Articles tagged with Cell Growth
Luis Cuello, a professor at TTUHSC, has developed a method to express human potassium channels in bacteria, allowing for large-scale biophysical studies. This technology will be used to target several channels relevant to diseases such as epilepsy, arrhythmia, and diabetes.
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
Researchers found that immune-modulating cells may slow the expansion of bulges in the aorta by creating a less-inflammatory environment. A second study discovered evidence that a COVID-19 infection promotes the enlargement of abdominal aortic aneurysms, which are extremely dangerous and potentially fatal if they rupture.
Researchers have identified distinct senescence subpopulations and dynamic changes in the transcriptome of human cells undergoing senescence. The study provides new understanding of the heterogeneous nature of senescence and its impact on aging diseases.
Researchers at City University of Hong Kong have developed a multifunctional additive that improves the efficiency and stability of perovskite solar cells by modulating film growth. The additive reduces defects, leading to higher power conversion efficiency and lower energy loss.
Researchers developed a method to predict DCIS progression to invasive breast cancer using mice with human DCIS cells. The study found molecular similarities between humans and mice, including the presence of HER2 protein increasing breast cancer risk.
Vogel and Benn's study replicates tissue growth in vitro, revealing the importance of ECM interactions. Myofibroblasts play a key role in wound healing and cancer progression, but their transformation into fibroblasts is influenced by ECM composition and structure.
A Finnish mitochondrial disease, GRACILE syndrome, exhibits cancer-like changes in cell proliferation, leading to premature ageing. Researchers have identified the c-MYC protein as a key player in this process, and a ketogenic diet has shown promise in reducing excessive cell growth.
Researchers have identified ATAD3A as a molecular determinant that favors the development of head and neck cancer. The protein is involved in various cellular processes, including energy metabolism and apoptosis. Targeting ATAD3A could offer a novel approach to developing effective anti-cancer therapeutics.
The study, led by Professor Takashi Miura of Kyushu University, has discovered that interdigitated cell boundaries have a mathematically scaling pattern with self-similarity. The team used the Edwards-Wilkinson model to simulate and understand the molecular mechanism responsible for these dynamics.
The study of nematodes' body size can inform scientists' understanding of cellular growth, with the goal of discovering novel genes that control cell size and potential targets for cancer treatment. Nematodes are a model species for biological studies due to their quick growth rate and ability to produce hundreds of eggs.
Researchers discovered how yeast cells transform their cytoplasmic biophysical properties to return to vegetative growth. The study sheds light on the mechanisms behind spore dormancy and its exit.
Researchers have successfully produced lab-grown fat tissue with a similar texture and make-up to naturally occurring fats from animals. The breakthrough could enable large-scale production of cultured meat with a more realistic texture and flavor.
Researchers have found that valosin-containing protein (VCP) is essential for KRAS-mutant pancreatic ductal adenocarcinoma cell growth and survival. Inhibiting VCP, combined with autophagy inhibition, enhances efficacy in preclinical studies.
Researchers found that cellular growth rate influences gene expression response, leading to unbalanced phenotypic states and a growth-rate-dependent phase transition. The study proposes a mathematical model explaining the bifurcation arising from the relationship between growth rates and gene expression.
Researchers found that senescence-associated exosomes (SA-EXOs) from MSCs induce fibrosis and activate invasive characteristics in neighboring cells via the TGF-β pathway. SA-EXOs play a large role in cancer-related fibrosis, and their unique miRNA content influences myofibroblast phenotypes.
Scientists from the University of North Carolina at Charlotte review nucleolar DNA damage response pathways to combat cancer. By attacking these mechanisms, researchers aim to disrupt cancer's reproduction and growth.
Researchers discover that inhibiting a gene crucial for DNA production can significantly reduce destructive cell proliferation and disease progression in pulmonary hypertension. This finding presents a potential treatment target for the condition, which affects females aged 30-60 with limited treatment options.
An international team of researchers has received $3 million to study how early gut development shapes children's health. They will collect tissue samples from diverse groups to understand the impact of environment, genetics, and other factors on gut development.
Two compounds, A5 and C1, have shown promising results in inhibiting the growth of glioblastoma cells, a type of aggressive brain cancer. Further research is needed to confirm their effectiveness on normal nerve cells and to move towards clinical trials.
Researchers explore cellular senescence's complex relationship with growth stimulation and cell cycle arrest, revealing potential anti-aging drug targets. Understanding these mechanisms is crucial for developing new treatments for age-related diseases.
Researchers at IRB Barcelona have discovered the ch-TOG protein's key role in microtubule initiation, crucial for cell functions and division. The protein facilitates the binding of tubulin molecules, enabling microtubule formation and growth.
Researchers discovered that non-vascular bryophytes like Marchantia polymorpha adapt their architecture in response to shade, using phytochromes to regulate branching. The study found a liverwort-specific microRNA and SPL gene controlling meristem function, differing from vascular plants.
Scientists at Cold Spring Harbor Laboratory have found a way to reprogram cells causing Ewing sarcoma to behave like normal connective tissue cells. By blocking the protein ETV6, cancer cells can be forced to take on a new identity and grow less aggressively.
Researchers at the University of Cologne discovered that bacterial membrane potential changes during biofilm formation, correlating with increased antibiotic tolerance. The study found characteristic patterns of polarization that evolve in space and time, which are linked to a change in oxygen availability.
Researchers found that EWS::FLI1 induces Slit2 expression, which activates Robo receptors and enhances Ewing sarcoma growth. Silencing Slit2 strongly inhibited Ewing sarcoma cell growth, providing an opportunity for targeted therapy.
Researchers from Washington University in St. Louis and Purdue University used single-cell data to develop a new framework for understanding the relationship between cell growth, DNA replication, and division in bacteria. They found that individual cells can exquisitely coordinate these processes, despite the 'noisiness' of each process.
Researchers at Washington University in St. Louis demonstrated that eukaryotic cells can control organelle size by exhibiting random bursts of growth, maintaining a narrow window of precision within this noise., The study suggests a biophysical mechanism for the robustness and universality of organelle size control.
Researchers identified key metabolic pathways in tumor-associated macrophages that contribute to cancer development and progression. Targeting these pathways may provide a new perspective for immunotherapy-based cancer treatments.
Researchers developed biosensors to measure real-time energy changes in plant cells, revealing the bioenergetics of pollen tube growth. The study found that mitochondrial respiration is a main source of cytosolic ATP, while plastid glycolysis supplies plastid ATP.
Research from Michigan Medicine reveals that high levels of ammonia in colon tumors can lead to reduced T cell growth and immunotherapy resistance. A study published in Cell Metabolism found that using an FDA-approved drug to lower ammonia levels made tumors more sensitive to treatment.
Researchers discovered two ion transport proteins, VCCN1 and KEA3, that dynamically adjust photosynthetic performance in response to light fluctuations. The study found that these proteins play a crucial role in protecting plants from excessive sunlight and optimizing growth under varying light conditions.
Scientists have decoded the signals plants send themselves to initiate photosynthesis, a process turning sunlight into sugars. The newly identified proteins control communication between plant cells and organelles, potentially leading to breakthroughs in cancer research and improving crop yields.
In a groundbreaking study, researchers at Eötvös Loránd University have found that gland cells in Drosophila melanogaster can remove defective secretory particles as early as the secretion process begins. This discovery sheds new light on crinophagy, a previously understudied process crucial for maintaining cellular quality and function.
Researchers developed a new computer model, quantitative fate mapping, to trace the origin of cells in fully grown organisms. The model helps spot which cells acquire alterations during development that change an organism's fate from healthy to disease states.
Researchers developed a customizable, strontium-loaded scaffold that promotes wound healing by stimulating gingival fibroblast activity. The scaffold increased cellular activity of isolated cells while showing minimal toxicity over four days.
Researchers at UNIGE and LMU discovered that immune system's anti-tumour activity peaks in the morning. Tumours implanted at night grew faster than those implanted in the afternoon. Administering immunotherapy treatments early morning significantly enhanced their effectiveness, suggesting a new strategy for cancer treatment.
Researchers developed a natural material derived from seaweed to promote vascular cell growth and prevent blood clots in heart bypass surgery. Fucoidan, a seaweed-derived compound, was added to synthetic blood vessels using nanotechnology, significantly reducing the chances of clots forming.
Scientists at Medical College of Georgia discover a new target to intervene in coronary artery disease, the most common type of heart disease. The target is ATIC, a gene essential for purine production, which increases in response to arterial disease.
A low-protein diet blocks nutrient signaling pathways that fire up a master regulator of cancer growth, leading to massive cell death. Researchers found this approach could be an alternative way to shut down mTORC and increase the efficacy of chemotherapy.
A team of researchers from Martin-Luther-University Halle-Wittenberg has discovered a transport pathway for manganese in plants and the role that BICAT3 plays in this process. The protein is responsible for transporting manganese to where it needs to go in plant cells, leading to improved crop growth.
Researchers discovered that the Memo1 protein binds copper ions, blocking toxic redox reactions that damage or kill cancer cells. The protein's interaction with copper also protects against metastasis formation in breast cancer cells. This finding opens up potential new treatments for cancer.
Researchers found that the Eya protein regulates cell contact behavior, allowing for self-organization of epithelial cells with nurse cells. This mechanism enables complex development processes, including egg chamber formation and sperm cell development, in Drosophila.
Researchers at Aston University have developed a method to produce high-quality biodiesel from spent coffee grounds by growing microalgae on the grounds. This innovative approach reduces competition with food crops and decreases greenhouse gas emissions from palm tree cultivation.
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
A new method of modifying our immune system has been demonstrated in a study published in Advanced Science, which could help treat skin cancer.
A novel synthetic energy system supports yeast cell growth and produces highly reduced chemicals, achieving high yields of biofuels. The system's reductive metabolism enables efficient energy production, overcoming stoichiometric constraints and outperforming natural metabolic processes.
Researchers at La Jolla Institute for Immunology discovered a direct link between TET protein loss of function and missing genes in embryonic stem cells, which can lead to cancer growth. The study found that TET proteins are crucial for maintaining genome stability, and their loss results in aneuploidies, a common feature of cancer cells.
A team from the University of Geneva has identified the structure of the SEA complex, a key regulator of cell growth, and how it controls the activity of the major regulator of cell growth, mTOR. The discovery provides new insights into how cells perceive nutrient levels to regulate their growth.
A new study reveals that urolithin A from pomegranates can rejuvenate T cells by recycling and renewing mitochondria, enhancing their ability to fight tumors. The researchers plan to investigate the application of urolithin A in clinical trials for colorectal cancer.
Researchers have developed a drug compound that stops cancer cell growth in mice with little effect on normal healthy cells, making it potentially nontoxic for patients. The therapy targets the epidermal growth factor receptor gene, which is overexpressed in about half of all triple-negative breast cancer cases.
Researchers discovered a molecular link between disrupted circadian rhythms and lung tumor growth, implicating a cancer-signature gene known as HSF1. Disrupted clocks may trigger lung tumors in individuals with irregular sleep patterns or night shifts.
Researchers found that increasing arginase 1 availability helps alleviate unhealthy responses and interrupt destructive inflammation in diabetic retinopathy and retinopathy of prematurity. This is achieved by reducing L-arginine levels, which in turn reduces inducible nitric oxide synthase activity.
The study reveals how the activating partner PI5P interacts with two different regions of regulatory protein UHRF1, showing its role in modulating complex proteins. This finding could breathe new life into the search for UHRF1-directed medicines.
Researchers at the University of Arizona have identified a protein called Ait1 that regulates cell growth in yeasts. This discovery presents new targets for developing antifungal drugs that can attack disease-causing yeasts while sparing human immune cells.
Researchers at the University of Helsinki have identified target genes of the MYC oncogene responsible for its growth-promoting effects. By modifying these genomic binding sites, they slowed down cell growth. This finding has significant implications for developing new cancer treatments.
Researchers at NUS have developed a method to produce cell-based meat using magnetic pulses, reducing reliance on animal products and increasing efficiency. This technology has the potential to revolutionize the food industry and improve regenerative medicine by stimulating the growth of healthy cells.
Researchers discovered a type of triple-negative breast cancer cell that can trigger dormancy, evading therapies and allowing for efficient survival in distant organs. This finding highlights the need for more selective therapeutic strategies targeting both dividing and invasive dormant cells.
Researchers at Washington University in St. Louis are developing a new wound dressing to overcome obstacles to healing in people with diabetes, including chronic inflammation and delayed growth of new blood vessels.
Researchers developed a light-based therapy, photodynamic therapy (aPDT), to combat antibiotic-resistant bacteria. The treatment showed promise in weakening bacteria, allowing lower doses of current antibiotics to effectively eliminate them.