Articles tagged with Cell Proliferation
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A molecular switch, p57, enables stomach stem cells to change allegiance from normal digestion to injury response, potentially leading to new treatments for gastric pathologies. The study's findings suggest that p57 is a key regulator of reserve stem cell state in gastric chief cells.
Researchers at Terasaki Institute for Biomedical Innovation have developed a flexible, antibacterial conductive hydrogel-ePatch that accelerates wound healing with minimal side effects. The e-Patch uses silver nanowires and alginate to promote cell proliferation and migration, resulting in faster wound closure and reduced scarring.
Researchers at Massachusetts General Hospital discovered that non-dividing colon cancer cells employ Warburg glycolysis to reduce toxic reactive oxygen species accumulation. This adaptation challenges the long-held dogma of the Warburg effect, highlighting the need for single-cell level analysis tools.
A new study led by Kelly Monaghan at West Virginia University suggests that interrupting the immune response may improve multiple sclerosis outcomes. The researchers found that targeting a specific protein called CCL17 can prevent the disease from attacking the central nervous system, leading to milder symptoms and delayed paralysis.
Researchers have identified a single gene, FOXG1, that can control brain cell growth in humans. The discovery provides hope for developing new treatments for neurodevelopmental disorders and stopping brain tumor cells from growing.
A new phenomenon was discovered where increased pressure leads to a sudden burst of rapid and coordinated cellular motion, spraying outwards from the tumour. This fluid-like pushing mechanism can kill cancer cells but also enables them to survive and multiply in new environments.
Researchers at Niigata University identified a novel Olig2 binding protein called Ddx20, which regulates RNA metabolism and transcription. Ddx20's interaction with Olig2 helps maintain cell survival and prevents apoptosis in neural progenitor cells.
Researchers from Tokyo Tech elucidated the molecular evolution of NRK, revealing a novel mechanism regulating placental development by modulating the CK2-PTEN-AKT pathway. The study showed that NRK underwent rapid molecular evolution to acquire its function in eutherian ancestors.
Researchers discovered that a transcription factor called MUTE induces a cell cycle inhibitor SMR4 to slow down the cell cycle, allowing for asymmetric division. A variant with excess SMR4 showed a longer cell cycle during symmetric division, revealing a crucial regulatory mechanism in plant stomatal development.
Research reveals YME1L protein balances cellular proliferation and quiescence in neural stem cells. Defects lead to premature conversion of stem cells into neurons, impairing long-term neural regeneration.
Researchers have developed a new therapeutic approach to block mutated RAS proteins, which are frequently found in cancers. The method, using small molecules, has the potential to work with multiple mutant forms of RAS in various types of cancers, including pancreatic, lung, and colorectal cancers.
Pulmonary lymphangioleiomyomatosis (LAM) is a rare cancer affecting up to 1 in 1 million women worldwide, characterized by uncontrolled tumor cell growth. Researchers aim to identify new therapeutic targets using extracellular vesicles, with the goal of developing new therapies for LAM patients.
A new study reveals that histone H3.3 plays a crucial role in maintaining the balance between self-renewal and differentiation of blood stem cells, leading to abnormalities when deleted. The protein anchors key epigenetic marks at developmental genes and endogenous retroviruses, contributing to an inflammatory response and skewed produ...
Breakthrough research reveals Tuberous Sclerosis Complex arises from human-specific progenitor cells, explaining its pathology. Human-derived cerebral organoid models shed light on complex brain development and potential mechanisms for other diseases.
Researchers used optical imaging to study the metabolic interactions between pancreatic cancer cells and surrounding non-cancer cells. They found that cancer cells can hijack the metabolic activity of these non-cancer cells to fuel tumor growth. This discovery could lead to new therapies targeting the tumor microenvironment.
A new model suggests that cell-to-cell communication plays a crucial role in determining cell fate, particularly in the development of blood cell types. This finding has significant implications for understanding cancer development and identifying leukemia cells of origin.
Researchers have discovered that intestinal bacteria can lead to more severe adhesions after abdominal surgery. The study found that mesothelial cells and EGFR signaling play a crucial role in the formation of these adhesions. The findings suggest that targeting EGFR may be a potential approach to reducing adhesion risk.
Researchers identified specific metabolic vulnerabilities in leukemia cell lines, including sensitivity to PI3K and fatty acid synthase inhibitors. The study highlights the potential for targeted cancer therapy by exploiting these dependencies.
Researchers at the University of Vermont have created the first living robots capable of reproducing, using AI-designed Xenobots. This groundbreaking achievement has significant implications for regenerative medicine, as it demonstrates a new form of biological self-replication.
Researchers used CRISPR gene-editing tools to show that a gene controlling bone growth in fish fins plays the same role in forming fingers and toes in four-legged creatures. The study suggests that the last common ancestor between ray- and lobe-finned fish already had the genetic toolkit to shape their appendages.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
A study investigates the role of the TGF-β/SOX9 axis in promoting cancer migration and invasion in oral squamous cell carcinoma. The research found that CAF-induced TGF-β1 upregulates SOX9 expression, leading to increased cancer invasiveness and poor prognosis. The findings suggest a potential therapeutic target for developing novel tr...
A new study provides evidence supporting the involvement of aquaporins in corneal cell proliferation and nerve regeneration, suggesting AQP5 induction as a potential therapy to accelerate corneal defect resurfacing. The study found that AQP5 deficiency can slow down corneal epithelial repair, but its specific mechanism remained unclear.
Researchers investigated the oncogenicity of human LAT1 in NIH/3T3 cells, finding it to be a promising anti-cancer target. Anti-LAT1 monoclonal antibodies inhibited cell proliferation and tumor growth, suggesting LAT1's potential for therapeutic development.
Researchers identified LAPAS1 as a novel E2F-regulated lncRNA that plays a role in human cancer and regulates cell-cycle progression and cell proliferation. Inhibition of LAPAS1 expression delays cell progression through S phase and inhibits proliferation of human cancer cells.
Reactive oxygen species (ROS) are naturally produced during biochemical reactions within cells. They can induce apoptosis by activating cell death pathways, but high levels can promote cell proliferation and tumor progression.
Scientists from UNIGE and UZH used a statistical physics approach to study wound healing, identifying the scales of dominant cell interactions that govern tissue growth. The results allow for better analysis of cell front behavior in both healthy tissue and tumour development.
Researchers identified how Wnt proteins orchestrate cell communication and patterning of body axis, revealing the role of Vangl2 in regulating cytoneme formation. Long and branched cytonemes reinforce distant Wnt signalling, leading to altered body axis patterning.
Researchers found that skeletal muscle satellite cells proliferate better in low glucose environments, contrary to conventional wisdom. This discovery could lead to significant breakthroughs in biomedical research and the development of new treatments for muscle loss associated with diabetes.
In mice, blood vessel cells produce factor that stimulates blood stem cells, maintaining their self-renewal capacity. However, production of this factor ceases with aging, leading to loss of self-renewal ability and weakening of the immune system.
Researchers describe an alternative mechanism for the placement of potassium ion channels in cardiac cell membranes, which is crucial for heart function and may contribute to cardiovascular diseases. This discovery could lead to a better understanding of cardiac physiology and the development of new treatments for related disorders.
A study published in Scientific Reports reveals the dopamine D2 receptor plays a crucial role in modulating Wnt expression and controlling cell proliferation, which may lead to new therapeutics for nephrology, endocrinology, and psychiatry. The findings also have implications for the development of precision medicine.
An international study used human retinal cells to demonstrate how the Toxoplasma parasite creates a distinctive eye lesion. Researchers identified proteins produced from infected cells that push neighboring uninfected cells to overgrow and create a characteristic lesion.
Scientists found that Nqo1 is necessary for liver cancer cells' ability to thrive by activating key pathways. Blocking Nqo1 dramatically suppresses liver cancer cell proliferation.
Research shows that branched actin transmits information to cells about their environment and regulates growth, a mechanism that can be targeted to fight certain types of cancer. Inhibiting branched actin formation prevents the growth of melanoma cells, offering new therapeutic options.
A new study in The FASEB Journal reveals that AICAr inhibits cell proliferation and has cytotoxic potential for childhood ALL cells by regulating nucleotide metabolism. The researchers confirm that Acadesine's inhibition of cell proliferation is independent of AMPK activation, but dependent on P53.
The study reveals that the WD40 repeats in AND-1 prevent nascent DNA cleavage by a nuclease, allowing for successful cell division. The discovery highlights the crucial function of AND-1 in protecting replicated DNA from degradation during replication and cell proliferation.
A new study reveals how KSHV protein LANA drives chromosomal instability, promoting cell proliferation and aneuploidy. The findings identify NNLS as a promising target for antiviral therapies.
Researchers found that fibroblast growth factor 2 (FGF2) promotes sperm production by expanding a subset of spermatogonial stem cells. FGF2 also acts on the testicular microenvironment to facilitate retinoic acid action, revealing its novel function in mouse testis.
Researchers at Kanazawa University identified a molecule called Spred1 that supports blood-cell production during dietary stress. In contrast, Spred1 deficiency promotes HSC self-renewal and resistance to physiological stress, but also increases the risk of certain cancers.
Scientists found that a small daily dose of Viagra significantly reduces colorectal cancer risk in genetically predisposed animal models. The drug works by increasing levels of cyclic GMP, which suppresses excessive cell proliferation and promotes normal cell differentiation.
The study reveals that protein ZO-1 perceives mechanical signals and activates cellular responses accordingly, influencing epithelial cell proliferation and differentiation. Targeted inhibition of ZO-1 in tumors could be a potential pathway to explore for cancer treatment.
Researchers at the University of Arizona found that even with perfect natural selection, aging would still occur due to cancer cells cheating the system. Slowing down one type of cell can lead to an increase in another problematic cell type, making it mathematically impossible to halt aging.
A subspecies of the bacterium Streptococcus gallolyticus actively promotes the development of colorectal cancer by driving CRC cell proliferation through β-catenin cell signaling. The study found that infected mice developed more tumors and greater β-catenin production than control mice.
Researchers discovered a novel epigenetic signaling axis involving PRC1, microRNA, and PRC2 that regulates the self-renewal and proliferation of neural stem/progenitor cells. The study found that Ezh2 represses miR-203 expression, which negatively regulates self-renewal and proliferation but promotes neuronal differentiation.
Researchers at Scripps Research Institute uncover how a protein called angiomotin regulates the Hippo-YAP pathway, a key signaling system in cells that controls cell growth and division. The study sheds light on the protein's role in cancer development and provides new insights into the mechanisms underlying diseases such as fibrosis.
The SETD8 enzyme regulates cellular senescence, a process where cells stop proliferating due to age or stress. Lowering SETD8 increases protein synthesis and growth arrest in senescent cells, promoting metabolic activities.
Physicists at Bielefeld University develop new nanoinjection method that increases survival rate of cells to 92%, surpassing traditional microinjection's 40% success rate. The technique enables precise delivery of fluorescent molecules into living cells, opening up new possibilities for cellular research and experimentation.
Researchers at Uppsala University have found a new principle for epigenetic changes, involving the tryptase enzyme that cleaves histone tails. This mechanism is crucial for maintaining cellular identity and preventing uncontrolled cell proliferation.
Research reveals that mutations in succinate dehydrogenase lead to distinct disease phenotypes, with tumors showing loss of complex I and impaired cellular fitness. Neurodegeneration, on the other hand, does not result in loss of complex I, leading to a metabolically different phenotype.
Researchers discovered a new mechanism explaining BPH development, linking inflammation and cell proliferation. Deleting the androgen receptor in prostate epithelial cells triggers an inflammatory response promoting luminal cell proliferation.
Researchers investigated the impact of vitamin D on vascular access outcomes in patients with chronic kidney disease, revealing potential benefits for reducing RAAS activity. Vitamin D deficiency has been linked to cardiovascular diseases, including CKD and ESRD-related complications.
Researchers at University of Tsukuba discover that dying epithelial cells suppress proliferation of regulatory T cells, promoting inflammation. Beneficial bacteria in the gut can help Treg cell proliferation, but this effect is blocked by apoptotic epithelial cells.
A new study reveals that chromosomes undergo a transformation in senescent cells, with some genes moving into more restrictive compartments. This change affects gene expression and may have implications for health conditions such as aging and cancer.
A study led by Mount Sinai researchers identifies zinc finger protein 217 (ZFP217) as a factor that regulates stem cell self-renewal and differentiation, potentially balancing medically useful qualities for therapeutic applications. The discovery builds on understanding epigenetic mechanisms controlling gene expression.
Researchers at RIKEN have discovered a method to maintain immune cells in a stem cell-like state by inhibiting differentiation, allowing them to proliferate extensively. This breakthrough could lead to the development of new treatments for regenerative medicine and immune therapy.
San Diego State University researchers have developed a way to use biotechnology to rejuvenate cardiac progenitor cells, which replicate indefinitely into new heart cells. By overexpressing an enzyme associated with cancer cell growth, they've shown promise in increasing cell proliferation and lifespan in mice, as well as human tissue.
Researchers developed a screening test to measure mutant huntingtin protein seeding in cerebrospinal fluid, distinguishing symptomatic Huntington's patients from gene carriers. This assay may accelerate the development of new drugs to treat this incurable disease by blocking cell-to-cell seeding.
Researchers at Instituto Gulbenkian de Ciencia discovered that proteins controlling cellular rigidity can induce the activation of factors promoting tumor growth. The study found that changes in the cell's skeleton dynamics lead to rearrangements in filaments, resulting in faster cell proliferation and tissue overgrowth.
Researchers discovered two potential therapeutic targets to treat pulmonary arterial hypertension, a deadly disease marked by high blood pressure in the lungs. The targets involve suppressing abnormal proliferation of smooth muscle cells and signaling molecules involved in the disease.