Articles tagged with Cell Growth
Researchers discovered that leukemia cells immediately unresponsive to treatment have high levels of SAMHD1, while those with acquired resistance use the enzyme DCK to activate nucleoside analogues. This finding may lead to better cancer therapies.
Researchers found that nanosilver treatment can increase the risk of recurrent infections when used long-term due to pathogen adaptation. Long-term exposure allows bacteria like Pseudomonas aeruginosa to evolve and resume normal growth upon discontinuation of treatment.
Researchers developed a new analytical technique to isolate and characterize individual organelles within cells, allowing for rapid chemical analysis. The study found heterogeneity among vesicle types, indicating the potential for earlier disease detection.
A multidisciplinary team discovers a new mechanism by which fission yeast cells acquire their tubular shape through secretion-induced plasma membrane flows. This process involves the coupling of exocytosis and protein motion, creating a self-sustaining pattern that establishes cell polarity.
Researchers at MIT developed a new way to grow pancreatic organoids using synthetic gel, allowing for study of interactions between tumors and environment. The gel can also be used to grow other types of tissue, including intestinal and endometrial tissue.
Recent study by Okayama University researchers reveals three photoinitiators cause faster increase in breast tumor growth in mice, with tamoxifen pretreatment reducing toxicity. The findings suggest photoinitiators could act as hormonal disruptions, raising concerns for patients and healthy individuals.
A new study proposes that protocells, the putative ancestors of modern living cells, used temperature differences to divide. This simple mechanism could underlie the growth and self-replication of these early cells.
A study analyzing 810 papers found that most cell culture experiments neglected environmental conditions, affecting the accuracy of results. The team recommends standard reporting procedures and instruments for better monitoring and control of culture environments.
Scientists from Nara Institute of Science and Technology have created a simple and fast method for detecting cell shape as they pass through a microfluidic channel. The team used changes in electrical impedance to measure the asymmetry of individual cells, which may greatly accelerate biological experiments.
A University at Buffalo-led study found that photobiomodulation therapy sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein controlling cell growth and division. The findings may improve therapeutic treatments for burn injuries worldwide.
Researchers from Nara Institute of Science and Technology developed a machine learning program that accurately predicts the location of proteins related to actin in cells. The program achieved a high degree of similarity with actual images, showing promise for future applications in cell analysis and artificial cell staining.
A standardized non-invasive clear cell likelihood score derived from MRI correlates with the growth rate of small renal masses. Small renal masses with higher scores are more likely to grow faster and may require earlier intervention.
Scientists developed a machine learning algorithm that uses artificial neural networks to accurately forecast cell size as it grows and divides. By recognizing patterns in the data, the computer can make more complex predictions than conventional methods, which rely on simplifying assumptions.
Chromosomal instability linked to cellular senescence in Drosophila study reveals mechanisms that could lead to reduced tumour growth and malignancy. Senescent cells cause inflammation and promote abnormal tissue growth.
Scientists at the University of Helsinki discovered that ECM protein Lama5 guides the growth and differentiation of epithelial cells in breast tissue, especially during pregnancy. The production of Lama5 strengthens the functionality of hormone-sensitive cells, allowing them to relay signals and support tissue growth.
Researchers discovered that plants use combined control of cytokinin and auxin to organize DNA damage responses, allowing continuous root growth. The study reveals a sophisticated way for plants to retain stem cells while maintaining their genomes in damaged plants.
Researchers at Salk Institute develop efficient method to produce insulin-producing cells from stem cells, bringing hope for type 1 diabetes treatment. The new approach resulted in beta cell yields of up to 80 percent and biologically functional transplanted cells in mouse model.
The Ras protein, involved in cancer development, is found to exist in a pair at the cell membrane. This pairing enhances signal transmission for cell growth, making it a potential target for cancer treatment. Bioinformatic methods and experimental data validate the structure of the interface between the two proteins.
Researchers discovered that hydraulic instability amplifies small volume differences between germ cells, leading to their selection for growth or shrinkage. The study reveals a mechanical mechanism governing the life and death decision in the nematode germline.
Researchers uncover how histone demethylase KDM5A promotes myeloma cell proliferation by regulating histone methylation. A novel KDM5 inhibitor inhibits cancer cell growth and is expected to develop into a new therapeutic strategy for multiple myeloma and other cancers.
Mouse and human lymphatic endothelial cells use primary cilia to direct lymphatic network growth during development and in response to inflammation and wound healing. The presence of functional cilia is necessary for healthy lymphatic vessel development and proper regulation of lymphangiogenesis.
A research team from the University of Münster has identified a new mechanism regulating cell growth in tuberous sclerosis complex (TSC), which affects one in 10,000 newborns. The study reveals how mutations can disrupt protein binding through a 'burr effect', leading to uncontrolled cell growth and tumour formation.
A recent study found that inhibiting key enzyme GSK3-beta with varying doses of CHIR 99021 promotes or constrains brain cell growth in minibrains, shedding light on its role in natural brain development. Low doses enhance proliferation and migration, while high doses limit growth and neuronal differentiation.
Biologists have discovered a new type of placental structure in animals, specifically in the group Cyclostomata from the phylum Bryozoa. This unique structure, called coenocytes, is formed through nuclear multiplication and cytoplasmic growth, unlike traditional cell fusion in animals.
A new study reveals a long-sought enzyme, AMBRA1, that prevents cancer by controlling proteins driving cell growth. The findings also suggest that an existing drug class may be able to reverse such defects in the future.
Researchers at VCU Massey Cancer Center have identified a crucial link between the development and growth of glioblastoma multiforme, the most aggressive type of brain cancer. The gene YTHDF2 drives increased cholesterol levels in GBM cells, paving the way for potential new treatments targeting this gene.
Researchers discover fruit fly egg takes an active role in its own growth and supports neighboring cells, challenging the long-held view of passive egg development. The findings highlight parallels to mammalian development and suggest bidirectional communication between oocyte and nurse cells.
Researchers tracked DNA changes in melanoma samples to understand how the disease progresses and develops resistance to treatment. The study revealed chaotic genetic changes that contribute to aggressive disease growth and treatment resistance, offering potential targets for new therapies.
Researchers at UC San Diego discover epigenetic mechanisms to accelerate muscle cell growth using pluripotent stem cells. Triggering specific factors can prime these cells for rapid regeneration.
A University of Tsukuba research team discovered that certain fungi can grow through narrow channels by altering their growth rate. This process allows them to maintain cell polarity and continue growing, whereas slower-growing species are impeded, resulting in defective cellular processes.
A new study at McGill University identifies a non-DNA based means by which sperm remember a father's environment and transmit that information to the embryo, affecting gene expression and leading to birth defects. The discovery opens new avenues for studying disease transmission and prevention.
USU researchers developed a three-dimensional cell culture surface using silkworm silk to grow skeletal muscle cells, outperforming traditional methods. Cells grown on silkworm silk showed increased mechanical flexibility and proper muscle fiber alignment, mimicking human skeletal muscle more closely.
A study from MIT reveals the APOE4 gene variant causes widespread disruptions in brain cells' ability to metabolize lipids and respond to stress. Supplementing with choline may reverse these effects, offering a potential new approach to treating Alzheimer's disease.
Scientists created a shape memory polymer to promote cardiomyocyte alignment and growth, providing a platform to study heart development and disease. The research uses stimuli-responsive biomaterials to mimic the dynamic microenvironment during heart development.
Researchers at Tokyo Medical and Dental University found that intermittent hypoxia inhibits mandibular cartilage growth in newborn rats. The study also showed decreased expression levels of genes TGF-β and SOX9 in jaw cartilage, while collagen X displayed increased expression.
Researchers have discovered a unique dependence of cancer cells on the protein KIF18A, which could lead to less harmful drug treatments for some cancers. International collaboration and data-sharing played a key role in this breakthrough discovery.
Researchers at Martin-Luther-University Halle-Wittenberg found that phosphatidylinositol 4,5-bisphosphate (PIP2) controls various aspects of cell growth in pollen tubes by influencing the distribution of enzymes and resulting effects on cytoskeleton stabilization and pectin secretion.
Researchers discovered a potential treatment approach for Hutchinson-Gilford progeria syndrome by blocking the ICMT protein, which improves affected cells without hindering growth and division. The study found that treating HGPS cells with C75, an ICMT inhibitor, delays cell deterioration and stimulates growth.
Researchers developed ice recrystallization inhibitors to halt ice growth in frozen samples, improving cell recovery and function. The technology prevents cellular damage caused by ice crystals, allowing for more efficient storage and transport of biological materials.
Researchers at Duke University developed a predictive theory for tumor growth that approaches the subject from a new point of view, using thermodynamics and physical space. The results demonstrate how a tumor's growth is directly tied to its need to create greater access to flowing nutrients and conduits for removing refuse.
Dr. Benjamin Tu's research on cellular roles of small molecule metabolites has led to the discovery of a unique pathway supporting cancerous cell growth. His work challenges the long-held belief that metabolites are merely passive in their function, unveiling that they may drive key cellular processes.
A biologist has created software tools to model cancer pathways and predict the efficacy of cancer drugs. The project aims to develop targeted treatments that target specific signaling networks in cancer cells, reducing harm to normal cells.
Autophagy enables efficient nutrient use and survival in cells by recycling amino acids. The study found that autophagy-derived metabolites, particularly serine, facilitate respiratory growth by supporting one-carbon metabolism and mitochondrial protein synthesis.
Researchers discovered that Wnt signalling enables steady cancer growth by balancing RAS-MAPK signalling. Inhibiting Wnt signalling can cause premature ageing and cellular senescence, leading to cancer cell death.
Sertraline's anti-cancer activity is attributed to its ability to inhibit the production of serine and glycine, two amino acids that stimulate cancer cell growth. The substance has shown promise in inhibiting breast cancer cell growth when used in combination with other therapies.
A new University of Colorado Boulder study sheds light on CDK7's role in controlling cell growth and transcription, potentially leading to new therapies for hard-to-treat cancers and rare developmental disorders. The findings suggest that CDK7 inhibitors could have distinct therapeutic advantages and result in more selective and less d...
The study reveals that KDM5A and PHF2 positively control the expression of pro-metastatic genes in Ewing sarcoma. These genes include L1CAM, which promotes migratory and invasive properties. The researchers identified KDM5A and PHF2 as novel disease-promoting factors and potential new targets for metastasis inhibition.
Research using functional MRI found that brain networks involved in movement planning and execution are activated differently based on the type of movement performed, even when using different body parts. The study suggests that these brain functions emerge from innate constraints in early development.
Researchers have developed a complex computer model that explains how bacteria optimize their protein production machinery for faster growth rates. The study reveals that the composition of individual components varies with growth conditions, and real E. coli bacteria use the 'cheapest' configuration to minimize resource usage.
Researchers found that moles stop growing due to normal cell-to-cell communication, not stress from cancer genes. This discovery could lead to new treatments for preventing skin cancer by exploiting existing mechanisms controlling cell growth.
The discovery of the COM1 gene reveals its role in controlling cell growth and influencing the properties of cell walls to form spikelets. This finding provides new insights into grass inflorescence architecture and may aid in increasing barley's yield potential.
Researchers have developed a computational approach called EpiMogrify that can predict the molecules needed to keep cells healthy in laboratory cultures. The model successfully identified molecules to maintain healthy nerve cells and heart cells, and predicted molecules that trigger stem cells to turn into specific cell types.
Plant proteins exhibit polarity, forming heads and tails in a stack of coins-like arrangement. This patterning is critical for cell orientation and coordination in plant growth. Researchers found that even isolated cells can become polarized, orienting their growth and guiding collective development.
Bacteria remain roughly the same size and shape due to a theoretical model that links random processes of growth and division, canceling each other out. This discovery may provide new insights into disease mechanisms, including cancer proliferation.
Researchers discovered that R-spondin treatment reduces intestinal tumor growth and promotes healthy epithelial cell function. The study suggests a new rationale for treating familial adenomatous polyposis patients with APC mutations.
Researchers at Institute for Basic Science have identified new subsets of gut connective cells crucial for lymphatic growth and fat digestion. The discovery sheds light on the mechanisms that impair lacteal regeneration and reveal a link between intestinal environment and cell interactions.
A study published in Nature Communications reveals how pollen tubes grow up to a thousand-fold to reach the ovule, creating electrical activity at the cell membrane and promoting faster growth. The findings have implications for understanding seed production, fungal growth, and neuronal development, and may lead to improved food crop v...
Researchers at Kumamoto University discovered that NSD2 enzyme prevents cellular senescence by maintaining cell growth and serum response. Reduced NSD2 leads to increased expression of genes related to cell aging and decreased activity of growth-promoting genes.
Researchers discovered that stressed bacteria's damage-containment system can become overwhelmed, prompting cells to activate alternative pathways for DNA replication and growth. This response allows cells to maintain normal functions under stressful conditions.
Researchers at Kyoto University discovered a novel method of communication among cells using 'mechano-chemical' signals. The findings show that the movement of one cell can trigger a cascading reaction resulting in collective cell migration.