Articles tagged with Cell Proliferation
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers identified abnormal keratin expression patterns in senescent ocular surface cells, which may contribute to severe ocular surface diseases. Gene expression profiles showed substantial differences between senescent and non-senescent cells, highlighting their potential role in pathology.
Researchers created a comprehensive index of human cells mapping sizes and abundance across the entire body. The study reveals surprising mathematical patterns underlying cell size and number, challenging fundamental understanding of cell growth and proliferation.
Researchers at UArizona Cancer Center have discovered a new class of iron-targeting compounds that exploit the iron dependency of malignant cells. These compounds could lead to the development of broad-spectrum, anticancer drugs targeting iron metabolism.
Imaging mass cytometry showcases odd numbers of proteins in kidneys of lupus patients, identifying novel markers for disease. The study found decreased and increased disease markers pointing to renal disease, with potential enlargement of glomeruli in some patients.
A recent study elucidated the role of EGF and its downstream signaling cascade in controlling oral keratinocyte behavior, offering new insights for pharmacological manipulation. The findings suggest that activating the EGF/EGFR pathway can enhance oral keratinocyte motility and proliferation.
Researchers have made a groundbreaking discovery in the developmental biology of Parhyale hawaiensis, a tiny crustacean with unique appendages. By tracking the development of an embryo, they found that cells divide and reorient themselves to maintain alignment with the head-tail axis, resulting in a robust and coordinated body structure.
Researchers have found a compound that can prevent cisplatin-induced renal toxicity and improve the outcomes of cancer treatment. The aromatic ketone 2',4',6'-trihydroxyacetophenone (THA) inhibits the CCBL1-mediated metabolism of cisplatin, reducing its toxic effects without affecting its potency.
A research team at Göttingen University has discovered that mobile and stationary cells have different mechanical properties due to their cytoskeleton. The study found that intermediate filaments, which are crucial for cell stability, exhibit metal-like plasticity when stretched, similar to non-biological materials.
Researchers found that GPR141 enhances cell migration and proliferation in breast cancer by activating the p-mTOR/p53 signaling pathway. Silencing GPR141 restores p53 expression and attenuates tumor growth, suggesting its role in regulating breast cancer progression and metastasis.
Scientists have defined a basic toolkit for forming tubular organs in animals, which is thought to be the foundation of organ development in vertebrates. The study uses the sea star as a model organism and reveals that cells can proliferate and migrate simultaneously during tube formation.
CARMN is a long noncoding RNA that regulates contractility in both blood vessels and the gastrointestinal tract. Without CARMN, mice cannot survive due to impaired GI tract contraction, leading to conditions like intestinal pseudo-obstruction.
Researchers review current treatment updates for systemic light chain (AL) amyloidosis, highlighting the need for early diagnosis and effective maintenance therapy. The article discusses the relationship between AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS), emphasizing the importance of regular monitoring.
A Finnish mitochondrial disease, GRACILE syndrome, exhibits cancer-like changes in cell proliferation, leading to premature ageing. Researchers have identified the c-MYC protein as a key player in this process, and a ketogenic diet has shown promise in reducing excessive cell growth.
Researchers found that when FXR1 is absent, vascular smooth muscle cells proliferate more slowly, become senescent, and scar tissue development is reduced. This suggests that drugs targeting FXR1 may treat vascular proliferative diseases such as atherosclerosis, restenosis, hypertension, and abdominal aortic aneurysm.
Researchers discuss rapamycin's potential to delay cancer onset by slowing cell proliferation and tumor progression. The mTOR pathway is involved in both cancer and aging, making rapamycin a promising chemopreventive agent.
Researchers generated a POLDIP2 knockout ARPE-19 cell line and found reduced mitochondrial superoxide levels, consistent with upregulated SOD2. The study demonstrates a potential role of POLDIP2 in regulating oxidative stress in AMD.
A WPI researcher is leading a three-year project to investigate the effects of stretching and blood flow on cardiovascular cells in tissue-engineered heart valves. The project aims to expand understanding of mechanical forces that propel cells in the body, with potential applications in other fields like cancer and wound healing.
Researchers identified high expression of glypican-1 in primary solid tumors, correlating with poor prognosis in various cancer types. Suppression of GPC1 attenuated cancer cell proliferation, suggesting its potential as a novel diagnostic tool and target for therapy.
Researchers discover a mechanism for shaping tissue boundaries during Arabidopsis root vascular tissue development. Positionally biased cell proliferation generates anisotropic compressive stress field, symmetrizing the boundary between xylem and procambium cells.
Researchers discover that inhibiting a gene crucial for DNA production can significantly reduce destructive cell proliferation and disease progression in pulmonary hypertension. This finding presents a potential treatment target for the condition, which affects females aged 30-60 with limited treatment options.
Scientists create hybrid composite scaffolds with aligned nanofibrous architectures to improve cell seeding efficiency, proliferation rates, and morphogenesis. The findings have potential applications in tissue repairing and regenerative medicine.
A recent study analyzed 7,301 metastatic breast cancer patients with MTAP loss, revealing younger age, higher TNBC cases, and BRCA1 mutations. The findings also suggest potential therapeutic agents targeting PRMT5 and MTA2 in MTAP-deficient cancers.
Glioblastoma patients have a median survival time of 15 months due to the rapid infiltration of brain tissue. Cellular senescence, previously thought to be only a marker of aging, is now linked to cancer progression, with senescent cells promoting tumor growth and immune evasion.
Researchers found that clearance of p16Ink4a-positive cells did not impact β-cell mass, but improved β-cell function and proliferative capacity in a subset of HFD mice. The targeted subpopulation of β-cells is non-proliferative and non-SASP producing.
Regulatory T cells suppress self-reactive T cells by controlling protein synthesis, maintaining immune tolerance and preventing autoimmunity. A small molecule inhibitor called RocA also shows promise in mitigating inflammatory responses.
Researchers found that female patients with diffuse large B-cell lymphoma treated in the afternoon had reduced mortality rates and cancer recurrence compared to those treated in the morning. The study suggests that timing chemotherapy delivery according to an individual's circadian clock may improve treatment outcomes.
Researchers from Tokyo Metropolitan University have discovered a protein called PDGF-B that not only promotes muscle growth but also enhances myotube maturation, leading to increased contractile strength. The findings offer a game-changing approach to treating muscle injuries and atrophy.
Researchers at La Jolla Institute for Immunology have discovered that OGT regulates mTOR, a key protein for mitochondrial powerhouses, keeping cells healthy. The study may lead to important medical advances in understanding cancers, diabetes, and cardiovascular disease.
Researchers have developed a system using microvesicles from algae that promote skin cell proliferation and migration, leading to increased collagen synthesis. The findings show promising results for the treatment of wounds and skin regeneration.
Researchers identified key metabolic pathways in tumor-associated macrophages that contribute to cancer development and progression. Targeting these pathways may provide a new perspective for immunotherapy-based cancer treatments.
Researchers at Washington University in St. Louis demonstrated that eukaryotic cells can control organelle size by exhibiting random bursts of growth, maintaining a narrow window of precision within this noise., The study suggests a biophysical mechanism for the robustness and universality of organelle size control.
The study shows that RXR ensures hematopoietic stem cells remain youthful and fit, reducing the risk of developing myeloproliferative syndromes. The regulatory action of RXR on these cells is essential for maintaining a balanced production of blood cell types throughout life.
A new review paper discusses the role of CDK4 in regulating the cell cycle and its involvement in cancer. The study highlights the importance of CDK4/6 inhibitors as treatments for ER+ breast cancer and their potential utility in multiple tumor types.
Researchers found that MK256 induced differentiation and maturation in leukemia stem cells, inhibiting proliferation of AML cell lines. The study also showed dose-dependent inhibition of the STAT pathway in both in vitro and in vivo studies.
Researchers found that overexpressing matriptase reduced myeloma cell proliferation and inhibited migration. Matriptase also blocked Src kinase activation, supporting its potential as a tumor suppressor in multiple myeloma. The study provides new insights into the role of matriptase in hematological malignancies.
The study reveals fundamental differences in cell regulation and energy metabolism between the mountain hare and brown hare, correlating with their distinct evolutionary histories. These findings provide insights into how genomic differences translate into adaptive phenotypic differences between species.
Researchers at UNIGE have discovered a way to overcome resistance to chemotherapy in colorectal cancer, using an optimized combination of tyrosine kinase inhibitors. This breakthrough opens up new avenues for developing targeted therapies that can effectively treat patients with low five-year survival rates.
A new experimental drug has shown promising results in treating liver cancer, with two patients experiencing a partial response to the treatment. The drug, NMS-01940153E, targets an enzyme that plays a critical role in cell division and growth, and its side effects are manageable.
A study from Tokyo Medical and Dental University reveals that the TGF-β signaling molecule can induce EMT in oral cancer cells, leading to high motility and metastatic potential. KRTAP2-3 expression is associated with poorer overall survival, suggesting its role as a prognostic biomarker.
Researchers at LSU Health New Orleans have identified a new drug target for triple-negative breast cancer, which lacks estrogen and progesterone receptors. The novel small molecule inhibitor NSC33353 works synergistically with doxorubicin to suppress the growth of TNBC cells.
Researchers aim to understand the role of FAK in promoting key changes in vascular smooth muscle cells that contribute to atherosclerosis. Preliminary evidence suggests that inhibiting FAK may block VSMC transdifferentiation and promote plaque stability.
A new epigenetics drug, tazemetostat, has been found to stop bladder cancer growth by activating the immune system, not just inhibiting tumors. The drug targets the EZH2 gene and is being tested in clinical trials for late-stage bladder cancer.
Researchers at NUS have developed a method to produce cell-based meat using magnetic pulses, reducing reliance on animal products and increasing efficiency. This technology has the potential to revolutionize the food industry and improve regenerative medicine by stimulating the growth of healthy cells.
Researchers at UVA Health System have made a groundbreaking discovery that could boost platelet production on demand to alleviate blood shortages. The finding offers hope for patients with thrombocytopenia and those receiving cord-blood transplants.
A team from UNIGE and HUG identified a protein regulation mechanism that reduces melanoma cells' capacity to adapt and resist treatment. They found that targeting this mechanism with an enzyme inhibitor reduces therapeutic resistance in all melanoma cells.
Researchers discovered a type of triple-negative breast cancer cell that can trigger dormancy, evading therapies and allowing for efficient survival in distant organs. This finding highlights the need for more selective therapeutic strategies targeting both dividing and invasive dormant cells.
A study at Washington State University has identified sulfatase-2 as a critical protein driving damage caused by rheumatoid arthritis. The discovery sheds light on molecular processes behind inflammation in the disease and could lead to improved treatments.
Researchers used artificial intelligence to demonstrate the correlation between cytoskeleton organisation and nuclear position in eukaryotic cells. The study successfully predicted the presence and location of nuclei in over 8,000 cells with high accuracy, transforming the way scientists approach complex biological systems.
A new study from the University of Alabama at Birmingham reveals how impaired metabolism due to mutations in succinate dehydrogenase B disables a normal bioenergetic sensing mechanism, leading to uncontrolled cell proliferation. This discovery sheds light on how cancer cells divide despite having a less efficient energy production.
Researchers develop NMR spectroscopy method with amplifier for accurate protein detection at physiological concentrations. This allows study of protein dynamics and behavior at native levels, shedding light on cell proliferation to tumor growth.
ARID1A-deficient bladder cancers are sensitive to combination therapies with the EZH2 inhibitor GSK-126 and inhibitors of PI3K, acting synergistically. The research found that tumors deficient in ARID1A protein have elevated levels of PIK3R3 and phosphoAKT.
A new study published in PLOS Biology reveals the significance of kinesins in basic cellular processes needed for malaria parasite development, multiplication and invasion. Researchers found that eight out of nine kinesins present in the parasite genome are required for cell proliferation to cell movement in mosquito hosts.
Researchers investigate astrocyte production in the brain, discovering distinct dynamics in different parts of the cortex. The study suggests that early exposure to specific genes regulates stem cell behavior, leading to variations in astrocyte generation.
Abemaciclib, a CDK4 & 6 inhibitor, showed profound inhibition of cell proliferation and triggered senescence and apoptosis in breast cancer cells. Continuous dosing provided sustained inhibition with irreversible effects through apoptosis, supporting the differentiated safety and efficacy profile.
Researchers identified immune endothelial cells promoting inflammation and developmental endothelial cells supporting cell development, regeneration, and proliferation. The study's findings may lead to targeted treatments for lung infections and acute respiratory distress syndrome.
A team of researchers has found a way to block the replication of one strain of the influenza virus in human cells by inhibiting a specific protein modification process called SUMOylation. This breakthrough could lead to highly effective treatments for the flu and other respiratory viruses.
Researchers found that severe asthma patients produce growth factors that block corticosteroids from working, leading to frequent breathing problems. This discovery may lead to new treatments targeting these growth factors to improve outcomes for patients with severe asthma.
A recent study published in Pharmaceutics suggests that berberine can suppress the proliferation of lung cancer cells, reduce airway inflammation, and modulate genes involved in inflammation. The researchers used liquid crystalline nanoparticles to enhance safety and effectiveness.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
A new mathematical theory explains how cells navigate the risk-speed tradeoff when dividing, balancing risk and speed to ensure survival. The theory applies broadly to all organisms, despite differences between yeast and mammalian cells.