Articles tagged with Cell Membranes
Researchers have discovered that palmitoylation can occur at the plasma membrane, paving the way for innovative drug discovery strategies. A novel tool, SwissKASH, allows for dynamic observation of this process, enabling precise targeting of oncogenic proteins in cancer therapy.
A research team revealed the mechanism of oxygen activation on Barium-containing perovskite materials. The study discovered that BaO/BaO2 nanoparticles precipitated on the surface of Ba-containing materials under high-temperature oxygen-rich conditions had ultra-high activity for oxygen activation.
Researchers developed a light-controllable time-domain digital coding metasurface that can manipulate microwave reflection spectra by time-varying light signals. The metasurface platform produces harmonics based on phase modulation, generating symmetrical harmonics and white-noiselike spectra.
Researchers developed new method to visualize CNS fibroblasts and their intercellular interactions in the CNS. The technique provides a detailed picture of CNS fibroblasts, including their location, size, morphology, and gene/protein expression patterns.
Researchers at Boston University have developed optoacoustic neurostimulation with single neuron and subcellular level precision. Optoacoustic neuromodulation may offer advantages over ultrasonic neuromodulation, including higher spatial temporal resolution.
A team of biochemists at the University of Groningen discovered that membrane thickness, lipid phase, and sterol type are key factors in determining permeability. This knowledge can help companies optimize microbial production and improve drug design.
Researchers at Jacobs University have developed a novel method for drug delivery using boron clusters, enabling efficient transport of bioactive substances into cells. The breakthrough has potential applications in overcoming antibiotic resistance and delivering innovative therapeutics, such as peptides and protein-based drugs.
A new study led by Kelly Monaghan at West Virginia University suggests that interrupting the immune response may improve multiple sclerosis outcomes. The researchers found that targeting a specific protein called CCL17 can prevent the disease from attacking the central nervous system, leading to milder symptoms and delayed paralysis.
The John Innes Centre researchers identified the role of the signaling protein CaM2, which regulates calcium channels and shapes calcium signals. This led to accelerated calcium frequency, earlier signaling with bacteria, and enhanced root nodule symbiosis in engineered legume roots.
Scientists developed a natural antibacterial texture inspired by insect wings, killing up to 70% of bacteria. The innovation aims to reduce food waste, particularly in meat and dairy exports, and extend the shelf life of packaged food.
Researchers have discovered an essential role of LCOR in enabling cancer cells to present tumour antigens, making them visible to the immune system. This approach increases the success of immunotherapy in triple-negative breast cancer, a subtype with low treatment response rates.
Researchers at Northwestern University discovered key structures controlling methane conversion in methane-eating bacteria, enabling potential human-made biological catalysts. The findings may lead to biotechnological applications such as harnessing methane from fracking sites or cleaning up oil spills.
Scientists have found complex signaling pathways in cells, using a technique called fluorescence microscopy to visualize nanodomains beneath the cell membrane. These domains can be thought of as pop-up factories that process signals from receptors on the cell surface.
Researchers found that the Klotho gene can suppress glioblastoma cell viability and induce apoptosis, leading to a significant decrease in tumor growth. The study contributes to the development of new diagnostic and treatment approaches for malignant brain tumors.
Researchers have found that autophagy helps form epithelial syncytia during wound healing, a process previously only observed in muscle and placenta development. This discovery highlights the importance of understanding autophagy's role in disease mechanisms.
Researchers have found that two receptors on the surface of endothelial cells come together to enable new blood vessel growth. The discovery reveals a new connection between copper metabolism and angiogenesis, highlighting CTR1 as a potential therapeutic target for conditions like ischemic heart disease.
Researchers discovered that bacteria suppress membrane protein transport in response to stress, using alarm hormones to regulate the process. This allows the microorganisms to slow down their cellular processes and recover when conditions become more favorable.
Researchers at Bielefeld University have identified five key characteristics of mitosis in the microalga Volvox carteri, including a porous nuclear envelope and crucial centrosome function. They used confocal laser scanning microscopy to capture high-resolution images of live cell division and gain insights into the complex process.
Researchers found that sugar-decorated proteins in mucus can bind to the coronavirus, keeping it from infecting cells. This discovery may explain why SARS-CoV-2 is more likely to spread through airborne droplets rather than surface transmission.
A joint research team from Peking University developed a fine-scale library of pH-sensitive polymeric nanoprobes to accurately measure acidification levels of virus-infected cell membranes or viral envelopes. The polymer, GPS6.8, has broad-spectrum and efficient antiviral effects.
Researchers at Scripps Research have revealed the three-dimensional structure of Flycatcher1, a protein channel in Venus flytraps that enables snapping shut. The structure shows similarities to other mechanosensitive ion channels found in various organisms, including plants and bacteria.
A novel immune-profiling method can return detailed immune cell type proportions using only DNA from blood, potentially allowing for individualized prediction of outcomes in immunotherapy patients. This approach offers the opportunity to ask and answer questions about the immune system in health and disease.
A study led by Przemyslaw Nogly at PSI has detailed insight into the mechanism of a light-driven chloride pump in bacteria, revealing how light energy converts to kinetic energy and transports chloride ions inside cells. The pump uses two molecular gates to ensure one-way transport, with the process taking around 100 milliseconds.
A new study from USF Health reveals that activated protein C may help improve aging patients' tolerance to reperfusion injury, a potentially adverse effect of treatment for ischemic heart disease. The researchers suggest that drugs derived from APC may limit ischemia and reperfusion-induced heart damage.
Scientists have identified hundreds of proteins constantly transported throughout healthy brain cells, offering a new understanding of neurological diseases like Alzheimer's and autism. The discovery reveals how protein transport goes awry in these conditions, paving the way for future research into intercellular communication.
Researchers at TTUHSC developed novel hydrophilic nanoparticles that target bacterial membranes, killing pathogens while sparing mammalian cells. The nanoantibiotics' size-dependent activity reveals a new blueprint for developing non-toxic and environmentally friendly antibiotics.
Researchers have developed a cream that prevents frostbite injuries in mice when applied to the skin before severe cold exposure. The cream, called SynAFP, reduces frostbite wound size and speeds healing compared to no treatment. Further studies are needed to determine its effects on humans.
An international team led by the University of Ottawa has published findings on the importance of the enzyme GCN5 in maintaining muscle integrity. The study discovered that GCN5 plays a crucial role in boosting the expression of key structural proteins, notably dystrophin.
A new study published in Developmental Cell reveals the mechanism of membrane curvature that allows cells to form pockets to capture substances. The researchers used high-resolution fluorescence imaging to watch these pockets form within live cells, providing a clearer understanding of how cells 'eat' and consume substances.
Researchers at Goethe University and the Max Planck Institute of Biophysics have gained new insights into how mitochondrial complex I facilitates proton transfer through water molecules. The study's high-resolution structure data enabled computer simulations that shed light on the protein's dynamics during its catalytic cycle.
Researchers have identified a novel immune-like mechanism by which healthy epithelial cells recognize and eliminate precancerous cells through a MHC class I-LILRB3 interaction. This process generates mechanical force to extrude the precancerous cells from the body, offering new hope for cancer prevention and treatment.
Researchers at the University of Bath have optimised a peptide that prevents alpha-synuclein misfolding, a key feature of Parkinson's disease. The new molecule, 4654W(N6A), has shown significant promise in lab experiments and could lead to the development of a disease-modifying treatment.
A flexible and easy-to-use micropen setup is capable of directly writing on surfaces to a microprecise level. The device allows for the printing of microarrays, lines, curves, and other structures in real-time using biomaterial or conductive ink.
Scientists discovered that fungal endophytes convert chitin to chitosan, a natural plant defense activator, to evade host defense. This conversion enables the fungus to live in symbiotic association with grasses, protecting them from biotic and abiotic stresses.
Researchers at MIT observed the intricate choreography of butterfly scales forming during metamorphosis, revealing a shingle-like pattern and nanometer-high ridges. The findings could inform the design of new materials like iridescent windows and waterproof textiles.
Researchers found that people with ALS have higher levels of arachidonic acid, a lipid involved in inflammation, and that tampering with this pathway can reduce muscle-weakening symptoms. The study suggests that targeting the arachidonic acid pathway may offer potential new therapies for Lou Gehrig's disease.
A study with lab-grown mouse cells reveals that lamin C plays a key role in maintaining the structural network under the cell's nucleus, ensuring proper DNA organization. This finding has significant implications for diagnosing and treating genetic disorders linked to DNA disorganization, such as progeria and muscular dystrophy.
Researchers developed a hybrid membrane using graphene oxide and tungsten trioxide nanoparticles to reduce vanadium ion permeation in VRFBs. The new membrane shows high ion selectivity, improving Coulombic and energy efficiency compared to commercial membranes.
Researchers at Okinawa Institute of Science and Technology (OIST) have developed a system to study cellular reactions in a way that more closely reflects how molecules behave in a living cell. By mixing a polymer with protein, they created membraneless droplets that can mimic the molecular properties of how molecules move in the cell.
Research identifies way of using nanoparticles to target and disrupt bacterial cells, making them more susceptible to standard antibiotic treatments. Laboratory studies show a strong effect in killing a range of bacteria, including some linked to hospital-acquired infections.
Research reveals that cancer cells have softer membranes than normal cells, but stiffening them can prevent abnormal changes in structure and motility. Stiffened breast cancer cells lost the ability to spread to the lungs in mouse experiments, suggesting a potential strategy for cancer treatments.
A team of scientists at KAUST has developed a novel approach for cleaning biofouled membranes in anaerobic bioreactors, combining UV irradiation with bacteriophages to eliminate bacteria. The method improved upon individual treatments and was proven effective over four cleaning cycles.
A postgenomic study reveals that an enriched environment stimulates sensory perceptions by regulating synapses and altering lipid metabolism. The researchers found 178 proteins and 20 lipids to be significantly regulated depending on the environmental condition.
Researchers identified a protein leakage related to chronic airway diseases, which restricts breathing. Decreasing this leakage could improve asthma and COPD management by relaxing airways.
A pilot study found improvements in memory, motor function, and processing skills in healthy individuals after receiving transcranial photobiomodulation therapy. The therapy, involving infrared light, has the potential to alleviate nerve cell damage and reduce symptoms of dementia.
The study assesses how temperature influences droplet size in elastic matrices, providing insights into biological molecule arrangement and condensate formation. It also explores the role of phase separation and its effect on droplet growth.
Researchers found that asymptomatic patients may not produce significant IgG antibodies, but rather a different kind of antibody count that can indicate disease severity. The study suggests using the ratio of these two counts as a marker to determine if a person has had COVID-19.
Researchers found glycerin, a natural ingredient in many skin lotions, reduces psoriasis symptoms by calming scaly patches and promoting healthy skin cell maturation. The study's results support anecdotal reports from patients with psoriasis, providing objective evidence of glycerin's effectiveness in combatting the condition.
Researchers at IOCB Prague have developed a novel antibacterial material called NANO-LPPO that can prevent infection and facilitate treatment of skin wounds. The material combines lipophosphonoxins with a nonwoven nanotextile, which releases active substances in response to bacterial presence.
Researchers at Uppsala University found that allergic stimulation activates mast cell precursor cells, which can produce cytokine IL-13 contributing to asthma development. This challenges the idea that only mature immune cells are involved in immune reactions.
Researchers have found a protein called CD47 on the surface of infected cells that may protect them from immune system recognition, resulting in more severe disease. High CD47 levels are associated with higher risk factors for severe COVID-19, including age and diabetes.
Researchers at the University of São Paulo found that a hypertonic saline solution can inhibit SARS-CoV-2 replication by up to 88% in human epithelial lung cells. The study suggests that the use of such a solution could contribute to the development of novel prophylactic interventions or treatments for COVID-19.
Actin filaments generate pushing forces to move the cell membrane. The capping protein regulates filament growth, promoting branching near the membrane through the Arp2/3 complex. A high-resolution structure reveals that capping protein blocks nucleation-promoting factors via a tiny 'tentacle' extension.
Researchers discover that sudden cardiac episodes are caused by a combination of genetic mutations and chemical modifications in heart cells. The study uses new technology to manipulate the protein, demonstrating that phosphorylation can affect its function, particularly when paired with mutations.
Researchers have determined the structure of a molecule that helps S. pneumoniae take up manganese, a mineral essential for its survival. This finding could aid in designing new drugs to block this pathway and deny the bacteria its manganese supply.
Scientists create a cell culture system where blood vessels can grow within a framework made of synthetic materials. The team investigates material properties that promote blood vessel formation and refines the model to improve its performance, paving the way for growing implantable tissues.
Researchers found a mutation in ELOVL4 enzyme impairs communication between neurons, leading to impaired motor control and coordination. The study provides new insights into the essential role of ELOVL4 in motor function and synaptic plasticity, suggesting potential therapeutic strategies for patients with spinocerebellar ataxia.
Researchers at the University of Warwick have discovered a protein called 'curly' that can bend the cytoskeleton of cells, twisting them into different shapes. This finding opens up new possibilities for engineering cells and understanding how they replicate.
A new technology developed at KAUST uses waste heat from solar cells to desalinate seawater, improving efficiency by up to 8% while reducing solar cell temperature. The device features a gravity-driven system and a special fabric that wicks away solid salts and minerals.
Researchers found changes in erythrocyte morphology and nanoparticles on cell surfaces during radiation therapy, which may indicate treatment effectiveness or prognosis. The study suggests that analyzing these changes could lead to the development of a diagnostic method for assessing RT efficacy.