Articles tagged with Cell Lines
Hokkaido University scientists have identified CDK6 as a promising target for treating adult T-cell leukemia/lymphoma (ATLL) with the drug palbociclib. The combination of palbociclib with everolimus also showed significant tumor growth reduction and minimal side effects in mice models.
Researchers uncover the pleiotropic functions of hnRNPK in regulating skeletal muscle cell differentiation, including inhibition of myoblast differentiation and suppression of genes involved in endoplasmic reticulum stress. The study suggests that targeting hnRNPK could be a potential therapeutic strategy for treating human disorders.
A new study found that traditional Chinese medicine Shengmai Yin increases the sensitivity of cancer cells to radiation, reducing radioresistance. By altering DNA methylation status, SMY enhances the efficacy of radiation therapy and reduces side effects.
Researchers at Tokyo University of Science have developed bionanoparticles derived from corn that selectively target and inhibit the growth of cancer cells, inducing tumor necrosis factor-α release. These findings suggest a novel, economical, and safe anti-cancer therapy approach.
A new cell line from human adult bone marrow can grow infinitely and differentiate into red blood cells, making it a potential source for generating endless amounts of RBCs. This breakthrough could simplify methods for establishing immortalized cell lines and select clones with maximum RBC production potential.
Researchers have identified several drug contenders that can block or reduce SARS-CoV2 infection in cells, including lactoferrin and MEK-inhibitors. These findings suggest potential efficacy against COVID-19 variants, with ongoing clinical trials to examine their ability to reduce viral loads and inflammation.
Researchers investigated the oncogenicity of human LAT1 in NIH/3T3 cells, finding it to be a promising anti-cancer target. Anti-LAT1 monoclonal antibodies inhibited cell proliferation and tumor growth, suggesting LAT1's potential for therapeutic development.
Researchers identified six novel molecular subtypes of thymic epithelial tumors that are independent of World Health Organization histologic type. The study used genomic information from The Cancer Genome Atlas dataset and the IU-TAB-1 cell line, and found no association between WHO histologic subtype and molecular subtypes.
Researchers have created live cell models that mimic mitochondrial disease cells, allowing for drug studies and further research into the disease. These cell lines have the potential to support upcoming research and provide relief to patients and their families.
Scientists have observed individual stony coral cells engulfing single-celled photosynthetic algae, crucial for keeping corals healthy. Around 40% of coral cells incorporated the algae in 30 minutes and remained healthy for a month, providing insights into the partnership between corals and dinoflagellates.
Researchers evaluated Tomivosertib's therapeutic potential on AML cells and found it to be highly effective at blocking eIF4E phosphorylation. Combination with Venetoclax resulted in synergistic anti-leukemic responses. The study also identified novel putative MNK1/2 interactors.
A study by Karan Bedi and colleagues found that RNA splicing is inefficient, leaving many intronic sequences unspliced. The team analyzed Bru-seq data from six cell lines and identified variable patterns of splicing across genes and cell types.
Research shows that relacorilant enhances paclitaxel-driven apoptosis in various cancer cell lines and xenograft models, providing a basis for its potential as an adjunct therapy. The study's findings support clinical benefits observed with relacorilant addition to paclitaxel-containing therapy in ovarian and pancreatic cancers.
The acylfulvene alkylating agent LP-184 demonstrates highly potent anticancer activity in NSCLC cell lines, correlating with PTGR1 transcript levels. It targets tumors regardless of co-occurring mutations but is especially effective in KEAP1 mutant settings.
The scientific community is urged to adopt more inclusive practices in preclinical and basic science research to promote personalized medicine. Researchers highlight the lack of diversity in commonly used human cell lines, which are predominantly of European descent, and emphasize the need for representative cell lines to better unders...
Researchers have successfully grown cells from stony coral Acropora tenuis, creating eight distinct cell types that can grow indefinitely. The cell lines hold promise for understanding coral interactions with photosynthesizing algae and bleaching processes.
A team of scientists at the University of Pennsylvania School of Medicine has identified nine potential COVID-19 treatments, including three FDA-approved drugs. The study found that these drugs, such as cyclosporine, work by inhibiting the replication of the virus in respiratory cells and suppressing inflammation.
Researchers have found that a chemical inhibitor called K777 can reduce the ability of SARS-CoV-2 to infect cells. Clinical trials are underway for its potential use in treating COVID-19, particularly in patients with severe cases.
A new cell line called ZMAC has been shown to significantly improve the success rate for isolating the PRRS virus, with a success rate of 57.6% compared to 26.3% for the current cell line MARC-145.
A recent collaborative study has shown that resveratrol's anti-inflammatory properties are mediated by the bitter receptor TAS2R50. The researchers found that this receptor type plays a role in reducing inflammatory markers released by gum cells when treated with surface antigens from bacteria.
Researchers from Far Eastern Federal University have discovered compounds in marine fungus Penicillium dimorphosporum that protect cells from paraquat's harmful effects. The substances showed a 40% increase in cell viability at low concentrations, and the scientists plan to study their mode of action and potential use with other drugs.
Ovarian clear cell carcinoma (OCCC) remains a rare subtype with poor prognosis. Simvastatin efficiently controlled OCCC proliferation and migration, demonstrating potential as a candidate drug.
Small cell lung cancer cells lack surface protein NKG2DL, allowing them to hide from immune system. Researchers found that expressing this protein on their surfaces can trigger an immune response and lead to smaller tumors with more activated immune cells.
Researchers found that microplastics can be internallyized by living cells after being exposed to natural aquatic environments, where biomolecules form an 'eco-corona' on the surface of particles. This process allows plastics to be internalized into tissue.
Researchers at Harvard University discovered a unique sensor system in octopus suction cups that allows them to detect and 'taste' molecules on objects, enabling the animals to identify prey. This novel chemotactile receptor system may also facilitate complex behaviors in octopuses and other cephalopods.
A collaboration between Synthego and The Krogan Lab used CRISPR-based genome engineering to study genes associated with SARS-CoV-2. This approach revealed key targets for potential coronavirus treatment, accelerating research in the fight against COVID-19.
A new radioimmunotherapy has proven effective in reversing resistance to the most commonly used lymphoma drug, rituximab. In a non-Hodgkin's lymphoma mouse model, the treatment substantially increased rituximab binding and antibody-dependent cellular cytotoxicity activity, resulting in significant tumor growth delay.
Lymphoma cells can resist therapy by evading apoptosis due to the presence of the Livin protein. Targeting Livin using inhibitors may be effective in refractory cases. Researchers have identified a promising immunotherapeutic strategy by combining CD40-mediated Fas expression with specific targeting of Livin.
A new study reveals that bats can host the Ebola virus without contracting the deadly disease, thanks to their unique cell structure. The research found that bat cells induce changes in the virus that make it less capable of harm, allowing it to coexist with its natural reservoir.
Researchers at UTSW Medical Center have identified BBOX1 enzyme as a viable target for triple negative breast cancer treatment. Overexpressing BBOX1 causes TNBC cells to proliferate, while eliminating it stops tumor growth.
Researchers at Goethe University Frankfurt and University of Kent have discovered that the enzyme SAMHD1 can split phosphate groups off nelarabine, making it less effective in B-ALL patients. This breakthrough could lead to more targeted treatment options for individual patients.
Researchers found that BI-D1870 inhibits AML cell proliferation and increases G2/M population without affecting CDC2 and CDC25C. The combination of BI-D1870 and vincristine synergistically increases mitotic arrest and apoptosis in AML cells, providing a promising novel approach to overcoming resistance.
Researchers from Kanazawa University discovered SLC35B1 as a crucial molecule in the detoxification process, enabling glucuronidation of drugs and toxicants. The study revealed that SLC35B1 significantly affects UGT activity when knocked down, suggesting its vital role in regulating this complex process.
A study found that survivin positivity by IHC correlates with shorter survival in Neuroendocrine tumors. Radiation exposure increases BIRC5 gene expression, which is associated with an inferior survival. Survivin long peptide-mimic vaccine shows promise in preclinical studies.
This study found that HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) cells exhibit enhanced radiosensitivity and increased cell motility after radiation therapy. In contrast, HPV-negative OPSCC cells show decreased radiosensitivity and reduced cell motility.
Researchers discovered a synthetic gold-based compound that inhibits adipogenesis and reduces key metabolites, potentially treating obesity. The D-AuNPs showed nontoxicity to cells at high concentrations, offering a new avenue for obesity medicine.
Scientists have discovered that the novel coronavirus SARS-CoV-2 primarily infects progenitor cells in the lungs and bronchi, which are responsible for producing cilia that sweep mucus and bacteria out of the lungs. The virus acts in a highly selective manner, dependent on certain human cells to spread and replicate.
EMBL scientists examined the molecular causes of a rare hereditary disease of the spine and ribs, revealing that errors in the segmentation clock can cause disorders. The researchers created a lab system to study this process, demonstrating that specific gene mutations, such as DLL3, are responsible for the condition.
Researchers found that DOT1L inhibition significantly reduces MM cell viability in vitro and inhibits xenograft growth in mice. Concomitant targeting of SETD1B enhances this effect, suggesting a novel therapeutic angle for cancer treatment.
The study found that SLC25A32 inhibition resulted in anti-proliferative effects on certain tumor cell lines, potentially by increasing reactive oxygen species. Treatment with riboflavin and glutathione rescued cancer cell proliferation upon SLC25A32 down-regulation.
Researchers found that bats' unique immune response drives viruses to replicate faster, making them deadlier in humans. The study suggests that disrupting bat habitats could increase the threat of zoonosis.
A new single-cell prenatal blood test can identify genetic abnormalities in fetuses with high accuracy, improving the likelihood of detection. The test uses a modified droplet digital PCR assay that assesses DNA from live cells without cell fixation or whole-genome amplification.
Researchers found that AEZS-108 upregulates the tumor suppressor gene MASPIN, inhibiting cell proliferation and inducing apoptosis in LHRH receptor-positive uveal melanoma cells. The study suggests that targeted cytotoxic LHRH analogs like AEZS-108 could serve as an effective treatment for patients with this disease.
A study from the Salk Institute identified over 2,000 previously unknown small open reading frames (smORFs) in human cell lines, expanding the number of human genes by 10%. These tiny genetic sequences may hold key to understanding human biology and developing new treatments for diseases like cancer and diabetes.
A new deep-learning platform, maui, analyzes multiple 'omics' datasets to identify relevant patterns and features associated with colorectal cancer. The platform was found to be more accurate and faster than other machine learning algorithms, and could potentially improve diagnosis and treatment options for patients.
The study evaluates the safety of conditionally immortalized proximal tubule epithelial cells for bioartificial kidney application, demonstrating lack of oncogenic properties and tumorigenic capacity. These cells show promise for clinical application as cell-based renal replacement therapy.
A new machine learning method called SNIPER has successfully applied to nine cell lines, providing missing information for how DNA is organized in the cell nucleus. This enables scientists to study differences in spatial organization related to subcompartments across those lines.
Quinacrine repurposed with cisplatin synergizes to reduce cancer growth, increasing median time to tumor volume by 12 days; enhances apoptosis and inhibits autophagy in HNSCC cells.
Researchers identified a key acid-activated protein channel (PAC) that could provide a new target for therapies for stroke, heart attack, cancer, and inflammation. The discovery was made by Johns Hopkins Medicine researchers who found the PAC protein in human cell lines using a novel method.
Researchers established two human pancreatic cancer cell sublines with high metastasis potential, MIA PaCa-2 In8 and Panc-1 In8, which demonstrated increased migration, invasion, and clonogenic abilities compared to their parental cells. The study also identified a dysregulated lncRNA-miRNA-mRNA competitive endogenous RNAs (ceRNAs) net...
The study found that using Research Resource Identifiers (RRIDs) in scientific papers can lower incidences of problematic cell-line use. This could lead to better reporting and future reproducibility efforts, ultimately aiding research data validity.
A new SVM-based method predicts enhancer regions with satisfactory performance, outperforming modern methods on various cell lines and tissues. The method achieves better results for adult-stage tissue predictions compared to fetal stages.
Soyasapogenol B (SSB) is a bioactive agent that can be loaded into Multi-Walled Carbon Nanotubes (MWCNTs) for targeted delivery. The SSB-loaded MWCNT systems exhibited controlled and sustained drug release profiles, with minimal cytotoxicity to normal melanocytes, liver cells, and breast carcinoma cells.
Researchers propose a support vector machine-based method to predict enhancers on multiple cell lines and tissues, achieving better performance than state-of-the-art methods. The findings indicate that predicting enhancers is easier for adult or young tissue samples compared to fetal samples.
A team of investigators from the University of Pittsburgh has identified compounds that block the reactivation of latent HIV-1 in a human cell line. The research, published in Antimicrobial Agents and Chemotherapy, found 12 kinase inhibitors that irreversibly blocked HIV-1 reactivation with minimal toxicity.
Researchers at Kanazawa University have identified three new compounds from the leaves of a threatened tropical plant species with potent antiproliferative activities against various human tumor cell lines. The study highlights the potential of rainforest plants as a rich source of bioactive natural products for cancer drug discovery.
The study reveals that the WD40 repeats in AND-1 prevent nascent DNA cleavage by a nuclease, allowing for successful cell division. The discovery highlights the crucial function of AND-1 in protecting replicated DNA from degradation during replication and cell proliferation.
A study published in Current Bioinformatics found that predicting enhancers in adult tissues is more accurate than in fetal stages. The researchers used support vector machines to analyze DNA sequences and histone modifications, achieving good performance on most cell lines and tissues, especially for heart and lung tissues.
Recent studies have raised safety concerns over CRISPR's precision in human cell lines, but companies are forging ahead with therapies. The technology makes double-stranded breaks at specific sites in DNA to repair defective genes.
Researchers have identified valuable pools of genetic material from cryopreserved cell lines, which may help guide a tailored recovery program for the northern white rhinoceros. The study's findings suggest that advanced sequencing technologies and novel reproductive strategies could improve recovery efforts for other endangered species.