Articles tagged with Embryonic Stem Cells
Researchers say stem cell therapeutics may offer therapy through simple cell replacement procedures to restructure damaged organs and tissues. However, factors related to patient selection need careful consideration due to stage and severity of disease, prior therapies, and immunosuppression.
Researchers at UCSD have discovered a novel signaling pathway and gene, Wnt16, essential for the formation of hematopoietic stem cells in vertebrate embryos. This breakthrough has significant implications for developing stem cell-based therapies for diseases such as leukemia.
Researchers at the Max Delbrück Center (MDC) have identified E-cadherin as a key molecule enabling embryonic stem cells to differentiate into diverse cell types. The study found that E-cadherin plays a crucial role in maintaining pluripotent stem cells and reprogramming somatic cells into induced pluripotent stem cells.
Scientists discovered an epigenetic marker system to predict the fate of progenitor cells, which can be used to guide stem-cell differentiation. This finding may lead to new approaches in regenerative medicine therapies, such as generating liver and pancreas cells for transplantation.
A recent study published in Nature has identified a key molecular mechanism that causes stem cells to differentiate into muscle cells in embryos. This breakthrough discovery could lead to new treatments for muscle dysfunction associated with aging and disease.
Researchers have identified stem cell population that can reverse nerve cell loss in individuals with Parkinson disease. Protein-based human iPS cells efficiently generate functional dopamine neurons and treat a rat model of the disease.
Researchers at Monash University have successfully reprogrammed healthy adult kidney cells into embryonic-like stem cells, offering a new approach to modeling genetic kidney disorders and developing personalized medicine. The breakthrough enables the creation of limitless patient-specific stem cell lines for drug testing and disease mo...
Researchers at UC San Diego found that induced pluripotent stem cells could be rejected by the immune system, challenging their potential as a promising means to develop stem cell therapies. The study suggests that iPSCs are subject to some of the same problems of immune system rejection as embryonic stem cells.
Adult planarians possess pluripotent stem cells capable of producing diverse tissue types, allowing for the rebuilding of entire organisms from a single cell. The discovery could lead to insights into human regenerative medicine, as many genes in the planarian genome have human counterparts.
Researchers at Johns Hopkins Medicine have successfully coaxed adult human cells into an embryonic state and used them to regenerate liver tissue in mice with chronic liver damage. The induced-pluripotent stem cells (iPSCs) showed promise as a potential alternative to liver transplants for patients with serious liver diseases, offering...
Stem cells extracted from human fat may revolutionize soft tissue reconstruction, cartilage and bone development, and cardiovascular disease treatment. The researchers have developed a technique to decellularize adipose tissue, creating a scaffold for stem cell growth.
Researchers have found that mouse induced pluripotent stem (iPS) cells and embryonic stem (ES) cells produce highly similar definitive endoderm when differentiated in vitro. This suggests that iPS cells could be used for developing cell-based therapies for diseased endoderm-derived tissues.
Researchers discovered that immune cells play a crucial role in the worsening of atopic dermatitis when exposed to food allergens, with implications for prevention and treatment. Additionally, studies identified TIF1-gamma as a tumor suppressor in mouse and human chronic myelomonocytic leukemia.
Researchers from Boston University's Center for Regenerative Medicine have demonstrated that induced pluripotent stem cells (iPSCs) can differentiate into definitive endoderm cells in vitro, with similar functional potential to embryonic stem cells. This finding is significant given the controversy surrounding iPSCs and their potential...
A Brazilian research team successfully established the first line of human embryonic stem cells (hES), but struggled to find a genetically diverse match for the diverse ethnic and genetic Brazilian population. The researchers overcame legal and ethical guidelines to create hES cell line BR-1, which is mostly European in origin.
UCLA researchers may have discovered a way to convert non-insulin-producing cells into functional beta cells, which could lead to a permanent solution for diabetes. The study found that chemical tags called methyl groups play a crucial role in maintaining cell identity and converting cells into insulin-secreting beta cells.
A Gladstone scientist has made two significant stem-cell discoveries, creating powerful new approaches for using stem cells and stem-cell-like technology. Dr. Sheng Ding reveals novel and safer methods for transforming embryonic stem cells into large numbers of brain cells and adult skin cells into neural stem cells.
Researchers at Johns Hopkins Medicine have created a simplified, cheaper method to generate functional heart cells from blood cells, reducing the risk of viral mutation and cancer. The process has shown high efficiency rates, with 94.5% beating heart cells formed in 11 different stem cell lines.
Researchers have discovered a new way to reprogram adult cells into an embryonic stem cell-like state using specific microRNAs and Hdac2 suppression, offering a more efficient alternative to traditional methods. This breakthrough could lead to improved strategies for developing stem cells for therapeutic use.
ES cells can differentiate into retinal precursors and form an optic cup-like structure in vitro without external signaling sources. The tissue undergoes a four-step morphological rearrangement to assume the optic cup shape, driven by cell division and epithelial expansion.
Researchers used human embryonic stem cells to study myotonic dystrophy type 1, revealing reduced expression of SLITRK genes in affected brains. The findings highlight the potential of embryonic stem cells for understanding complex diseases like muscular dystrophy.
Dr. Paul Tesar's research enhances understanding of pluriportent stem cells used to study debilitating diseases. His findings have potential to prevent or repair damage caused by disease, aging, and injury.
Researchers developed induced conditional self-renewing progenitor cells, which can differentiate into active neurons and other brain cell types. The new stem cell approach shows promising results in an adult rat model of intracerebral hemorrhagic stroke, with no adverse effects observed over five months.
Researchers at Stanford University School of Medicine successfully derived neurons with symptoms of Parkinson's disease from a patient's skin cells. These neurons exhibit key features of the condition, including oxidative stress and Lewy body formation, in a short timeframe.
A Stanford study finds a short-term treatment with three immune-dampening drugs allows human embryonic stem cells to survive and thrive in mice. The breakthrough may enable humans to accept transplanted stem cells intended for disease or injury treatment without powerful immunosuppressant medications.
Scientists have discovered a new way to generate human motor nerve cells, helping research into motor neurone disease. This breakthrough enables the creation of different types of motor neurons, allowing researchers to study their vulnerability to disease.
Scientists have successfully fused human stem cells derived from fat tissue with muscle cells from rat hearts, forming new muscle cells that beat. This achievement demonstrates the potential for regenerative medicine to heal damaged hearts without transplantation.
A recent study found that reprogramming stem cells leads to genomic aberrations and genetic mutations similar to those in cancer cells. This raises concerns about the safety and effectiveness of using these cells for regenerative medicine applications.
Researchers identify significant differences in timing of cell fate commitment between mice and cattle, raising implications for embryonic stem cell generation. The study shows that the early implantation process is driven by a key evolutionary step enabling early implantation in mice.
A new method allows for quick and comprehensive characterization of induced pluripotent stem cells (iPS) and embryonic stem cell lines, enabling high-throughput assessment of quality and differentiation efficiency. The approach yields genome-wide reference maps detailing epigenetic and gene expression landscapes.
A recent survey of US stem cell scientists reveals substantial negative impacts of ongoing policy uncertainty on their work, including changes to science type and quality, delays in new projects, and hindered collaborations.
Scientists found reprogramming errors in iPS cells, including a common defect near telomeres and centromeres. These hotspots resist non-CG methylation, but CG islands are affected, potentially limiting the fate of iPS cells.
Researchers at Johns Hopkins have found a way to reprogram adult cells with the properties of embryonic stem cells using a small blood sample. The new method avoids creating DNA changes that could lead to tumor formation, resulting in safer and more reliable iPS cells for research and potential clinical applications.
Researchers at Scripps Research Institute successfully converted adult skin cells into beating heart cells through a direct reprogramming strategy, bypassing the need for embryonic-like stem cells. This breakthrough discovery has the potential to lead to new treatments for diseases such as heart disease, Parkinson's, and Alzheimer's.
Researchers at the Technical University of Munich have received prestigious ERC Grants to develop new therapies against multi-resistant germs, study interactions between cellular components, and improve algorithms for image processing. The grants total €9.8 million.
Scientists have developed Australia's first adult induced pluripotent stem cell lines for the rare genetic disease Friedreich Ataxia, enabling the development of new treatments. The iPS cells were characterized to become specific cell types, including heart and nerve cells, which are affected by the disease.
Researchers developed a gene therapy strategy using parthenogenetic embryonic stem cells, which can differentiate into multiple tissue types and potentially reduce rejection problems. The approach shows promise for treating autosomal dominant diseases like Beta Thalassemia, tuberous sclerosis, or Huntington's disease
Scientists found that hepatocyte-like cells derived from iPS cells exhibit 80% similar gene expression to those from embryonic stem cells, but less than that of real human liver cells. The study suggests that further adaptation is needed for iPSC-derived hepatocytes to be used in treating liver diseases.
Shinya Yamanaka and Rudolf Jaenisch receive the prestigious award for their groundbreaking work on induced pluripotent stem cells, revolutionizing regenerative medicine. The MGH recognizes their contributions to unlocking new treatments for human diseases.
Researchers at Stanford University School of Medicine have identified over 2,000 genetic regions, called enhancers, that trigger gene expression in human embryonic stem cells. These enhancers play a crucial role in regulating cell-type-specific gene expression during early development.
Researchers successfully created complex, functioning intestinal tissue in a lab using pluripotent stem cells, opening doors to unprecedented studies of human intestinal development and disease. The breakthrough also paves the way for therapeutic applications, including transplantation and drug absorption.
Researchers at Georgetown University Medical Center have successfully turned human testes cells into insulin-producing islet cells, offering a potential new treatment for type 1 diabetes. The study used spermatogonial stem cells extracted from testicular tissue to produce insulin-secreting beta islet cells without the use of extra genes.
A Penn study found that HDAC enzymes are essential for proper skin formation and development. Inhibiting these enzymes may be able to shut down the growth of tumors resembling embryonic skin cells.
Researchers at Hebrew University found that induced pluripotent stem (iPS) cells undergo abnormal chromosomal changes, including trisomy and up-regulation of specific genes, which can lead to tumorigenic risk. This discovery hinders progress on using iPS cells in future therapy.
Researchers have identified the origin of olfactory ensheathing cells (OECs), which promote nerve repair in the central nervous system. OECs are derived from neural crest cells, which can be grown in large quantities from adult stem cells.
A fully defined culture system has been developed to grow human embryonic stem cells in the lab, reducing guesswork and increasing safety. The system uses a synthetic substrate and defined growth medium, allowing for up to three months of cell culture with minimal batch-to-batch variability.
Researchers found that adult cells from patients with Rett Syndrome could be transformed into induced pluripotent stem cells, which formed functional neurons in cell culture. However, these cells exhibited abnormalities that could be reversed by treating them with drugs, suggesting a potential therapeutic window before disease onset.
A team of researchers has generated 100 new lines of human induced pluripotent stem cells (iPSCs) from individuals with lung diseases, including cystic fibrosis and emphysema. The new stem cell lines could lead to new treatments for these debilitating diseases.
Researchers found that low-level lead exposure during gestation increases retinal progenitor cell proliferation and rod photoreceptor and bipolar cell neurogenesis in mice. This discovery could potentially treat retinal degenerations and blindness by transforming human embryonic retinal stem cells into neurons.
Researchers at UCSF are advancing human embryonic stem cell-based strategies to treat neurological diseases and liver failure. They will investigate novel strategies using embryonic neurons to inhibit hyperactivity in the nervous system and develop therapeutically effective liver cells from human embryonic stem cells.
Researchers found that sidestream smoke from harm reduction cigarettes impairs human embryonic stem cell growth more than conventional brand smoke. Studies used human embryonic stem cells to measure and compare the toxicity of mainstream and sidestream smoke.
A team of Singaporean scientists has made a major breakthrough by discovering the most important genes in human embryonic stem cells, which are crucial for treating debilitating conditions. The researchers identified a particular gene called PRDM14 that makes it easier to turn adult cells into pluripotent stem cells.
A novel protein called ORCA has been identified as crucial for the initiation of DNA replication and the organization of heterochromatin in mammalian cells. Its depletion leads to defects in cellular proliferation and cell cycle arrest, highlighting its critical role in controlling uncontrolled cell growth.
Menstrual blood-derived stem cells may aid in brain repair following stroke, with no risk of creating tumors. The study aims to advance the clinical application of self-donor cell therapy for stroke patients.
Researchers at McLean Hospital have been awarded a $1.9 million grant to continue their research into creating human induced pluripotent (iPS) stem cells using a method that eliminates cancer risks. The goal is to develop universal red blood cells and platelets for transfusion, eliminating immune rejection problems.
A new study reveals that mesenchymal stromal cells from wisdom teeth can be reprogrammed into stem cells, offering a potential source of treatment for patients. The cells displayed varying degrees of robustness and proliferated up to 100 times more efficiently than typical skin-cell-derived iPS cells.
The 2010 Balzan Prizewinners were announced in Milan for their groundbreaking work in European History, The History of Theatre, Stem Cells, and Mathematics. Carlo Ginzburg won for his work on European History, while Manfred Brauneck received the prize for The History of Theatre.
Researchers at UCLA found that female induced pluripotent stem cells (iPS) retain an inactive X chromosome, similar to most female human embryonic stem cells. This discovery has critical implications for studying X-linked diseases and could lead to a unique form of gene therapy.
Scientists have devised a method to coax mouse embryonic stem cells into forming highly specific motor neuron subtypes. This achievement may prove useful for future therapies for motor neuron diseases. The study provides new insight into motor neuron differentiation and demonstrates the ability to generate defined motor neuron subtypes.
The new journal aims to evaluate the safety and effectiveness of cell medicine in treating debilitating and fatal disorders. The journal features a diverse global editorial board and publishes papers on cell therapy with direct clinical relevance.