Articles tagged with Cell Proliferation
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A Goethe University-led study reveals how mutations in the SPRTN enzyme cause chronic inflammation and premature ageing. The research team found that damaged DNA in the cell nucleus leaks into the cytoplasm, activating defense mechanisms and leading to chronic inflammation.
Researchers at OIST have discovered that certain cancers can 'lose their sense of time' to avoid cellular stress responses. The study highlights the role of USP28 in stabilizing p53, a known tumor suppressor, and how mutations in this protein can disrupt its function.
Scientists have discovered a protein called SCEP3 that ensures even chromosome segregation in plants, preventing infertility and genetic diseases. This finding has implications for plant breeding and understanding human fertility, with the equivalent gene SIX6OS1 potentially playing a role in promoting correct chromosome segregation.
Researchers have identified a novel principle in biology that mathematically explains why the growth of organisms slows as nutrients become more abundant. The global constraint principle unifies two classic biological laws and provides a fresh perspective for looking at growth across all forms of life.
AcCELLerate has partnered with ATCC to provide customized Master, Working, and assay-ready instaCELL banks for research clients. Researchers will gain access to high-quality, authenticated cell lines with increased assay reproducibility.
Researchers discovered that a collective of epithelial cells can work together to sense beyond their direct environment, up to 100 microns away. This new ability allows cancer cells to migrate and evade detection with enhanced precision, making it a potential target for therapy.
A recent study found that menin promotes bladder cancer malignancy by enhancing TFAP2C/β-catenin signaling, suggesting its potential as a therapeutic target and prognostic marker. Menin upregulates TFAP2C expression, which regulates β-catenin gene transcription via binding to its proximal promoter.
Researchers developed a machine learning model that accounts for biological variability to identify optimal formulations for serum-free culture media. The model achieved approximately 1.6-fold higher cell density compared to commercially available products.
Researchers at the Salk Institute have identified dozens of microproteins that play a crucial role in regulating fat cell proliferation and lipid accumulation. This breakthrough discovery offers new potential drug targets for treating obesity and metabolic disorders, building on recent advances in CRISPR gene editing technologies.
Researchers identified a new strategy to repair damaged heart tissue by reactivating the PSAT1 gene through synthetic modified messenger RNA. The study found that mice treated with PSAT1-modRNA showed robust increases in cardiomyocyte proliferation, reduced tissue scarring, and improved heart function.
Researchers have discovered a key role of centrosomes in signaling cells to proliferate despite DNA damage, enabling cancer resistance. The study suggests targeting Polo-like kinase 1 could prevent adaptation to therapy-induced DNA damage and drug resistance.
Researchers developed an AI tool called AAnet to characterize cancer cell diversity, identifying five distinct cell groups with different gene expression profiles. This could lead to more targeted therapies and improved patient outcomes.
Researchers developed a systems approach to measuring organelle changes in living cells as they grow. The study found that certain organelles grow faster than others and that the vacuole plays a key role in buffering the cell against randomness.
Researchers at CNIC uncover how the heart forms during earliest embryonic development, shedding light on congenital heart defects and regenerative medicine. The heart originates from two separate cell populations that coordinate their formation simultaneously.
Dr. Cara Boutte is studying how certain bacteria grow by building their cell walls, which could lead to more effective antibiotics. Understanding this growth pattern could help scientists develop targeted and effective treatments for infections like tuberculosis.
Researchers at MIT developed a method to quickly measure cell density, which can predict whether immunotherapies will work in patients or how tumors will respond to drug treatment. The technique uses a combined microfluidic device and fluorescent microscope to measure up to 30,000 cells in an hour.
A team of researchers has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer. The study highlights how the metabolic environment of tumors influences T cell function, opening new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
Researchers at City of Hope discovered that mutated cells can persist for years without becoming cancer and require an additional inflammatory push for malignancy to occur. Chronic inflammation is a key trigger for tumor formation, making it essential to avoid situations like high-fat diets and obesity.
Researchers uncover a universal mechanism by which CDK7 controls human cell proliferation, shutting down key transcription factors within minutes. This breakthrough could lead to more precise cancer therapies with less collateral damage.
GTF3C2 expression is upregulated in HCC tissues, promoting tumor growth and poor survival outcomes. The GTF3C2/USP21/MEK2/ERK1/2 pathway regulates HCC cell proliferation and tumor growth.
This study investigates TNIP1's role in regulating cell proliferation and apoptosis in breast cancer. TNIP1 knockdown was found to induce growth arrest and activate the NF-κB pathway, leading to increased apoptosis in breast cancer cells. The findings highlight TNIP1 as a crucial marker for breast cancer therapies.
Researchers at Osaka Metropolitan University assessed target genes in canine hepatocellular carcinoma (HCC) to develop molecular targeted therapies. The study identified potential gene targets, including PDGFB, which may improve treatment options for unresectable HCC.
A University of Ottawa neuroscientist has led a Canadian research team to discover how neural stem cells integrate signals from different cell types and decode them. The study found that low daughter cell numbers trigger activation, while high numbers keep them in quiescence, offering new insights into cellular relationships and potent...
Researchers at Texas A&M University have uncovered a mechanism behind cancer progression: the stiffening of tumor cell's environment. This spreading causes increased cell proliferation and tumor growth.
A recent study has identified Kif23 as a key regulator of embryonic brain development, highlighting its potential link to microcephaly. The research found that Kif23 is essential for neural progenitor cell proliferation and differentiation, with deficiency leading to decreased cell growth and increased apoptosis.
Researchers at Osaka Metropolitan University found that suppression of Pcdh8 is essential for proper notochord elongation in zebrafish embryos. This study may lead to novel tumor therapies in humans due to the gene's role in controlling cell proliferation.
Researchers at Tokyo University of Science have successfully captured viral infection process under a light microscope using the giant Mimivirus. The footage showcases the proliferation of the virus and its release from cells, highlighting its biological significance in ecosystems.
A new University of Cincinnati Cancer Center study reveals how copper helps clear cell renal cell carcinoma cells grow and advance. Copper accumulation is associated with worse outcomes for patients with ccRCC, and it boosts energy and growth in cancer cells.
Researchers found a link between non-functional p53 genes and the regenerative cell state in ulcerative colitis, leading to cancer progression. A new diagnostic test could identify aberrant cells earlier using molecular tools.
A glitch in protein synthesis, known as stop codon readthrough, may affect tumour growth and cancer cell proliferation. The study found that preventing this process can lead to increased degradation of target proteins and a delayed cell cycle, resulting in slower tumour growth.
Scientists identified key changes in chromosome structure and gene expression that affect stem cell function during aging. Blocking a specific gene, ced-6, triggered stem cell exhaustion at any age, indicating a general process that maintains balance when proliferation is too high.
A new study reveals a link between senescent cells and the protein HIRA, which helps pack and unpack DNA. The research team discovered that HIRA is necessary for the cells to begin emitting inflammatory molecules, leading to chronic inflammation in the body.
Texas A&M researchers are investigating the use of extracellular vesicles to deliver immune-suppressing proteins, potentially reducing the immune system's attack on insulin-producing beta-cells. The goal is to develop a novel treatment for type 1 diabetes, which currently has only lifelong insulin therapy as an approved option.
Researchers at CUNY ASRC identify distinct histone tag in adult oligodendrocyte progenitor cells that regulates their proliferation and may lead to innovative therapies for neurodegenerative diseases. The discovery holds promise for advancing myelin repair and improving patient outcomes.
Researchers found that cell nuclei control tissue stiffness and ordering in eye and brain tissues, revealing a new role for the nucleus in organ formation. This discovery challenges existing views on tissue organization and has implications for understanding diseases associated with impaired architecture.
Researchers found that hyperactivated neurons drive cancer proliferation and that serotonin uptake by ependymoma cells promotes tumor growth. Inhibiting this process blocked tumor growth, opening doors for drug discovery.
A distinct TNF-α signaling program has been identified as a key driver of epithelial cancer development, contributing to cell proliferation and invasion. The researchers found that this program is active in both normal tissues and tumors, but its level of activity correlates with tumor aggressiveness.
Researchers explore various immunotherapies, including immune checkpoint inhibitors and adoptive cell therapies, as promising treatments for hepatocellular carcinoma. The review aims to overcome current limitations of targeted therapies by regulating the body's immune systems.
A team of researchers has discovered a mechanism by which the liver's immune cells are suppressed in chronic hepatitis B, leading to organ damage. The 'sleep timer' function allows immune cells to weaken their activity over time, preventing them from proliferating excessively and causing further damage.
Researchers investigate chemical modifications to genetic regulation mechanisms, finding that Set8 controls gene activity through a mechanism other than histone modification. This study refines our understanding of genetic regulation relevant to human diseases like cancer.
Research reveals that pregnancy-related brain impairment affects live-bearing fish, particularly in decision-making and sensory reception. Unlike mammals, pregnant fish show decreased cell proliferation in olfactory regions, compromising scent interpretation.
A growth factor called BMP7 has been found to promote cardiomyocyte proliferation and regeneration in both zebrafish and adult mice. This discovery offers a promising new approach to treating heart disease by stimulating cardiac muscle cell regrowth even in later stages of life.
Researchers found that miR-377 reduces MYC mRNA levels, leading to increased Bax and PTEN expression and decreased CDK4. This results in induced apoptosis, inhibited proliferation, and arrested cell cycle in prostate cancer cells.
The study investigates the anticancer potential of CLK kinase inhibitors 1C8 and GPS167, which inhibit CLOCK kinases and affect cancer cell proliferation. The compounds also alter the expression and alternative splicing of transcripts involved in EMT and antiviral immune response.
Researchers at Goethe University Frankfurt have discovered thalidomide derivatives that target and degrade BCL-2, a protein essential for the survival of cancer cells. The derivatives bind to CRBN, reprogramming its binding surface to mark BCL-2 for degradation, ultimately leading to cell death.
Researchers have uncovered a novel regulator governing how cells respond to mechanical cues, finding that ETV4 bridges cell density dynamics to stem cell differentiation. This discovery has significant implications for controlling cancer cells through mechanical cues.
Researchers employ a geology tool to analyze hydrogen atoms in cancer cells, finding a distinct ratio compared to healthy tissue. This discovery may lead to new ways to spot cancer early on and inform strategies for studying its growth and spread.
Researchers investigate senescence phenotypes of human corneal endothelial cells upon treatment with ultraviolet (UV)-A. Cells exhibit enlarged morphology, increased β-galactosidase activity and decreased proliferation. UV-A-induced senescent cells show similar gene expression profiles to ionizing radiation (IR)-induced cells.
Researchers developed novel therapeutic bispecific antibodies targeting IgM and B-cell surface antigens, which directly inhibited cell proliferation via cell-cycle arrest and apoptosis in vitro. These findings suggest that anti-IgM/B-cell surface antigen-binding specific antibodies are promising therapeutic agents for B-cell malignancies.
Researchers discovered MIA-602's effectiveness against Doxorubicin-resistant acute myeloid leukemia (AML), demonstrating reduced cell viability and tumor volume. The study suggests MIA-602 as a potential alternative treatment approach for AML, potentially circumventing chemotherapy side effects.
The European LeukemiaNet has published two-part guidelines for adult acute lymphoblastic leukemia treatment, covering diagnostics, prognostic factors, response assessments, and comprehensive management. These recommendations are based on a decade of systematic work by European experts, improving the prognosis of adult patients with ALL.
Researchers have uncovered the molecular and ultrastructural features of BCAS1+ cells in diffuse gliomas, highlighting their proliferative capacity and distribution. The study provides a comprehensive characterization of the BCAS1+ cell population within diffuse gliomas, shedding light on its role in tumor malignancy.
Next-generation mobile networks are being optimized for increased data loads and faster speeds using AI-driven techniques. The technology enables instantaneous communications between devices and the environment.
Cancer stem cell-derived exosomes (CSC-Exos) are essential for communication between CSCs and other cells in the tumor microenvironment, contributing to cancer progression. The editorial highlights their potential as a novel clinical tool for diagnosis, prognosis, prevention of tumor recurrence, and therapeutic strategy
Researchers identified Benidipine as a compound promoting the death of cigarette smoke-induced senescent lung cells, improving lung emphysema. The dihydropyridine family of calcium channel blockers constitutes a new class of senolytics that could improve lung diseases.
Researchers at Goethe University Frankfurt have identified a specific gene locus, MYNRL15, that is critical to the survival and replication of leukemia cells. Inhibiting this gene has been shown to deactivate genes necessary for AML cell survival, offering a new possibility for fighting leukemia.
Researchers have identified a new therapeutic target for pulmonary hypertension treatment by discovering an epigenetic pathway mediated via the protein SPHK2 that can reduce and potentially reverse vascular remodeling. This discovery offers new hope for treating pulmonary hypertension, which is a complex and often fatal condition.
A preclinical study by Weill Cornell Medicine researchers reveals that activating a pathway to promote cell division can expand insulin-producing cells without impairing their function. The study's findings support the concept that beta cell mass can be expanded without compromising function.
Scientists have developed a technique to restore the function of human-derived GPCR proteins in yeast cells, which could accelerate research and lead to more effective treatments. The approach, using error-prone polymerase chain reaction, introduces random mutations that enhance protein stability and function.
Macrophages produce polyamines spermidine and spermine, which benefit epithelial cells, promoting their proliferation and defense mechanisms. This "commensal metabolism" supports the efficient self-renewal of the intestinal epithelium.