Articles tagged with Cell Growth
A study published in Nature reveals that bone growth in mice follows the same principles as cell production in blood and other tissues. The discovery suggests that bone growth may be more dynamic than previously thought, with cells generated from a stem-cell like progenitor cell.
Scientists at IST Austria found a new mechanism for lateral inhibition in zebrafish ovarian follicles, where the most rapidly growing cell inhibits its neighbors through mechanical compression. This process leads to the formation of a micropyle precursor cell critical for fertilization.
MIT researchers found that excessive protein production leads to senescence and cell division impairment when cells grow too large. They discovered the limiting factor in cell growth is DNA amount, not chromosome number.
MIT researchers have developed a new toxicity test that can measure chemical effects on cell survival with greater sensitivity than popular tests. The MicroColonyChip system uses tiny wells to form small colonies, allowing for rapid results in just a few days.
A new method of growing stem cells has been discovered using the tropoelastin protein, which could lead to significant cost savings in treatment options. This breakthrough discovery, published in PNAS, uses a cost-effective approach to encourage the growth and recruitment of mesenchymal stem cells.
Cells maintaining their shape and proportions are crucial for successful reproduction through cell division. Fission yeast cells, studied in the research, found that a cell's shape determines where it will divide, highlighting the fundamental biological basis of scaling.
Researchers have created mice with unusually short and long tails through genetic engineering, revealing key roles for the Lin28 and Hox13 genes in regulating tail development. The study provides new insights into the complex mechanisms controlling tail formation and has potential implications for understanding developmental and pathol...
Researchers studied HeLa cells and found that cancer cells accumulate harmful mutations, but about 13% of cells remain mutation-free. This allows them to survive despite reducing their growth rate and chromosome numbers. The study suggests that high rates of deleterious mutations are necessary for the population to die out.
International research teams identify key regulatory networks controlling radial growth in plants, enabling the development of more efficient carbon sinks and increased vegetable crop yields. The study reveals complex mechanisms behind plant stem cell activity and vascular tissue formation.
A recent study elucidates how methionine controls cell growth programs by setting into motion a metabolic program for cell proliferation. Methionine activates key nodes in metabolism that produce critical substrates and co-factors fueling the production of amino acids and nucleotides, critical for growth.
Scientists developed a nonmagnetic high-pressure cell to preserve neutron spin polarization, enabling three-dimensional analysis of electron spin arrangements. This technique has potential applications in developing new materials with multiferroic properties and controlling spins.
Scientists discover compound inhibiting SRPK1, a key gene controlling RNA splicing, effectively kills MLL-rearranged AML cells. The research offers a potential new approach to treating acute myeloid leukaemia with minimal harm to healthy blood cells.
Researchers observed age-related changes in T cell mitochondrial size and respiratory capacity. Supplementing aged mice with formate and glycine improved T cell survival and growth, suggesting potential therapeutic strategies for boosting immune responses in older individuals.
Michael Hall's discovery of the TOR protein as a central controller of cell growth and metabolism has contributed to our understanding of cancer development. Rapamycin and its derivatives are now used in targeted cancer treatment, extending life expectancy for some patients with advanced cancer.
Russian scientists developed a new surgical technique using drug-eluting balloon catheters to treat bifurcation lesions in coronary arteries. The method showed lower rates of repeated luminal occlusion and fewer long-term complications compared to traditional single-stent methods.
Researchers at Johns Hopkins Medicine have found a link between low levels of specific microRNA molecules and the development of pediatric brain tumors. Increasing these molecules may potentially treat low-grade gliomas, which affect mostly school-age children and young adults.
A study reveals putative epigenetic signatures of chronic undernutrition tied to growth stunting in humans. Chronic undernutrition can result in persistent effects throughout adulthood, with changes in histone methylation patterns found in peripheral blood mononuclear cells from undernourished children.
Researchers discovered that LMI1 protein limits cell growth, preventing large cells from developing into other tissue types, resulting in smaller leaves despite early cell growth. The study also found that LMI1 regulates pea leaf morphology by producing thread-like tendrils at the tip of the leaf and large stipules at the base.
Researchers at the Max Planck Institute for Plant Breeding Research have discovered a protein called LMI1 that regulates leaf growth and shape. The study found that LMI1 limits cell division, preventing cells from developing into other types and reducing the size of organs.
Researchers are using lab-grown mini retinas to understand the connection between the eye and brain, with a focus on restoring vision in people with damaged retinal ganglion cells. The study found that a protein called Netrin-1 significantly increased axon outgrowth from these cells.
Researchers at the University of Texas at Austin have developed a near-infrared laser that can change the size and shape of a block of gel-like material while human or bacterial cells grow on it. This tool holds promise for biomedical researchers seeking to shed light on how to grow replacement tissues and organs.
A new type of molecule blocks the action of genes that drive therapy-resistant prostate cancer growth, reducing cell proliferation by 95%. The cyclic peptoids also blocked a key growth signal in live animal tests.
Researchers at OIST modified bacterial cells to form elaborate shapes, including stars, triangles, and pentagons, demonstrating the adaptability of bacterial cell division machinery. These findings suggest that geometry is not an obstacle to ring formation and have implications for developing new antibiotics.
A large prospective cohort study found that higher levels of prolactin in women are associated with a lower risk of developing type 2 diabetes. Women with the highest 25% of prolactin levels were 27% less likely to develop T2D than those in the lowest 25%. The association was similar regardless of menopausal status and other risk factors.
Genetic mutations in non-small cell lung cancer blur cells' perception of key growth signals, leading to excessive growth and tumor formation. Researchers use optogenetics to reveal that blurring signal timing may explain why targeted drugs can paradoxically activate the pathway.
UBC researchers have discovered an internal messaging system in plants that regulates cell growth and division, enabling them to survive harsh conditions and compete successfully under favorable conditions. The system is driven by a protein called CLASP, which plays a crucial role in cell growth and division.
Researchers found that cells undergo self-destruction via trigger waves that travel at a constant speed of nearly 30 micrometers per minute. This process enables large distances to be covered without losing strength or speed, challenging previous assumptions about cell death propagation.
Harry Noller receives 2019 BPS Ignacio Tinoco Award for his pioneering studies on the structure, dynamics, and function of the ribosome. He is recognized for promoting an inclusive and collaborative research environment that positively impacts his community.
A team of scientists from the University of Nebraska-Lincoln has developed a method to increase the yield of clean, renewable energy source bio-hydrogen. By temporarily inactivating a gene that slows hydrogen production, they created a new strain of bacteria that produces 46% more hydrogen than naturally occurring forms.
A new study reveals that rapid cell division powers the growth of the small intestine, a critical discovery for understanding congenital short bowel syndrome. Researchers witnessed an intricate cellular dance, where cells must navigate to maintain proper length and prevent deadly conditions.
Princeton researchers found that cells repairing DNA damaged by antibiotics before resuming growth had a better chance of surviving treatment. Cells that make repairs before resuming growth are generally the ones that survive as persisters.
A study published in PLOS Biology found that mice can stimulate local growth while suppressing overall growth, enabling damaged tissues to recover and achieve symmetrical adult form. The placenta plays a crucial role in regulating overall growth rate and body proportions during development.
Researchers at NYU School of Medicine discovered that mTORC1 regulates cell crowding, which can cause proteins to solidify and interfere with cellular functions. The study suggests that malfunctioning mTORC1 may contribute to the development of aging diseases.
Researchers found a strong negative correlation between pancreatic cell size and lifespan in 24 mammalian species. Animals with larger cells tend to age faster, while smaller cells are associated with longer lifespans.
Research reveals that cells must grow large enough to produce four key proteins before committing to division. This mechanism, discovered in budding yeast cells, may hold clues for controlling abnormal cell growth and its link to diseases like cancer.
A new study by researchers at Albert Einstein College of Medicine and Shanghai Jiao Tong University School of Medicine identified an enzyme that helps cancer cells make the building materials they need to quickly proliferate. Inhibiting this enzyme could slow down cancer growth, leading to more effective treatments.
Researchers discovered that plant statoliths exhibit fluid behavior due to molecular 'motors' stirring them about, enabling the detection of slightest gravity changes. This finding provides insight into what makes plants sensitive to gravity.
Researchers at Osaka University discovered that Pib2 interacts with the TOR complex to detect glutamine levels, regulating cell growth and autophagy. The study found that glutamine binding activates the TOR complex, leading to controlled cellular responses.
Researchers have developed a system to profile every cell in developing zebrafish and frog embryos, revealing the comprehensive landscape of gene expression events that mark new cell states and types. This work provides a significant resource for studying developmental biology and disease.
A team of scientists led by Alex Schier has developed a new method to trace the entire history of individual cell differentiation. They discovered that cells can leave their initial path and change their identity, leading to a more flexible developmental program than previously thought.
Scientists at Uppsala University have discovered that multiple viruses, including adenovirus, influenza virus, HIV, and herpes simplex virus, rely on the host protein ZC3H11A for efficient growth. The protein is involved in a previously unknown mechanism for handling stress in cells.
A new study found that e-liquid ingredients can vary widely in toxicity, with some being more toxic than nicotine alone and propylene glycol and vegetable glycerin. The researchers developed a system to rapidly evaluate e-liquid toxicity using plastic plates with tiny wells containing human cells exposed to different e-liquids.
Researchers developed a new screening technique to evaluate e-liquid toxicity, finding that some ingredients are more toxic than others. The study suggests that even small doses of propylene glycol and vegetable glycerin can significantly reduce cell growth rates, highlighting the need for further regulation of e-liquid ingredients.
Researchers at KIT used high-resolution microscopy to observe the growth of mold fungi in living cells, gaining a comprehensive model for directed cell growth. The study reveals the role of vesicle transport in polar growth and has implications for understanding fungal growth and its applications.
A dietary supplement commonly used to strengthen joints can also speed the growth of a type of melanoma, according to preclinical research. Chondroitin sulfate boosts growth in melanoma cells carrying the V600E mutation, but not other types, and may pose risks for people with elevated melanoma risk.
A new approach reveals how cells in developing embryos regulate their identity and determine their fate. The study identifies thousands of previously unknown regulatory elements used only in a subset of cells, providing insights into cellular development.
A team of researchers at Michigan Technological University has created 3D substrates that mimic the natural heart environment, enabling cardiomyocytes to mature more quickly and have improved functionality. This breakthrough could lead to more effective treatment options for individuals with heart injuries.
Researchers created a new type of microfluidic device using collagen-based membranes to mimic the growth of human intestinal cells. The results showed that colon cells grown on the collagen membrane were more viable and differentiated compared to those in other devices.
The study developed an optical tool that can read metabolism at subcellular resolution without perturbing cells or destroying them. The method identifies specific metabolic signatures associated with diabetes, cancer, cardiovascular, and neurodegenerative diseases.
Researchers developed a visible neural network, DCell, that uses real-world cellular behaviors and constraints to predict cellular growth. The system can simulate cellular growth nearly as accurately as a real cell grown in a laboratory.
Researchers discovered that DNA acts as an 'air-in-a-balloon' mechanism to inflate bacterial cells, beyond its genetic information role. This finding has implications for understanding cell formation and growth, potentially revealing insights into the origins of cellular life.
Researchers at the University of Wisconsin-Madison identified the structural basis for how tightly bound protein complexes are broken apart to become inactivated. The structure shows that TIRPL can attack active PP2A complexes, changing their conformation and making them fall apart robustly.
Researchers have identified 'sleeper cells' that can survive antibiotics and lie in a dormant state. These cells can evade detection using traditional methods, making them a significant public health concern.
Researchers identify subset of natural killer cells that secrete growth-promoting factors, reversing impaired fetal growth. These cells may hold key to treating fetal growth restriction and recurrent spontaneous abortion, improving maternal-fetal microenvironment.
A study by Indiana University researchers found a link between the fragile X syndrome gene and excessive tissue growth. The discovery reveals a key biological mechanism behind the physical and mental impairments caused by fragile X syndrome, which affects 1 in 4,000 males and 1 in 6,000 females.
A study found that microRNA-31 accelerates intestinal stem cell growth, potentially leading to bowel cancer. The molecule's levels increased after radiation exposure, suggesting a role in regeneration, while also promoting tumor growth.
Scientists at Newcastle University have developed a coating that allows individual stromal cells to detach from the surface, enabling continuous cell growth. This innovation can produce up to a billion cells per week, making it ideal for cell-based therapies requiring large numbers of cells.
The heat-treated EF-2001 β-glucan exhibited antioxidative potential, anti-tumor activities, and immune-enhancing response in mice. Lymphocyte and polymorphonuclear leukocyte ratio increased upon treatment with EF-2001.
Researchers have created a novel cell scale that enables measuring the mass of living cells with high resolution and monitoring their weight changes over time. This allows tracking of fluctuations during the cell cycle, substance influence on cell mass, and viral infection effects.
Researchers uncover fossil evidence of a novel growth mechanism used by the Earth's first trees, allowing them to achieve large sizes. The study reveals that these early forests played a critical role in shaping global processes.