Natural Killer cells have been found to play a key role in responding to checkpoint inhibitors, which are transforming the treatment of cancer. Researchers discovered that these cells can produce the same checkpoint receptor molecules as T cells, enabling them to respond directly to the therapy.
A microfluidic device created by Cornell University scientists can corral viable sperm in minutes, improving IVF chances. The device uses rheotaxis to separate highly motile sperm from weaker ones, reducing the time-consuming and tedious process of conventional methods.
Human clinical trials for DesignMedix and Portland State's anti-malarial drug DM1157 have begun, assessing the drug's safety and absorption in healthy volunteers. The Phase I study aims to overcome growing resistance among malaria medicines, with potential approval for treatment of millions.
Researchers at Hokkaido University create photoelectrode that harnesses 85% of visible light, 11 times more efficient than previous methods. The innovative design uses gold nanoparticles to absorb a broad range of wavelengths, enabling efficient conversion of sunlight into renewable energy.
A pilot initiative found that home blood pressure monitoring improved hypertension control in 86% of patients. The study also showed significant cost savings from reduced office visits and emergency department costs.
A study presented at the American Heart Association's Joint Hypertension 2018 Scientific Sessions found that lifestyle changes, including a healthier diet and regular exercise, can greatly decrease the number of patients who need blood pressure-lowering medicine. By making these changes, nearly half of participants were able to reduce ...
A study has identified a single gene called insulin-like peptide 2 (ILP2) as the key determinant of queen and worker roles in ants. The gene is activated by better nutrition and stimulates ovaries to trigger reproduction, explaining the emergence of social behavior in insects.
Researchers found that acute changes in extracellular matrix components can trigger rapid changes in cell metabolism and migration, potentially leading to cancer metastasis. The study suggests targeting tumor metabolism by altering the extracellular matrix could lead to new cancer treatments.
Tropical Storm Florence is experiencing temporary wind shear, causing cloud top temperatures to warm, but forecasters predict it will restrengthen into a hurricane over the weekend. Large swells are expected to affect the US East Coast and Bermuda, resulting in life-threatening surf and rip currents.
A new study published in Science shows that large-scale solar and wind farms in the Sahara could more than double precipitation, increase vegetation cover by up to 20%, and lead to substantial improvements in rainfed agriculture. The findings have major implications for addressing sustainability challenges in the Energy-Water-Food nexus.
A study published in Cancer Immunology Research found that immune checkpoint inhibitors showed high efficacy and low toxicity in treating HIV-associated Kaposi's sarcoma. The treatment resulted in partial or complete remission in over 65% of patients, with limited side effects compared to standard chemotherapy.
A team of researchers has developed a new proactive defense technique called moving target defense (MTD) to protect computer systems from cyberattacks. MTD involves changing the IP address of computers frequently enough to confuse attackers and make it harder for them to exploit vulnerabilities.
A research team led by Tohoku University has revealed the evolution of a gene related to psychiatric traits. The SLC18A1 gene variant is associated with schizophrenia, bipolar disorder, anxiety, and neuroticism, suggesting that natural selection may have shaped human psychiatric diversity.
The University of California, Davis, is targeting underrepresented students in geoscience fields through a five-year project funded by the National Science Foundation. The initiative aims to increase diversity in these areas by providing scholarships and field experiences for eligible students. It will also test a research question abo...
A new study published in Icarus challenges the International Astronomical Union's 2006 definition of a planet, which requires a celestial body to clear its orbit. Researchers argue that this standard is not supported by scientific literature and propose a new classification method based on size and gravitational dominance.
A study by Aarhus University found moderate agreement among farmers, veterinarians, and livestock drivers in evaluating cull cow lameness and fitness for transport. The researchers used video sequences to assess cow fitness, with varying levels of agreement within and between groups.
Researchers at NUST MISIS and University of Calgary create method to monitor virus spread and immune system response in real-time using intravital microscopy. This breakthrough enables visualization of virus behavior in tissues and organs of living animals.
The new guidelines focus on the needs of clinicians and managers providing rehabilitation care for patients with moderate to severe TBI. The guidelines cover topics such as intensity and frequency of services, managing behavioral disorders, and social participation.
Researchers identified unique cell populations in human joint cartilage, crucial for cushioning and often lost in arthritis. Stem cell-derived cartilage can be transplanted into arthritic rats to regenerate the superficial zone, potentially leading to better treatments.
Researchers from the University of Bristol have developed autonomous sensor pods called 'dragon eggs' that can withstand harsh conditions around active volcanoes, providing valuable real-time data on volcanic activity. The innovative technology has numerous applications, including remote monitoring of glaciers and geological faults.
A study by Dr Harry Witchel at Brighton and Sussex Medical School found that smiling is linked to subjective engagement, not happiness. In one-to-one Human-Computer-Interaction experiments, participants smiled more when answering questions incorrectly.
The study found that the shared lifetime between grandmothers and their grandchildren significantly increased over time, especially in the 20th century. In the 1950s, 96% of grandchildren lived longer than their grandmother, highlighting the importance of grandmothers' influence on family life.
A new study suggests that Democrats' greater inclusiveness and willingness to integrate members of other groups into their party may have weakened party cohesion, ultimately leading to Hillary Clinton's election defeat. Republicans, on the other hand, displayed solidarity only with their own group, enabling them to act as a single entity.
The team aims to develop a modular and scalable interface system that can modulate and monitor large-scale activities in the nervous system, with potential applications for pain management, epilepsy, and neurological disorders. They plan to advance bioluminescence imaging instead of fluorescence to enable long-term cortical imaging wit...
The Samara University team has developed a reliable and inexpensive propulsion system for maneuvering nanosatellites, using a water-alcohol mixture as the working body. The system can be equipped with any CubeSat space vehicle and expands the capabilities of nanosatellites, enabling them to solve complex problems in outer space.
The American College of Medical Genetics and Genomics emphasizes the need for affordable treatment options for rare and ultra-rare diseases. Key recommendations include preventing abuses of the Orphan Drug Act and aligning drug packaging with dosing recommendations to reduce waste. The organization urges policymakers to develop simple,...
Researchers from Charité - Universitátsmedizin Berlin have developed a new generation of pain medications that can prevent brain- and gut-related side effects associated with conventional opioids. The drugs are designed to work only at sites affected by injury or inflammation.
Researchers at the Salk Institute and University of Florida used cryo-electron microscopy to image an AAV2 virus with improved resolution. The study reveals key changes in the viral portal that enable it to be less infectious, potentially informing gene therapy applications for various diseases.
A proof-of-concept blood pressure app has been developed using iPhone optical and force sensors, rivalling arm-cuff readings. The app aims to improve hypertension awareness and control rates, potentially reducing cardiovascular disease and mortality.
A team of researchers discovered that nearly 90% of professionals in science, art, and film have at least one hot streak, with some having multiple. Despite no detectable change in productivity during hot streaks, their outputs are significantly better than the median.
Researchers found that toddlers aged 21-31 months prefer the high-status puppet in a conflict of interest scenario, but avoid the one that wins by force. This suggests that human nature is aware of social status and acknowledges it, unlike other primates.
A protein called Staufen1 accumulates in cells of patients with degenerative ataxia or amyotrophic lateral sclerosis (ALS), suggesting a potential therapeutic target. Depleting Staufen1 from affected mice improved symptoms, revealing a novel avenue for treating neurodegenerative diseases.
Researchers discovered that regulatory T-cells can inhibit the activity of telomerase in effector lymphocytes, causing telomere loss and cell death. This mechanism, based on physiological ageing of immune cells, has potential for treating autoimmune diseases and preventing implant rejection.
Researchers at the University of Colorado Anschutz Medical Campus have discovered that T cells elicited from subunit vaccines can reproduce without glucose, supporting their expansion and potentially defeating cancerous tumors. This finding has major implications for the development of immunotherapies for cancer patients.
Researchers have developed a technique to control individual molecules for a millionth of a billionth of a second, reducing reaction time by over two orders of magnitude. This breakthrough enables precise control over chemical reactions at the single molecule level, opening up new avenues for nanoscale research and discovery.
Researchers found that individuals with higher dispositional mindfulness exhibited greater deactivation of the posterior cingulate cortex and less activation in the default mode network. This led to reduced pain reports. The study suggests a neural basis for why some people may feel less pain than others.
A new study reveals that OLM cells in the hippocampus play a key role in controlling anxiety and risk-taking behavior. The manipulation of these cells can modulate anxiety and may lead to breakthroughs in treating pathological anxiety.
Researchers identified gene mutations that drive melanoma in dogs, which can inform treatment strategies for both species. The study found mutations in the PTPRJ tumor suppressor gene and cancer-activating mutations in the RAS gene, providing a genetic bridge between canine and human melanoma.
Jizhong Zhou receives the 2019 American Society for Microbiology Award for Environmental Research for groundbreaking discoveries in microbial ecology and environmental genomics. His work has transformed our understanding of microbial biodiversity and ecosystem functions.
A recent study by US Army Research Laboratory scientist Dr. James Schaffer and his collaborators found that users' subjective satisfaction with their decisions is strongly influenced by their cognitive state and traits, not just the system's user experience.
A recent study found that black adults are at higher risk for dangerous blood pressure spikes, with nearly 90% of those experiencing hypertensive crisis being black. The study also revealed that anemia and chronic kidney disease can increase the risk of hypertensive emergencies.
A recent study published in Nature Ecology & Evolution found that superbugs like MRSA have a complex evolutionary history, with cows being the source of strains causing human infections worldwide. The research highlights the importance of monitoring antibiotic resistance and developing strategies to minimize its spread.
Researchers have discovered two brain regions - the prefrontal cortex and hippocampus - whose activity patterns are characteristic of the process of forgetting. Voluntary forgetting enables humans to focus on tasks and is crucial for emotional wellbeing.
A new study found that coal-fired power plants require 13 times more land to be carbon neutral than solar panel manufacturing, making solar the more efficient option. To achieve carbon neutrality with coal, 89% of US land would need to be covered in forests or optimal crops.
Hurricane Olivia's eye is clearly visible in infrared imagery from NASA's Aqua satellite, surrounded by extremely cold cloud top temperatures of minus 63 degrees Fahrenheit. The storm is moving west-northwest at 15 mph with maximum sustained winds near 125 mph and is expected to weaken slowly through the weekend.
Researchers at Ural Federal University developed new adsorbents and enzymatic catalysts using modified halloysite nanotubular materials with unique functional properties. The breakthrough technology enables cost-effective extraction of non-ferrous metals and efficient biotechnological hydrolysis processes.
Researchers found that averaging two independent participants' results significantly improved screening accuracy for detecting rare objects in real-world contexts. This method reduces the likelihood of harmless items being wrongly flagged as suspicious and can be applied to various tasks, such as airport security and radiology.
Hurricane Norman is being battered by strong wind shear, causing it to weaken and move northwest of the Hawaiian Islands. The storm's maximum sustained winds are near 85 mph, with higher gusts and a large swell affecting east-facing shores.
A recent study highlights the potential for misinterpretation of Prostate-Specific Membrane Antigen (PSMA) PET results, which can affect diagnostic accuracy and guide therapy. Researchers urge nuclear medicine physicians to analyze PSMA-ligand uptake in conjunction with lesion localization to avoid misdiagnosis.
NASA's Aqua satellite detected Tropical Depression Gordon's center over Arkansas on September 7, with maximum sustained winds near 10 mph. The depression is expected to produce total rain accumulations of 3-6 inches, causing local flooding and flash flooding in Missouri and the Midwest.
Chronic diseases are linked to disrupted healing cycles caused by cellular miscommunication, preventing the completion of the natural healing process. This blocks the cycle, leading to persistent conditions like cancer, diabetes, and neurological disorders.
A new study published in the American Journal of Respiratory and Critical Care Medicine found that New York State's sepsis reporting mandate led to improved care and reduced mortality rates for critically ill patients. Patients who received standardized treatment protocols had shorter hospital stays and lower mortality rates.
A University of Exeter study found captive flamingos engage in significant foraging and roam more widely at night compared to daytime hours. The birds tend to be more active at night, mirroring their natural behavior in the wild, suggesting an innate need to remain active.
The TCS SP8 FALCON system enables fast fluorescence lifetime imaging and fluorescence correlation spectroscopy, allowing scientists to investigate protein environments with high accuracy. This technology facilitates advanced techniques in protein biology, including dynamic maps of protein interactions in living cells.
Scientists investigate the type characteristics of extreme precipitation events and their flood risk in the Yangtze-Huaihe River Valley. Persistent EPEs are linked to continuous flood peaks and severe floods. The study also identifies areas with high flood risk, particularly in rapidly urbanizing regions.
A new study from Linköping University in Sweden has found a significant association between lifetime sexual and physical abuse and the risk of sports-related injury in female athletes. The research highlights the importance of addressing emotional scars left by abuse to prevent overuse injuries.
Scientists developed a bioadhesive, wirelessly-powered implant emitting light to kill cancer cells, promising effective treatment for internal organ cancers. The device overcomes limitations of conventional photodynamic therapy by providing continuous, local light delivery.
Researchers will use drones to provide high-resolution mapping and imagery of eelgrass communities, engaging the public through citizen science. The project aims to understand environmental factors contributing to wasting disease in eelgrass and predict where it's likely to occur.
Researchers found that Hsp90 stimulates exosome release, a process linked to neurodegenerative diseases and cancer. This novel function could inform drug development for these conditions.
Scientists at the University of Bristol have developed protocell communities that can exhibit cooperative and antagonistic behavior by responding to a chemical signal. The study demonstrates a new approach to creating synthetic soft materials with life-like properties.