Articles tagged with Embryonic Stem Cells
A gene called Chd1 has been found to be critical in maintaining the pluripotent state of embryonic stem cells. This discovery could lead to a greater understanding of how cells acquire specialized states and provide a strategy for efficiently reprogramming mature cells back into the pluripotent state.
Researchers at Newcastle University have successfully created human sperm from embryonic stem cells, allowing them to study the causes of infertility and potentially develop new treatments. The technique uses germline stem cells developed from male embryos, which are then prompted to mature into fully functional sperm.
Researchers at Max-Planck-Gesellschaft have developed a method to convert adult testis cells in mice into pluripotent stem cells, which can form all types of body tissue, without the use of introduced genes, viruses, or reprogramming proteins. The culture conditions were found to be crucial for the success of the process.
Researchers found distinct gene expression signatures in embryonic stem cells and induced pluripotent stem (iPS) cells, indicating they are not perfectly similar despite sharing potential to become all body tissues. The study aims to understand the biological significance of these differences and their impact on iPS cell function.
Researchers found that human female embryos inactivate one X chromosome prior to implantation, which may affect laboratory culture conditions and embryo survival. This process is thought to have remained unchanged throughout evolution and has implications for human embryonic stem cell research.
A new study reveals that three cell-signaling pathways work simultaneously to direct pancreas and liver progenitor cells to mature into their final state. The research provides insight into the basis of tissue development and how it can be manipulated for regeneration and development from embryonic stem cells.
Researchers at MU develop method to transform fibroblasts from a pig's connective tissues into induced pluripotent stem cells. The new approach eliminates genetic incompatibility issues and allows for long-term animal models, paving the way for more accurate tests of stem cell therapies.
Scientists found that adult muscle stem cells can regenerate muscles after injury without the two key embryonic muscle cell genes Pax3 and Pax7. This discovery challenges current research on muscular dystrophy and regenerative medicine, suggesting that age-matched stem cells may be more effective for therapy.
Johns Hopkins researchers have made a breakthrough in editing human stem cells, enabling the development of patient-specific therapies for rare blood diseases like paroxysmal nocturnal hemoglobinuria (PNH). The team successfully targeted and edited a gene responsible for causing PNH, improving on standard gene targeting technology.
Researchers have successfully created pig stem cells using somatic cells from pigs with hooves, opening doors to creating models for human genetic diseases and developing resistant pigs. The discovery has far-reaching implications for animal and human health.
Researchers have successfully generated genetically corrected blood cells from skin cells of Fanconi anemia patients using gene therapy and cell reprogramming techniques. This breakthrough could lead to the development of a new treatment for the disease, which affects the bone marrow and causes a lack of white blood cells.
A team of researchers has successfully developed a combined stem cell-gene therapy approach that cures human Fanconi anemia, a genetic disorder causing bone marrow failure and cancer. The treatment uses induced pluripotent stem cells to differentiate into healthy blood cells, offering a potential cure for the disease.
Researchers successfully transplanted embryonic stem cells into mouse embryos, demonstrating a capacity to recover from cardiac injury in adulthood. The study provides evidence for preventive regenerative medicine to treat myocardial infarction through prophylactic intervention.
Researchers have discovered that a beating heart and blood flow are necessary for the development of the blood system, which relies on mechanical stresses to cue its formation. Compounds that modulate blood flow had a potent impact on the expression of a master regulator of blood formation, known as Runx1.
Co-transplanting bone marrow stem cells with embryonic stem cells eliminates tumor formation in spinal cord injury (SCI) laboratory animals. The study suggests that BMSCs induce differentiation of undifferentiated ES cells into a neuronal lineage, resulting in suppression of tumor growth.
Researchers at Hebrew University of Jerusalem neutralized tumor growth in human embryonic stem cells by identifying and inhibiting the survivin gene. This breakthrough paves the way for further progress in stem cell therapy for diseases like diabetes, Parkinson's disease, and heart failure.
Researchers successfully transform human skin cells into mouse muscle cells and vice versa, providing insight into cell specialization and potentially bypassing stem cells. This breakthrough may lead to novel treatments for diseases by directly generating necessary cells.
Researchers at Scripps Research Institute successfully generate embryonic-like stem cells from adult cells using chemical programming, overcoming safety concerns associated with genetic manipulation. This breakthrough has the potential to revolutionize personalized stem cell-based medicine for various diseases.
Scientists have successfully reprogrammed blood cells into cells that mimic embryonic stem cells, opening up new avenues for research and potential treatment of diseases. The discovery provides an accessible source of stem cells, which can be used to study various diseases and develop new therapies.
Researchers at the Burnham Institute developed a protocol to differentiate human embryonic stem cells into committed neural precursor cells, which can be used for transplantation. The C-NPCs were transplanted into mice and became active neurons without generating tumor outgrowth.
Scientists have developed a new method to create safe and effective embryonic-like stem cells using tiny molecules called microRNAs. This breakthrough technology eliminates the risks associated with traditional DNA-based methods, making it a promising step towards regenerative medicine.
Researchers from the University of Wisconsin successfully generated human embryonic stem cells that can produce myelin, a finding with potential for both basic and clinical research. The process takes 14 weeks compared to 2 weeks for mouse ES cells.
Researchers have developed a method to generate complex, multilayer oral tissues using human embryonic stem cells. The tissues mimic normal oral cavity tissues and show promise for treating oral diseases through transplantation.
Scientists have discovered that amniotic fluid contains a new source of stem cells with potential therapeutic applications. These cells, known as AFKL cells, can generate all blood cell lineages in experiments and exhibit self-renewal capabilities, similar to other stem cells.
Researchers at UW-Madison have developed a new method to generate induced human pluripotent stem cells (iPS) without using viral vectors or exotic genes. This breakthrough removes key safety concerns and genetic artifacts that could compromise therapeutic safety or skew research results.
Scientists at Georgetown University Medical Center have extracted stem/progenitor cells from human testes and converted them back into pluripotent embryonic-like stem cells. These cells can morph into any cell type, offering a potential cure for diseases such as brain neurons or pancreatic tissue.
Researchers have successfully isolated human auditory stem cells from fetal cochleae and found they can differentiate into sensory hair cells and neurons. This breakthrough has the potential to develop a new treatment for deafness, with implications for studying ear development and modeling drug screening.
Scientists at Rockefeller University have uncovered a gene control mechanism that guides epidermal skin stem cells in mouse embryos, tempering the development of the skin barrier. The findings provide insights into therapeutic advances for prematurely born infants with underdeveloped skin.
Researchers have discovered that the Shp2 protein plays a critical role in controlling the pathways that decide whether human and mouse embryonic stem cells differentiate or self-renew. The study found that Shp2 acts as a coordinator to fine-tune signal strength, providing insight into fundamental signaling mechanisms.
Scientists at Whitehead Institute have successfully removed cancer-causing genes from human skin cells reprogrammed into embryonic-stem-cell-like state, creating patient-specific stem cells. These cells can be matured into dopamine-producing neurons, which degenerate in Parkinson's disease patients.
Scientists at Stanford University School of Medicine have identified a protein complex that plays a pivotal role in controlling the ability of embryonic stem cells to become any cell type. The finding is an important advance in harnessing the unique abilities of embryonic stem cells to treat disease and generate replacement tissue.
Dr. Nagy's method uses a novel wrapping procedure to deliver specific genes, overcoming major hurdles for personalized stem cell therapies. The breakthrough accelerates stem cell technology and provides a road map for new clinical approaches to regenerative medicine.
Scientists at UCLA have successfully differentiated human induced pluripotent stem (iPS) cells into electrically active motor neurons, similar in function and efficiency to those derived from human embryonic stem cells. This discovery may open the door for new treatments for neurological disorders using patient-specific cells.
Scientists successfully generated functionally mature motor neurons from induced pluripotent stem cells, paving the way for new treatments of amyotrophic lateral sclerosis and spinal cord injury. This study offers a promising alternative to embryo-derived cells for regenerative medicine.
A Johns Hopkins engineer is working on coaxing human stem cells to form new blood vessels that could replace damaged tissue in people with heart disease and other illnesses. The researcher, Sharon Gerecht, aims to understand the molecular signals that cause stem cells to differentiate into blood vessels.
Researchers discovered protein Bud14 inhibits formin interactions, regulating actin filament length. This discovery advances understanding of cell division and development, with implications for human health conditions such as infertility and deafness.
Scientists have successfully derived brain stem cells from human embryonic stem cells, providing a continual in vitro supply of diverse types of neural cells. These cells can serve as an inexhaustible source for studying neurodegenerative diseases and possible active agents directly in human neural cells.
Researchers at the University of Wisconsin-Madison have made a breakthrough in growing functional heart cells from induced pluripotent stem cells, paving the way for potential therapies for heart failure patients. The discovery uses a virus to reprogram skin cells into embryo-like states and could potentially lead to new treatments.
Researchers found that leukemia stem cells (LSCs) are maintained by a self-renewing program similar to pluripotent embryonic stem cells. This study challenges the notion of LSCs as rare, immature cells and suggests a link between their activation and poor prognosis in leukemia.
This issue of Cold Spring Harbor Protocols features two protocols: one for stem cell differentiation using the OP9-DL1 system, and another for RNA interference in plants using viral vectors. These methods provide new tools for understanding T-lymphocyte lineage commitment and gene silencing in plants.
A new class of nonprotein coding genes, known as lincRNAs, has been discovered in mammals with critical regulatory roles in health and disease. The study reveals that these long RNAs play important roles in regulating cellular processes such as cell proliferation, immune signaling, and stem cell biology.
Researchers at Stanford University School of Medicine have identified a protein called TCAB1, which is crucial for telomerase to repair the ends of chromosomes. This discovery may lead to new anti-cancer therapies by blocking the inappropriate expression of TCAB1 in human cancer cells.
Scientists have successfully reprogrammed human induced pluripotent stem (iPS) cells into the cells that eventually become eggs and sperm. This breakthrough may lead to new treatments for infertility using patient-specific cells. However, further research is needed to determine if iPS-derived germ cells can correctly regulate themselves.
A therapy developed at UC Irvine will become the world's first embryonic stem cell treatment tested in humans, targeting patients with acute spinal cord injury. The U.S. FDA has approved a clinical trial led by Geron Corp., which aims to restore electrical conduction and mobility in paralyzed individuals.
Researchers discovered that long stretches of DNA containing many genes are silenced in cells as they mature, rather than individual genes. This epigenetic modification, called LOCKS, plays a crucial role in cell differentiation and development.
The San Diego Epigenome Center will study epigenetic processes controlling gene regulation, differentiation in human embryonic cells, and DNA methylation. The goal is to develop more effective ways to prevent and treat disease.
Researchers led by Nancy Speck identified the location and developmental timeline of bone marrow stem cell formation in mouse embryos. Understanding this process may help manipulate embryonic stem cells to generate new blood cells for therapy.
Researchers at Boston University have created a more efficient way to generate induced Pluripotent Stem (iPS) cells using a single lentiviral vector. This breakthrough reduces the risk of genomic integrations and cancer-causing genes, paving the way for human clinical trials.
Scientists at Stanford University School of Medicine and UC-San Francisco have successfully isolated stem cells from human testes, which can differentiate into various types of tissues. The findings suggest that these cells are not as pluripotent as embryonic stem cells but have unique therapeutic applications.
Researchers at MIT have created a highly efficient method for pairing and fusing cells, which should facilitate the study of genetic reprogramming in hybrids. This innovation, led by Joel Voldman and Rudolf Jaenisch, improves upon existing cell fusion techniques by increasing the success rate to around 50%.
Researchers at USC have successfully derived authentic embryonic stem cells from rats, which will facilitate the creation of animal models for studying human diseases such as cancer and diabetes. This breakthrough finding represents a major advancement in stem cell research.
Scientists have developed a cocktail that can capture and maintain indefinitely the most fundamental of embryonic stem cells from essentially any mammal. The discovery allows researchers to produce genetically altered strains of rats with conditions mimicking human disease in a targeted way, making it easier to study human diseases.
Researchers successfully reprogrammed cells from patients with difficult-to-study diseases, creating 'stem-cell-like' cells that can be induced to assume new identities. This innovation holds promise for understanding disease development and potentially treating conditions like Parkinson's disease and type 1 diabetes.
Researchers have developed a method to create novel types of stem cells, offering opportunities for expanding research and drug discovery. The technique enables the creation of rat and human pluripotent stem cells with characteristics similar to mouse embryonic stem cells.
Thomson's discovery of human embryonic stem cells and development of induced pluripotent stem cells launched the field of stem cell science. His work has the potential to help find the root cause of disease, test new drugs at the human cellular level, and offer regenerative therapies.
A leading British researcher predicts a boom in stem cell drug testing under Obama's administration, offering a viable alternative to animal-based heart cell tests. The UK has already established a special public-private research program to harness the potential of human embryonic stem cells for safer medicine.
Scientists have developed a new method for converting adult cells into embryonic stem cell-like cells using a single virus, cutting the number of viruses used from four to one. This approach eliminates the risks associated with multiple viruses and could potentially be used to treat diseases such as Parkinson's and diabetes.
A UC Riverside study reveals that harm-reduction cigarette smoke retains toxicity and can adversely affect reproductive development in mice and may pose risks to human pregnancies. The research found that both mainstream and sidestream smoke from traditional and harm-reduction brands are toxic to pre-implantation embryos.
Researchers at UCLA have discovered that blood stem cells are made by endothelial cells during mid-gestational embryonic development. This finding has significant implications for the treatment of blood disorders and cancers, as it could lead to new therapies for conditions such as leukemia.
Researchers have identified a stage during dopamine neuron differentiation that may be an ideal time to collect human embryonic stem cells for transplantation to treat Parkinson's disease. Lmx1a-positive cells with TrkB surface marker can be selected using magnetic-activated cell sorting or fluorescence-activated cell sorting.