Articles tagged with Adult Stem Cells
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Researchers at Hong Kong University of Science and Technology discovered a key mechanism controlling muscle stem cell dormancy, involving the release of conserved introns upon activation. This discovery sheds light on the importance of Intron Retention (IR) in regulating gene expression and stem cell quiescence.
Scientists studied mouse tail skin expansion from birth to adulthood, finding that it grows by a factor of 15 through self-duplication of developmental progenitors. Cell proliferation rates decreased over time, while single-cell RNA sequencing revealed molecular features of developmental progenitors.
Computer simulations visualize the molecular processes involved in converting adult cells into stem cells. The study reveals that a pioneer transcription factor called Oct4 plays a crucial role in opening chromatin to allow gene expression.
Using a combination of pluripotent stem cells and machine learning, researchers have improved how they generate lung cells. This technique enables the growth of lung cells in a laboratory for over a year, allowing for better modeling of lung diseases and potential personalized treatments.
Dr. Allon M. Klein receives the Dr. Susan Lim Award for his groundbreaking contributions to stem cell and developmental biology, including novel approaches to adult stem cell self-renewal and a cell-isolation system for transcriptional analysis.
Researchers at Baylor College of Medicine have identified a new mechanism that contributes to adult bone maintenance and repair. Periosteal stem cells, previously poorly understood, play a major role in bone healing and respond to mechanical injury and inflammatory molecules, offering potential therapeutic applications for conditions l...
Researchers at University of Wisconsin-Madison find pIC accelerates cellular maturation, leading to more mature and functional cardiac muscle cells. The compound activates epigenetic changes, including increased expression of the JAG1 gene, resulting in improved contractility and electrical efficiency.
Researchers at Rutgers University have identified a new factor essential for maintaining stem cells in the brain and gut, whose loss contributes to anxiety and cognitive disorders. The study reveals that this gene product supports multiple types of adult stem cells, including those critical for cognitive function and intestinal renewal.
A team of researchers has shown that a single population of stem cells in mice generates new neurons throughout their lifetime, contributing to embryonic, early postnatal, and adult neurogenesis in the hippocampus. This finding suggests that the brain has the capacity for continuous improvement and adaptation.
Scientists at University of California San Diego School of Medicine use single-cell RNA sequencing to define cell types in human testes, opening a path for new strategies to treat male infertility. The study identifies spermatogonial stem cells and biomarkers that could help develop protein cocktails to drive cell proliferation.
Scientists from the Diabetes Research Institute renewed their original theory that pancreatic progenitor cells exist and can regenerate in humans. The study's findings could potentially address a major challenge in type 1 diabetes by regrowing patients' own insulin-producing cells.
Researchers at Duke University Medical Center have developed a technique to expand umbilical cord blood stem cells, which appears safe and restores blood count recovery faster than standard cord blood transplant in adults with blood cancer.
Researchers at Stanford University discovered that adult mouse skeletal stem cells revert to an earlier developmental stage when tasked with regenerating large portions of bone and tissue. This process, called de-differentiation, allows the cells to become more primitive and express genes typically found in early embryonic development.
A new study approach reveals that healthy adults have between 50,000 and 200,000 blood-creating stem cells in their bone marrow. This finding opens up new opportunities for studying how stem cells change during ageing and disease, and may lead to insights into cancer development and effective stem cell therapies.
Researchers have identified a way to expand blood-forming adult stem cells from human umbilical cord blood, increasing their availability for transplant patients. This breakthrough could lead to more people being able to receive life-saving treatments without a suitable bone marrow match.
Researchers at the University of Adelaide successfully applied cell transplantation therapy to replace damaged cells in CF patients, providing a potential cure. The innovative method involves harvesting adult stem cells from the lungs, correcting them with gene therapy, and reintroducing them back into the patient.
Researchers have developed a new protocol to produce mature human podocytes from induced pluripotent stem cells, offering a robust source for scientific studies and potential cell therapies for kidney diseases. The method has been confirmed to exhibit transcriptomic and protein expression profiles matching those of mature podocytes.
Researchers at the University of Calgary have shed new light on the identity of brain stem cells that exhibit neural stem cell function. The study found that ependymal cells do not become neural stem cells when activated by injury, but rather regulate their function.
Doctors at the University of Illinois Hospital have cured seven adult patients with sickle cell disease using compatible donor stem cells. The new transplant protocol allows for half-matched donors, significantly increasing potential donors and improving treatment outcomes.
Researchers at the University of Basel have developed a method to generate stable cartilage tissue from adult human mesenchymal stem cells by inhibiting specific signaling pathways. This breakthrough has significant implications for the treatment of joint diseases and injuries.
Researchers at Gladstone Institutes have uncovered the role of MYC and LIN41 in reprogramming cells. They found that MYC helps cells overcome a roadblock, while LIN41 blocks another protein that causes the roadblock, allowing adult cells to successfully convert into induced pluripotent stem cells.
Researchers at Duke-NUS Medical School have identified key regulators of the intestinal stem cell niche, including hormones R-spondins and Wnts. The team's study shows that subepithelial myofibroblasts are essential sources of these hormones, highlighting the close interaction between epithelial stem cells and their niche.
Researchers at Columbia University created adult-like cardiac model using induced pluripotent stem cells with electric and mechanical stimulation. The resulting tissue mimics the human heart's behavior after just four weeks of culture.
Researchers from Arizona State University reveal a hidden secret of the immortality enzyme telomerase, which holds promise for reversing cellular aging and extending human lifespan. Understanding the enzyme's mechanism may lead to effective anti-aging therapeutics.
Tufts researchers have developed a method to regenerate adult stem cells in the nasal tissue, improving sense of smell in mice. The discovery uses Yamanaka factors and offers a more efficient alternative to existing induced pluripotent stem cell technology, with implications for treating various tissue degeneration associated with aging.
Scientists in Canada converted adult mouse respiratory tract cells into large populations of induced progenitor-like cells using an interrupted reprogramming strategy. These cells retained a residual memory of their parental cell lineage and showed potential as a cell replacement therapy in mice with cystic fibrosis.
The University of Louisville has received a $13.8 million grant from the NIH to study a promising new adult cardiac stem cell that may treat heart failure. The research aims to repair damaged heart tissue and make the heart stronger, potentially revolutionizing heart disease treatment.
Researchers at Scripps Research Institute discover a way to reprogram mature skin-like cells into stem cells using antibodies, potentially reducing mutations and improving properties. This method could lead to personalized cell therapies and organ regeneration.
Researchers have discovered that Pramel7 protein is responsible for maintaining embryonic stem cells' perfect pluripotency. This discovery holds promise for developing treatments for complex bone fractures.
A new two-part system turns embryonic or adult stem cells into the desired target cell type, reproducing flawlessly. The system uses a DNA plasmid that makes cells glow green when exposed to blue light, allowing researchers to track its removal and control gene expression.
Scientists at the University of Seville have found that adult carotid body mother cells can transform into both blood vessels and neurons. This breakthrough could lead to new treatments for pediatric tumors and Parkinson's disease, as these stem cells may contribute to tumor growth.
UC Berkeley scientists have developed a new technique to track individual stem cells in the nose, uncovering clues that could help restore smell to those who have lost it. The team used single-cell RNA sequencing and statistical analysis to identify the molecules that trigger stem cell differentiation into specific cell types.
A University at Buffalo research team has successfully reprogrammed adult skin cells into neural crest cells, a type of stem cell, without adding foreign genetic material. These cells can differentiate into various cell types found in the spinal cord and brain, holding promise for studying genetic diseases and generating regenerative t...
Researchers at the University of Tsukuba found that KLF4 promotes metabolic shift towards glycolysis and inhibits oxidative phosphorylation, enabling cells to acquire pluripotency. This discovery sheds light on the mechanisms underlying induced pluripotent stem cell generation.
A Clemson University professor has been awarded a grant to investigate how chronic, low-level exposure to arsenic affects developing children and sensitive embryos. The research aims to pinpoint the specific developmental time frames most susceptible to arsenic's adverse effects.
Researchers found that stem cells collected directly from human fat (ASCs) can make more proteins, replicating and maintaining their stability. This discovery holds promise for new therapies against aging-related diseases, with the goal of understanding how ASCs maintain an open chromatin profile with aging.
A new report from the Stowers Institute for Medical Research has discovered that adult planarian stem cells called neoblasts arise during a specific stage of embryonic development. These cells retain the ability to access embryonic developmental programs during adulthood, allowing them to drive regeneration of lost body parts.
Johns Hopkins researchers successfully created mature heart muscle cells from human or animal stem cells by implanting them into newborn rat hearts. The host animal's biological signals and chemistry enabled the immature cells to mature, overcoming a developmental blockade.
Scientists have developed a new, controllable CRISPR genome editing platform called sOPTiKO that can be used in every cell type and at every stage of development. This allows researchers to rapidly investigate the changing role of genes as cells develop into different tissues.
Researchers compared three types of adult stem cells from 14 patients to determine their cardiac repair potential. Right atrial stem cells had the greatest protective effect on heart muscle cells, while ventricular stem cells promoted new blood vessel formation.
Researchers at Rockefeller University and La Jolla Institute for Allergy and Immunology found that Zika virus can infect adult brain cells, specifically neural progenitor cells, leading to cell death and reduced neuron generation. This may have implications for cognitive decline and conditions such as depression and Alzheimer's disease.
Researchers discover Zika virus kills off neural stem cells in adult mice, raising concerns about its impact on the adult brain. The study found a 4- to 10-fold drop in adult stem cell proliferation, which could have implications for learning and memory.
Researchers found that neural stem cells in the hippocampus use the Drosha protein to regulate their differentiation into specific cell types. The discovery challenges the long-held view that stem cell differentiation is controlled solely by the local environment.
Researchers discovered that introducing the embryonic gene Nanog into aged stem cells can reverse cellular processes associated with age-related disorders, such as weak bones and clogged arteries. This breakthrough could lead to new treatments for conditions like Alzheimer's disease.
Researchers developed a microfluidic chip to study adipose-derived adult stem cells' development into mature fat cells. The platform successfully converted cells into mature fat cells while decoding signalling pathways.
Scientists at Massachusetts General Hospital developed a new procedure to generate and expand airway stem cells from lung tissue samples, allowing for multiple generations of cultures. This breakthrough may lead to improved treatments for airway diseases like asthma and COPD.
Researchers at the University of Pennsylvania have discovered that lab-made stem cells often retain errors in DNA folding, leading to incomplete differentiation into adult cells. The team suggests ways to minimize these errors and has developed high-resolution maps of genome folding in iPS cells.
A recent study tracked developing cells in an adult mouse brain, finding that the brain prunes back excess dendrite branches to achieve optimal design. This pruning process may hold implications for understanding neurological disorders such as autism, intellectual disabilities, and schizophrenia.
A team led by John P. Cooke identified reactive oxygen species as critical to the transformation of adult somatic cells into induced pluripotent stem cells (iPSCs). The researchers discovered that a 'Goldilock's zone' of free radical generation is optimal for iPSC production, with too little or too much ROS impaireding colony formation.
Researchers at Gladstone Institutes develop a new method to create three-dimensional human heart tissue from stem cells, addressing limitations of existing techniques. This breakthrough enables scientists to study heart cells in their proper context, enhancing the discovery of treatments for heart disease.
Researchers at Johns Hopkins Bloomberg School of Public Health have discovered a way to encourage adult stem cells to proliferate and differentiate into testosterone-producing cells. The findings could lead to the development of transplantable cells that can produce testosterone, avoiding side effects associated with current treatments.
Scientists at Gladstone Institutes discover a new type of cell that can organically develop into heart cells and replicate. The induced expandable cardiovascular progenitor cells (ieCPCs) significantly improved heart function in mice after a heart attack, offering a promising potential treatment for heart failure.
A study by the University of Texas M.D. Anderson Cancer Center reveals that adult stem cells in the prostate basal cell layer express genes similar to those found in deadly prostate cancer, offering a potential new line of treatment for highly aggressive and therapy-resistant forms.
A Phase 2 study found that patients treated with MultiStem therapy experienced a complete or near full recovery from their stroke after one year, with 23.1% achieving this outcome compared to 8.2% of placebo patients. The therapy appears to reduce local inflammatory response and protect neurons in the brain.
Researchers at Harvard Medical School have identified a gene, CAF1, that erases a cell's memory, making it more susceptible to reprogramming and making the process quicker and more efficient. This discovery enables the production of stem cells and may provide a general key to facilitate cellular reprogramming.
The study reveals how the Gtl2 locus, located on mouse chromosome 12qF1, restricts metabolic activity in hematopoietic stem cells to prevent oxidative damage. The researchers found that non-coding RNAs produced by the Gtl2 locus suppress mitochondrial biogenesis and metabolism, reducing reactive oxygen species and preventing cell death.
Researchers create insulin-producing cells using adult tissue and transcription factors, offering a potential cure for type 1 diabetes. The cells can be transplanted into diabetic mice and may lead to clinical trials for human patients.
Researchers have successfully directed adult stem cells to turn specifically into muscle using a new method that mimics the body's natural approach. This breakthrough could potentially help treat patients with muscular dystrophy, as well as address spinal cord injuries and other conditions.
Researchers at UT Southwestern Medical Center identified a cell type that generates new heart muscle cells, which can divide and replenish damaged heart tissue. The discovery uses a new cell-tracing technique that may prove useful for regenerating diseased hearts and has implications for cellular turnover in other organs.
A molecular switch controlling heart cell maturation has been discovered, enabling the creation of adult-like heart cells in a laboratory setting. The discovery may lead to new methods for treating heart disease using stem cells.