Articles tagged with Adult Stem Cells
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Researchers have devised a clonal strategy to ensure adult epidermal stem cells meet the highest safety criteria before use in treatments. The approach involves cultivating, genetically modifying and testing individual cells to guarantee their viability and safety.
Researchers have identified a specific population of stem cells in the skin that exclusively generate and maintain Merkel cells, crucial for touch sensation. Removing these cells led to a permanent reduction in Merkel cells, highlighting their unique role.
Scientists at Indiana University and colleagues have demonstrated a technique for correcting genetic mutations in sperm-producing adult stem cells, a breakthrough that could prevent inherited defects in future generations. The method uses homologous recombination to repair flawed segments of DNA with correct ones.
Researchers discovered a subset of cartilage-making cells that replicate themselves and drive bone growth, offering new hope for children with facial deformities. The findings could lead to the development of new treatments for corrective facial surgery in children.
Researchers at Harvard University have successfully reprogrammed adult cells into insulin-producing beta cells in mice, showing promise for treating both Type 1 and Type 2 diabetes. The study's long-term findings suggest that the newly created cells remain functional over a period of approximately half the animal's normal lifespan.
Researchers at NYSCF found that SCNT-derived cells and IPS cells share similar genetic profiles, suggesting both methods are effective in generating stem cells. The study's findings imply that further investigation is needed to determine the suitability of each method for treating chronic diseases.
Scientists have developed a method to inject tonsil-derived stem cells into damaged livers, potentially treating liver disease without surgery. The technique uses a heat-sensitive liquid to grow liver cells on a 3-D scaffold, showing promise as an injectable tissue engineering approach.
Researchers at NYU Langone Health have discovered a highly efficient method for generating pluripotent stem cells, increasing yields by over 20-fold compared to standard protocols. The new technique uses vitamin C and two other compounds to modulate enzymes involved in cell reprogramming.
Researchers at Hebrew University develop a new cocktail of genes to coax adult cells into pluripotent stem cells, producing high-quality results. The new approach improves upon existing methods by reducing genetic abnormalities and increasing the proportion of successful cell reprogramming.
Adult stem cells in fruit flies undergo self-renewal and differentiation through competition between Bam and COP9 proteins. This study reveals the molecular mechanisms controlling balance between these functions, which could inform therapies to regenerate diseased tissue.
Researchers have identified biochemical pathways that can inhibit reprogramming of gene activity in adult human cells, increasing the efficiency of stem-cell production. This breakthrough could lead to accelerated development of replacement tissue for failing body parts.
Researchers have successfully reprogrammed adult patient cells into pluripotent stem cells using nuclear transfer, a breakthrough that could lead to personalized genetic therapy and cell replacement.
A new study suggests that low testosterone exposure in the womb may influence male susceptibility to serious health conditions like obesity and heart disease. Researchers found that reduced testosterone levels in fetal testes can impair Leydig cell function, leading to lifelong health consequences.
Researchers at CU-Boulder have identified two key pathways affecting skeletal muscle renewal, which could lead to the development of therapeutic treatments for age-related muscle wasting. The study found that altering these pathways enhances muscle stem cell renewal and improves muscle regeneration in aged mice.
Scientists have successfully differentiated human pluripotent stem cells into kidney tubular cells using a specific cocktail of chemicals. The resulting cells expressed key markers and could form functional tubules when transplanted into adult mouse kidneys.
A recent study published in Stem Cells has identified brown fat stem cells in adult humans, which may lead to new treatments for heart and endocrine disorders. The discovery could help increase the body's own ability to make brown fat or find novel ways to directly implant the cells into patients.
Researchers identify genes that promote stem cell self-renewal and tissue repair, opening up possibilities for metabolic drugs to enhance regeneration. A network of RNA-binding proteins regulates stem cell function and tissue growth during fetal development.
A human clinical study has demonstrated that participants taking Natura Therapeutics' NutraStem Cardio showed a significant increase in cognition compared to age-matched individuals taking a placebo. The results improved decision-making speed across a two-month test period.
Researchers have identified a source of gut stem cells that can repair damaged gut tissue in mice with inflammatory bowel disease. These stem cells were found to be actively dividing and could form mature intestinal tissue under the right conditions.
Research reveals that stomach chief cells can revert to stem cells even without noticeable injury, suggesting a potential new approach for repairing stomach damage. The findings also hint at the possibility of using this process to prevent stomach cancers.
Researchers find removing MBD3 protein increases efficiency of stem cell reprogramming from 1% to 100%, allowing for faster production of cells for medical use. This breakthrough provides a deeper understanding of embryonic development and could advance treatment of various diseases.
Researchers from CNIO successfully produce embryonic stem cells directly from living adult mice, exhibiting primitive totipotent characteristics and broader differentiation capacity than in vitro-derived cells.
Researchers discovered 10 specialized subregions within the midgut of fruit flies, each with unique stem cell functions. These regional differences may explain why some organs generate cancer frequently while others rarely. The study sheds light on the intricate relationships between tissue organization and stem cell function.
Researchers developed a protocol for isolating and expanding large numbers of multipotent fetal dermal cells (MFDCs) that display several advantages over adult dermal cells, including greater cellular yield after isolation and the retention of differentiation potential. The MFDCs were proven safe and efficacious in treating pediatric b...
A new finding by Weill Cornell Medical College researchers could improve the safety and performance of reprogrammed cells. The study found that an enzyme called activation-induced cytidine deaminase (AID) helps in the process of changing adult human cells into induced pluripotent stem cells (iPS cells). These iPS cells can be developed...
Researchers at the Buck Institute manipulated a signaling pathway implicated in Barrett's esophagus, suggesting a change in stem cell function as the cause of this transformation. This discovery may lead to new targets for therapies and inform the development of more effective treatments for Barrett's esophagus.
Researchers at the University of Edinburgh have made a breakthrough in understanding how induced pluripotent stem cells (iPSCs) are created. They found that the process is not just a reversal of normal cell generation, but involves changes to skin cells during reprogramming. This discovery could lead to more efficient and cost-effectiv...
Researchers at the University of Michigan have developed a method to build robust blood vessels using adult stem cells, which may lead to new treatments for circulatory diseases such as diabetes. The technique involves injecting endothelial cells and support cells into a scaffolding carrier, resulting in mature, functional capillaries.
For the first time, researchers have isolated adult stem cells from human intestinal tissue, providing a much-needed resource for scientists to study human stem cell biology. The isolated stem cells can be used to explore new treatments for inflammatory bowel disease and chemotherapy side effects.
Engineered stem cells produce US2 protein to increase survival by 59%, potentially improving treatment for bowel disease, traumatic brain injury, and organ transplants. The modified cells can modulate inflammation and promote healing, offering new hope for patients in need of regenerative therapies.
Researchers found that stem cell therapy stimulates the heart's natural repair mechanism, boosting production of adult heart cells and recruitment of existing stem cells. The treatment enhances heart structure and function, with new muscle formed being functional and durable.
A new study reveals that leprosy bacteria reprogram adult Schwann cells into stem cell-like cells and convert them to muscle-like cells, spreading infection. This finding could lead to the development of new therapeutic strategies and regenerative medicine tools.
Scientists have identified stem cells in the adult pancreas that can be turned into insulin-producing cells, offering a potential cure for type 1 diabetes. This breakthrough discovery provides further evidence of the existence of stem cells beyond embryos and may lead to new treatments for the condition.
A leading bone marrow transplant expert recommends changing current practice to use adult stem cells from bone marrow instead of peripheral blood for unrelated donor transplants. This change can significantly reduce the risk of chronic graft-versus-host disease, a debilitating side effect of transplantation.
Researchers identified epigenetic changes that occur in adult stem cells to generate different body tissues. The study shows that laboratory-created muscle and bone cells resemble those found in nature and are biologically secure for implantation.
Researchers at the University of Maryland School of Medicine have found that cardiac stem cells from newborns have a three-fold ability to restore heart function compared to adult-derived cells. This discovery may lead to new treatment options for congenital heart syndrome and improve heart function in children by up to 15 percent.
Researchers have successfully grown healthy small-diameter blood vessels using adult stem cells extracted during liposuction. These lab-grown vessels may replace the need for grafts from elsewhere in the body or artificial blood vessels, reducing risks of clotting and rejection.
Researchers at the University of Maryland School of Medicine have discovered that adult stem cells from bone marrow can transform into cells of other organs, such as the heart, brain, and pancreas. This breakthrough has significant implications for treating diseases like diabetes, Parkinson's, and Alzheimer's.
Notre Dame has established professorships in adult stem cell research thanks to a $5 million gift from the Gallagher family. The new positions aim to accelerate the discovery of treatments for degenerative diseases, such as Type 1 diabetes and Parkinson's disease, using non-embryonic stem cells.
Scientists have developed a synthetic surface that allows adult-derived stem cells to thrive and transform into multiple cell types, including bone cells. Transplanting these bone cells into mice resulted in four times more new bone growth compared to without the extra bone cells.
Researchers discovered dynamic changes in gene regulation in human stem cells, affecting their ability to serve as models for human disease and development. The study found that these cells can change their epigenomes, leading to unexpected outcomes in cell-based models of diseases like Lesch-Nyhan disease.
The University of Louisville has established a cardiac clinical research center thanks to a $3.4 million NIH grant. Researchers will test the safety and effectiveness of adult stem cell therapies for cardiovascular disorders.
Researchers have developed a synthetic version of the essential protein Oct4, which enhances the effect of genes needed for stem cells. This breakthrough enables more efficient generation and maintenance of stem cells, with potential applications in regenerative medicine and disease treatment.
A University of Minnesota-led research team has proposed a mechanism for controlling embryonic stem cell proliferation and differentiation. The study reveals that two enzymes, ERK1 and ERK2, inactivate the protein Klf4, allowing cells to differentiate into adult cells.
Researchers generated induced pluripotent stem (iPS) cells from ear tissue of adult snow leopards, paving the way for cryopreservation and cloning techniques to save endangered species. This breakthrough raises hopes for the conservation of the snow leopard and other cat family members.
Bioengineers at Rensselaer Polytechnic Institute receive $2 million NIH grant to study how chemicals in drugs and environment impact stem cells. The team aims to develop a new predictive safety screening tool that eliminates animal testing.
Adult stem cells have been found in the retina of the eye, which can divide and form other cell types. This discovery opens up potential treatments for diseases like age-related macular degeneration, as these cells may be able to repair damaged tissue.
A study published in Cell Stem Cell reveals that adjusting the levels of reprogramming factors can significantly impact the quality and fidelity of induced pluripotent stem (iPS) cells. This finding explains the variability in iPS cell quality reported in recent studies, which has sparked debate about their therapeutic potential.
Researchers at Inserm have successfully rejuvenated cells from elderly donors, erasing signs of aging and demonstrating the reversibility of cellular aging. The breakthrough uses a new 'cocktail' of six genetic factors to reprogram senescent cells into functional induced pluripotent stem cells.
A new study reveals that adult stem cells can reshape organs in response to changes, with implications for diabetes and obesity. Intestinal stem cells respond to increased food intake by producing more cells, expanding the gut's size.
Researchers found Sox2 expression in various adult tissues, including stomach, testes, and cervix, confirming its status as a widespread marker of adult stem cells. These cells can give rise to all mature cell types in their respective tissues.
A study from UNC Chapel Hill School of Medicine has illuminated a critical step in demethylation, giving stem cell researchers information to reprogram adult cells. The disappearance of chemical tags is a passive process, not catalyzed by an enzyme.
Researchers at Penn State College of Medicine found a way to generate antigen-specific T cells using induced pluripotent stem (iPS) cells, which could lead to a simpler and more efficient method for using the body's immune system to fight cancer. The study, published in Cancer Research, used iPS cells from mice converted into immune ce...
Researchers have shown they can reverse the aging process for human adult stem cells, which are responsible for helping old or damaged tissues regenerate. The study found that suppressing the accumulation of toxic transcripts from retrotransposons allows for rejuvenation and resetting of 'aged' human stem cells.
Patients in another clinical trial have reached the two-year mark following infusion of processed adult stem cells, while a new $12.8 million NIH grant renewal aims to perfect cardiac stem cell therapy for heart regeneration after a heart attack.
UT Southwestern researchers have found a way to regulate adult blood stem cells to overcome an immune response that leads to transplant rejection. The study successfully supports human and mouse blood stem cells through culture, enabling significant repopulation of healthy cells in rodent recipients.
Researchers at Tel Aviv University have discovered that adult-derived stem cells can retain 'memories' of their pancreatic beta cell origins, making them more efficient at producing insulin. This breakthrough may pave the way for new treatment options for juvenile or type 1 diabetes.
Researchers at Duke University Medical Center discovered that neighboring ependymal cells maintain a structure that keeps neural stem cells
Scientists at the University of Texas Health Science Center have identified a marker on the surface of adipose stem cells that produce white adipose tissue, a key contributor to obesity. The researchers developed a peptide probe targeting this marker, which may help deliver drugs to slow fat expansion and aid in weight loss efforts.
Researchers found that studying both types of stem cells has become more common, with a growing proportion of papers combining adult and embryonic stem cells. This means that banning either type of research could harm the field overall. The study suggests that federal funding for one area could negatively impact the other.