Articles tagged with Cell Growth
Researchers led by Jianyi Zhang aim to find key pathways for reprogramming adult heart muscle cells to proliferate in response to a heart attack, potentially leading to improved heart attack recovery through growth of new heart muscle cells. The grant will fund three projects at UAB and two other universities.
Biomedical engineers have created a novel 3D synthetic structure that mimics the extracellular matrix, guiding neural progenitor cells and promoting their differentiation. The results show promise for developing brain-healing treatments, including biogels that can repair and regrow brain tissue after a stroke or other trauma.
A groundbreaking study by Hebrew University researchers has discovered the most primitive blueprint for embryo cell creation. The team identified 14,000 sites in the DNA that control the development of all embryonic organs.
The study reveals how the EGF receptor changes its shape when binding to its target, triggering cell growth and proliferation. The findings could lead to the design of new cancer drugs that evade resistance, says MIT chemist Gabriela Schlau-Cohen.
Researchers have discovered a key protein regulating pancreatic cancer cell growth and spread, which can be manipulated to reverse the process. Boosting levels of GREM1 has been shown to turn back aggressive tumours, making them easier to treat.
Researchers at Cold Spring Harbor Laboratory have discovered a protein interaction that may be an Achilles heel of tuft cell lung cancer. Disrupting this interaction could lead to more targeted therapies for the deadly disease, which originates from cells known as tuft cells.
Gram-negative bacteria rely on cell wall to synchronize outer membrane building, but a new study identified 'old' peptidoglycan as the key factor controlling this process. Disrupting this mechanism makes Gram-negative bacteria vulnerable to targeted antibiotics.
Researchers at EMBL discovered how messenger RNA molecules bind to and regulate the enzyme ENO1, which breaks down glucose. This riboregulation process can determine cell growth and differentiation, with potential implications for understanding cancer.
Researchers at the University of Cincinnati are studying how lipids help fortify lung cancer cells and if targeting them can lead to better outcomes. The team discovered that lipids play a crucial role in cancer cell growth, membrane fortification, and energy production.
A team of researchers at the University of Texas at Austin has developed a new therapeutic that uses transmembrane stem cell factor to treat ischemia and stroke without causing allergic reactions. The therapeutic, delivered in engineered lipid nanocarriers, shows promise in enhancing revascularization in ischemic tissues.
Researchers led by Atsuo Sasaki aim to identify mechanisms behind cell movement and energy allocation in cancer cells, with potential applications beyond cancer treatment. They will use scanning ion-conductance microscopy and machine learning technology to study the role of GTP in cellular migration.
Researchers from China have developed a novel bioconjugate that can suppress the growth of K-Ras mutant pancreatic tumors. The conjugate, which targets folate receptors and macropinocytosis, was found to be highly cytotoxic and effective at suppressing tumor growth.
New research reveals that age-induced changes in lung fibroblasts reactivate dormant melanoma cells, promoting growth and metastasis. The study found that WNT5A signaling pathway regulates tumor cell dormancy and metastasis initiation, with increased sFRP1 secretion facilitating reactivation in the aged lung.
The MIT team developed wavelength-induced frequency filtering (WIFF), a novel photonic technique that dramatically improves fluorescent sensor signals. This allows for the implantation of sensors as deep as 5.5 cm in tissue, enabling applications such as tracking specific molecules inside the brain or monitoring drug effects.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
A Kyoto University study has discovered that c-type natriuretic peptide facilitates intracellular calcium signaling in chondrocytes to stimulate long bone growth. This finding may lead to the development of new bone growth-stimulating agents for treating developmental disorders.
Researchers at MIT discovered that cells shed 4% of their mass before cell division to eliminate toxic components. This process allows newborn cells to start with fresh, functional contents, which may help explain why neurons accumulate toxic proteins in Alzheimer's disease.
Researchers at University of California - San Diego use electrical shocks to manipulate the demographic of bacterial communities, changing the ratio of cell types and controlling biofilm development. This technology offers a new tool to destabilize biofilms in healthcare and agriculture settings.
Researchers found that genetic mutations in the MAPK pathway, key to normal cell growth, can also make head and neck cancer vulnerable. Individualized genomic analysis can identify specific mutations and target drugs, offering a promising approach to precision medicine.
A new Cambridge study has discovered that the sex of a fetus can affect placenta function, diet-induced maternal obesity, and stress. Designing sex-specific therapies and personalized lifestyle interventions could have lifelong health benefits for children.
A study suggests that the powerhouse-pruning protein Drp1 plays a crucial role in generating energy for new blood vessel growth, particularly under low oxygen conditions. When oxygen levels are low, Drp1 gets modified to produce reactive oxygen species (ROS), which enables glycolysis and subsequent cell signaling.
Researchers discovered that elevated blood fats in people with metabolic diseases create stress in muscle cells, leading to cell death and worsening the illness. Ceramides, a signal created by stressed-out cells, can be passed on to other cells, increasing the risk of severe symptoms.
New research from Rutgers University sheds light on the genetic mechanisms of reproductive disorders, including infertility and miscarriage. The study reveals how the RNA helicase YTHDC2 regulates meiosis, a critical step in egg and sperm development.
Researchers used single cell RNA-sequencing to identify specific cells and genes in maize roots responsible for nitrate uptake. The study provides valuable insights into optimizing root nutrient uptake ability in crops.
Researchers at Karolinska Institutet identified a novel protein mechanism that inhibits tumour growth in ER-negative breast cancer, leading to improved prognosis. High levels of GIT1 were associated with reduced tumour growth and better outcomes in ER-negative patients.
Researchers have identified a single gene, FOXG1, that can control brain cell growth in humans. The discovery provides hope for developing new treatments for neurodevelopmental disorders and stopping brain tumor cells from growing.
Dr. Zhiqiang Lin has been awarded a $3.2 million NIH grant to investigate the roles of YAP and IRF2BP2 in the cardiac innate immune response, with the goal of reducing cardiac inflammation and promoting heart recovery after a heart attack.
A team from UNIGE has identified a potential target for restoring the efficacy of standard breast cancer treatment. The loss of SPRED2 protein leads to tumor proliferation even with tamoxifen treatment. Combining tamoxifen with an inhibitor of estrogen-independent cell activation may be promising for resistant patients.
Researchers have found that two receptors on the surface of endothelial cells come together to enable new blood vessel growth. The discovery reveals a new connection between copper metabolism and angiogenesis, highlighting CTR1 as a potential therapeutic target for conditions like ischemic heart disease.
Researchers at the University of Washington developed an AI-designed protein that can awaken individual dormant genes by disabling chemical 'off switches'. This approach allows for safe upregulation of specific genes to affect cell activity without permanently changing the genome.
Researchers at Bielefeld University have identified five key characteristics of mitosis in the microalga Volvox carteri, including a porous nuclear envelope and crucial centrosome function. They used confocal laser scanning microscopy to capture high-resolution images of live cell division and gain insights into the complex process.
Researchers have identified a crucial nuclear transport mechanism essential for organ growth and development, involving the protein YAP. The study shows that YAP interacts with importin-7 to control its nuclear entry, regulating cell and tissue growth, and potentially targeting diseases such as atherosclerosis and cancer.
Researchers at Tohoku University developed a new lab-based system to grow human muscle cells that contract vigorously. They found that muscle cells from patients with sporadic inclusion body mitosis (sIBM) have similar muscular properties to healthy humans but exhibit altered responses to exercise.
Researchers discovered that a transcription factor called MUTE induces a cell cycle inhibitor SMR4 to slow down the cell cycle, allowing for asymmetric division. A variant with excess SMR4 showed a longer cell cycle during symmetric division, revealing a crucial regulatory mechanism in plant stomatal development.
Scientists at Michigan Medicine have developed a new way to grow tiny models of organs, called organoids, using a simple suspension culture. This breakthrough improves the understanding of human development and could lead to new insights into disease.
Researchers at Tokyo University of Science have developed bionanoparticles derived from corn that selectively target and inhibit the growth of cancer cells, inducing tumor necrosis factor-α release. These findings suggest a novel, economical, and safe anti-cancer therapy approach.
A University of Illinois study discovered that cadherin proteins can sense mechanical stress and alter cell communication, promoting tissue growth and tumorigenesis. The findings suggest a potential mechanism for preventing certain types of tissue growth by mutating cadherin molecules.
Researchers monitored cell environments for three days, finding significant differences from native conditions. The team aims to develop recommendations on improving culture conditions and reduce environmental instability.
Researchers found that hyaluronic acid is not only present in pancreatic tumors but also serves as a nutrient source for cancer cells. This discovery indicates potential new treatments for pancreatic cancer by targeting the sugar scavenging pathway.
Researchers identify genetic circuit that senses cell development stage, triggering deactivation of X chromosome. The discovery reveals a division of labor among genetic switches, providing clues for future study on X chromosome inactivation.
Researchers found that CBD shrinks glioblastoma tumors by reducing inflammation and restoring immune balance. The compound also suppresses key proteins involved in tumor growth and spread, making it a potential novel adjunct therapy for glioblastoma patients.
A new model suggests that cell-to-cell communication plays a crucial role in determining cell fate, particularly in the development of blood cell types. This finding has significant implications for understanding cancer development and identifying leukemia cells of origin.
Researchers have discovered that HIV drugs may be effective in treating low-grade brain tumours, specifically meningioma and acoustic neuroma. High levels of HERV-K proteins were found to stimulate the growth of these tumours, and targeted drugs have been identified to reduce their growth.
Researchers from the Oxidative Stress and Cell Cycle Research Group at UPF have discovered a mechanism by which cells stop their polarized growth when under stress conditions. The study, published in Cell Reports, found that the MAP kinase Sty1 pathway deregulates the equilibrium between Cdc42 activators and inhibitors.
A recent study by NTU Singapore and Singapore General Hospital found that mutations in the DDX3X gene are responsible for chemotherapy resistance in some blood cancer patients. The study also discovered that STAT inhibitors can effectively kill lymphoma cells with DDX3X mutations, providing hope for new treatment options.
Researchers at Lehigh University are working on a project funded by the Good Food Institute grant to adapt human tissue engineering techniques for growing meat in the lab. The team is developing a scaffold for meat cells to grow on and using electrochemistry, nanomaterial design, and liposomal delivery vehicles to promote fibrous growth.
Researchers discovered a newly defined domain in a protein that regulates gene expression under high-energy conditions. Cells adapt to changing nutrient environments by switching between specialized gene expression programs, which are triggered by different molecular tags on histones.
A team of researchers has developed a Dynamic Sampling Platform to analyze cells in real-time, overcoming the time-consuming and expensive process of biomanufacturing. The platform provides insight into cell behavior and biochemical information needed for process control, potentially lowering the cost of cell therapies.
A team of researchers from UC Riverside has discovered how a small molecule called auxin triggers the growth process in plants. By analyzing cell walls, they found that auxin lowers pH levels, causing cells to become acidic and soften, allowing them to expand and grow.
Researchers found that blood stem cells, which are among the smallest cells in the body, lose their ability to perform their normal function — replenishing the body’s blood cells — as they grow larger. However, when the cells were restored to their usual size, they behaved normally again.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
A team led by David Kaplan at Tufts University aims to produce an alternative food source using cell-grown meat, driving efforts to enhance food sustainability and nutrition. The five-year project will combine interdisciplinary teams to evaluate consumer acceptance, environmental impact, and economic viability.
Researchers describe disassembly of Drosophila fly trachea during metamorphosis, revealing two-stage process involving cell shrinkage and death. The study highlights intricate involvement of physical mechanisms and biological signalling in regulating cellular decisions.
Researchers at MIT develop a method to decode images of cells in a tissue to determine its phase, which can indicate its developmental stage or cancer progression. The technique uses triangular order parameters to characterize tissue states, allowing for quicker and less invasive diagnoses.
Researchers found that slow release of TT-10 from nanoparticles improved heart function after a heart attack, accompanied by increased cardiomyocyte proliferation and smaller infarct size. The study suggests that PLGA nanoparticles could be used to improve treatment administration efficiency for cardiovascular drugs.
Scientists at Lewis Katz School of Medicine discovered that reintroducing the protein LIN28 into adult heart stem cells improves their chances of survival. This breakthrough could lead to new treatments for heart disease using stem cell therapy.
A new study from MIT reveals that calorie-restricted diets slow tumor growth in mice by reducing fatty acid availability, while ketogenic diets have limited effect. The findings offer insight into how dietary interventions might be combined with existing or emerging drugs to help patients with cancer.
Plant biologists at Washington University in St. Louis have developed the first artificial scaffolds that can support individual plant cells, mimicking the properties of plant cell walls. The scaffolds demonstrate promising results for studying plant cell adhesion and growth.
Researchers discovered that leukemia cells immediately unresponsive to treatment have high levels of SAMHD1, while those with acquired resistance use the enzyme DCK to activate nucleoside analogues. This finding may lead to better cancer therapies.
Researchers found that nanosilver treatment can increase the risk of recurrent infections when used long-term due to pathogen adaptation. Long-term exposure allows bacteria like Pseudomonas aeruginosa to evolve and resume normal growth upon discontinuation of treatment.