Articles tagged with Embryonic Stem Cells
Researchers at the Genome Institute of Singapore have identified the genetic molecule Tbx3, which significantly improves the quality of induced pluripotent stem cells (iPS cells). The study successfully produced iPS cells that can recapitulate entire developmental processes and exhibit superior ability for germ-line transmission.
Researchers found that microRNAs play a weak role in regulating mRNA stability in mouse oocytes lacking the Dicer enzyme. This suggests that reducing miRNA activity may be essential for oocyte-to-zygote transition, contributing to mRNA accumulation and stability.
Researchers created a comprehensive map of DNA methylation in human stem cells, identifying previously unknown patterns and associations between methylation and gene expression. The study provides a significant step towards understanding the regulation of cell differentiation and development.
Researchers created a detailed map of the human epigenome during embryonic development, identifying patterns of DNA methylation and its role in regulating gene expression. This breakthrough has significant implications for targeted differentiation of stem cells into specific organs, a crucial consideration for stem cell therapy.
Materials scientists at the University of Washington have developed a three-dimensional scaffold made from natural materials that mimic the binding sites for stem cells. Human embryonic stem cells grow and multiply readily on this structure, offering a clean and biodegradable alternative to traditional feeder layers.
Researchers have successfully developed a new stem cell treatment that can arrest acute lung injury in mice, paving the way for potential treatments of respiratory diseases. The experimental treatment uses transplantable lung cells derived from human embryonic stem cells and has shown promising results in tests on mice with damaged lungs.
Scientists discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system. Bone marrow cells fuse with embryonic stem cells, creating hybrid cells that can evade immune rejection without drugs.
Researchers at Yale University have discovered that stopping the expression of two genes Lin28 and Oct4 can reduce ovarian cancer cell growth and survival. This could lead to more effective treatments for this deadly form of cancer, which has a high recurrence rate and resistance to treatment.
Researchers at Stanford University School of Medicine have successfully converted mouse skin cells directly into functional nerve cells using just three genes. This breakthrough finding could revolutionize human stem cell therapy and change our understanding of cellular specialization.
Shinya Yamanaka has developed a method to reprogram adult skin cells into pluripotent stem cells, eliminating the need for embryos. This breakthrough will aid research into preventing birth defects and improving baby health.
The Coriell Institute for Medical Research will enhance its collection of carefully maintained human cell lines by adding induced pluripotent stem (iPS) cells carrying disease gene mutations. The addition will enable scientists to study a wide range of diseases and make the repository an even more valuable resource.
A study led by NYSCF Fellow Daylon James has generated a human embryonic stem cell line to measure and boost endothelial cell production, establishing a standard methodology for producing functional endothelial cells from hESCs. The cells can now be used for pre-clinical assessment of vascular disease in large animal models.
Researchers from Singapore's A*STAR report a novel transcription factor, Nr5a2, can replace classical reprogramming factors to increase iPS cell efficiency. This breakthrough has significant implications for cell-therapy-based medicine and the creation of organs for replacement or transplantation.
A team of scientists at Weill Cornell Medical College has developed a new approach to turn human embryonic and pluripotent stem cells into plentiful, functional endothelial cells, critical for blood vessel formation. This breakthrough technique boosts the efficiency of producing these cells by up to 40-fold.
Researchers have developed an efficient way to genetically modify human embryonic stem cells using bacterial artificial chromosomes, which can increase the yield by up to 20%. This approach enables the rapid development of stem cell lines that can serve as models for human genetic diseases and testbeds for potential treatments.
A protein complex called elongator may play a significant role in erasing epigenetic instructions on sperm DNA, enabling the formation of new embryos. This discovery could have implications for stem cell research and cancer treatment.
Researchers found that vitamin C accelerates gene expression changes and promotes efficient iPSC generation. The study suggests a simple way to improve iPSC production, which can be considered a reversal of the aging process at the cellular level.
Researchers have identified a critical component, Jarid2, of the delicate balancing act between stem cell specialization and cellular chaos. The study reveals how Jarid2 recruits PRC2 to genes important in differentiation and modulates its activity to keep it poised for action.
A University of Michigan research team analyzed 47 embryonic stem cell lines and found they lacked genetic diversity, with most derived from northern and western European ancestry. The lack of diversity raises concerns about unequal access to therapies for certain groups.
Researchers at the Broad Stem Cell Research Center found that tissue-specific genes are indeed marked by transcription factors, potentially crucial for stem cell function. The study suggests that faithful marking of these genes may be essential for pluripotency and efficient differentiation of stem cells.
Researchers discuss consent, privacy and clinical translation issues in iPS cell study. The emergence of iPS cells adds new challenges to the legal and social debates in stem-cell science.
A team of researchers has identified the Chd1 gene as a crucial regulator of open chromatin in embryonic stem cells, enabling their ability to differentiate into any cell type. The study provides important insights into the mechanisms of stem cell pluripotency and opens up new avenues for the development of stem cell therapies.
Scientists have discovered a new type of stem cell in the skin that acts like embryonic stem cells, generating various cell types and aiding in hair growth and wound healing. The dermal stem cells may hold the key to treating baldness and other neurological disorders.
Scientists have demonstrated that stem cells found in amniotic fluid can form three-dimensional aggregates of cells known as embryoid bodies, which suggests they may be useful for treating a wider array of diseases and conditions. The findings suggest that the amnion cells have greater potential than thought and may be able to form man...
Researchers at I-STEM Institute have made significant breakthrough in stem cell research by recreating a whole epidermis from human embryonic stem cells. The goal is to provide an unlimited resource of cells as an alternative treatment for victims of third-degree burns and patients with genetic diseases affecting the skin.
Researchers have successfully generated human epidermis from human embryonic stem cells, providing a potential unlimited resource for temporary skin replacement in patients with large burns. The skin substitute was shown to be functional and structurally consistent with human skin after just 12 weeks of grafting onto mice.
Researchers developed a protocol to direct the hepatic specification of ES cells using valproic acid and cytokines, resulting in functional hepatocytes. This study may aid hepatocyte transplantation and provide an in vitro model for understanding liver development.
Researchers from NC State University have identified a gene called FoxJ1 that tells embryonic stem cells in the brain when to stop producing nerve cells. This discovery advances understanding of the nervous system and its development, with potential applications for conditions like Parkinson's disease and Alzheimer's.
Researchers have detected distinct molecular disparities between induced pluripotent stem cells and their parental cells, including differences in epigenetic signatures. These findings provide new insights into the fundamental nature of stem cells and may inform therapeutic applications.
Researchers in Belgium successfully differentiated human embryonic stem cells (hESC) into major cell types of lung epithelial tissue using an air-liquid interface. The technique could provide an alternative to lung transplants for patients with chronic pulmonary disease and cystic fibrosis.
Researchers found that trophoblast stem cells (TSCs) can survive in female mice livers without ovarian hormones, but not in male liver's even after castration. This study suggests a new approach for therapeutic cell transplantation using TSCs.
Researchers at Stanford University School of Medicine have successfully turned human embryonic stem cells into precursors for sperm and eggs in the laboratory. This breakthrough could help unlock the mysteries of infertility, particularly in cases where an inability to produce eggs or sperm is the cause.
The National Institute of General Medical Sciences (NIGMS) is accelerating basic studies of induced pluripotent stem cells (iPS) using $5.4 million in Recovery Act funding. Scientists at 16 institutions will investigate iPS cell properties and derivatives for therapeutic applications.
Researchers have successfully transformed human embryonic stem cells into germ cells, a breakthrough that could help identify causes of unexplained infertility and birth defects. The discovery opens new avenues for research and may lead to the development of diagnostic tools to pinpoint genetic changes underlying infertility.
Researchers transform adult eye cells into artificial stem cells without introducing foreign genetic materials, offering a promising approach to treat degenerative diseases such as Parkinson's and heart disease. This technique could facilitate autologous cell transplantation, bypassing ethical concerns with embryonic stem cells.
Embryonic stem cells exhibit sensitivity to localized cyclic forces due to their softness, affecting gene expression and differentiation. The study suggests that applying controlled mechanical forces could be a new method for directing cell behavior, with implications for therapeutic cloning and regenerative medicine.
The company has developed a 2-week method for generating human induced-pluripotent stem cells with a 200-fold increase in yield. This breakthrough has broad implications for pharmaceutical-grade iPSCs production without genetic modification at commercial scale.
Scripps Research scientists have made a breakthrough in creating stem cells from adult human tissue using three small drug-like chemicals. The new technique is 200 times more efficient and twice as fast than conventional methods, solving two major challenges in the development of stem-cell-based medicine.
Researchers at the Salk Institute provide the first detailed map of the human epigenome, which regulates gene function beyond DNA sequence. The study reveals a novel DNA methylation pattern unique to stem cells, influencing their pluripotent state and disease development.
Researchers at Duke University have successfully grown a three-dimensional 'patch' of heart muscle cells using embryonic stem cells and a novel mold design. The patch exhibited the ability to contract and conduct electrical impulses, crucial attributes of native heart muscle cells.
Researchers have successfully reprogrammed human umbilical cord blood cells into cells with properties similar to human embryonic stem cells. This breakthrough identifies cord blood as a potential alternative to adult cells for generating cells with theoretically limitless potential.
Researchers at the Salk Institute have successfully reprogrammed umbilical cord blood cells to function like embryonic stem cells, creating a potential source for patient-specific stem cells. The new method reduces the need for expensive and time-consuming genetic modifications, making it a safer alternative for clinical applications.
Researchers successfully preserved retina structure and function in animal model of retinal degeneration using human embryonic stem cell-derived pigment-containing visual cells. The study promotes potential future use of cell replacement therapies to treat devastating eye diseases.
University of Michigan researchers have successfully induced embryonic stem cells to differentiate into parathyroid cells producing a hormone essential for maintaining bone density. The goal is to prevent osteomalacia, a severe form of bone loss affecting tens of thousands in the US.
A new study resolves the mystery of Merkel cell development, finding that they originate from the embryonic epidermis. Adult skin stem cells also replenish the Merkel cell population as they die off over time.
Scientists create induced pluripotent stem cells from human neural stem cells using a footprint-free methodology, retaining some gene expression of the original donor cells. The study reveals that these cells maintain a 'transcriptional signature' similar to human embryonic stem cells.
Blood vessels can spur their own growth and deliver oxygen to tissues and tumors through internal cues. The study found that a protein called Flt-1 plays a key role in regulating this process.
A University of Wisconsin-Madison team successfully grew multiple types of retina cells from two types of stem cells, suggesting a potential future in repairing damaged retinas. The discovery will also lead to laboratory models for studying genetically linked eye conditions and screening new drugs.
Researchers have successfully modified a human embryonic stem cell line to glow red when it becomes a red blood cell, representing a significant step towards generating mature red blood cells from human stem cells. This breakthrough could aid in tracking the differentiation of embryonic stem cells into specific cell types.
Researchers from the University of Cambridge have identified a critical protein called Nanog that plays a pivotal role in creating pluripotent cells. By understanding how Nanog influences other molecules, scientists hope to develop more efficient and safe methods for harnessing stem cells for medical applications.
Researchers have developed a new technique to efficiently edit genes in human embryonic stem cells, enabling the creation of specific cell types for modeling genetic diseases. The method uses zinc finger nucleases to cut out one gene and substitute it with another, allowing precise control over gene expression.
Researchers have successfully created various types of mature white blood cells from embryonic and adult stem cells, opening up new possibilities for studying disease development and treatment. The technique could produce cells tailored to specific infections or tumors, making it a potential tool for safety screening of new drugs.
A study by researchers at the Salk Institute has found that tumor suppressor p53 plays a crucial role in controlling somatic cell reprogramming. The study showed that p53 activation prevents cells from reverting back to a less specialized state, which could have implications for cancer development and pluripotent stem cell technology.
Only two human embryonic stem cell lines, H1 and H9, have been used routinely in research, with the majority of requests coming from these lines. This finding raises concerns about the impact on future research and the need for a more diverse range of cell lines.
A team at WPI and CellThera has discovered a novel method to turn on stem cell genes in human fibroblasts by manipulating culture conditions. This breakthrough could lead to treatments for human diseases and traumatic injuries by coaxing patient cells to repair and regenerate damaged tissues.
Scientists at University of Illinois successfully convert spermatogonial stem cells into prostate, skin and uterus epithelium using mesenchyme interaction. The approach may provide an alternative to embryonic stem cell use.
Scientists have reprogrammed mouse fibroblasts to create whole mice using tetraploid complementation, a significant advancement in understanding induced pluripotent stem cells. This achievement offers hope for overcoming embryo destruction in pluripotent cell derivation and potentially revolutionizing regenerative medicine.
The sea lamprey's genome is extensively reorganized during development, with growing embryos discarding millions of units of DNA. This process reveals a dynamic and flexible genome that challenges traditional views on vertebrate genome stability.
Researchers at Cincinnati Children's Hospital Medical Center have identified a master regulator gene for early embryonic development of the pancreas and other organs. The study reveals that Sox17 acts like a toggle or binary switch, instructing cells to become either pancreatic or part of the biliary system.
Researchers at UT Southwestern Medical Center have discovered a gene that activates in mouse embryonic stem cells, allowing them to grow and divide rapidly in the lab. This breakthrough could enable scientists to maintain ES cells from other species, leading to new discoveries in medical research.