Articles tagged with Cell Proliferation
A team from UNIGE and HUG identified a protein regulation mechanism that reduces melanoma cells' capacity to adapt and resist treatment. They found that targeting this mechanism with an enzyme inhibitor reduces therapeutic resistance in all melanoma cells.
Researchers discovered a type of triple-negative breast cancer cell that can trigger dormancy, evading therapies and allowing for efficient survival in distant organs. This finding highlights the need for more selective therapeutic strategies targeting both dividing and invasive dormant cells.
A study at Washington State University has identified sulfatase-2 as a critical protein driving damage caused by rheumatoid arthritis. The discovery sheds light on molecular processes behind inflammation in the disease and could lead to improved treatments.
Researchers used artificial intelligence to demonstrate the correlation between cytoskeleton organisation and nuclear position in eukaryotic cells. The study successfully predicted the presence and location of nuclei in over 8,000 cells with high accuracy, transforming the way scientists approach complex biological systems.
A new study from the University of Alabama at Birmingham reveals how impaired metabolism due to mutations in succinate dehydrogenase B disables a normal bioenergetic sensing mechanism, leading to uncontrolled cell proliferation. This discovery sheds light on how cancer cells divide despite having a less efficient energy production.
Researchers develop NMR spectroscopy method with amplifier for accurate protein detection at physiological concentrations. This allows study of protein dynamics and behavior at native levels, shedding light on cell proliferation to tumor growth.
ARID1A-deficient bladder cancers are sensitive to combination therapies with the EZH2 inhibitor GSK-126 and inhibitors of PI3K, acting synergistically. The research found that tumors deficient in ARID1A protein have elevated levels of PIK3R3 and phosphoAKT.
A new study published in PLOS Biology reveals the significance of kinesins in basic cellular processes needed for malaria parasite development, multiplication and invasion. Researchers found that eight out of nine kinesins present in the parasite genome are required for cell proliferation to cell movement in mosquito hosts.
Researchers investigate astrocyte production in the brain, discovering distinct dynamics in different parts of the cortex. The study suggests that early exposure to specific genes regulates stem cell behavior, leading to variations in astrocyte generation.
Abemaciclib, a CDK4 & 6 inhibitor, showed profound inhibition of cell proliferation and triggered senescence and apoptosis in breast cancer cells. Continuous dosing provided sustained inhibition with irreversible effects through apoptosis, supporting the differentiated safety and efficacy profile.
Researchers identified immune endothelial cells promoting inflammation and developmental endothelial cells supporting cell development, regeneration, and proliferation. The study's findings may lead to targeted treatments for lung infections and acute respiratory distress syndrome.
A team of researchers has found a way to block the replication of one strain of the influenza virus in human cells by inhibiting a specific protein modification process called SUMOylation. This breakthrough could lead to highly effective treatments for the flu and other respiratory viruses.
Researchers found that severe asthma patients produce growth factors that block corticosteroids from working, leading to frequent breathing problems. This discovery may lead to new treatments targeting these growth factors to improve outcomes for patients with severe asthma.
A recent study published in Pharmaceutics suggests that berberine can suppress the proliferation of lung cancer cells, reduce airway inflammation, and modulate genes involved in inflammation. The researchers used liquid crystalline nanoparticles to enhance safety and effectiveness.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
A new mathematical theory explains how cells navigate the risk-speed tradeoff when dividing, balancing risk and speed to ensure survival. The theory applies broadly to all organisms, despite differences between yeast and mammalian cells.
A molecular switch, p57, enables stomach stem cells to change allegiance from normal digestion to injury response, potentially leading to new treatments for gastric pathologies. The study's findings suggest that p57 is a key regulator of reserve stem cell state in gastric chief cells.
Researchers at Terasaki Institute for Biomedical Innovation have developed a flexible, antibacterial conductive hydrogel-ePatch that accelerates wound healing with minimal side effects. The e-Patch uses silver nanowires and alginate to promote cell proliferation and migration, resulting in faster wound closure and reduced scarring.
Researchers at Massachusetts General Hospital discovered that non-dividing colon cancer cells employ Warburg glycolysis to reduce toxic reactive oxygen species accumulation. This adaptation challenges the long-held dogma of the Warburg effect, highlighting the need for single-cell level analysis tools.
A new study led by Kelly Monaghan at West Virginia University suggests that interrupting the immune response may improve multiple sclerosis outcomes. The researchers found that targeting a specific protein called CCL17 can prevent the disease from attacking the central nervous system, leading to milder symptoms and delayed paralysis.
Researchers have identified a single gene, FOXG1, that can control brain cell growth in humans. The discovery provides hope for developing new treatments for neurodevelopmental disorders and stopping brain tumor cells from growing.
A new phenomenon was discovered where increased pressure leads to a sudden burst of rapid and coordinated cellular motion, spraying outwards from the tumour. This fluid-like pushing mechanism can kill cancer cells but also enables them to survive and multiply in new environments.
Researchers at Niigata University identified a novel Olig2 binding protein called Ddx20, which regulates RNA metabolism and transcription. Ddx20's interaction with Olig2 helps maintain cell survival and prevents apoptosis in neural progenitor cells.
Researchers from Tokyo Tech elucidated the molecular evolution of NRK, revealing a novel mechanism regulating placental development by modulating the CK2-PTEN-AKT pathway. The study showed that NRK underwent rapid molecular evolution to acquire its function in eutherian ancestors.
Researchers discovered that a transcription factor called MUTE induces a cell cycle inhibitor SMR4 to slow down the cell cycle, allowing for asymmetric division. A variant with excess SMR4 showed a longer cell cycle during symmetric division, revealing a crucial regulatory mechanism in plant stomatal development.
Research reveals YME1L protein balances cellular proliferation and quiescence in neural stem cells. Defects lead to premature conversion of stem cells into neurons, impairing long-term neural regeneration.
Researchers have developed a new therapeutic approach to block mutated RAS proteins, which are frequently found in cancers. The method, using small molecules, has the potential to work with multiple mutant forms of RAS in various types of cancers, including pancreatic, lung, and colorectal cancers.
Pulmonary lymphangioleiomyomatosis (LAM) is a rare cancer affecting up to 1 in 1 million women worldwide, characterized by uncontrolled tumor cell growth. Researchers aim to identify new therapeutic targets using extracellular vesicles, with the goal of developing new therapies for LAM patients.
A new study reveals that histone H3.3 plays a crucial role in maintaining the balance between self-renewal and differentiation of blood stem cells, leading to abnormalities when deleted. The protein anchors key epigenetic marks at developmental genes and endogenous retroviruses, contributing to an inflammatory response and skewed produ...
Breakthrough research reveals Tuberous Sclerosis Complex arises from human-specific progenitor cells, explaining its pathology. Human-derived cerebral organoid models shed light on complex brain development and potential mechanisms for other diseases.
Researchers used optical imaging to study the metabolic interactions between pancreatic cancer cells and surrounding non-cancer cells. They found that cancer cells can hijack the metabolic activity of these non-cancer cells to fuel tumor growth. This discovery could lead to new therapies targeting the tumor microenvironment.
A new model suggests that cell-to-cell communication plays a crucial role in determining cell fate, particularly in the development of blood cell types. This finding has significant implications for understanding cancer development and identifying leukemia cells of origin.
Researchers have discovered that intestinal bacteria can lead to more severe adhesions after abdominal surgery. The study found that mesothelial cells and EGFR signaling play a crucial role in the formation of these adhesions. The findings suggest that targeting EGFR may be a potential approach to reducing adhesion risk.
Researchers identified specific metabolic vulnerabilities in leukemia cell lines, including sensitivity to PI3K and fatty acid synthase inhibitors. The study highlights the potential for targeted cancer therapy by exploiting these dependencies.
Researchers at the University of Vermont have created the first living robots capable of reproducing, using AI-designed Xenobots. This groundbreaking achievement has significant implications for regenerative medicine, as it demonstrates a new form of biological self-replication.
Researchers used CRISPR gene-editing tools to show that a gene controlling bone growth in fish fins plays the same role in forming fingers and toes in four-legged creatures. The study suggests that the last common ancestor between ray- and lobe-finned fish already had the genetic toolkit to shape their appendages.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
A study investigates the role of the TGF-β/SOX9 axis in promoting cancer migration and invasion in oral squamous cell carcinoma. The research found that CAF-induced TGF-β1 upregulates SOX9 expression, leading to increased cancer invasiveness and poor prognosis. The findings suggest a potential therapeutic target for developing novel tr...
A new study provides evidence supporting the involvement of aquaporins in corneal cell proliferation and nerve regeneration, suggesting AQP5 induction as a potential therapy to accelerate corneal defect resurfacing. The study found that AQP5 deficiency can slow down corneal epithelial repair, but its specific mechanism remained unclear.
Researchers investigated the oncogenicity of human LAT1 in NIH/3T3 cells, finding it to be a promising anti-cancer target. Anti-LAT1 monoclonal antibodies inhibited cell proliferation and tumor growth, suggesting LAT1's potential for therapeutic development.
Researchers identified LAPAS1 as a novel E2F-regulated lncRNA that plays a role in human cancer and regulates cell-cycle progression and cell proliferation. Inhibition of LAPAS1 expression delays cell progression through S phase and inhibits proliferation of human cancer cells.
Reactive oxygen species (ROS) are naturally produced during biochemical reactions within cells. They can induce apoptosis by activating cell death pathways, but high levels can promote cell proliferation and tumor progression.
Scientists from UNIGE and UZH used a statistical physics approach to study wound healing, identifying the scales of dominant cell interactions that govern tissue growth. The results allow for better analysis of cell front behavior in both healthy tissue and tumour development.
Researchers identified how Wnt proteins orchestrate cell communication and patterning of body axis, revealing the role of Vangl2 in regulating cytoneme formation. Long and branched cytonemes reinforce distant Wnt signalling, leading to altered body axis patterning.
Researchers found that skeletal muscle satellite cells proliferate better in low glucose environments, contrary to conventional wisdom. This discovery could lead to significant breakthroughs in biomedical research and the development of new treatments for muscle loss associated with diabetes.
In mice, blood vessel cells produce factor that stimulates blood stem cells, maintaining their self-renewal capacity. However, production of this factor ceases with aging, leading to loss of self-renewal ability and weakening of the immune system.
Researchers describe an alternative mechanism for the placement of potassium ion channels in cardiac cell membranes, which is crucial for heart function and may contribute to cardiovascular diseases. This discovery could lead to a better understanding of cardiac physiology and the development of new treatments for related disorders.
A study published in Scientific Reports reveals the dopamine D2 receptor plays a crucial role in modulating Wnt expression and controlling cell proliferation, which may lead to new therapeutics for nephrology, endocrinology, and psychiatry. The findings also have implications for the development of precision medicine.
An international study used human retinal cells to demonstrate how the Toxoplasma parasite creates a distinctive eye lesion. Researchers identified proteins produced from infected cells that push neighboring uninfected cells to overgrow and create a characteristic lesion.
Scientists found that Nqo1 is necessary for liver cancer cells' ability to thrive by activating key pathways. Blocking Nqo1 dramatically suppresses liver cancer cell proliferation.
Research shows that branched actin transmits information to cells about their environment and regulates growth, a mechanism that can be targeted to fight certain types of cancer. Inhibiting branched actin formation prevents the growth of melanoma cells, offering new therapeutic options.
A new study in The FASEB Journal reveals that AICAr inhibits cell proliferation and has cytotoxic potential for childhood ALL cells by regulating nucleotide metabolism. The researchers confirm that Acadesine's inhibition of cell proliferation is independent of AMPK activation, but dependent on P53.
The study reveals that the WD40 repeats in AND-1 prevent nascent DNA cleavage by a nuclease, allowing for successful cell division. The discovery highlights the crucial function of AND-1 in protecting replicated DNA from degradation during replication and cell proliferation.
A new study reveals how KSHV protein LANA drives chromosomal instability, promoting cell proliferation and aneuploidy. The findings identify NNLS as a promising target for antiviral therapies.
Researchers found that fibroblast growth factor 2 (FGF2) promotes sperm production by expanding a subset of spermatogonial stem cells. FGF2 also acts on the testicular microenvironment to facilitate retinoic acid action, revealing its novel function in mouse testis.
Researchers at Kanazawa University identified a molecule called Spred1 that supports blood-cell production during dietary stress. In contrast, Spred1 deficiency promotes HSC self-renewal and resistance to physiological stress, but also increases the risk of certain cancers.
Scientists found that a small daily dose of Viagra significantly reduces colorectal cancer risk in genetically predisposed animal models. The drug works by increasing levels of cyclic GMP, which suppresses excessive cell proliferation and promotes normal cell differentiation.
The study reveals that protein ZO-1 perceives mechanical signals and activates cellular responses accordingly, influencing epithelial cell proliferation and differentiation. Targeted inhibition of ZO-1 in tumors could be a potential pathway to explore for cancer treatment.
Researchers at the University of Arizona found that even with perfect natural selection, aging would still occur due to cancer cells cheating the system. Slowing down one type of cell can lead to an increase in another problematic cell type, making it mathematically impossible to halt aging.
A subspecies of the bacterium Streptococcus gallolyticus actively promotes the development of colorectal cancer by driving CRC cell proliferation through β-catenin cell signaling. The study found that infected mice developed more tumors and greater β-catenin production than control mice.