A recent survey conducted by the Fred Hutchinson Cancer Research Center found that nearly three-quarters of pediatric cancer patients in western Washington use alternative therapies. The most common types of alternative medicine used were herbal and high-dose vitamin supplements, which were reported to have substantial improvements in ...
Researchers developed a Herceptin-DM1 conjugate that targets HER2-positive breast cancer and shows complete regression in mice. Additionally, a new Bcr-Abl inhibitor called PD173955 demonstrates greater potency than Gleevec against leukemia cells, providing new hope for treatment-resistant cancers.
A new study by Yale University aims to investigate the effectiveness of a tailored home-based exercise regimen on quality of life and functional capacity in heart failure patients. The research also seeks to assess the program's financial practicality and potential cost savings compared to traditional care.
The study, published in the New England Journal of Medicine, found that estrogen replacement therapy for secondary stroke prevention was not beneficial. The Yale team also discovered a borderline higher risk of fatal stroke among women taking estradiol.
The Global Litter Invertebrate Decomposition Experiment (GLIDE) aims to advance understanding of soil and litter fauna's distribution, diversity, and importance in ecosystem processes. The study will provide unprecedented data on the animals involved in litter decomposition across different biomes and latitudes.
Yale scientists have successfully immunized mice against West Nile virus, providing a promising lead for developing a vaccine for humans. The vaccine was developed using a protein found in the virus and showed complete protection against the disease.
Researchers at Thomas Jefferson University found that daily doses of Angiostatin, combined with radiation, caused a partial response in patients with advanced cancer. The treatment was well-tolerated, with few side effects reported.
The ACS Scholars Program provides financial support to minority students pursuing undergraduate studies in chemistry and related disciplines. With over $850,000 in awards anticipated for the next two semesters, the program aims to increase diversity in the chemical sciences workforce. Students can receive up to $3,000 per year and bene...
Researchers at University Hospitals of Cleveland report promising results from Phase I trials of a new cancer drug, Combretastatin A4 Prodrug. The study showed significant reduction in tumor blood flow after infusion of the drug, with some patients experiencing complete remission and prolonged periods of freedom from disease progression.
A multidisciplinary team led by David E. Sahn will explore access to health education and nutrition, including HIV/AIDS, poverty traps, and food insecurity. The research aims to better understand the economic and social constraints that hinder Africa's poor from prospering in growth-oriented reforms.
A new NHLBI study found that high-normal blood pressure increases the risk of heart attack, stroke, and heart failure by 1.5 to 2.5 times in 10 years compared to optimal blood pressure levels. The study also showed a continuous increase in cardiovascular events with age, especially in older adults.
Researchers discovered that Foxo1 is involved in regulating glucose metabolism and promoting insulin resistance in cultured kidney cells. Increased Foxo1 activity was linked to decreased insulin sensitivity, highlighting its potential as a therapeutic target for treating related disorders.
A new patented technique uses titanium dioxide nanoparticles to bind and remove mercury from combustion exhausts, trapping the toxic metal with high effectiveness. The process leverages photocatalytic properties of titanium dioxide to oxidize mercury, making it a promising solution for controlling mercury emissions.
Researchers found that small doses of suramin enhanced chemotherapy effectiveness in treating advanced stage IIIB/IV lung cancer. The tumors halved in seven patients and didn't progress in eight, showing a potential treatment option for patients with metastatic lung cancer.
The Yale-Griffin Prevention Research Center is studying the effects of lifestyle interventions such as stretching, breathing exercises, and yoga on managing asthma symptoms. Asthma affects approximately 12 million American adults, resulting in significant healthcare costs.
Researchers found four characteristics independently associated with recent overdoses in a San Francisco Bay Area population: homelessness, lengthy prison sentences, and sex work. Targeted interventions to decrease overdose risk are urgently needed, according to the study's lead author.
Researchers at Ohio State University are studying a new treatment that blocks the production of Bcl-2, a protein overexpressed in many cancers, and found nearly half of 20 patients responding favorably. The treatment showed safety and induced disease remission in some patients.
The study found that 43.4% of elderly heart attack patients are anemic, and those with lower blood counts have higher mortality rates. Blood transfusions significantly reduce mortality risk in these patients, even at higher blood count levels than previously thought.
The project aims to improve and conserve local, traditional crops being overlooked by major international research programs. Farmers will be actively involved in selecting and multiplying varieties of neglected crops, with new technologies for better cultivation and use.
Researchers from Yale and University of Chicago discovered a 40-foot long Sarcosuchus imperator crocodile fossil, estimated to be the largest known so far. The fossil was found in Cretaceous rocks in central Niger and is believed to have lived for approximately 42 years before reaching adulthood.
Yale researchers have created a microchip that can analyze virtually all yeast proteins, holding promise for advances in studying protein function in other organisms. The technology allows for faster understanding of protein interactions and could lead to breakthroughs in diagnostic methods, drug discovery, and therapies.
Researchers found that HHV-6 inhibits early-stage HIV variants by blocking CCR5 receptors, slowing their reproduction. The harmless herpesvirus may create favorable conditions for later-stage HIV variants that use CXCR4 receptors.
A study of 1,596 children in Rochester, NY, found that 8% had Tourette's and 27% had some tic disorder, with mild symptoms being more prevalent. Research suggests that tics can be an indicator of a subtle brain developmental disorder.
The Sandia-developed decontamination formulation has been selected to help rid Capitol Hill buildings of anthrax contamination. It is a non-toxic, non-corrosive, and environmentally friendly cocktail that neutralizes both chemical and biological agents in minutes.
Preliminary findings from a deep-sea expedition have uncovered a vast array of new species in the Atlantic Ocean's abyssal plains. The discovery, part of the DIVA project, confirms the diversity of deep-sea life and reveals significant differences in sediment structure and fauna composition across different sites.
Research has identified DDR2 as a key player in the development of hepatic fibrosis, a liver disease characterized by excessive scar tissue buildup. High levels of DDR2 expression have been linked to advanced fibrosis and poor patient outcomes.
A new study from Massachusetts General Hospital suggests that HMO gatekeeping policies may not be effective in reducing specialty visits. The study found a small increase in new specialty visits, but no change in overall rates of specialist visits.
GammaDelta T cells are activated by bacterial pathogens, recognizing and responding to peptidoglycan patterns. They release pro-inflammatory cytokines to coordinate an immune response, providing innate protection against bacterial infections.
Researchers found that bone marrow-derived cells contribute to tumor blood vessel formation and promote growth. Targeting specific VEGF receptors blocks tumor formation, offering potential new therapeutic approaches.
Researchers found that patients who received intercessory prayer in addition to coronary stenting had better clinical outcomes than those treated with standard stenting therapy alone. Noetic interventions, including prayer and guided imagery, were shown to reduce adverse outcomes by 25-30 percent.
Researchers analyzed wood samples from the King Midas tomb, finding that a soft-rot fungus was fueled by nitrogen from the king's body and meat-based food sources. The study may provide insights into preserving historical sites from fungal degradation.
Researchers found that bovine thrombin causes an immune response similar to lupus in mice and can lead to post-operative complications. Bovine thrombin is a potent enzyme used in surgical procedures, but its use should be restricted to life-saving surgeries due to the risk of autoimmune responses.