The CNIC study reveals two distinct mechanisms by which cells detect and respond to forces of varying strength, one mediated by caveolae and the other by newly discovered dolines. This finding has significant implications for understanding pathological processes such as atherosclerosis and neurodegenerative diseases.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalNature Cell Biology·TypeExperimental study·DateJan 2, 2023
Researchers have made a breakthrough in precision oncology for patients with metastatic urothelial carcinoma, identifying that certain cell surface molecules decrease or are absent in these patients, making them resistant to the new drug enfortumab vedotin.
SourceUniversitatsklinikum Bonn·JournalClinical Cancer Research·DateDec 30, 2022
A UMass Amherst microbiologist is working to develop new treatments for tuberculosis by targeting the bacteria's surface structure. The goal is to create a drug that can disrupt the cell envelope, making the bacteria vulnerable to attack.
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers have developed a simple mechanical model to understand how viruses replicate inside cells, highlighting the crucial role of virus size in this process. The optimal size range for efficient viral replication is suggested to be between 60nm and 100nm in diameter.
SourceUniversity of British Columbia·JournalJournal of The Royal Society Interface·TypeComputational simulation/modeling·DateDec 19, 2022
Researchers have developed a nano-scale platinum-cobalt alloy to reduce the need for rare and expensive platinum in hydrogen fuel cells, enhancing performance and stability. The new alloy achieves superior results at lower costs, paving the way for wider adoption of fuel-cell technology.
SourceParticuology·JournalParticuology·TypeExperimental study·DateDec 15, 2022
Researchers found that simultaneously targeting two signalling switches can severely inhibit tumour angiogenesis, cancer growth and metastasis in multiple models of cancer. This approach has the potential to restrict a cancer's ability to escape therapy by rapidly destroying the VEGF receptor when both receptors are targeted.
SourceUniversity of East Anglia·JournalCancer Research Communications·TypeExperimental study·DateDec 12, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Computational models of bacterial cell walls can predict interactions with antimicrobials, enabling rapid screening for effective molecules. The models reveal differences in cell wall permeability between Gram-negative and Gram-positive bacteria.
SourceIndian Institute of Science (IISc)·JournalBiointerphases·DateDec 7, 2022
A systematic review of 36 studies found that influenza vaccination reduced the risk of SARS-CoV-2 infection by 20% and poor outcomes like ICU admission and death by 17-31%. The findings suggest that routine influenza vaccination could offer non-specific immunity against COVID-19 symptoms.
SourceCactus Communications·JournalChinese Medical Journal·TypeMeta-analysis·DateNov 22, 2022
A study at the University of Gothenburg discovered a unique quick-closing valve in the aquaporins of climbing perch fish, allowing them to rapidly regulate water in their cells. This finding could lead to the development of new drugs for cancer and Alzheimer's disease by understanding how brain cell aquaporins function.
SourceUniversity of Gothenburg·JournalLife Science Alliance·DateNov 21, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers at Binghamton University discover that sodium/proton exchanger 1 (NHE1) and SWELL1 proteins regulate cancer cell migration, offering insights into metastasis. The study's findings could have wide implications for slowing down or halting the deadly disease.
SourceBinghamton University·JournalNature Communications·DateNov 8, 2022
Researchers developed a model to simulate red blood cell destruction in high shear flows, revealing acceleration as a major factor. They recommend adding flow buffers to VADs to reduce hemolysis, aiming to improve hydraulic performance and patient outcomes.
SourceAmerican Institute of Physics·JournalPhysics of Fluids·DateNov 1, 2022
Researchers at UNIGE have discovered a way to overcome resistance to chemotherapy in colorectal cancer, using an optimized combination of tyrosine kinase inhibitors. This breakthrough opens up new avenues for developing targeted therapies that can effectively treat patients with low five-year survival rates.
SourceUniversité de Genève·JournalCancers·TypeNews article·DateOct 27, 2022
Researchers at John Innes Centre found that amino acid waves, not calcium waves, mediate plant responses to stress. Glutamate released from wounds triggers a wave of calcium responses in plant tissues.
SourceJohn Innes Centre·JournalScience Advances·TypeExperimental study·DateOct 21, 2022
A recent study led by Dr. Luis Cuello and Alain J. Labro found that a known Shaker channel mutation differs structurally from its human counterparts, with implications for drug development and ion transport mechanisms. The research reveals a unique conformation of the W434F mutant that is distinct from wild-type channels.
SourceTexas Tech University Health Sciences Center·JournalScience Advances·TypeObservational study·DateOct 11, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A WVU biomedical engineer is working on a rapid diagnostic tool that can detect tick-borne infections such as Lyme disease via a blood sample on a single chip. The tool uses dielectrophoresis and machine-learning to detect diseases within one to two weeks after onset, reducing the risk of hospitalization and chronic conditions.
Researchers from the Institute of Physical Chemistry, Polish Academy of Sciences, have developed a novel polymer-based solution that enables easy delivery of large molecules to cells. By applying hypertonic solutions, they can induce osmotic stress and relax the cell membrane, allowing for precise control over molecule transfer.
SourceInstitute of Physical Chemistry of the Polish Academy of Sciences·JournalJournal of Colloid and Interface Science·DateSep 22, 2022
Researchers at Duke University have identified a previously unknown barrier that separates the bloodstream from smelling cells in the upper airway of mice, which may hinder the effectiveness of vaccines. The BOB barrier also allows antibody-secreting plasma cells to produce neutralizing antibodies locally.
SourceDuke University·JournalImmunity·TypeExperimental study·DateSep 21, 2022
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers at KAUST developed conductive membranes that stimulate microbial growth and separate biochemical products, reducing the CO2 conversion time from over 30 days to just one month. The membranes use nickel nanoparticles to catalyze hydrogen production, enhancing efficiency and stability in microbial electrosynthesis systems.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalChemical Engineering Journal·DateSep 20, 2022
A study by the University of Geneva team shows that disrupted circadian clocks lead to a rigidity in the membrane of pancreatic endocrine cells, affecting their function. The researchers also found that lipid profiles oscillate more during the day than previously thought, particularly in phospholipids and sphingolipids.
SourceUniversité de Genève·JournalPLOS Biology·TypeNews article·DateSep 19, 2022
Researchers at UNSW Sydney discovered that T cells use mechanical forces to propel lytic granules towards cancer cell membranes. The study found that the shape of the target membrane plays a crucial role in T cell-mediated cancer cell killing, with a bias towards outwardly curved membranes.
SourceUniversity of New South Wales·JournalDevelopmental Cell·TypeExperimental study·DateSep 15, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new study provides valuable insights into the roles of B cells and plasma cells in early-stage lung cancer biology, highlighting their influence on tumor development and treatment outcomes. The research also reveals environmental factors and molecular features that contribute to the landscape of infiltrating immune cells.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalCancer Discovery·DateSep 13, 2022
The study found that colloidal membranes transition from flat disc-like shapes to saddle-like shapes as the fraction of short rods increases. The saddles then merge into more complex structures like catenoids and four-noids, exhibiting properties similar to biological membranes.
SourceIndian Institute of Science (IISc)·JournalProceedings of the National Academy of Sciences·DateSep 12, 2022
Researchers at Duke University have discovered a protein called GarD that cloaks Chlamydia bacteria from the host cell's immune system, allowing it to evade detection and elimination. Mutating this protein makes the bacteria vulnerable to destruction, offering new avenues for treatment.
SourceDuke University·JournalCell Host & Microbe·TypeExperimental study·DateSep 8, 2022
Biochemists have discovered that glutathione, an antioxidant, plays a crucial role in moving iron-sulfur cofactors across cell membranes. This finding could lead to better understanding and treatment of diseases caused by impaired iron metabolism, such as Friedreich's ataxia.
SourceOhio State University·JournalNature Communications·TypeComputational simulation/modeling·DateSep 2, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers have developed a new labeling technique to analyze exosomes from specific cell types, providing insights into their role in both health and disease. The technique allows for the identification of protein cargo and RNA in exosomes, enabling the study of cellular communication and potential monitoring of response to treatment.
SourceMedical College of Georgia at Augusta University·JournalJournal of Extracellular Vesicles·DateAug 30, 2022
A study by Kumamoto University researchers found that a defective isoform of the SIGIRR gene activates an inflammatory pathway associated with cystic fibrosis. This defect leads to decreased expression and function of anti-inflammatory molecules, resulting in severe inflammation.
SourceKumamoto University·JournalInternational Journal of Molecular Sciences·TypeExperimental study·DateAug 26, 2022
A new class of light-activated hemithioindigo molecules developed by Rice University scientists kill specific Gram-positive bacteria and their biofilms. The molecules induce reactive oxygen species that chemically attack and destroy drug-resistant cells, offering a safer alternative to conventional antibiotics.
SourceRice University·JournalAdvanced Science·TypeExperimental study·DateAug 25, 2022
Research reveals that smaller artificial cells lead to greater separation of molecules, allowing for a new approach to manipulate material properties. This discovery has potential applications in pharmaceuticals and cosmetics industries.
SourceUniversity of Tokyo·JournalACS Materials Letters·TypeExperimental study·DateAug 24, 2022
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A study reveals that four nonexcitatory amino acids can cause irreversible brain destruction after a stroke or traumatic brain injury. The amino acids flood the brain cells, leading to swelling and cell death.
SourceMedical College of Georgia at Augusta University·JournalGlia·DateAug 23, 2022
The TMDU research team successfully transplanted a mini organoid into a patient with Ulcerative Colitis, showing potential for a radical cure. The treatment uses the patient's own cells and minimally invasive colonoscopy, reducing transplant rejection risk and laparotomy needs.
Researchers at Johns Hopkins Medicine discover that nasal cell receptors activate few G protein molecules to produce a signal, contradicting the mainstream idea of high amplification. The study found that the probability of an odorant receptor activating just one G protein is 1 in 10,000, supporting weak signaling.
SourceJohns Hopkins Medicine·JournalProceedings of the National Academy of Sciences·DateAug 18, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A new device replicates short sections of human blood vessels allowing for variable flow conditions that mimic the body. Researchers can now watch what's happening inside treated grafts down to individual cells.
SourceMcMaster University·JournalAdvanced Functional Materials·DateAug 11, 2022
A new study provides critical insights into the pGC-A membrane receptor, a vital component of cardiovascular regulation. The research offers a clearer understanding of this complex receptor and its signaling mechanisms, paving the way for new anti-hypertensive drugs.
SourceArizona State University·JournalScientific Reports·TypeExperimental study·DateAug 5, 2022
Researchers discovered that vitamin K acts as an antioxidant, inhibiting ferroptotic cell death and identifying FSP1 as the warfarin-insensitive enzyme responsible. This finding has implications for treating Alzheimer's disease and acute organ injuries.
SourceUniversity of Ottawa·JournalNature·TypeNews article·DateAug 3, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A new photoswitching fingerprint analysis overcomes the sub-10 nm resolution barrier in super-resolution microscopy, enabling the imaging of dynamic interactions with other molecules in cells. This breakthrough reveals molecular functions and architectures at the nanoscale, shedding light on cellular processes such as learning and memory.
SourceUniversity of Würzburg·JournalNature Methods·TypeExperimental study·DateAug 2, 2022
Scientists at La Jolla Institute for Immunology discover how gut barrier cells send secret messages to patrolling T cells, keeping them alive and active. The study sheds light on conditions like inflammatory bowel disease and highlights the importance of HVEM protein in maintaining a healthy gut microbiome.
SourceLa Jolla Institute for Immunology·JournalScience Immunology·TypeExperimental study·DateJul 29, 2022
A study published in Nature Physics reveals that specialized cell movement may explain the progression of cancer and cystic fibrosis. Cells with ruffled edges sense viscosity and adapt to increase their speed, moving faster through mucus than blood. This discovery sheds light on disease mechanisms and potential treatments.
SourceUniversity of Toronto·JournalNature Physics·TypeExperimental study·DateJul 25, 2022
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers have published the first-ever look at a key stage in the life cycles of measles and Nipah viruses, revealing how future therapies might stop these viruses. The study identifies how paramyxoviruses utilize a host cell lipid for viral spread, providing a new target for developing inhibitors of the assembly process.
SourceLa Jolla Institute for Immunology·JournalScience Advances·TypeExperimental study·DateJul 20, 2022
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
SourceXi'an Jiaotong-Liverpool University·JournalACS Nano·TypeExperimental study·DateJul 20, 2022
A team of researchers from Tokyo University of Science has developed a novel multi-proton carrier complex that shows efficient proton conductivity even at high temperatures. The resulting starburst-type metal complex acts as a proton transmitter, making it 6 times more potent than individual imidazole molecules.
SourceTokyo University of Science·JournalChemistry - A European Journal·TypeExperimental study·DateJul 18, 2022
Researchers at Tokyo Institute of Technology have successfully synthesized a synthetic mechanosensitive potassium channel, exhibiting stimuli responsiveness and selective ion transport. The new ion channel could lead to breakthroughs in therapeutic treatments for ion-channel related diseases.
SourceTokyo Institute of Technology·JournalJournal of the American Chemical Society·TypeExperimental study·DateJul 15, 2022
Researchers have found that high levels of iron can generate toxic free radicals, which damage lipids and ultimately lead to cell death. The team is exploring the use of compounds like JKE-1674 to induce ferroptosis in prostate cancer cells, making them more vulnerable to treatment.
SourceMedical College of Georgia at Augusta University·DateJul 7, 2022
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Using nearly two decades of research and ultrabright X-ray beams, scientists have created a detailed structural map of the nuclear pore complex (NPC), a key regulator of cellular operations. The results provide significant implications for understanding disease mechanisms and developing new treatments.
SourceDOE/Argonne National Laboratory·JournalScience·DateJul 6, 2022
The study reveals how the EGF receptor changes its shape when binding to its target, triggering cell growth and proliferation. The findings could lead to the design of new cancer drugs that evade resistance, says MIT chemist Gabriela Schlau-Cohen.
SourceMassachusetts Institute of Technology·JournalNature Communications·DateJul 6, 2022
Researchers at A*STAR's Institute of Molecular and Cell Biology developed a bio-functional thermogel that prevents retinal scarring in pre-clinical models. The thermogel modulates cellular behavior to prevent scar membrane formation, offering a novel therapy for proliferative vitreoretinopathy.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalNature·DateJul 4, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
The University of Houston research team has successfully developed a method for 3D printing organic semiconductor devices using multiphoton lithography, enabling the creation of highly conductive microstructures. The technology has potential applications in emerging fields such as nanoelectronics and bioelectronics.
SourceUniversity of Houston·JournalAdvanced Materials·DateJun 24, 2022
Scientists at UC Santa Barbara have discovered a novel membraneless organelle called BAG2 condensate that can sweep up faulty proteins, including tau protein associated with Alzheimer's disease. The discovery could lead to new treatments for neurodegenerative conditions by targeting misfolded proteins before they cause damage.
SourceUniversity of California - Santa Barbara·JournalNature Communications·DateJun 13, 2022
Researchers have used high-speed 4D neutron computed tomography to visualize the three-dimensional water distribution within fuel cells. This allows for optimized channel design and increased efficiency, as excess water can be drained without compromising membrane integrity.
SourceHelmholtz-Zentrum Berlin für Materialien und Energie·JournalNature Communications·TypeExperimental study·DateJun 3, 2022
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers at Johns Hopkins Medicine discovered a molecular connector, BASP1, that helps cocaine latch on to brain cells, even at low doses. This finding may explain why women are more susceptible to cocaine addiction and could lead to new treatments.
SourceJohns Hopkins Medicine·JournalProceedings of the National Academy of Sciences·DateJun 2, 2022
Researchers at Rice University have developed molecular machines that can kill bacteria using visible light, targeting gram-negative and gram-positive bacteria. The breakthrough study uses rotors spinning at millions of times per second to break up biofilms and persister cells, making these infections more treatable.
SourceRice University·JournalScience Advances·TypeExperimental study·DateJun 1, 2022
Researchers at the Lew lab have created a novel hardware and algorithm that enables visualization of cell membranes and molecular motions in six dimensions. This breakthrough allows for the observation of 3D structures with additional information on molecular orientation, providing new insights into biological systems.
SourceWashington University in St. Louis·JournalOptica·TypeComputational simulation/modeling·DateMay 26, 2022
A Brazilian group developed a peptide called Rb4 that triggers necrosis in murine melanoma cells and inhibits the viability of human cancer cells. In mice, Rb4 reduced lung metastasis and slowed subcutaneous melanoma growth, increasing survival by 25%.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalScientific Reports·DateMay 20, 2022
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A UNIGE team discovered that cells in curved tissues swell by 50% before returning to normal, opening avenues for in vitro organ culture. This active phenomenon can be harnessed to control spontaneous growth of organoids and develop new materials with volume increase upon folding.
SourceUniversité de Genève·JournalDevelopmental Cell·TypeNews article·DateMay 13, 2022
A Kyoto University study has discovered that c-type natriuretic peptide facilitates intracellular calcium signaling in chondrocytes to stimulate long bone growth. This finding may lead to the development of new bone growth-stimulating agents for treating developmental disorders.
SourceKyoto University·JournalCell Biology·TypeExperimental study·DateMay 12, 2022
Researchers created synthetic proteoglycans to dissect their functions in health and disease, discovering new insights into their roles in early cell development and cancer cell spreading. They found that both GAG chains and core proteins contribute to proteoglycan function.
SourceScripps Research Institute·JournalNature Chemical Biology·DateMay 12, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers found significantly higher levels of MMP-2 and MMP-8 in tracheal aspirate samples from COVID-19 patients, contributing to inflammation and tissue damage. The study's findings suggest a novel mechanism underlying severe lung complications and potential new therapeutic targets.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalBiomolecules·DateMay 12, 2022
A team of researchers from Kumamoto University has developed a transformable polyrotaxane carrier that can facilitate genome editing using Cas9RNP with high efficiency. The carrier, called amino-PRX, is multi-step transformable and has low cytotoxicity, making it an enormously promising candidate for safe and efficient delivery.
SourceKumamoto University·JournalApplied Materials Today·TypeExperimental study·DateMay 11, 2022
Researchers at Arizona State University have designed and constructed artificial membrane channels using DNA, allowing selective transport of ions, proteins, and cargo. The channels can be opened and closed with a lock and key mechanism, enabling diverse scientific domains such as biosensing and drug delivery applications.
SourceArizona State University·JournalNature Communications·TypeExperimental study·DateMay 10, 2022
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
The study found that gut microbiota releases membrane vesicles containing bacterial DNA, which triggers the cytosolic cGAS-STING-IFN-I axis to protect distal organs against viral infections. Antibiotic treatment impairs this ability, making mice more susceptible to viral infections.
Researchers found phosphatidylinositol bisphosphate (PIP2) essential for epithelial cell-cell adhesion and maintaining cellular identity. PIP2 regulates epithelial properties by recruiting Par3 to the plasma membrane, facilitating the formation of adherens junctions and preventing epithelial-mesenchymal transformation.
SourceTokyo University of Science·JournalNature Communications·TypeExperimental study·DateMay 9, 2022