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Nanobody-based 3D immunohistochemistry allows rapid visualization in thick tissue samples

Researchers have developed a new 3D-IHC technique that improves the speed, depth, and sensitivity of immunolabeling in thick tissue samples using nanobodies fused with peroxidase. The method enables ultra-fast and high-resolution mapping of neurons and glia in 1-mm-thick brain tissues.

SourceJuntendo University Research Promotion Center·JournalCommunications Biology·TypeExperimental study·DateJun 19, 2025

Expression of carbonic anhydrase IX as a novel diagnostic marker for differentiating pleural mesothelioma from non-small cell lung carcinoma

This study investigates the use of carbonic anhydrase IX (CAIX) as a diagnostic marker for distinguishing pleural mesothelioma from non-small cell lung carcinoma (NSCLC). CAIX expression is found to be highly sensitive and specific in detecting pleural epithelioid mesothelioma, comparable to or better than existing mesothelial markers.

SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Pathology·DateOct 26, 2024