Articles tagged with Blood Cells
A new study published in Stem Cell Reports found no evidence of the existence of very small embryonic-like stem cells (VSELs), which could have been used for regenerative medicine. The researchers refuted claims of VSELs' potential, calling into question current plans for a clinical trial.
A new mechanism, critical for maintaining the balance between active and reserve hematopoietic stem cells, is identified through genomic imprinting. This process prevents premature activation of the reserve pool, ensuring its long-term maintenance.
Scientists have developed a method to generate functional blood vessels lasting up to nine months using human induced pluripotent stem cells. The breakthrough could lead to new treatments for cardiovascular disease and diabetes.
A new study confirms that the body generates hydrogen sulfide (H2S) as a signaling molecule for cardiovascular health. The researchers developed a chemical probe that reacts with H2S and allows them to visualize its presence in live human cells.
Researchers at Mount Sinai have made a breakthrough in programming blood-forming stem cells, which could lead to the development of patient-specific blood products. The study uses mouse fibroblast cells and identifies a combination of four genetic factors that can generate blood vessel precursor cells with hematopoietic cells.
The study reveals HDAC3 plays a key role in regulating gene expression, chromatin structure, and genome stability. Disruption of HDAC3 expression leads to impaired hematopoiesis, highlighting its importance in stem cell functions and bone marrow failure syndromes.
Researchers found that HDAC3 is essential for DNA replication in hematopoietic progenitor cells and plays a critical role in Alzheimer's disease pathogenesis by binding to the cellular protein FCγRIIb, which activates cell stress and death pathways. The study also identified a link between FCγRIIb and memory impairment in AD patients.
Dr. Jennifer Gillette is studying the role of hematopoietic stem cells in directing the creation of new blood vessels at the site of a crisis, such as a heart attack. Her research aims to improve treatment responses for heart disease and potentially benefit cancer patients who receive hematopoietic stem cell transplants.
A team of researchers at the University of Minnesota has discovered that a single gene, Mesp1, can be used to create different cell types, including heart, blood, and muscle cells, from stem cells.
Researchers at the University of Luxembourg have developed a computer-based method to analyze biological data and identify unique factors for 166 different human cell types. These master regulators determine cell development and distinguish between cell types, paving the way for potential cell replacement therapies.
Researchers discovered that cells beyond the nose have receptors for sensing odors, raising questions about whether organs 'smell' food. The study's findings could revolutionize our understanding of how we experience flavors and aromas.
Researchers have developed a multi-stage, multi-orifice flow fractionation system to detect and separate circulating tumor cells (CTCs) from blood with high efficiency, improving separation efficiency to 98.9%. The device, called MS-MOFF, employs hydrodynamic sorting and can collect viable CTCs after sorting.
Research at Baylor College of Medicine found that bone marrow cells producing BDNF travel to the hypothalamus, where they fine-tune appetite. A bone marrow transplant restoring the gene for BDNF can normalize appetite and reduce overeating in mice with insulin resistance.
Researchers at the University of California, Berkeley have discovered a sirtuin protein that can reverse age-related degeneration in mice by rejuvenating aged blood stem cells. The study provides new hope for targeted treatments for age-related diseases and opens up possibilities for a 'molecular fountain of youth'.
A new study suggests that maintaining a healthy environment for haematopoietic stem cells (HSCs) is more effective than targeting leukaemia stem cells (LSCs). This approach could lead to earlier and more targeted treatment of leukaemia by reducing competition between healthy and cancerous cells.
Researchers aim to develop better ways to treat patients by eliminating all cancer cells and avoiding disease relapse. They will study how cancer cells evade treatment by hiding in protective compartments inside the body.
Researchers at Johns Hopkins University have developed a method to control the fate of human stem cells, producing two types of smooth muscle cells necessary for building tiny networks of veins and arteries. This breakthrough could lead to new treatments for heart disease, diabetes, and cancer.
Scientists at the University of Cambridge have developed a way to create induced pluripotent stem (iPS) cells from a routine blood sample. This method could lead to new treatments for cardiovascular diseases by using patients' own cells to repair damaged tissue.
Researchers at MIT developed a microfluidic device that captures circulating tumor cells using DNA 'tentacles' inspired by jellyfish. The device increases flow rates 10 times higher than existing ones, enabling rapid processing of blood samples and potential monitoring of cancer patients.
A novel blood test detects and monitors brain cancer biomarkers using nanotechnology and NMR technology, offering a promising diagnostic tool for glioblastoma multiforme patients. The study demonstrates excellent detection accuracy and potential for quick results from small blood samples.
Researchers at the University of Helsinki have discovered stem cells that play a crucial role in new blood vessel growth, offering new opportunities in treating cardiovascular diseases, cancer, and other conditions. The discovery could lead to more effective treatments if these cells can be isolated and efficiently produced.
Scientists found that clot-busting enzyme t-PA also removes necrotic cells from the body. The process involves a blood clot-like structure, allowing for efficient removal without damage to the body.
Stem cells found in cord blood have the ability to migrate to the intestine and contribute to its cell population, suggesting a potential treatment for inflammatory bowel disease. The cells' innate ability to form blood vessels may also improve vessel abnormalities found in IBD.
Researchers discovered that tumor suppressor genes TSC and PTEN regulate stem cell-like blood precursor cells in fruit flies. The TOR pathway uses these genes to gauge nutrition levels and stress, expanding or increasing the number of blood progenitor cells. High levels of ROS were found to be valuable in this context.
Researchers found that acetaldehyde, formed after alcohol metabolism, damages DNA and triggers cancer. People of Asian descent with a genetic variant are more susceptible to esophageal cancer due to impaired acetaldehyde conversion.
Researchers at Johns Hopkins have successfully converted adult blood cells into induced pluripotent stem cells (iPS) using a virus-free method, achieving efficiencies of 50-60% in laboratory experiments. This breakthrough could lead to new treatments for cancer and regenerative medicine applications.
Bioengineers and biochemists at Penn State developed acoustic tweezers that can manipulate living materials like blood cells and small organisms using sound waves. The device can precisely trap and move cellular-scale objects essential for fundamental biomedical research, offering a cost-effective alternative to optical tweezers.
Researchers at Purdue University are working on a new type of bioactive coating for stents used to treat brain aneurisms, including those caused by head trauma from bomb blasts. The coating is designed to attract magnetized cells to repair blood vessels damaged in trauma, offering a regenerative approach to treating the condition.
Two UC Davis faculty members, Frederic Chedin and Noriko Satake, received Individual Biomedical Research Awards to explore novel approaches to understanding autoimmune diseases. Paula Goines, a postdoctoral researcher, will also receive funding for her work on autism research using nerve cells grown from adult stem cells.
Researchers at the University of Washington have found that cells in blood vessel walls pull more tightly together when flowing past rapidly, reducing vascular leakage and potentially leading to new drug designs and improved surgical procedures. This discovery highlights the role of cellular forces in the progression of cardiovascular ...
Researchers identify key interaction between JAK2 and SOCS3 proteins, providing potential therapeutic targets for myeloproliferative diseases. The discovery could lead to a new class of drugs with greater specificity than current treatments.
Researchers at URMC discovered a link between leukemia cells and bone formation, finding that leukemia alters the balance of osteoblast and osteoclast activity. The study suggests that targeting osteoclasts could be a potential treatment strategy for leukemia.
Scientists have identified endothelial and perivascular cells as the key creators of the niche that nurtures haematopoietic stem cells. This discovery could lead to increased safety and effectiveness of bone marrow transplantation by replicating signals that promote blood-forming stem cell expansion.
Research reveals that aging-related tissue degeneration is caused by defects in energy metabolism of tissue stem cells. Early antioxidant treatment may partially prevent these defects, indicating a key role for oxygen radicals in regulating stem cell function.
Researchers at UCLA have discovered that two-way signaling between niche cells, the progenitor cells themselves, and their daughter blood cells is necessary for maintaining a balanced population of blood cells. This balance ensures the creation and maintenance of the blood supply in Drosophila fruit flies.
A team led by Nancy Speck at the University of Pennsylvania School of Medicine has discovered a molecular marker for hematopoietic stem cells, providing insights into their origin and development. This finding could help manipulate embryonic stem cells to generate new blood cells for therapy in leukemia patients
Researchers at the University of Cincinnati have developed a method to isolate and collect fragile prostate cancer cells using inertial microfluidic technology. The approach uses cell size for separation, eliminating the need for biological markers or external forces.
A team of UBC researchers found nearly double the density of capillaries in brain tissue from Alzheimer's mouse models and human samples compared to healthy individuals. This 'neo-angiogenesis' may lead to a breakdown of the blood-brain barrier, allowing harmful substances to enter the brain.
Researchers will use induced pluripotent stem cells and genome editing technology to recreate participants' own heart artery-lining cells in a dish. The goal is to understand how the 9p21 'gene desert' region contributes to heart disease.
Researchers at Columbia University have established a new method to repair damaged hearts using a tissue-engineering platform. This breakthrough enables heart tissue to repair itself and has the potential to combat cardiovascular disease, one of the most serious health problems today.
Experts recommend collecting peripheral blood stem cells from Fukushima radiation workers to prepare for potential future stem cell transplants. This technique has several advantages over allogeneic transplantation, including reducing the risk of graft-versus-host disease and immunosuppression.
Researchers at Johns Hopkins Medicine have created a simplified, cheaper method to generate functional heart cells from blood cells, reducing the risk of viral mutation and cancer. The process has shown high efficiency rates, with 94.5% beating heart cells formed in 11 different stem cell lines.
Researchers at Brandeis University have developed a method to study the splicing of pre-messenger RNA molecules using lasers and a custom microscope. This technique allows for the visualization of the spliceosome's assembly process in unprecedented detail, providing insights into the fundamental biology of protein synthesis.
Researchers at the Walter and Eliza Hall Institute will receive $21.3 million to study genetic changes in cancer and develop new diagnosis, treatment, and prevention approaches. The institute will also lead a $17.1 million program to study blood cell production and function.
A new study by Columbia University engineer Sam Sia reveals a surprising range of variation in individual cells' behavior during blood vessel formation. The research found that genetically identical cells exhibit distinct patterns of cell-shape changes that are not reflected in bulk averages.
Researchers found that hematopoietic stem cells can shift between rapidly dividing and dormant states, suggesting a more equal sharing of blood cell production burden. This adaptability allows cells to respond quickly to life-threatening situations, such as bacterial infections.
Researchers at Johns Hopkins have found a way to reprogram adult cells with the properties of embryonic stem cells using a small blood sample. The new method avoids creating DNA changes that could lead to tumor formation, resulting in safer and more reliable iPS cells for research and potential clinical applications.
Pitt researchers have successfully grown arteries with high elasticity using baboon smooth muscle cells, containing 20% of the protein elastin found in natural arteries. The process resembles how it would be used in a patient and has the potential to overcome a major barrier to creating living-tissue replacements for damaged arteries.
Researchers successfully transplanted cord blood-derived cells into a severely brain-injured child, showing improvement after six months. The study found that the cells persisted in the brain hemisphere and improved functional neurological impairment.
A Purdue University study reveals that Listeria can pass between intestinal cells and trigger a mechanism to increase its ability to enter the cells. This allows the bacteria to cause infection even at low doses.
The National Science Foundation has recognized three projects with Breakthrough Awards: an artificial retina restoring sight to the blind; a system using controlled rocking to help buildings withstand earthquakes; and a low-cost medical microscope for detecting malaria-infected blood cells.
Researchers at the University of East Anglia have made a groundbreaking discovery in cancer treatment. They found that cells can switch from blood vessel to lymphatic cells, potentially changing how anti-cancer drugs are tested.
Cincinnati Children's Hospital Medical Center has been named a national Center of Excellence for Molecular Hematology to accelerate the discovery of new therapeutic approaches for conditions like sickle cell anemia and leukemia. The center will also help speed the transition of new therapies from research to clinical trials.
Researchers aim to establish dosing and safety guidelines for transplanting human umbilical cord blood cells into animal models of Alzheimer's disease. The goal is to gain FDA approval for clinical trials with patients suffering from mild to moderate Alzheimer's disease.
Suncica Canic develops computer models to simulate stent interactions with blood and cells, improving stent compatibility and reducing complications. Her research aims to help doctors choose the right stents for their patients and optimize stent design for specific procedures.
Researchers have isolated the first stage of tissue production in human embryonic stem cells, marking a significant breakthrough in regenerative medicine. The discovery may lead to the development of safer tissues for use in treating various medical conditions, including leukemia and sickle cell anemia.
Researchers found that induced pluripotent stem cells (iPS cells) retain a 'memory' of their tissue of origin, making it harder to differentiate into other cell types. However, additional steps or drugs can erase this memory, making iPS cells comparable to nuclear transfer stem cells.
Researchers are developing a method to identify and purify stem cells from patients themselves that can give rise to beating heart cells. This approach aims to create an ideal product for transplant to repair heart damage caused by heart attack or cardiomyopathy.
A new study found that high concentrations of cocoa flavanols decrease blood pressure and improve the health of blood vessels in patients with heart disease. Flavanols, found in foods like cocoa products, tea, and fruits, have a cardio-protective benefit for heart disease patients.
A study published in Journal of Experimental Medicine identifies distinct HSC populations with varying propensities to generate specific blood cell types. The research reveals that high CD150 expression is associated with a 'latent' or 'delayed' ability to generate new blood cells.