Articles tagged with Embryonic Stem Cells
Engineers and physicians at the University of Washington have developed a scaffold that supports the growth and integration of stem cell-derived cardiac muscle cells. The scaffold accelerates oxygen and nutrient supply to transplanted tissue, promoting heart repair and vascular tissue engineering.
Researchers at UCSF have successfully purified one type of human embryonic stem cell using a novel, high-throughput strategy that avoids genetic engineering. The technique links two existing technologies and enables the separation of pure stem cells from teratoma-forming cells at a rate of about 25,000 cells per second.
Researchers found that human embryonic stem cells and reprogrammed cells exhibit very few differences in gene expression signatures and are nearly indistinguishable in their chromatin state, according to Whitehead Institute researchers. This study suggests that reprogrammed cells may indeed hold clinical promise ascribed to them earlier.
Researchers have devised a three-ingredient molecular cocktail that transforms fibroblasts into beating heart cells, potentially solving the issue of cardiac muscle regeneration in heart disease. The cocktail, tested on mice, shows promise in producing new cardiac muscle cells more efficiently than induced pluripotent stem cells.
Researchers at Gladstone Institutes found a way to make beating heart cells from body's own cells, helping to regenerate damaged hearts. The new method directly reprograms structural cells called fibroblasts into cardiomyocytes without needing stem cell state.
Researchers have successfully reprogrammed adult mouse fat cells and neural cells to become induced pluripotent stem cells (iPS) that can differentiate into various cell types. The study demonstrates that adipose tissue-derived cells are the most amenable to reprogramming, making them a promising source for clinical applications.
Researchers have isolated the first stage of tissue production in human embryonic stem cells, marking a significant breakthrough in regenerative medicine. The discovery may lead to the development of safer tissues for use in treating various medical conditions, including leukemia and sickle cell anemia.
Researchers found that induced pluripotent stem cells (iPS cells) retain a 'memory' of their tissue of origin, making it harder to differentiate into other cell types. However, additional steps or drugs can erase this memory, making iPS cells comparable to nuclear transfer stem cells.
Researchers at MGH Center for Regenerative Medicine found that reprogrammed induced pluripotent stem cells (iPSCs) retain some characteristics of their cell of origin, which can both assist and complicate future uses. Cellular memories fade with successive generations.
Researchers at UNC Health Care have made a breakthrough in understanding the role of Tet 1 protein in maintaining stem cell pluripotency. The study found that Tet 1 helps stem cells renew themselves and stay undifferentiated, paving the way for personalized therapies.
Researchers are developing a method to identify and purify stem cells from patients themselves that can give rise to beating heart cells. This approach aims to create an ideal product for transplant to repair heart damage caused by heart attack or cardiomyopathy.
Researchers have discovered that axolotls possess pluripotent cells in their embryos, similar to those found in mammals, offering a unique opportunity to study the properties of embryonic stem cells. This breakthrough supports the development of regenerative medicine and provides insights into the evolution of stem cell properties.
Researchers at Boston Children's Hospital found a gene that regulates transcriptional elongation, enabling the body to rapidly produce mature red blood cells. This discovery may have implications for treating severe anemia and leukemia by understanding how the body can quickly switch on production of red cells.
Researchers at UC San Diego identify new signaling pathway critical for embryonic stem cells' self-propagation, finding that inhibiting this pathway reduces teratoma formation. This breakthrough enables a potential solution to the major obstacle in developing human embryonic stem cell therapies.
Researchers have successfully reprogrammed human blood cells to an embryonic stem-cell-like state, opening up new possibilities for studying genetic and molecular mechanisms of blood disorders and other diseases. This breakthrough uses frozen blood samples from blood banks, providing a readily available source of pluripotent stem cells.
Researchers at Tel Aviv University have successfully tracked the progression of adult stem cells through live imaging, gaining insight into how they are reprogrammed and evolve over time. This breakthrough could lead to more efficient and effective cell reprogramming techniques for treating diseases such as Parkinson's.
A team of researchers has discovered a protein called Ronin that recruits a co-regulator to bind to a specific DNA sequence, enabling the growth of embryonic stem cells. This finding may also contribute to understanding cancer growth and development.
Female human embryonic stem cells show variations in X chromosome inactivation as early as five passages, suggesting culture conditions can impact cell safety. The study's findings may have implications for cancer development and disease treatment, prompting further research on uniforming X chromosome inactivation patterns.
A Texas A&M researcher has found that early mammalian embryos possess three stem cell lineages with different viral silencing strategies, including XEN cells that exhibit rapid and aggressive silencing of retroviruses. The study provides new insights into fetal diseases and has profound implications for diagnosis and treatment.
Researchers from the University of Texas Medical Branch at Galveston have successfully grown new lung tissue using embryonic stem cells and decellularized rat lungs. The breakthrough, published in Tissue Engineering Part A, paves the way for potential applications in treating severe lung disorders such as cystic fibrosis.
Researchers at Thomas Jefferson University identified a protein interaction controlling the silencing of Oct4, a key transcription factor necessary for embryonic stem cells to remain pluripotent. The study suggests that attenuated stem cell differentiation contributes to aging by leading to organ or tissue function decline.
Researchers at the University of Michigan have developed a new synthetic stem cell growth matrix that overcomes major challenges in human embryonic stem cell research. The new coating, made from a water-soluble gel, has been shown to support long-term growth and maintenance of pluripotency in human embryonic stem cells.
Researchers at Karolinska Institutet have successfully cultured human embryonic stem cells under chemically controlled conditions without the use of animal substances. This breakthrough enables large quantities of human embryonic stem cells to be produced in a completely defined environment, paving the way for future clinical uses.
Researchers have successfully attached imaging probes to glycans in zebrafish embryos just seven hours after fertilization, allowing for the first-ever images of glycan activity on embryonic cells. This new technique enables scientists to study physiological changes during embryogenesis without damaging the embryos.
Researchers found that CDP-choline can reduce cell death and ceramide levels, preventing damage when exposure to alcohol is stopped. The study suggests a potential preventive measure for fetal alcohol syndrome.
Scientists at UCI created an eight-layer, early-stage retina from human embryonic stem cells, a complex tissue structure that could lead to transplant-ready retinas for treating eye disorders. The breakthrough uses differentiation technique to create multiple cell types necessary for the retina, mimicking early-stage retinal development.
Rensselaer Polytechnic Institute has been awarded a four-year $2.45 million grant from the New York Stem Cell Science Program to create an upstate center of excellence for basic stem cell research. The grant will be used to build sophisticated laboratories with high-throughput culture and imaging equipment, enhancing stem cell research...
Embryonic stem cells can switch between different cell types, indicating a potential for pluripotency. Researchers hope to understand this process to create specific cell types in the lab.
Researchers found that low oxygen levels prevent X chromosome inactivation in human embryonic stem cells, which can lead to a less flexible and pluripotent state. The study suggests that conventional lab methods may not be optimal, and alternative approaches are needed to maintain human ES cells' pluripotency.
Researchers have successfully generated mouse cells that resemble human inner-ear hair cells in a petri dish. This breakthrough could lead to significant scientific and clinical advances along the path to curing deafness. The study provides a protocol for generating millions of functional hair cells from renewable sources.
A new study compares induced pluripotent stem (iPS) cells and embryonic stem cells in modeling fragile X syndrome, a genetic disorder. The research reveals that the two cell types behave differently in the disease model, with iPS cells not fully replicating the gene silencing process.
Researchers discovered that human embryonic stem cells (hESCs) and lineage-committed cells have drastically different epigenomic landscapes. The unique epigenome of each cell type directs the cell to interpret its genetic information differently in response to environmental factors, influencing their development and function.
Researchers have developed a method to convert human induced pluripotent stem (iPS) and embryonic stem (ES) cells to a more flexible state, similar to mouse ES cells. This breakthrough could improve the efficiency of gene targeting and potentially lead to new therapeutic applications for human ES and iPS cells.
Dr. Shinya Yamanaka's pioneering work on induced pluripotent stem cells eliminates need for embryonic stem cell harvesting from human embryos. The discovery has the potential to correct or repair birth defects in children, offering hope for preventions and treatments.
The study found that embryonic stem cell metabolites have highly unsaturated structures compared to mature cells, and levels decrease as they mature. The researchers also discovered a pattern in the chemistry that mirrors the cells' increasing biological maturity.
A new study in embryonic stem cells uncovered a transcription control mechanism that regulates expression of 80% of mammalian genes. The cancer-causing gene c-Myc plays a significant role in releasing transcriptional pausing, leading to hyper-proliferation characteristic of cancer cells.
Researchers at MGH-CRM and HSCI discovered that a key gene cluster is silenced in most iPSCs, limiting their developmental potential. However, some iPSC lines with the normal activation of this cluster were able to generate live animals, offering a promising approach for improving iPSC reprogramming.
Researchers from Université de Montrêl have discovered a molecular switch that enables yeast to make critical decisions about its fate, including choosing a suitable mate. This study provides valuable insights into the mechanisms underlying sexual mate selection and has potential applications in understanding human development and disease
Researchers have identified a cluster of small RNA that correlates with pluripotency in induced-pluripotent stem cells, enabling the distinction of more viable cell lines. This discovery is expected to improve the production of full pluripotent iPS cells and their application in disease therapy.
The Rutgers Stem Cell Research Center has derived new human embryonic stem cell lines, addressing concerns of contamination in previously approved lines. The center also offers a training course for stem cell scientists, with over 100 trained researchers to date.
Researchers at UTHealth are developing new strategies to derive hematopoietic stem cells from pluripotent stem cells, which could potentially treat blood diseases. Additionally, they are exploring gene-corrected induced pluripotent stem cells for treating two pediatric lung diseases, Surfactant Protein B Deficiency and Cystic Fibrosis.
Researchers solve the decade-old mystery of fragile human embryonic stem cells by discovering two novel synthetic small molecule drugs that promote cell survival. The team also unravels the mechanisms behind e-cadherin's role in cell signaling, providing a new understanding of stem cell biology and paving the way for potential therapies.
A University of British Columbia graduate student has discovered a mechanism to silence retroviruses, which could lead to new cancer treatments. The protein ESET is crucial in preventing endogenous retrovirus activity in mouse embryonic stem cells and may hold promise for cancer therapies.
A team of researchers led by Dr. Christopher Fasano successfully derived floor plate tissue from human embryonic stem cells, a crucial signaling center in brain development. This achievement paves the way for better understanding of neurodegenerative diseases like Parkinson's.
Scientists at UCSF have developed a novel cell-based strategy to treat Parkinson's disease by transplanting embryonic neurons into the striatum, improving motor function and balance in rats. The approach may offer a more precise effect than traditional strategies and has implications for other neurodegenerative diseases.
Researchers at the NIA have discovered a key to ES cell rejuvenation in the gene Zscan4, which restores telomere length through recombination. This process enables infinite generations of functional ES cells, offering new insights into aging research and regenerative medicine.
A recent study by Mount Sinai researchers demonstrates that skin cells found in human amniotic fluid can be efficiently 'reprogrammed' to pluripotency, a characteristic similar to human embryonic stem cells. This breakthrough has significant implications for stem cell research and patient care.
A mathematical model predicts complex signaling patterns in fruit fly embryos, shedding light on stem cell differentiation and potential applications in tissue engineering. The study aims to better understand how to control similar cells in a laboratory setting.
Researchers at Case Western Reserve University have found a way to use the sleeve-like cover on bone to heal serious bone injuries faster and more simply than current methods. They developed an artificial sleeve that spurs fast healing when a car wreck, bomb blast or disease leaves too little cover.
Researchers found that human and mouse embryonic stem cells have distinct responses to growth factors, rendering animal models less reliable for preliminary tests. Human ES cells will remain essential for stem cell research due to their superior performance in tissue differentiation.
Researchers at Stanford University School of Medicine discovered that restricting genetic splicing variants decreases as embryonic stem cells differentiate into specialized cells. This finding provides new insights into the complex process of neural differentiation and potential implications for human development.
Researchers at Columbia University Irving Medical Center successfully used mouse embryonic stem cells to replace diseased retinal cells and restore sight in a mouse model of retinitis pigmentosa. The study showed promising results, with one-fourth of the mice regaining vision after receiving the stem cells.
A new study reveals that chromatin regulatory proteins, Smc2 and Smc4, play a crucial role in maintaining genome stability in embryonic stem cells. The authors found that condensins promote mitotic progression and interphase chromatin compaction, leading to massive DNA damage and cell death when blocked in these cells.
US government's lifting of restrictions on federally-funded stem cell research has helped scientists focus on science, but limitations remain. George Daley will discuss the current climate and potential of induced pluripotent stem cells (iPS) in treating devastating diseases.
A UCSF team recommends modifying NIH stem cell guidelines to protect the rights of individuals donating egg or sperm to patients undergoing in vitro fertilization. The guidelines currently give IVF patients unrestricted authority over embryos leftover after fertility treatments.
Researchers are developing non-controversial alternatives to human embryonic stem cells by transforming adult skin cells into stem cells using a molecular toolkit. Chemists aim to identify drug-like substances that can reprogram mature cells into stem cells, bypassing the need for gene therapies.
A new study finds that induced pluripotent stem cells differentiate less efficiently and faithfully than embryonic stem cells, which are considered the 'gold standard' for all pluripotent stem cells. Despite their limitations, induced stem cells can still be used for certain applications, such as testing potential new drugs.
Researchers at UC San Diego have identified the region in vertebrates where adult blood stem cells arise during embryonic development. This discovery is a critical step towards developing safer and more effective stem cell therapies for patients with leukemia, multiple myeloma, and other diseases.
Researchers at the Genome Institute of Singapore have identified the genetic molecule Tbx3, which significantly improves the quality of induced pluripotent stem cells (iPS cells). The study successfully produced iPS cells that can recapitulate entire developmental processes and exhibit superior ability for germ-line transmission.
Researchers created a detailed map of the human epigenome during embryonic development, identifying patterns of DNA methylation and its role in regulating gene expression. This breakthrough has significant implications for targeted differentiation of stem cells into specific organs, a crucial consideration for stem cell therapy.