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Scientists discover new '3D genome organizer' linked to fertility and cancer

A new '3D genome organizer' has been discovered, crucial for sperm production in mice, and highly expressed in human immune cells and blood cancers. Blocking this complex may slow cancer growth and lead to new infertility treatments.

SourceInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University·JournalNature Structural & Molecular Biology·TypeExperimental study·DateAug 25, 2025
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Recapitulating egg and sperm development in the dish

Researchers at Wyss Institute develop in vitro method to induce meiosis in human cells, enabling replication of critical step in egg and sperm cell development. The breakthrough could lead to modeling defects and creating healthy gametes for individuals with infertility.

SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalScience Advances·TypeExperimental study·DateAug 15, 2025

Bar-Ilan University researchers produce “laboratory testicles”

The team successfully created 'laboratory testicles' that closely simulate a natural testicle, allowing for the potential production of sperm cells in the lab. The artificial testicles were cultured from immature testicular cells sampled from neonatal mice and showed signs of meiosis, a process in which gametes are produced.

SourceBar-Ilan University·JournalInternational Journal of Biological Sciences·DateFeb 20, 2024

Rewiring blood cells to give rise to precursors of sperm

Scientists have successfully transformed blood cells into sperm precursors in marmoset embryos using a step-by-step process. The study, published in eLife, opens up new avenues for studying primate biology and developing novel assisted reproductive technologies.

SourceUniversity of Pennsylvania·JournaleLife·TypeExperimental study·DateFeb 21, 2023
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