Articles tagged with Blood Cells
Researchers at Memorial Sloan Kettering Cancer Center found that elevated p53 levels maintain a cell's dormant state, making it resistant to chemotherapy and radiation. Targeting specific genes involved in quiescence may enhance anticancer effects.
Researchers have identified a group of dormant stem cells in mouse bone marrow that divide only five times throughout their lifespan, equivalent to one cell division in 18 years. These 'sleeping' stem cells can rapidly self-renew and replace damaged bone marrow in emergency situations.
Researchers at Stanford University School of Medicine have shown that distinct groups of proteins each control one of four simple activities involved in the cells' collective migration. The study overturns an assumption common in genomics and provides a powerful tool for developing new therapeutics.
Researchers have discovered a possible therapy for mucolipidosis type IV (ML4), a disease causing nerve cell death and progressive motor function loss in children. Introducing normal blood cells into genetically modified fruit flies with ML4 symptoms delayed cell death, suggesting bone marrow transplantation as a treatment option.
A Queen's University study has shed new light on the control of a cell enzyme implicated in tissue damage after heart attacks and strokes. The research team discovered a way to block the enzyme's activity, which could lead to new drug treatments for stroke and heart disease.
The cullin family of proteins is involved in regulating the degradation of proteins that control blood cell development. A study published in Blood found that targeting this protein may lead to improved therapies for leukemia and other blood cancers.
Blood vessel cells can be instructed to form three-dimensional, tube-like structures using a special type of 'instructor' molecule. This discovery may lead to the development of new stem cell-based therapies for organ transplantation.
Researchers at Cincinnati Children's Hospital Medical Center have discovered a central molecular switch that instructs cells to form sensory nerves or blood cells. The switch, which involves the competition between Hox and Senseless genes, regulates genetic signals that determine cell differentiation.
Researchers successfully grew functional human blood vessels in mice using adult human donor cells, creating a new model for tissue engineering. The study used a combination of two types of progenitor cells to form a small ball of healthy blood vessels, with the ability to rapidly grow two-layered vessels without embryonic stem cells.
Scientists at WashU Medicine have successfully directed mouse embryonic stem cells to build the heart using the Mesp1 gene, a crucial discovery that may lead to new therapies using human stem cells. The study found that Mesp1 regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ES cells.
A supercomputer was used to explore the biochemical landscape and find memory switches. Researchers found nearly 4,500 reaction topologies that demonstrate switching behavior, revealing a comprehensive map of biochemical switches.
Researchers found that phosphate-binding drugs can decrease vascular calcification, which is a major source of cardiovascular risk in CKD patients. These treatments may also reduce the activity of genetic programs that stimulate bone-forming cells in blood vessel walls.
A team of scientists at the Joslin Diabetes Center has identified a key regulator of hematopoietic stem cell migration and proliferation, which could lead to improved bone marrow and blood cell transplants. The discovery also holds promise for treating type 1 diabetes and enhancing recovery from infections after transplantation.
Researchers use bioengineering techniques to create functional adult-like cells from embryonic stem cells and adult blood stem cells, paving the way for new medical treatments
Researchers are conducting a US trial using purified adult stem cells to treat critical limb ischemia, a condition that affects 1.4 million people and can lead to amputation. The study aims to grow new blood vessels and restore circulation in legs with severely blocked arteries.
Researchers have made significant progress in cardiac stem cell therapy, exploring novel delivery methods and strategies to improve cell survival. These advancements aim to overcome the challenges of poor vascular supply and inflammation after a heart attack, paving the way for more effective treatments.
Researchers discovered a novel type of stem cell in menstrual blood that can rapidly replicate and develop into various cell types, including heart, liver, and lung cells. This breakthrough could lead to innovative treatments for damaged tissues and diseases such as diabetes and liver failure.
Research at the Medical College of Georgia found that regular brushing can cause minor cell damage, leading to increased calcium influx and triggering internal membrane repair. This process may promote gum health by stimulating collagen growth and strengthening tissue response to mechanical stress.
UNSW researchers have uncovered a naturally occurring mechanism to control 'bad' cells causing blood vessel blockages while leaving 'good' cells unaffected. This discovery could benefit those undergoing heart surgery or haemodialysis by targeting specific gene suppressors like YY1.
Researchers found Ago2 necessary for normal blood cell development, but its role is independent of slicer activity. Ago2 regulates miRNA biogenesis in blood cells through translational control.
A team of students has invented a protective pouch that could improve cell therapy for diabetes patients. The pouch, made from nylon mesh and metal stents, holds microcapsules containing therapeutic cells, allowing them to thrive and produce insulin in the body.
A new study published in PLoS Biology found that cells change size and shape to form the heart's chambers, with blood flow and cardiac contractility influencing cell shape. The researchers propose a balance of internal and external forces necessary for optimal chamber curvature, potentially underlying some types of heart disease.
Private cord blood banking is praised as a way to increase available cells, with Richard Branson's Virgin Health Bank offering processing and storage options. The bank's dual public-private approach donates one-fifth of samples to those in need at no cost.
A new study by researchers at the University of Miami reveals that nicotine can accelerate the progression of kidney disease in smokers. Human mesangial cells were found to express nicotinic receptors, which are activated by nicotine and lead to increased cell proliferation and fibronectin production.
Researchers have made a breakthrough in molecular technology that could help deliver life-saving drugs directly to cancer-ridden cells. The discovery involves attaching therapeutic drugs to molecules using tiny molecules that can travel through the bloodstream.
Researchers discovered that arsenite destabilizes lysosomes, breaking them apart and releasing enzymes that destroy APL cells. This finding could inform further research into treating APL, a rare cancer caused by chromosome fusion.
A study by researchers at the University of Pennsylvania School of Medicine has identified a key regulatory protein, Klf2, that translates blood flow into gene expression. Klf2 is activated by rapid, pulsed blood flow and plays a crucial role in maintaining vessel tone and regulating smooth muscle contraction.
Researchers at Mayo Clinic have devised a novel approach to improving the effectiveness and safety of heart stents by magnetizing healing cells from a patient's blood. The cells are quickly drawn to magnetically coated stents, reducing blood clot formation by lining the site fully and quickly.
Researchers at the University of Minnesota have successfully differentiated umbilical cord blood stem cells into type II alveolar cells, which can secrete surfactant and repair airways. This breakthrough may lead to new treatments for lung diseases like cystic fibrosis.
Researchers developed a new mouse strain with a gene mutation that mimics human leukemia. The study found that the mutation affects Hox genes, leading to rapid cell growth and increased lifespan of cancer cells. The findings suggest that understanding this process could lead to new therapeutic options for AML patients.
Researchers at University of California - San Diego found that mechanical stretching activates cellular protein JNK, damaging cells and contributing to atherosclerosis. This discovery may help design better treatment approaches for cardiovascular disease.
Researchers at Joslin Diabetes Center found that circulating bone-marrow derived cells do not produce oocytes or facilitate their ovulation. The study used a parabiotic mouse model and hormones to stimulate ovulation, demonstrating that oocytes are not seeded by blood-borne cells.
Researchers found that MEF protein enables hematopoietic stem cells to remain in a quiescent state, allowing for rapid repopulation of depleted blood cells after treatment with chemotherapy or radiation. This could lead to improved recovery and enhanced resistance to chemotherapeutic drugs.
Researchers discovered that a protein called MEF regulates the quiescence of blood stem cells, enabling them to recover more efficiently after treatment with chemotherapy or radiation. This could lead to improved recovery and reduced myelotoxicity in cancer patients.
Research reveals a homing mechanism for bone marrow-derived progenitor cell recruitment to neovasculature. This process is crucial in cancer progression as it enables tumors to acquire new blood vessels.
A study by UF researchers reveals that diabetic patients' cells have difficulty repairing damaged blood vessels due to low nitric oxide levels. The team found a way to improve the cells' movement and repair ability using nitric oxide, opening up possibilities for new treatments.
Researchers create conditional mouse model to study CBFB-SMMHC, a fusion protein linked to 12% of human AML cases. The model shows that CBFB-SMMHC induces abnormal preleukemic blood cell progenitors, leading to AML development in adult mice.
Melbourne-based researchers Dr Anthony Hannan and Dr Stephen Nutt have won $1 million Pfizer Fellowships to investigate environmental factors affecting brain diseases and blood cell development. Their work aims to develop new therapeutic approaches for devastating conditions like Huntington's disease, schizophrenia, and leukaemia.
Researchers found that vasostatin, a protein gene incorporated into an adenovirus vector, effectively blocks the formation of new blood vessels and curbs tumour growth in mice with pancreatic cancer. This approach may represent a promising therapeutic option for malignancy with a poor prognosis.
Researchers have discovered that stem cells derived from human heart tissue can develop into cardiospheres that express normal properties of primitive heart tissue. These cardiospheres were then grown in the laboratory and injected into mice with lab-induced heart attacks, where they migrated to damaged tissue and regenerated, improvin...
Researchers at USF Health found that cord blood cells administered two days post-stroke reduced brain inflammation and improved recovery in rats. The study challenges the notion of immediate cell death in the brain's core region, suggesting a delayed process of apoptosis may occur instead.
Researchers found menin promotes acute leukemia by working with mutated MLL proteins, leading to the formation of cancer cells. Removing menin stops cell proliferation and allows cells to mature into healthy blood cells.
K-State researchers aim to develop a chemical that can close gap junctions, preventing the spread of damaged eye cells. The team faces challenges in delivering the chemical into the eye without causing damage to the retina.
Researchers are exploring a new approach to treating blood cancers by exploiting the natural process of programmed cell death, known as apoptosis. This could potentially kill tumour cells more effectively and improve treatment outcomes. The Leukemia and Lymphoma Society is providing strong support for this research.
Researchers at Johns Hopkins Medicine have successfully grown human stem cells in a lab setting that mirrors the natural developmental process of blood cells. The study provides unprecedented insight into how stem cells specialize into blood cells, shedding light on the mechanisms behind leukemia and lymphoma.
The Duke team successfully engineered new blood vessels from vascular cells of four elderly men with heart disease, extending their lifespan indefinitely. The treated smooth muscle cells were then impregnated into a biodegradable polymer tube and grew for up to seven weeks, forming functional-like arteries.
EndGenitor Technologies Inc. will market test kits for researchers to detect endothelial stem and progenitor cells, which can be used to treat chronic degenerative diseases associated with aging. The company aims to create cell therapy products using the 'ancestor' cells discovered by Drs. Mervin C. Yoder Jr. and David A. Ingram Jr.
Enterococcus faecalis uses a Sonar-like system to detect human blood cells and produce a toxin in response, providing a potential mechanism for developing new antibiotic treatments. This discovery could also be adapted to help the aging population cope with vision loss.
Researchers discovered tPA's toxic effects on brain cells and blood vessels, leading to devastating brain injuries. A compound called APC counters these harmful effects, showing promise for improved stroke therapy.
Researchers discover that Kaposi's sarcoma virus can reprogram blood vessel endothelial cells into lymphatic cells, driven by the gene Prox1. This finding provides a potential target for new therapies against the disease.
Researchers have identified a potential new source of stem cells for treating liver damage, offering hope for improved care. The study found that umbilical cord blood cells may differentiate into functional liver cells after transplantation, providing a promising therapeutic avenue for acute and chronic liver injury therapy.
Researchers found that adult cells descended from renin-producing cells can re-express the renin gene in response to stress, revealing a 'memory' of their original lineage. This ability allows these cells to rapidly respond to changes in blood pressure and sodium levels.
A study by Lund scientists has shown that adult stem cells cannot form new heart muscle cells after a heart attack. The transplanted cells retain their identity as blood cells and fuse with heart muscle cells outside the infarcted area.
A new MRI technique allows researchers to capture moving images of blood traveling through vessels non-invasively. This technology can easily be applied to existing MRI machines, enabling real-time physician-scanner interaction and detailed analysis of cardiovascular disease.
Research suggests that bone-marrow-derived stem cells do not differentiate into new heart muscle cells when injected into damaged hearts. Instead, they mature into traditional blood lineage cells. This challenges the idea of using stem cell therapy to repair damaged hearts and raises questions about alternative approaches.
The Mixed-Lineage Leukemia (MLL) gene plays a crucial role in blood cell development, with its absence resulting in the failure to produce normal blood cells. MLL regulates critical genes necessary for hematopoiesis, a complex process of blood cell formation.
Researchers have discovered a link between the ratio of two energy-compounds and increased blood flow in brain cells. By modulating this ratio, scientists can better understand how blood circulation is activated in the brain, potentially leading to new treatments for diseases like Alzheimer's and diabetes.
Researchers at the University of Rochester Medical Center have identified a key role for bone-forming osteoblasts in controlling the expansion of blood-forming stem cells. The discovery could lead to new treatments for bone marrow-transplant patients, who often face challenges due to limited stem cell availability.
A UCSF-led study found no evidence of trans-differentiation when bone marrow-derived cells fused with damaged tissue in mice, casting doubt on their potential as a treatment for brain and heart diseases. The researchers suggest that cell fusion might be a physiological mechanism for repairing damaged cells, but more research is needed.
Researchers found that zebrafish mutants with severe anemia had a mutation in the cdx4 gene, which led to improved blood cell development when hox genes were injected. This study provides insights into normal blood formation and may lead to more effective treatments for devastating blood disorders like leukemia.