Articles tagged with Embryonic Stem Cells
Researchers at King's College London have made a breakthrough in developing xeno-free human embryonic stem cell lines that are suitable for public benefit. The lines will be grown and processed by the UKSCB to provide stem cell stocks for clinical research and treatment.
A recent study published in Developmental Cell suggests that the reach of parental control in embryonic development may be longer than thought. The research found evidence that genetic marks from sperm can be passed on to embryos, influencing gene expression later in development.
A study published in Cell Stem Cell reveals that adjusting the levels of reprogramming factors can significantly impact the quality and fidelity of induced pluripotent stem (iPS) cells. This finding explains the variability in iPS cell quality reported in recent studies, which has sparked debate about their therapeutic potential.
Researchers found that newly derived human embryonic stem cell lines have a better molecular signature than established lines, indicating higher quality and potentially better performance in disease modeling. The study suggests that maintaining the original state of X chromosome inactivation could be crucial for achieving optimal results.
A collaborative study from the International Stem Cell Initiative analyzed human pluripotent stem cells' genetic stability and found that 75% remained normal after prolonged culture. However, researchers detected genetic changes similar to those seen in human cancers, highlighting the need for detecting and eliminating abnormal cells.
Researchers identified a portion of the genome mutated during long-term culture of human embryonic stem cells, which may compromise their utility for regenerative medicine. The study highlights the importance of understanding genetic changes in hESCs and their potential impact on cell therapy applications.
Researchers have found that B-type lamins are necessary for proper organ development, but not for the replication and differentiation of embryonic stem cells. Mice deficient in B-type lamins were born with developmental defects, highlighting the protein's importance in tissue organization.
A team of Wisconsin scientists reports that lab-grown neurons can successfully fuse with the brain's wiring and send/receive signals. The study uses optogenetics to modulate transplanted cells, opening doors for light-based stimulation technology in treating neurodegenerative disorders.
Researchers have successfully differentiated mouse ES cells into a tissue resembling the adenohypophysis, the hormone-secreting component of the pituitary gland. The self-organized tissue exhibits functional hormone secretion and can compensate for pituitary function in mice.
Researchers identify oncostatin M as a key player in the self-healing powers of the heart, allowing damaged heart muscle cells to reversion and produce new cells. This discovery holds promise for treating heart disease, but further research is needed to pinpoint the precise window of application.
Researchers at Inserm have successfully rejuvenated cells from elderly donors, erasing signs of aging and demonstrating the reversibility of cellular aging. The breakthrough uses a new 'cocktail' of six genetic factors to reprogram senescent cells into functional induced pluripotent stem cells.
A new therapy approach targets a self-renewal pathway in embryonic stem cells to eliminate cancer stem cells in pancreatic cancer. In mice with human pancreatic cancer tumors, the combination of Nodal/Activin pathway inhibition and chemotherapy led to 100% survival after 100 days.
Researchers have created melanocytes from mouse tail cells using inducible pluripotent stem cells, offering potential benefits for tissue transplantation, cancer treatment, and drug discovery. The lab-made cells can be studied to understand the development of conditions like vitiligo and melanoma.
A study found that amino acid concentrations were reduced in cloned embryos compared to in vitro fertilized pregnancies. This may explain developmental abnormalities and complications leading to embryo death. The findings highlight the importance of researching maternal-embryo interactions.
Researchers have discovered that lab-grown embryonic stem cells express the protein Blimp1, which represses differentiation and enables them to form cells of almost any type. This finding could help inform the development of induced pluripotent stem cells, a new type of stem cell derived from adult cells.
Christoph Lepper, a Carnegie staff associate, received the NIH Director's Early Independence Award for his groundbreaking research on skeletal muscle biology. The award aims to launch talented young scientists into independent positions directly out of graduate school.
Researchers found Sox2 expression in various adult tissues, including stomach, testes, and cervix, confirming its status as a widespread marker of adult stem cells. These cells can give rise to all mature cell types in their respective tissues.
Lack of compensation for human egg donors could stall recent breakthroughs in stem cell research due to difficulty in recruiting altruistic donors. A recent study on somatic cell nuclear transfer (SCNT) has created the first human stem cell line, but more donor eggs are needed to advance research.
Research reveals a link between diabetes and cancer, showing that cancer-promoting proteins like Lin28a can increase insulin sensitivity in mice, while others with high let-7 levels become more resistant to diabetes.
Scientists at Johns Hopkins Medicine have corrected the genetic alteration causing sickle cell disease by using a patient's own stem cells. The team found four working iPS cell lines containing correct copies of the hemoglobin gene and successfully converted them into immature red blood cells.
Researchers at Stanford Medicine have engineered human heart cells that respond to light, using optogenetics. These light-sensitive cells could lead to a new class of pacemakers and genetically matched replacement heart cells, potentially replacing traditional electrical pacemakers and addressing tissue rejection issues.
Researchers at University of Wisconsin-Madison report 99% protein similarity between two types of do-it-all stem cells, shedding light on their potential applications in cell replacement therapies. The study measured over 6,000 proteins using mass spectrometry and provides insights into their biological role.
Scientists at UCSF discover that fetal tissue, called mesenchyme, secretes chemicals essential for mature beta cell formation. This breakthrough may lead to new ways of addressing Type 1 and Type 2 diabetes, including generating fully functional beta cells from stem cells or increasing beta cell numbers in people with Type 2 diabetes.
Researchers identified a protein that helps maintain mouse stem cell pluripotency by activating signal pathways via CC chemokine ligand 2 (CCL2). This finding offers insights into cultivating human iPS/ES cells without feeder cells, reducing the risk of contamination and health risks.
Scientists discover large RNAs regulate embryonic development by physically interacting with proteins, suggesting a critical role in developmental decisions. The study reveals that lincRNAs may play similar roles in most cells and could be engineered to target key genes in disease.
Researchers have created a more precise system for growing cells by replacing neighboring cells and extracellular matrix with synthetics. This approach reduces uncertainty and biological contamination, facilitating the formation of artificial tissues.
Scientists describe an advance in encouraging stem cells to make decisions about their fate using chemically defined surfaces. This technology holds promise for regenerative medicine, including growing organs for transplants and tissues for treating diseases.
Researchers have discovered that human amniotic fluid-derived stem cells (hAECs) can differentiate into various cell types, including those found in the lungs. Transplanted hAECs were shown to reduce pulmonary fibrosis and enhance lung regeneration in animal models of lung disease.
Researchers at Tel Aviv University have discovered that oral mucosa stem cells can be manipulated into fetal-like stem cells with high therapeutic potential for treating neurodegenerative, heart, and autoimmune diseases. The cells can be derived from a small biopsy of tissue and show minimal discomfort and healing time.
Researchers found that human embryonic stem cell-derived cells bear striking differences from human tissue cells in gene expression, functionality, and appearance. The cells' developmental maturity is also a concern, particularly for transplantation and disease modeling, as they may not mature to the same levels as adult cells.
Researchers at Stanford University School of Medicine have developed a way to remove pluripotent human embryonic stem cells from their progeny before transplanted into patients. The technique uses antibodies to recognize and bind to only pluripotent cells, eliminating the risk of teratomas.
Scientists have successfully turned mouse embryonic stem cells into healthy sperm by coaxing them into primordial germ cells. This breakthrough allows for the potential creation of fertile offspring using induced pluripotent stem cells from adult skin cells.
UC Davis investigator provides roadmap to overcome obstacles for using induced pluripotent stem cells to treat various human diseases. The technology has the potential to bypass immunological problems inherent in traditional stem cell therapy.
Researchers develop a method to convert human skin cells into neurons, offering a potential shortcut for generating replacement therapies. The new approach has already yielded insights into Alzheimer's disease and could be used for testing new drug candidates.
A scientist at the Gladstone Institutes has discovered a way to convert human skin cells into brain cells, offering new hope for regenerative medicine and personalized drug discovery. The breakthrough discovery allows for efficient and robust methods to transform adult skin cells into neurons capable of transmitting brain signals.
Researchers will create the largest library of sickle cell disease-specific iPS cell lines to study the disease's genetic context and develop new therapies. The goal is to understand how specific genes behave in different tissues and clarify the mechanisms by which a gene associated with a disease affects tissue biology.
Researchers at UCLA have created the first genome-wide mapping of 5-hydroxymethylcytosine (5hmC) in human embryonic stem cells, discovering its role in activating genes. The study's findings may lead to better understanding of gene regulation and potential cancer control.
Researchers at Hebrew University have successfully identified and isolated 'organizer' cells in human embryos, which are responsible for determining the shape of the embryo during development. This breakthrough could lead to better understanding of embryonic development and potential applications in treating spinal damage.
Scientists at USC have proven that oncogenes can convert normal cells into stem-like cells, leading to a new approach in treating diseases with stem cell therapy. The study successfully converted human skin cells into brain cells by suppressing p53, suggesting it determines cell fate rather than only cancer outcome.
Researchers at Stowers Institute for Medical Research discovered the role of Super Elongation Complex (SEC) in controlling gene expression during early development. They found that SEC facilitates coordinated and rapid induction of genes, including Hox genes, which are essential for embryonic development.
A recent stem cell study has found that the protein molecule E-cadherin, which plays a key role in cancer, also regulates up to 25% of genes within cells. This unexpected discovery could lead to new cancer treatments by understanding why some cancer cells are difficult to eradicate.
Researchers at Tel Aviv University have discovered that adult-derived stem cells can retain 'memories' of their pancreatic beta cell origins, making them more efficient at producing insulin. This breakthrough may pave the way for new treatment options for juvenile or type 1 diabetes.
Researchers have created a new model to study germ cell tumors in testes by transplanting embryonic stem cells into mouse models. The resulting tumors mimic the early stages of tumor development and offer valuable insights into the genetic regulation of these cancers. This approach has potential applications for developing novel therap...
Researchers have successfully reprogrammed adult body cells into iPS cells, which can be taken directly from each patient and genetically redirected to replace ailing cells. While iPS technology holds promise, it still faces challenges and is not yet ready for widespread use.
Researchers found that early embryos with chromosomal abnormalities can undergo a process of genetic normalization, leading to the correction of errors. This discovery has significant implications for preimplantation genetic screening and future stem cell treatments.
Researchers at Harvard Medical School have developed a new automated bioprinting approach that improves the uniformity and control of embryonic stem cell droplet size. The method delivers faster droplet formation, printing 160 droplets per second compared to traditional manual pipetting methods.
Researchers at U-M found that mutations caused by aging or disease can lead to a loss of cell identity, resulting in gene expression changes. This instability can have significant impacts on physiological functions, including arrhythmia in mice.
A recent Nevada study found that over two-thirds of respondents approved using therapeutic cloning and stem cells to cure cancer or treat heart attacks. For treatment of less-serious conditions, approval rates were lower but still significant. The study suggests a strong public support for stem cell research in the US.
Researchers discovered that Barrett's esophagus arises from embryonic cells present in all adults, which can rapidly grow and form unusual tissue when the esophagus is damaged by acid reflux. This finding provides a potential target for preventing esophageal cancers.
Research reveals that leftover embryonic cells found in all adults may be precursors of deadly esophageal cancers, including Barrett's esophagus. The study suggests targeting these precursor cells as a potential strategy for stopping the disease before it starts.
A international consortium has developed a novel method to target specific genes in mouse embryonic stem cells, allowing for the disruption of almost 9,000 genes. This resource will enable researchers to study gene activity in models of human disease, advancing our understanding of gene function and its role in mammalian biology.
Robert Blelloch's groundbreaking research on microRNAs in embryonic stem cells and cancer has shed light on the molecular mechanisms regulating cell fate transitions. His work holds promise for developing new therapeutic strategies, including inducing adult cells to de-differentiate into pluripotent stem cells.
Researchers have found that adult stem cells from the human olfactory system can provide a new source of cells to treat brain disorders. These cells, known as OE-MSCs, have been shown to migrate to damaged areas and stimulate nerve cell growth, improving learning and memory in mice.
Researchers found that studying both types of stem cells has become more common, with a growing proportion of papers combining adult and embryonic stem cells. This means that banning either type of research could harm the field overall. The study suggests that federal funding for one area could negatively impact the other.
A new study by researchers at Stanford University School of Medicine and others found that curtailing human embryonic stem cell research would negatively impact induced pluripotent stem cell research. The study refutes the idea that iPS cells can replace embryonic stem cells in research.
A new study by University of Michigan researchers suggests that banning federal funding for human embryonic stem cell research would have disastrous consequences on the use of induced pluripotent stem cells (iPS cells). The two cell types are complementary and interdependent research tools, and their use has become intertwined. As a re...
Researchers say stem cell therapeutics may offer therapy through simple cell replacement procedures to restructure damaged organs and tissues. However, factors related to patient selection need careful consideration due to stage and severity of disease, prior therapies, and immunosuppression.
Researchers at UCSD have discovered a novel signaling pathway and gene, Wnt16, essential for the formation of hematopoietic stem cells in vertebrate embryos. This breakthrough has significant implications for developing stem cell-based therapies for diseases such as leukemia.
Researchers at the Max Delbrück Center (MDC) have identified E-cadherin as a key molecule enabling embryonic stem cells to differentiate into diverse cell types. The study found that E-cadherin plays a crucial role in maintaining pluripotent stem cells and reprogramming somatic cells into induced pluripotent stem cells.
Scientists discovered an epigenetic marker system to predict the fate of progenitor cells, which can be used to guide stem-cell differentiation. This finding may lead to new approaches in regenerative medicine therapies, such as generating liver and pancreas cells for transplantation.