Glioblastoma Cells

Study finds cancer location determines how testosterone regulates tumor growth

Brown Health researchers identify key molecule behind 'exceptional responders' with glioblastoma

Researchers discovered a powerful molecule called miR-181d that weaks tumors and helps the immune system fight back against glioblastoma. The study found that tumors in 'exceptional responders' contain higher levels of miR-181d, which blocks cancer cells' ability to repair DNA damage.

Study reveals dynamic interactions between brain tumors and immune cells

Researchers at DZNE discovered complex, situation-dependent interactions between glioblastoma cells and microglia in the brain. The study found that microglial activity changes as tumors spread, influencing containment and spread of the disease.

Virus-based therapy boosts anti-cancer immune responses to brain cancer

A single injection of an oncolytic virus recruits immune cells to penetrate and persist deep within brain tumors, inducing long-term infiltration of immune T cells. This therapy expands pre-existing T cells in the brain, leading to a therapeutic benefit for patients with glioblastoma.

A bioadhesive patch inspired by mussel adhesion eliminates cells from the most aggressive brain tumor

A bioadhesive patch inspired by mussel adhesion has been developed to eliminate glioblastoma cells. The patch targets remaining cancer cells after surgery, inducing cell death through oxidative stress.

Scientists ID potential treatment for deadliest brain cancer

Researchers at the University of Virginia Health System have identified a molecule that blocks the gene responsible for glioblastoma, a fast-growing and deadly brain cancer. The compound shows promise in preventing the invasive cancer from spreading through the brain without causing harm to healthy tissue.

Taming tumor chaos: Brown University Health researchers uncover key to improving glioblastoma treatment

Researchers identified a crucial factor that may help improve treatment for glioblastoma, one of the most aggressive and common forms of adult brain cancer. They discovered a small molecule called miR-181d acts like a master switch that controls how much MGMT is produced by each glioblastoma cell.

Canadian scientists uncover hidden cells fueling brain cancer — and a drug that could stop them

Researchers discovered that certain brain cells support glioblastoma growth by sending signals that strengthen the tumour. Blocking this communication slowed the cancer's growth significantly, suggesting an existing HIV medication could be repurposed to treat glioblastoma.

Customized cells to fight brain cancer

Researchers at UNIGE and HUG have developed CAR-T cells capable of destroying glioblastoma cells by targeting specific proteins present in the tumour environment. The new approach has shown promising results in animal models, paving the way for clinical trials in humans.

National Cancer Institute grants support efforts to understand how fluid flow drives deadly brain cancer

Researchers at Virginia Tech's Fralin Biomedical Research Institute are studying how fluid flow contributes to the spread of glioblastoma tumors. They will use focused ultrasound and advanced MRI techniques to build a map of fluid flow in the whole brain and test the effectiveness of drug delivery.

Repeated brain tumor sampling uncovers treatment response in patients with glioblastoma

A multi-institutional study found that serially testing tumor samples can detect immune system activation in recurrent glioblastoma even when traditional imaging measures cannot. The researchers used multi-omic analysis and integrated data from various sources to show positive changes in the tumor microenvironment over time.

AI distinguishes glioblastoma from look-alike cancers during surgery

A Harvard Medical School-led research team developed an AI tool called PICTURE that can reliably tell apart glioblastoma and primary central nervous system lymphoma during surgery. The tool distinguishes between the two cancers with near-perfect accuracy, reducing errors in diagnosis and guiding critical treatment decisions.

Glioblastoma cells “unstick” from their neighbors to become more deadly

Researchers found that glioblastoma cells in clusters are less deadly than those that disperse from these clusters. The dispersed cells are more plastic and resistant to therapy, making them a major contributor to treatment resistance and poor patient outcomes.

Identifying the Interactions That Drive Cell Migration in Brain Cancer

A team of Japanese researchers has identified shootin1b as a protein that promotes cell migration in glioblastoma, the most common and difficult-to-treat brain tumor. By suppressing abnormal activity of shootin1b, the study suggests a potential target for preventing glioblastoma spread.

Brain cancer cells can be ‘reprogrammed’ to stop them from spreading

Scientists have found a way to stop brain cancer cells from spreading by 'freezing' hyaluronic acid molecules in place. This approach could lead to a new type of treatment for glioblastoma, the most aggressive form of brain cancer.

Gene networks decode human brain architecture from health to glioma

Gene coexpression analysis reveals optimal markers of cell types and states, providing opportunities for developing novel biomarkers and targeted treatment strategies for glioma patients. Dr. Oldham's work tackles the reproducibility crisis in science, emphasizing data metadata standardization.

MD Anderson Research Highlights for June 11, 2025

Researchers at MD Anderson have made significant progress in treating non-small cell lung cancer (NSCLC) by combining chemotherapy, immunotherapy, and surgery. They found that pre-surgical combination therapy showed promising results, with high rates of pathological complete response and major pathological response.

Terasaki Institute researchers develop a 3D microphysiological system modeling pericyte-induced chemoresistance in glioblastoma

Scientists at Terasaki Institute engineer a novel 3D glioblastoma model that mimics brain tissue and pericyte role, showing increased resistance to chemotherapy. The model increases sensitivity of GBM cell lines to TMZ by 22-32%.

New compound targets circadian clock machinery in cells to fight glioblastoma

Researchers have developed a new compound, SHP1705, that selectively attacks glioblastoma stem cells by hijacked circadian clock proteins. The compound was found to be safe and well-tolerated in humans during a phase 1 clinical trial.

UT Health San Antonio-led research discovers a way to slow or block recurrence of glioblastoma

Researchers at UT Health San Antonio have discovered a way to delay or even block recurrence of the deadliest brain cancer after radiation by targeting senescent cells with experimental 'senolytic' drugs. This approach shows promise in preventing tumor growth and improving patient survival.

Treatment strategy reprograms brain cancer cells, halting tumor growth

Researchers combine radiation with a plant-derived compound to combat glioblastoma, forcing cancer cells into a dormant state. The approach significantly slows tumor growth and improves survival in mice models, offering a potential new avenue for combating this deadly form of brain cancer.

Tumor-secreted protein may hold the key to better treatments for deadly brain tumor, study finds

A study suggests targeting endocan, a protein produced by endothelial cells in blood vessels, could slow tumor growth and make glioblastoma more vulnerable to existing treatments. The discovery may lead to new strategies to combat glioblastoma, which has an average lifespan of just 12-15 months.

Glioblastoma: A mechanism that helps tumor cells multiply discovered

Research discovered that chloride ion channels play a role in glioblastoma cell division and proliferation. By blocking these channels, replication can be stopped, pointing to ion currents as a potential target for therapeutic approaches.

Circular peptides in violets may aid in the fight against glioblastoma

Scientists at Brain Chemistry Labs discovered a promising compound called kalata B1 from violets that enhances the activity of chemotherapy TMZ against glioblastoma cells. The synthetic version of kalata B1 showed equal efficacy to the natural molecule, offering a potential new treatment option for patients.

Researchers develop promising therapy treatment that can kill glioblastoma cells in newly discovered brain pathway

A new pathway used by cancer cells to infiltrate the brain has been discovered, offering hope for glioblastoma treatment. Researchers developed a CAR T cell therapy targeting this pathway, showing promise in blocking and killing tumor cells.

Using AI, USC researchers pioneer a potential new immunotherapy approach for treating glioblastoma

Scientists used AI to identify genes that can convert brain cancer cells into immune cells, increasing survival chances by up to 75% in mouse models. The approach bypasses the blood-brain barrier, offering new hope for aggressive cancers.

Nanosurgical tool could be key to cancer breakthrough

Researchers have developed a nanosurgical tool that enables them to study individual living cancer cells in real-time, allowing for vital understanding of how they react to treatment and change over time. This breakthrough could lead to more effective cancer medication, particularly for glioblastoma, the deadliest form of brain tumour.

ATR inhibition using gartisertib in patient-derived glioblastoma cell lines

Researchers identified gartisertib as a potent ATR inhibitor that enhances cell death in patient-derived glioblastoma cell lines. The study also showed synergy between gartisertib and TMZ+RT treatment, with higher sensitivity to gartisertib observed in MGMT promoter unmethylated cells.

Understudied cell in the brain could be key to treating glioblastoma

A new study found that perivascular fibroblasts support the creation of an immunosuppressive tumor microenvironment, allowing glioblastoma to evade the immune system. The fibroblasts may also promote stem-like cancer cells that rarely divide, leading to poor survival outcomes.

Discovery of protein-protein interaction lays foundation for future glioblastoma therapy

Researchers at The Hospital for Sick Children have discovered a designer peptide that targets a previously unknown protein-protein interaction in glioblastoma cells, resulting in the death of tumor cells across all subtypes. The treatment approach showed robust therapeutic efficacy and no side effects in preclinical models.

Cancerous brain tumor cells may be at ‘critical point’ between order and disorder, study suggests

Research suggests that glioblastoma cells possess large-scale coordination, allowing them to respond unison to therapies. Disrupting this organization may result in more powerful treatments for brain tumors.

New research may hold key to better treatments for aggressive brain cancer

A team of researchers has discovered that a naturally produced chemical in the body helps glioblastoma cells go unrecognized by the immune system. The findings could lead to the development of new and more effective treatments for this aggressive brain cancer.

Researchers identify two compounds capable of inhibiting growth of brain tumor cells

Two compounds, A5 and C1, have shown promising results in inhibiting the growth of glioblastoma cells, a type of aggressive brain cancer. Further research is needed to confirm their effectiveness on normal nerve cells and to move towards clinical trials.

Pusan National University researchers identify therapeutic targets to overcome radioresistance of brain cancer cells

A team of researchers from Korea and USA identified the importance of lipid homeostasis in overcoming brain cancer radioresistance. They found that regulating diacylglycerol kinase B and diacylglycerol acyltransferase 1 could potentially sensitize brain cancer cells to radiotherapy, offering a new treatment strategy.

Cracking the mystery behind a deadly brain cancer

A team of researchers from Cold Spring Harbor Laboratory has made a breakthrough in understanding the deadly brain cancer glioblastoma. By linking the BRD8 protein to another key protein, P53, they have identified a potential target for new treatments that could extend patient survival and improve outcomes.

Federated machine learning enables the largest brain tumor study to-date, without sharing patient data

A massive collaborative study using federated learning developed a model that enhances identification and prediction of boundaries in three tumor sub-compartments without compromising patient privacy. The dataset, comprising 6,314 glioblastoma patients from 71 sites globally, is the largest and most diverse ever considered.

New method eradicates deadly brain tumors by ‘starving’ them of energy source

Researchers at Tel Aviv University develop a groundbreaking method to eradicate glioblastoma brain tumors by targeting astrocytes and starving them of energy. The study found that in the absence of these brain cells, tumor cells die and are eliminated, offering a promising basis for developing effective medications.

Treatment which ‘switches off’ cancer cells and limits tumour growth, could make aggressive brain tumour easier to treat

Researchers have discovered a potential new treatment for glioblastoma, which targets 'kinase' proteins to limit tumour growth and improve existing chemotherapeutic drugs. This breakthrough therapy may provide hope for patients with aggressive brain tumours, offering a more effective and sustainable approach to treatment.

Houston Methodist researchers identify an immunotherapy target to combat glioblastomas

Glioblastomas, the deadliest brain cancer, have evaded immune cells by promoting immunosuppressive myeloid cells. Researchers identified S100A4 as a key molecule that can selectively target these immune suppressive cells. This discovery paves the way for new therapeutic strategies to restore antitumor action in glioblastoma patients.

Triggering cellular apoptosis by optical targeting

Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.

Scientists identified a gene mechanism probably suspending the development of a malignant brain tumor

Researchers found that the Klotho gene can suppress glioblastoma cell viability and induce apoptosis, leading to a significant decrease in tumor growth. The study contributes to the development of new diagnostic and treatment approaches for malignant brain tumors.

CBD reduces glioblastoma’s size, supportive environment in experimental model

Researchers found that CBD shrinks glioblastoma tumors by reducing inflammation and restoring immune balance. The compound also suppresses key proteins involved in tumor growth and spread, making it a potential novel adjunct therapy for glioblastoma patients.

First 3D-bioprinting of entire active tumor

Researchers at Tel Aviv University successfully printed the first entirely active and viable glioblastoma tumor using a 3D printer. The 3D-bioprinted model includes functional blood vessels that simulate a real tumor, making it a promising tool for predicting treatment efficacy and drug development.

Microglia, Stockholm syndrome and miraculous cures in glioblastoma patients

Researchers at the University of Minnesota identified a new drug target for glioblastoma patients who defy conventional wisdom by surviving beyond expectations. Glioblastoma cells subvert immune system cells called microglia and macrophages, leading to tumor growth.

Researchers link cellular transport pathway to aggressive brain cancer

Researchers at McGill University identified a new cellular pathway controlling cell surface receptor proteins that limits brain tumor growth and spread. Restoring the activity of Rab35, a protein involved in this pathway, may be a new therapeutic strategy for glioblastoma.

Novel RNA factors may help cancer cells thrive

Researchers identified a circular RNA, circ2082, and an RNA-binding protein, RBM3, that form a complex with the enzyme DICER to disrupt microRNAome regulation in glioblastoma cells. This leads to increased survival rates in mice and longer lifespans in human patients with circ2082-dependent signatures.

Anti-diarrhoea drug drives cancer cells to cell death

Researchers found that loperamide triggers autophagic cell death in glioblastoma cells by inducing ER stress, opening new avenues for treatment strategies. The mechanism may also be applicable to other diseases where ER degradation is disrupted.

Cancer-killing T cells 'swarm' to tumors, attracting others to the fight

Researchers discovered that immune system T cells can home-in on tumor cells independently of intermediary immune cells and release chemical signals that attract more T cells. This 'swarming' behavior could help develop new cancer therapies targeting solid tumors, currently less responsive to immunotherapies.

Molecules responsible for radio-resistant glioblastoma identified

Glioblastoma multiforme is the most aggressive brain cancer with low five-year survival rate due to rapid development of radioresistance. Researchers from Hokkaido University and Stanford University identified Rab27b and epiregulin as key molecules contributing to radioresistance.

Unexpected associations found between drug response and cell changes in brain cancer

Researchers at Uppsala University have discovered new ways to combine drugs for glioblastoma patients, tailoring therapy to individual tumours. The study characterised how genetic aberrations influence drug effectiveness, revealing two main subgroups based on response and mutations.

New imaging technique enables the study of 3D printed brain tumors

A new imaging technique allows researchers to study 3D printed brain tumors in unprecedented detail, revealing how treatments affect complex tumor cells. This method provides a more accurate evaluation of drug effectiveness than traditional methods, which could lead to improved treatment outcomes for patients with glioblastomas.

Texas A&M CVM study finds new pathway for potential glioblastoma treatment

Researchers at Texas A&M University have found that the AH receptor can actually block invasion of glioblastoma cells, rather than promoting it. Adding certain ligands to the receptor has been shown to inhibit cell invasion and provide additional protection to the brain.

Single-cell sequencing reveals glioblastoma's shape-shifting nature

A recent study using single-cell sequencing has revealed that glioblastoma, a deadly brain cancer, can shift among four distinct cell types, each requiring separate targeted therapy. The findings indicate a need for combination treatments and provide new insights into the cancer's plastic nature.

Cancer cells are quick-change artists adapting to their environment

Researchers found cancer stem cells can change surface markers in response to environmental stressors, making targeted therapies less effective. The study's findings could lead to more optimized treatments by understanding how tumor cells adapt to their microenvironment.

Researchers discover the Achilles' heel of an aggressive brain cancer

Researchers at University of Helsinki found that MDGI protein plays a key role in regulating lysosomal membrane stability. Inhibiting this protein causes glioblastoma cell death, particularly with antihistamine clemastine, which can cross the blood-brain barrier.

Researchers unlock secret of deadly brain cancer's 'immortality'

A study at UCSF discovered how a mutation in the TERT promoter gene confers immortality on tumor cells, enabling their aggressive growth. Eliminating a specific protein subunit using CRISPR-based gene editing slowed cancer cell growth.

Dying cancer cells make remaining glioblastoma cells more aggressive and therapy-resistant

A recent study reveals that dying glioblastoma cells can communicate with remaining tumor cells through extracellular vesicles, increasing aggressiveness and therapy resistance. This mechanism may provide a new target for novel cancer therapies to treat glioblastoma and potentially other cancer types.

Researchers find new target on lethal brain tumor that can be hunted by immune cells

A team of researchers has genetically engineered cancer-killing immune cells to hunt brain tumors displaying CSPG4, a highly prevalent molecular target. The approach holds promise for controlling tumor growth in glioblastoma patients, who currently have limited treatment options with survival benefits of less than a year and a half.

Zika virus could help combat brain cancer

Researchers found that Zika virus infection causes death of glioblastoma cells, a common and aggressive type of brain tumor. The study suggests that genetically modifying Zika virus to produce the digoxin molecule could be an alternative treatment for glioblastoma.

Texas A&M research shows biological clocks could improve brain cancer treatment

Glioblastoma, a type of brain cancer with a grim prognosis, may be treatable more effectively when administered at specific times of day. Researchers found that the circadian rhythm controls daily rhythms in a key protein associated with tumor growth, and inhibiting its activity can reduce invasive properties.