Articles tagged with Cell Lines
Researchers at UNIGE developed a screening technique called Synthetic Tandem Repeat PROMoter (STAR-PROM) to identify transcription factor serum response factor (SRF), which activates genes and influences cellular structure. The technique allows for the discovery of factors modulating gene expression in various contexts, including drug ...
Researchers have found that Salmonella bacteria change key cells in the intestine to cross the gut wall and infect vital organs. This allows Salmonella to thrive and cause severe symptoms like diarrhoea, fever, and even death in young children.
In pre-clinical experiments, Angiocidin reduced acute myeloid leukemia (AML) cells by almost two-thirds, demonstrating its potential as a safer treatment alternative to standard-of-care chemotherapy agents like Ara-C. The protein also stimulated maturation in affected white cells, causing them to behave like normal cells.
A recent study has confirmed that an association between XMRV and prostate cancer was due to laboratory contamination. The researchers found that the virus was introduced into prostate tissue samples through contact with a different cell line, which had been contaminated with XMRV in the 1990s.
Researchers have discovered a human peptide that effectively blocks HIV entry into cells by targeting specific targets on both the virus and the cells. The peptide, human neutrophil peptide 1, prevents early and late stages of HIV-cell fusion and inhibits viral uptake without compromising cell function.
A US study demonstrates that hepatitis C virus (HCV) replication can be limited by innate immune responses in murine cells. Inactivating these pathways and expressing entry factors enables infection and support of HCV replication.
A preclinical study found that patients with KRAS gene mutations have a worse prognosis and do not respond well to targeted therapies. However, patients with KRAS-mutant tumors may respond well to treatment with antifolates, especially if the mutation is not amplified.
A team of researchers identified a beta-1 integrin signaling pathway crucial for HNSCC resistance to radiotherapy. Inhibiting this pathway sensitized cells to radiation and delayed tumor growth in mice.
Scientists at Johns Hopkins Medicine discovered an energy sensor mechanism that helps regulate cell energy storage. The study found that a protein called AMPK, which acts like an energy thermostat, is affected by acetyl groups added to it.
Researchers found grape seed extract to be effective in killing head and neck squamous cell carcinoma cells without harming healthy cells. The extract damages cancer cells' DNA and prevents repair pathways from functioning.
Researchers used Cell-CT technology to examine cells in 3D, revealing subtle cellular details inaccessible by conventional microscopy. The study found that cancerous cells had distinct nuclear shapes and sizes, which can be used as biosignatures for disease staging and diagnosis.
Researchers at Moffitt Cancer Center found MK1775 effective in treating sarcoma cells, inducing apoptosis and causing cell death, regardless of p53 mutation status. The study suggests that Wee1 inhibition by MK1775 may represent a novel approach in treating sarcomas.
A recent study found that antifolate drugs may be effective against non-small cell lung cancer (NSCLC) patients with specific mutations in the KRAS gene. The treatment can stop the KRAS gene from being expressed, leading to cancer cell death.
Researchers discovered that a calcium-sensing receptor plays a major role in the development of hypercalcemia, a deadly syndrome associated with squamous-cell lung cancers. The receptor releases a hormone that sets off a biological cycle leading to bone erosion and calcium release, ultimately promoting cancer growth and spread.
A Syracuse University research team has created a temperature-sensitive shape memory polymer substrate that can change shape under cell-compatible conditions. The breakthrough, led by James Henderson and Kevin Davis, offers potential solutions for current limitations of static substrate research in bioengineering.
Scientists at IRB Barcelona discovered that some brain tumors in fruit flies use the genetic program of germline cells to grow. Silencing specific genes leads to healthy brains, highlighting their crucial role in tumor development. This finding offers new insights into cancer research and potential treatment approaches.
UC Davis researchers have identified a new inducible pathway for repairing DNA damaged by oxygen radicals, which could lead to a better understanding of the causes of some cancers. The discovery involves an enzyme called NEIL1 that detects and repairs aberrant bases before changes in the genome become permanent.
Researchers at Scripps Research Institute have identified two proteins, Piezo1 and Piezo2, that play a crucial role in mechanotransduction - the conversion of mechanical force into chemical signals. This discovery could lead to new treatment approaches for pain, deafness, and cardiac function.
The Mayo Clinic team created four new ATC cell lines with distinct molecular mutations, which will aid in testing new treatments and potentially lead to improved survival rates. The researchers also found that these cell lines reactivate a tumor suppressor gene called RhoB, leading to growth suppression.
Researchers found that CD74 is expressed on colon epithelial cells, increasing their survival upon MIF stimulation. Stimulation of CD74 led to Akt phophorylation and Bcl-2 expression, resulting in elevated cell survival. This discovery may open a new target for colorectal cancer research.
A new human hepatoma multidrug resistant cell line, SK-Hep1/CDDP, was established to elucidate the biological mechanisms of MDR in hepatocellular carcinoma. This cell line can be used to test new therapeutic agents and explore targeted approaches for improving MDR cancer therapy.
Researchers find that stress hormones can protect ovarian cancer cells from anoikis, promoting tumor growth. Higher levels of activated FAK are linked to accelerated mortality in ovarian cancer patients.
Research reveals that HGF-induced invasion of cholangiocarcinoma is mediated by distinct signaling pathways, with PI3K pathway being common and ERK1/2 playing a key role depending on activation duration. This understanding may aid in identifying therapeutic targets for individual patients.
Researchers verified that three commonly used esophageal adenocarcinoma cell lines were actually from lung carcinoma, colorectal adenocarcinoma, and gastric fundus carcinoma. This finding highlights the importance of authenticating cell lines to ensure accurate treatment strategies for esophageal cancer patients.
Biomethylation of arsenic compounds causes oxidative DNA damage, enhancing their toxicity and potentially carcinogenicity. Methylation-competent cells exhibited rapid cancer cell acquisition after peak oxidative DNA damage.
Researchers found Chrysanthemum indicum extract inhibits cancer cell proliferation and induces apoptosis in hepatocellular carcinoma cells. The extract also arrests the cell cycle by regulating key proteins, suggesting its potential as a novel cancer treatment.
A new NIST assay using a 'glow or no glow' technique can detect ricin, a lethal toxin, at low doses and measure its potency with high precision. This standardized sample will aid in the accuracy of detection equipment and decontamination procedures.
Researchers found that cancer cells use many normal proteins to cope with stress and maintain their abnormal state. This discovery highlights the importance of stress management genes as potential therapeutic targets for treating tumors driven by Ras mutations.
Researchers developed DNA-like compounds that effectively inhibit cells responsible for systemic lupus erythematosus, a potentially groundbreaking treatment. The findings demonstrate the anti-inflammatory effects of class R inhibitory oligonucleotides and could lead to new therapies.
Scientists at Johns Hopkins discovered that cell-to-cell contact revs up microRNA production, a key regulator of gene expression. The study found that physical contact is the critical factor influencing microRNA abundance, with increasing cell density leading to increased microRNA production in all tested cell lines.
Researchers used computational approaches to analyze a human myeloid leukemia cell line's transcription factor network. They identified specific subnetworks of proteins that play a role in cell differentiation, and found the network to be redundant and resilient.
A study published in the World Journal of Gastroenterology has discovered a significant link between aryl hydrocarbon receptor (AhR) expression and gastric cancer. The research suggests that AhR may be a potential therapeutic target for gastric cancer treatment.
Beta-1 integrin's role in regulating cell behavior and extracellular matrix assembly is crucial for understanding diseases like cancer and fibrosis. The study identifies a key protein, talin, involved in controlling fibronectin fibril formation.
Research suggests that stress can increase the production of proteins that support tumor growth and angiogenesis in aggressive melanoma cells. Beta-blocker medications may slow this process, offering potential improvements for patients' quality of life.
Researchers discovered that Myxococcus xanthus uses a rippling motion to hunt other bacteria, with the pattern adapting to prey density. The study found that individual cells line up and move in an alternating pattern, producing high and low cell density waves.
Researchers found a group of 48 genes that can predict susceptibility to toxic compound MNNG, leading to varying cell responses. The study appears in Genes and Development, providing new insights into how individuals respond to chemotherapy.
University of Manchester researchers have taken a systematic approach to studying anti-mitotic drugs, revealing a profound variation in cell behavior among different tumors. The study aims to improve the effectiveness of these drugs while reducing side effects such as nerve damage.
The study found that 34% of polyadenylated transcripts mapped to non-annotated genomic regions, indicating a large number of novel gene candidates. Additionally, the researchers identified 94,241 splice junctions, with 4,096 novel variants, highlighting exon skipping as the most prevalent form of alternative splicing.
Researchers found that LYN kinase activation is associated with imatinib resistance in CML patients, a mechanism not explained by BCR-ABL mutations. Blocking LYN kinase restores imatinib responsiveness and triggers cell death.
Researchers link fever to life-threatening changes in the heart's electrical cycle of LQT-2 patients, a genetic condition characterized by prolonged QT intervals. Fever triggers abnormal electrical currents in heart cells, potentially leading to ventricular arrhythmias and heart failure.
Researchers at Baylor College of Medicine used high throughput microscopy to study the regulation of estrogen receptor-alpha, finding that its response depends on the manner of regulation. The technique enabled them to analyze thousands of images of cells and differentiate between ligand- and steroid-dependent regulation.
Researchers created a novel cell line that replicates the full spectrum of systemic metastatic cancer, enabling new discoveries about the role of macrophages in cancer's spread. The model has been shown to produce tumors in 100% of mice with healthy immune systems, paving the way for new therapies targeting these cells.
Research suggests that MUC1 mucin variable number of tandem repeats polymorphism influences H pylori binding to gastric cells. Adhesion levels are higher in clones with larger VNTR regions, contributing to the understanding of H pylori infection pathogenesis.
Researchers at Scripps Research Institute have developed two new tests that can identify lethal prion strains quickly and accurately. The tests, the Standard Scrapie Cell Assay and the Cell Panel Assay, significantly accelerate prion research by producing results in under two weeks.
Researchers develop synthetic compound that promotes death of lung-cancer cells and tumors by mimicking natural 'death-promoting' protein Smac. The compound was effective against nearly one-quarter of lung-cancer cell lines tested, with some breast cancer and melanoma cells also showing sensitivity.
Researchers found that FTY720 prevents disease in mouse models of leukemia caused by the cancer protein BCR-ABL. Nitric oxide inhalation also accelerates restoration of liver function after transplantation, reducing hospital stay times.
Researchers found that odorants in spices and fragrances can trigger serotonin release, leading to gastrointestinal reactions. Sacral nerve stimulation has also shown potential for relieving symptoms of idiopathic constipation, with long-term results indicating improved bowel habits and reduced straining.
Researchers at the University of Pittsburgh School of Medicine have discovered a potent and selective killer of leukemia cells, specifically cyanidin-3-rutinoside, a naturally occurring compound found in many fruits and vegetables as well as red wine. This finding offers hope for a more targeted and less toxic therapy for leukemia.
Researchers at the University of Minnesota have identified a cell line resistant to retroviruses, including HIV, which is able to withstand infection and attack by the virus. This discovery provides a potential new target for developing more effective drugs to combat HIV and AIDS.
The study found that phosphatase 2A activation modulates key cell survival molecules and induces growth suppression, cell differentiation, and apoptosis in BCR/ABL cell lines. Restoration of PP2A activity in CML-BC patient cells counteracted leukemia development.
The National Stem Cell Bank (NSCB) will provide comprehensive characterization of human embryonic stem cell lines and distribute them to investigators at a lower cost. This move aims to increase the use of stem cells in research and potentially lead to therapies for diseases, with WiCell handling technical support and training.
A new method to create a reversibly immortalized beta-cell line offers significant progress in developing an effective treatment for type 1 diabetes. The breakthrough, achieved by manipulating human beta-cells, has successfully controlled blood sugar levels in diabetic mice for over 30 weeks.
Prostate cancer cells manipulate Wnt signaling proteins to establish themselves in bone tissue, producing dense bony lesions characteristic of prostate cancer. The study found that altered levels of Wnt activity promote osteoblastic lesions, while high levels of DKK-1 inhibit Wnt activity, leading to highly osteolytic tumor lesions.
A team of researchers has isolated the Ephrin-B2 cell surface protein as a functional receptor for both Hendra and Nipah viruses, shedding light on their ability to infect a wide range of hosts. The finding holds promise for developing countermeasures to prevent and treat these emerging global health threats.
Researchers identified genes that govern the development of brown fat cells, which burn energy and generate heat. The discovery may lead to new tools to fight obesity by targeting specific genes with drugs or agents.
The LigAmp test detects single nucleotide differences in cancer and HIV, improving diagnosis and monitoring. Researchers have identified potential mutations for early cancer detection and drug resistance in HIV patients.
Researchers are testing a new flu vaccine grown in insect cell lines, which could reduce production time by one to two months. The study aims to evaluate the effectiveness of the experimental vaccine in healthy adults aged 18-49, with potential benefits including reduced costs and increased dose strength.
Researchers found low-dose radiation killed up to twice as many cells as high-dose, suppressing ATM protein's repair mechanism. The study suggests using viruses to deliver ATM-blocking drugs to cancer cells, which shows promise in killing more cancer cells than traditional radiation.
Researchers found that ES cell lines can restore blood cells, including immune systems, in mice without being rejected. This breakthrough has potential advantages over traditional bone marrow or blood donations, offering a renewable source with low risk of graft-versus-host disease.
A new toxicity test uses human growth hormone-secreting cell lines to detect toxic compounds, reducing the need for animal testing. The test, developed by Italian researchers, can identify low concentrations of chemicals that current methods may miss.