Articles tagged with Cell Growth
Researchers have discovered that the regulatory protein FoxM1 is crucial for the growth of malignant childhood brain tumors, medulloblastomas. The level of FoxM1 expressed in tumor cells significantly correlates with patient survival time, making it a useful prognostic marker to guide treatment strategies.
JDRF-funded researchers identify a protein and chemical compound that stimulate beta cell growth, providing a new drug target for diabetes treatment. The discovery may lead to the development of tests to measure beta cell number using Tmem27 fragments as a biomarker.
Researchers have created a more precise system for growing cells by replacing neighboring cells and extracellular matrix with synthetics. This approach reduces uncertainty and biological contamination, facilitating the formation of artificial tissues.
Researchers have developed a new imaging method, spatial light interference microscopy (SLIM), that can measure cell mass with high accuracy. SLIM offers insights into the debated problem of whether cells grow at a constant rate or exponentially.
Scientists from Scripps Research Institute have defined the structure of one of the cell's most basic engines required for cell growth. The study reveals a series of redundant mechanisms that assure production of critical cellular building blocks while avoiding missteps, which could lead to disease.
Researchers have identified a key gene that enables the brain to continue growing while other organs shut down in fetal development. This genetic link may hold clues for understanding intra-uterine growth restriction and its potential links to metabolic disease later in life.
A study by Andrew Weng and colleagues identifies insulin growth factor-1 (IGF-1) as a key driver of cancer growth in T cell acute lymphoblastic leukemia. Blocking the IGF-1 receptor improves survival rates in mice, suggesting a potential new treatment strategy.
Researchers at Scripps Research Institute have discovered a mechanism enabling cancer cells to sustain abnormal growth by nullifying natural defense against uncontrolled division. Cks proteins overexpression causes incipient cancer cells to ignore braking signals, leading to unchecked cell division.
The University of Colorado Boulder's BioServe Space Technologies will carry five CU-Boulder-built payloads aboard the final space shuttle mission. The payloads include an antibody experiment to treat bone loss in astronauts and a salmonella vaccine development project.
Researchers found that O-glycosylation is essential for root hair growth in Arabidopsis thaliana, increasing growth by 200 times. Blocking this reaction inhibits growth, while over-expressing enzymes involved doubles length and density.
Researchers at the IRCM have made a significant breakthrough in understanding the Sonic Hedgehog protein's role in cancer development. The team found that specific receptors play a crucial role in transmitting signals from the protein, which could lead to new avenues for treating diseases such as cancer.
Johns Hopkins researchers have discovered a direct link between MCM proteins and the oxygen-sensing HIF-1 protein. The study found that MCM proteins mediate crosstalk between cell division machinery and environmental factors, controlling cell growth based on oxygen availability.
Scientists at Dana-Farber Cancer Institute discovered that cyclin D1 helps cancer cells repair DNA damage caused by radiation treatments, making tumors resistant to the therapy. Blocking cyclin D1 levels in cancer cells makes them more sensitive to radiation and certain cancer drugs.
Researchers at Queen Mary University of London found that relocating Met molecules from the inside to the cell surface could halt cancer growth and shrink tumours. This approach may lead to new drugs for treating aggressive breast and lung cancers.
Muscle cell fusion is crucial for understanding normal muscle growth and regeneration after injury or disease. Johns Hopkins researchers discovered the role of a regulatory protein called Blown Fuse in facilitating muscle cell merging by disrupting the WASP-WIP protein duo, which regulates cytoskeleton dynamics.
Researchers found that a specific section of the AKAP12 gene responds to retinoid treatment, reducing vascular cell growth. The study suggests that this gene could be a target for treating vascular diseases and potentially other cancers.
Researchers discovered a link between cell rigidity and proteins associated with cancer activity, using innovative collaboration between physics and cell biology. Exerting mechanical force on cells activates Rho GEF proteins, leading to tumor growth and metastasis.
A study found that earlier springs can enhance xylem growth in black spruce, but colder summers can negate this effect. The research suggests that the amplitude of summer warming temperatures plays a crucial role in wood production.
Researchers found that even those with low faecal haemoglobin concentrations are at increased risk of developing colorectal cancer. Higher initial faecal haemoglobin concentration is linked to a greater likelihood of developing the disease.
A University of Iowa study finds that patients treated with antidepressants after a stroke have significantly greater improvement in physical recovery than those on placebo. The study demonstrates that this effect continues to improve for at least nine months after the medication is stopped.
Researchers at University of Washington and Washington State University found that combining high-pressure oxygen with artemisinin increases cancer cell death by 50% compared to using artemisinin alone. Artemisinin, a natural malaria remedy, has been shown to kill cancerous cells in previous studies.
Researchers studying historical collections found that a marine bryozoan's growth doubled between 1990 and the present, indicating an increase in polar carbon sinks. The shift is likely due to ozone losses and increased wind speeds, which boost plankton production.
A study by RUB researchers found that sugar residues in the extracellular matrix control the growth and survival of motoneurons, a type of nerve cell. The study, published in Journal of Neuroscience Research, reveals that certain sugar residues can promote or inhibit neurite growth and cell death.
Five scientists with novel approaches to fighting cancer have been awarded the Damon Runyon-Rachleff Innovation Award, receiving a total of $2.25 million over three years. The recipients aim to significantly impact cancer prevention, diagnosis, and treatment through their pioneering ideas.
Scientists at the University of Michigan have identified a crucial biochemical pathway involved in catch-up growth, which is triggered by changes in oxygen levels. The research has implications for understanding why babies who experience catch-up growth are at higher risk for later life health problems.
Researchers at EUREKA have developed a new laser-based technology to create nano-structured polymers that enable faster and more efficient growth of human skin cells. This innovation has the potential to revolutionize nanotech medicine, allowing for the creation of artificial implants and tissue engineering.
The University of Michigan has developed a biosensor that can measure the growth and drug susceptibility of individual bacterial cells without a microscope. This breakthrough technology promises to speed up the treatment of bacterial infections, reduce healthcare costs, and combat antibiotic resistance.
A study published in PLoS Biology found that p53 determines organ size by regulating tissue growth. The protein's activation in response to stress leads to a coordinated reduction in the growth of healthy tissues, allowing damaged areas to repair themselves.
Researchers found that moderate alcohol consumption inhibits notch, preventing buildup of smooth muscle cells in blood vessels and contributing to narrowed arteries. This discovery could lead to the development of a new treatment for heart disease.
University of Illinois researchers developed microsensors that can track individual cells' masses and divisions over time. They found that cells grow faster as they grow heavier, rather than at a fixed rate throughout the cell cycle. The sensors also allow for imaging and tracking of cellular processes in conjunction with changes in mass.
Researchers at Brown University have discovered a couple of prime suspect genes, MqsR and MqsA, that control the formation of biofilms by regulating persister cell growth. The investigation provides a new avenue for developing novel sets of antibiotics targeting these proteins.
Researchers use snapdragon flower as model to study genetic and chemical cues that shape biological structures, revealing key role of genes in controlling cell growth and orientation. The study also suggests evolutionary tinkering played a role in shaping complex forms.
Researchers at the University of Pennsylvania School of Medicine have discovered a way to harness the power of a 2-sided immune cell to shrink tumors. The study found that targeting a specific protein pathway could lead to improved treatment outcomes for cancer and some autoimmune diseases.
Researchers have discovered a potent toxin in scorpion venom that can prevent neointimal hyperplasia, a leading cause of heart bypass graft failure. The compound, margatoxin, is up to 100 times more effective than other known inhibitors, offering new hope for patients undergoing bypass surgery.
Researchers found that TAL1 promotes the expression of NKX3.1 in T cell acute lymphoblastic leukemia cells, driving their growth and proliferation. Eliminating NKX3.1 halted the growth of these cancerous cells in culture and after injection into mice.
McGill researchers discovered how cells identify and recycle proteins by capturing an image of the UBR box component. This finding holds promise for understanding and treating Johanson-Blizzard syndrome, a rare disease causing deformations and mental retardation.
Scientists at MIT have developed a new synthetic surface that allows human pluripotent stem cells to stay alive and continue reproducing themselves for at least three months. This breakthrough enables the growth of large quantities of cells, necessary for treating diseases such as Parkinson's disease and spinal cord injuries.
Researchers at U of Alberta have found a potential treatment for pulmonary hypertension by targeting the mitochondria in lung blood vessel cells. They discovered that dichloroacetate and trimetazidine can increase mitochondrial activity, inducing cell death and regressing the disease in animal models.
Engineers and physicians at the University of Washington have developed a scaffold that supports the growth and integration of stem cell-derived cardiac muscle cells. The scaffold accelerates oxygen and nutrient supply to transplanted tissue, promoting heart repair and vascular tissue engineering.
Scientists at EMBL identified two proteins, PRC1 and kinesin-4, that control the formation and size of microtubule overlaps in the spindle. This adaptive mechanism ensures the overlap remains constant without affecting microtubules elsewhere in the cell.
The 'life between the sheets' hypothesis proposes that structured compartments formed between layers of mica could have sheltered and evolved pre-life molecules. Mica's unique properties make it an ideal environment for life to emerge, with its ability to withstand wet/dry cycles and provide a stable surface for cells to develop.
The researchers created a library of micromolded, hexagonally spaced elastomeric micropost arrays to study the effects of substrate flexibility on stem cell development and adhesion. The system allowed them to modulate the rigidity and flexibility of the substrate surface without changing its adhesive properties.
The study found that Musashi levels increased dramatically as the disease became more aggressive, suggesting it may be a target for future therapies. The researchers also discovered that blocking Musashi could inhibit blast-crisis CML by forcing immature cells to mature and differentiate.
Researchers at Duke University have identified a direct connection between plant development and growth, revealing that the Short-root protein controls the activity of genes involved in cell division. This discovery has significant implications for our understanding of growth and development in plants and potentially other species.
A team of researchers has discovered a protein called Ronin that recruits a co-regulator to bind to a specific DNA sequence, enabling the growth of embryonic stem cells. This finding may also contribute to understanding cancer growth and development.
Researchers found APC plays a crucial role in renovating the actin cytoskeleton by triggering actin assembly, offering a second way mutations in APC could lead to cancer. The study suggests APC's impact on the cytoskeleton may contribute to cancer development, especially when its actin-binding section is mutated.
A new study reveals that a protein called Flower marks weaker cells for elimination, allowing fitter neighbors to dominate. This process of cell competition may provide insight into pathological conditions like cancer and aging.
Researchers at the University of Michigan have developed a new synthetic stem cell growth matrix that overcomes major challenges in human embryonic stem cell research. The new coating, made from a water-soluble gel, has been shown to support long-term growth and maintenance of pluripotency in human embryonic stem cells.
Researchers at the University of Florida have discovered that a gene called Sonic hedgehog controls the speed of cell division, which may contribute to genital defects. The study found that slower cell division rates can lead to underdeveloped and malformed genitalia in mice.
A research team from NIST and NIH developed a technique to rapidly optimize 3D cell growth media to meet the developmental needs of specific cell types. They found that cells prefer softer environments for development, but those in stiffer gels are more active in building bone tissue.
Researchers found that blocking a receptor thought to mediate cell suicide in normal cells paradoxically stopped tumor growth. The study suggests using a drug that blocks the receptor to treat cancer. Further research will explore how this receptor promotes tumor growth and develop new therapies.
Embryonic stem cells can switch between different cell types, indicating a potential for pluripotency. Researchers hope to understand this process to create specific cell types in the lab.
Researchers found that four caged xanthones significantly inhibit CCA cell lines by increasing apoptosis-promoting proteins and decreasing apoptosis-inhibiting proteins. The compounds' chemical structure diversity reflects their biological activities, with isomorellinol exhibiting the highest potential.
Researchers at University of Leeds and Charité University Medical School have discovered that 'junk' DNA promotes cancer cell growth in patients with Hodgkin's lymphoma. Long terminal repeats (LTRs) are a form of genetic material that can activate cancer genes, leading to the growth of cancer cells.
Women with preeclampsia have reduced incidence of breast cancer, possibly due to soluble endoglin inhibiting cell growth. However, pups born from mothers with preeclampsia are more likely to develop breast tumors.
Researchers at Boyce Thompson Institute have discovered a complex sequence of events that create distinction between protoxylem and metaxylem cells. MicroRNA 165/6 moves out from its source cells to dissolve target messenger RNAs, leading to specific cell types developing in plants.
A new standardized testing method for cranberry products reveals the effectiveness of urinary tract infection (UTI) treatments. The BL-DMAC method accurately quantifies PAC levels in products, ensuring accurate labeling and consumer selection.
Researchers expanded a method to move proteins inside cells to specific organelles, enabling rapid manipulation of protein activities. By studying the signaling protein Ras, they gained insights into how proteins contribute to cellular responses and signal division and growth.
Researchers at MIT and Harvard developed a new sensor to measure the rate of cell mass accumulation, finding that individual cells exhibit varying growth rates. The discovery sheds light on how cells control their growth, with implications for understanding cancer development.
Scientists identified 'growth genes' that stimulate rapid growth in young animals, which are then progressively turned off as organs mature. This process, controlled by organ development, limits excessive growth and explains why organs maintain proportional size.