for diseases such as heart disease, Parkinson's, and Alzheimer's.
Shinya Yamanaka and Rudolf Jaenisch receive the prestigious award for their groundbreaking work on induced pluripotent stem cells, revolutionizing regenerative medicine. The MGH recognizes their contributions to unlocking new treatments for human diseases.
A UCSF team found that the human fetal immune system arises from a different source than the adult immune system and is more tolerant of foreign substances. This discovery may help explain why many infants born to HIV-positive mothers are not infected with the disease.
Researchers at Georgetown University Medical Center have successfully turned human testes cells into insulin-producing islet cells, offering a potential new treatment for type 1 diabetes. The study used spermatogonial stem cells extracted from testicular tissue to produce insulin-secreting beta islet cells without the use of extra genes.
A recent study published in Stem Cells journal has awarded human cord-blood research with a $10,000 prize for its potential to cure acute kidney injury. The research revealed the regenerative potentials of human cord-blood stem cells as a future cell therapy.
A UCSF-led team discovered a key reason why blood stem cells are prone to developing genetic mutations that can lead to adult leukemia. They found that quiescent blood stem cells use an error-prone DNA repair mechanism, which can result in chromosomal instability and contribute to hematopoietic abnormalities.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have found that adult stem cells vital for lung repair are associated with a poor prognosis in patients who develop cancer. These cells may mutate into cancer-causing stem cells, making them a potential target for prevention strategies and new targeted therapies.
Researchers found that human embryonic stem cells and reprogrammed cells exhibit very few differences in gene expression signatures and are nearly indistinguishable in their chromatin state, according to Whitehead Institute researchers. This study suggests that reprogrammed cells may indeed hold clinical promise ascribed to them earlier.
Researchers at Gladstone Institutes found a way to make beating heart cells from body's own cells, helping to regenerate damaged hearts. The new method directly reprograms structural cells called fibroblasts into cardiomyocytes without needing stem cell state.
Stem cell differentiation is a crucial process that can be accelerated using a novel type of matrix, adjusting its stiffness without altering its chemical composition. By analyzing traction forces and cellular behavior, researchers predict stem cell differentiation as early as Day 1.
Researchers used nanoparticles to destroy atherosclerotic plaque in pigs, reducing plaque volume by 56.8% after six months. Combining nanoparticles with adult stem cells showed the greatest reductions in plaque volume and signs of new blood vessel growth.
Researchers found that induced pluripotent stem cells (iPS cells) retain a 'memory' of their tissue of origin, making it harder to differentiate into other cell types. However, additional steps or drugs can erase this memory, making iPS cells comparable to nuclear transfer stem cells.
Researchers at Stanford University School of Medicine developed a technique to grow muscle stem cells on a synthetic matrix that mimics the elasticity of real muscle, allowing them to maintain their self-renewing properties. This breakthrough may revolutionize the production of adult stem cells for therapies.
A new technique developed by Professor Fiona Watt's team allows for the examination of individual stem cells to learn about their biology and screen new drugs. This approach has demonstrated its potential to encourage stem cells to repair damaged tissues.
Researchers at Tel Aviv University have successfully tracked the progression of adult stem cells through live imaging, gaining insight into how they are reprogrammed and evolve over time. This breakthrough could lead to more efficient and effective cell reprogramming techniques for treating diseases such as Parkinson's.
Researchers at Rice University and the University of Cambridge have created a computer model that accurately describes the behavior of three regulatory proteins in hematopoietic stem cells. The Scl-Gata2-Fli1 triad is thought to be the master-level regulator for these self-renewing cells, which produce new blood cells.
A new strategy for reprogramming human adult cells into induced pluripotent stem (iPS) cells has been successfully developed, eliminating the need for oncogenes. This innovation offers improved safety and efficiency for producing patient-specific stem cells for therapeutic applications.
Scientists have developed tissue-engineered grafts composed of adult stem cells that can replace synthetic vascular bypass grafts. The study found that these grafts prevented clotting and thickening of the graft wall, improving their effectiveness in treating peripheral artery disease and dialysis access grafting.
A new study led by LSU researcher Mandi Lopez aims to improve treatment of broken bones in horses. Adult equine stem cells have shown promise in repairing bone injuries, but little research has been done on the best combinations of stem cells and carriers.
Researchers at University of California - Berkeley found an insulin-like signal necessary to keep stem cells alive in the adult brain. Blocking apoptosis genes alone is not enough, as neural stem cells also require an insulin-type signal to persist. The study suggests that manipulating the insulin pathway may be essential for re-growin...
Researchers discovered endothelial cells can grow copious amounts of adult stem cells and their progeny over weeks, revolutionizing organ regeneration and cancer cell growth inhibition. This vascular-cell model could manufacture unlimited blood-related stem cells for transplantation.
Researchers at UTHealth have demonstrated that transplanting genetically modified adult stem cells into an injured spinal cord can help restore electrical pathways associated with movement. The new cells, called oligodendrocyte precursor cells, facilitate remyelination and increase behavioral recovery.
Researchers propose a model of adult stem cell regulation that explains how coexistence of quiescent and active stem cell populations supports tissue renewal and regeneration. The new model suggests separate functional roles for both sub-populations, which may also contribute to cancer drug resistance.
A protein complex called elongator may play a significant role in erasing epigenetic instructions on sperm DNA, enabling the formation of new embryos. This discovery could have implications for stem cell research and cancer treatment.
A novel framework encourages adult stem cells to differentiate into heart cells by mimicking the elasticity alterations that occur in protein scaffolds. More cardiomyocytes were formed on this framework than with conventional techniques, suggesting improved cardiac differentiation.
A new study suggests that adult stem cells can differentiate into heart cells to repair damage, offering a promising new treatment for heart attack patients. The Phase I trial showed significant improvements in heart function and reduced arrhythmias after administration of the stem cells.
Researchers from NC State University have identified a gene called FoxJ1 that tells embryonic stem cells in the brain when to stop producing nerve cells. This discovery advances understanding of the nervous system and its development, with potential applications for conditions like Parkinson's disease and Alzheimer's.
Scientists at Gladstone Institute of Cardiovascular Disease and Stanford University School of Medicine are developing induced pluripotent stem cells to repair damaged heart muscle. The $10 million, 7-year project aims to identify and characterize progenitor cell lines and develop new clinical strategies for regenerative therapies.
The National Institute of General Medical Sciences (NIGMS) is accelerating basic studies of induced pluripotent stem cells (iPS) using $5.4 million in Recovery Act funding. Scientists at 16 institutions will investigate iPS cell properties and derivatives for therapeutic applications.
Scripps Research scientists have made a breakthrough in creating stem cells from adult human tissue using three small drug-like chemicals. The new technique is 200 times more efficient and twice as fast than conventional methods, solving two major challenges in the development of stem-cell-based medicine.
The Gladstone Institute of Neurological Disease and partners will use induced pluripotent stem (iPS) cell technology to develop human neurons with Huntington's disease characteristics, offering hope for new treatments. The goal is to understand the molecular differences between mice and humans that lead to ineffective therapies.
Researchers at LA BioMed will investigate the potential of ESAI's drug, KRONOS IV, to activate adult stem cells and provide long-term correction for male erectile dysfunction in an aged population. The study aims to understand how the drug works on tissue repair and identify potential systemic effects.
Researchers have developed a new technique to efficiently edit genes in human embryonic stem cells, enabling the creation of specific cell types for modeling genetic diseases. The method uses zinc finger nucleases to cut out one gene and substitute it with another, allowing precise control over gene expression.
Researchers have successfully created various types of mature white blood cells from embryonic and adult stem cells, opening up new possibilities for studying disease development and treatment. The technique could produce cells tailored to specific infections or tumors, making it a potential tool for safety screening of new drugs.
Scientists identify key molecular players responsible for reversion of adult cells into a primordial, stem cell state. By reducing activity of Jak and STAT proteins, researchers found fewer cells to revert back to stem cells, with only 60% regaining their stem cell population.
Researchers successfully used induced pluripotent stem (iPS) cells to treat heart damage caused by infarction. The treatment restored heart muscle performance, stopped progression of structural damage, and regenerated tissue at the site of heart damage.
Researchers at Max-Planck-Gesellschaft have developed a method to convert adult testis cells in mice into pluripotent stem cells, which can form all types of body tissue, without the use of introduced genes, viruses, or reprogramming proteins. The culture conditions were found to be crucial for the success of the process.
Researchers successfully transplanted embryonic stem cells into mouse embryos, demonstrating a capacity to recover from cardiac injury in adulthood. The study provides evidence for preventive regenerative medicine to treat myocardial infarction through prophylactic intervention.
Researchers at Scripps Research Institute successfully generate embryonic-like stem cells from adult cells using chemical programming, overcoming safety concerns associated with genetic manipulation. This breakthrough has the potential to revolutionize personalized stem cell-based medicine for various diseases.
Researchers develop novel method to identify stem cells in pancreas, showing acinar cells produce digestive enzymes and may have carcinogenic properties. The breakthrough paves the way for further study on proliferation mechanisms and potential dangers of these cells.
Researchers at St. Jude Children's Research Hospital have found that cells isolated from the eye are not retinal stem cells, contradicting previous findings. Instead, they suggest that re-engineering stem cells to develop photoreceptor cells could be a promising approach to restore vision in people with retinal degeneration.
The study found that delivering a potent form of autologous adult stem cells into the heart muscle of patients with severe angina improved exercise tolerance and reduced episodes of chest pain. Six months after the procedure, treated patients were able to walk longer on a treadmill than those in the placebo group.
Researchers at UW-Madison have developed a new method to generate induced human pluripotent stem cells (iPS) without using viral vectors or exotic genes. This breakthrough removes key safety concerns and genetic artifacts that could compromise therapeutic safety or skew research results.
Researchers have developed a new technique to mobilize specific types of adult stem cells into the bloodstream using new drug combinations. This method aims to accelerate tissue regeneration and repair in cases of heart disease or sports injuries, potentially treating autoimmune diseases like rheumatoid arthritis.
Scientists have developed a new method for converting adult cells into embryonic stem cell-like cells using a single virus, cutting the number of viruses used from four to one. This approach eliminates the risks associated with multiple viruses and could potentially be used to treat diseases such as Parkinson's and diabetes.
Scientists have successfully transplanted a single adult stem cell into a live mammal and shown that it can self-renew and repair damaged tissue. The study used genetically engineered cells to track their dynamics, demonstrating the ability of these cells to proliferate and engraft into injured muscle tissue.
Researchers have shown that adult heart muscle stem cells can regenerate tissue and improve heart function when a gene regulator is suppressed. The study found that blocking beta-catenin led to enhanced differentiation of resident precursor cells, reducing ischemic cardiac remodeling in mice.
Researchers successfully recreate a functional stem-cell niche in adult mice, enabling further study of stem cell development and fate. The discovery has potential implications for leukemia treatment and bone healing.
Researchers at Tufts University have discovered that changes in membrane voltage control the timing of differentiation in adult human stem cells. The study found that hyperpolarization is a characteristic of differentiated cells and acts as an instructive signal to induce or inhibit differentiation.
A recent study by MIT biologists has found that DNA packaging plays a crucial role in directing stem cells towards becoming specific types of adult cells. The researchers discovered that chromatin structure, specifically the variant histone H2AZ, influences gene expression and cell fate.
Researchers at the University of Michigan have identified a molecular checkpoint system in adult stem cells that prevents abnormal cell division, which can lead to cancer. The system detects misaligned centrosomes and stops cell division, preventing over-proliferation and tumor formation.
Dr. Shinya Yamanaka's laboratory has eliminated the need for a virus to introduce genes into adult cells, improving the safety of induced pluripotent stem (iPS) cell technology for regenerative medicine applications.
Researchers have identified two genes that regulate stem cell function in planarians, which could provide insights into adult tissue maintenance and regeneration. The study also reveals the role of PTEN in controlling stem cell proliferation and regeneration.
Researchers at the University of Utah have identified two early steps in adult stem cell differentiation using DNA 'tattoos' on planarian cells. The study found 259 genes associated with stem cells and their daughters, shedding light on how multipotent stem cells take differentiation decisions.