Articles tagged with Blood Cells
The Mixed-Lineage Leukemia (MLL) gene plays a crucial role in blood cell development, with its absence resulting in the failure to produce normal blood cells. MLL regulates critical genes necessary for hematopoiesis, a complex process of blood cell formation.
Researchers have discovered a link between the ratio of two energy-compounds and increased blood flow in brain cells. By modulating this ratio, scientists can better understand how blood circulation is activated in the brain, potentially leading to new treatments for diseases like Alzheimer's and diabetes.
Researchers at the University of Rochester Medical Center have identified a key role for bone-forming osteoblasts in controlling the expansion of blood-forming stem cells. The discovery could lead to new treatments for bone marrow-transplant patients, who often face challenges due to limited stem cell availability.
A UCSF-led study found no evidence of trans-differentiation when bone marrow-derived cells fused with damaged tissue in mice, casting doubt on their potential as a treatment for brain and heart diseases. The researchers suggest that cell fusion might be a physiological mechanism for repairing damaged cells, but more research is needed.
Researchers found that eliminating or overexpressing the cdx4 gene affected blood-cell formation and Hox gene expression in zebrafish. The study's findings could help reveal how cdx4 fusions disrupt normal hematopoiesis and contribute to human leukemias.
Researchers found that zebrafish mutants with severe anemia had a mutation in the cdx4 gene, which led to improved blood cell development when hox genes were injected. This study provides insights into normal blood formation and may lead to more effective treatments for devastating blood disorders like leukemia.
Researchers have discovered a genetic signature, known as the IFN expression signature, associated with severe lupus symptoms. This signature is linked to interferon activity and has implications for developing new therapies to block IFN pathways in patients with severe lupus.
Researchers developed a system to study blood vessel development without mural cells, revealing that angiopoietin-1 partially restores large vessel structure. The study suggests Ang1 is crucial for normal vessel stability and highlights the importance of pericytes in maintaining vascular networks.
A recent study has found that gut bacteria interact with the intestine to regulate blood supply, with Bacteroides thetaiotaomicron stimulating blood vessel development. The research suggests a key developmental program shared by intestinal bacteria and their host is essential for healthy development.
Researchers found that cord blood cells improved neurological function in rats with traumatic brain injury, suggesting a new approach for treating this condition. The cells helped promote brain self-repair by stimulating trophic factors and cytokines, which led to better movement, balance, and reflex responses.
Researchers discovered the ancestral role of VEGF protein guiding developing blood cells to their destinations. The findings suggest that blood vessels may have evolved from blood cells, a theory supported by studies on fruit fly embryos.
Dartmouth Medical School biochemists identify a transport receptor that selects soluble proteins for export from cells, resolving a long-standing puzzle. The discovery opens up new avenues for understanding protein secretion and its role in diseases such as hemophilia.
Researchers found that human umbilical cord blood cells improved motor and sensory abilities in rats after stroke, even when administered a week after onset. The study suggests these cells may be used to treat early stroke and other traumatic brain injuries through less invasive IV administration.
Researchers found that bone marrow-derived cells contribute to tumor blood vessel formation and promote growth. Targeting specific VEGF receptors blocks tumor formation, offering potential new therapeutic approaches.
Researchers discovered that blood vessels signal pancreatic cell differentiation, challenging the long-held assumption that organs develop independently. The study found that removing blood vessels from pancreatic tissue disrupts normal gene expression and insulin production.